Putative DNA replication licensing factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM8 - putative

Species:

Leishmania infantum

UniProt:

A4HSF2_LEIIN

TriTrypDb:

LINF_050008300

Length:

997

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0042555	MCM complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0032392	DNA geometric change	7	7
GO:0032508	DNA duplex unwinding	8	7
GO:0051276	chromosome organization	5	7
GO:0071103	DNA conformation change	6	7
GO:0071840	cellular component organization or biogenesis	2	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.448
CLV_NRD_NRD_1	167	169	PF00675	0.559
CLV_NRD_NRD_1	181	183	PF00675	0.577
CLV_NRD_NRD_1	207	209	PF00675	0.487
CLV_NRD_NRD_1	389	391	PF00675	0.497
CLV_NRD_NRD_1	432	434	PF00675	0.641
CLV_NRD_NRD_1	710	712	PF00675	0.313
CLV_NRD_NRD_1	757	759	PF00675	0.653
CLV_NRD_NRD_1	925	927	PF00675	0.683
CLV_PCSK_KEX2_1	180	182	PF00082	0.633
CLV_PCSK_KEX2_1	207	209	PF00082	0.487
CLV_PCSK_KEX2_1	389	391	PF00082	0.497
CLV_PCSK_KEX2_1	432	434	PF00082	0.641
CLV_PCSK_KEX2_1	757	759	PF00082	0.653
CLV_PCSK_KEX2_1	925	927	PF00082	0.683
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.604
CLV_PCSK_SKI1_1	140	144	PF00082	0.442
CLV_PCSK_SKI1_1	218	222	PF00082	0.632
CLV_PCSK_SKI1_1	233	237	PF00082	0.234
CLV_PCSK_SKI1_1	566	570	PF00082	0.378
CLV_PCSK_SKI1_1	614	618	PF00082	0.285
CLV_PCSK_SKI1_1	669	673	PF00082	0.293
CLV_PCSK_SKI1_1	790	794	PF00082	0.401
CLV_PCSK_SKI1_1	926	930	PF00082	0.557
DEG_APCC_DBOX_1	938	946	PF00400	0.569
DEG_SCF_TRCP1_1	847	852	PF00400	0.653
DEG_SPOP_SBC_1	620	624	PF00917	0.578
DOC_ANK_TNKS_1	180	187	PF00023	0.630
DOC_ANK_TNKS_1	3	10	PF00023	0.700
DOC_ANK_TNKS_1	475	482	PF00023	0.708
DOC_CKS1_1	105	110	PF01111	0.661
DOC_CYCLIN_RxL_1	787	797	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.362
DOC_MAPK_MEF2A_6	566	573	PF00069	0.493
DOC_MAPK_MEF2A_6	586	593	PF00069	0.383
DOC_MAPK_NFAT4_5	566	574	PF00069	0.578
DOC_PP1_RVXF_1	518	524	PF00149	0.646
DOC_PP1_RVXF_1	788	795	PF00149	0.391
DOC_PP2B_LxvP_1	366	369	PF13499	0.399
DOC_PP2B_LxvP_1	783	786	PF13499	0.571
DOC_PP4_FxxP_1	689	692	PF00568	0.493
DOC_SPAK_OSR1_1	727	731	PF12202	0.468
DOC_USP7_MATH_1	211	215	PF00917	0.441
DOC_USP7_MATH_1	22	26	PF00917	0.543
DOC_USP7_MATH_1	279	283	PF00917	0.578
DOC_USP7_MATH_1	321	325	PF00917	0.613
DOC_USP7_MATH_1	345	349	PF00917	0.626
DOC_USP7_MATH_1	408	412	PF00917	0.525
DOC_USP7_MATH_1	507	511	PF00917	0.664
DOC_USP7_MATH_1	514	518	PF00917	0.660
DOC_USP7_MATH_1	519	523	PF00917	0.580
DOC_USP7_MATH_1	620	624	PF00917	0.571
DOC_USP7_MATH_1	710	714	PF00917	0.507
DOC_USP7_MATH_1	833	837	PF00917	0.659
DOC_USP7_MATH_1	914	918	PF00917	0.714
DOC_USP7_UBL2_3	987	991	PF12436	0.542
DOC_WW_Pin1_4	104	109	PF00397	0.643
DOC_WW_Pin1_4	190	195	PF00397	0.675
DOC_WW_Pin1_4	218	223	PF00397	0.619
DOC_WW_Pin1_4	242	247	PF00397	0.493
DOC_WW_Pin1_4	288	293	PF00397	0.535
DOC_WW_Pin1_4	316	321	PF00397	0.489
DOC_WW_Pin1_4	39	44	PF00397	0.580
DOC_WW_Pin1_4	418	423	PF00397	0.665
DOC_WW_Pin1_4	718	723	PF00397	0.493
DOC_WW_Pin1_4	864	869	PF00397	0.485
LIG_14-3-3_CanoR_1	168	177	PF00244	0.567
LIG_14-3-3_CanoR_1	248	256	PF00244	0.576
LIG_14-3-3_CanoR_1	407	413	PF00244	0.584
LIG_14-3-3_CanoR_1	49	55	PF00244	0.468
LIG_14-3-3_CanoR_1	520	530	PF00244	0.669
LIG_14-3-3_CanoR_1	550	556	PF00244	0.493
LIG_14-3-3_CanoR_1	711	715	PF00244	0.513
LIG_BRCT_BRCA1_1	523	527	PF00533	0.587
LIG_CtBP_PxDLS_1	561	566	PF00389	0.493
LIG_deltaCOP1_diTrp_1	29	36	PF00928	0.531
LIG_EH1_1	147	155	PF00400	0.329
LIG_EH1_1	96	104	PF00400	0.494
LIG_eIF4E_1	148	154	PF01652	0.331
LIG_FHA_1	139	145	PF00498	0.564
LIG_FHA_1	49	55	PF00498	0.468
LIG_FHA_1	550	556	PF00498	0.504
LIG_FHA_1	627	633	PF00498	0.498
LIG_FHA_1	677	683	PF00498	0.582
LIG_FHA_1	693	699	PF00498	0.417
LIG_FHA_1	747	753	PF00498	0.493
LIG_FHA_1	93	99	PF00498	0.556
LIG_FHA_2	219	225	PF00498	0.459
LIG_FHA_2	266	272	PF00498	0.491
LIG_FHA_2	310	316	PF00498	0.578
LIG_FHA_2	373	379	PF00498	0.417
LIG_FHA_2	55	61	PF00498	0.604
LIG_FHA_2	639	645	PF00498	0.493
LIG_FHA_2	654	660	PF00498	0.493
LIG_FHA_2	724	730	PF00498	0.448
LIG_FHA_2	889	895	PF00498	0.493
LIG_Integrin_RGD_1	476	478	PF01839	0.715
LIG_LIR_Apic_2	275	279	PF02991	0.578
LIG_LIR_Gen_1	145	156	PF02991	0.426
LIG_LIR_Gen_1	221	231	PF02991	0.331
LIG_LIR_Gen_1	57	66	PF02991	0.444
LIG_LIR_Gen_1	726	734	PF02991	0.493
LIG_LIR_Gen_1	91	102	PF02991	0.532
LIG_LIR_Nem_3	145	151	PF02991	0.428
LIG_LIR_Nem_3	155	160	PF02991	0.374
LIG_LIR_Nem_3	221	226	PF02991	0.452
LIG_LIR_Nem_3	57	62	PF02991	0.452
LIG_LIR_Nem_3	726	731	PF02991	0.493
LIG_LIR_Nem_3	908	912	PF02991	0.488
LIG_LIR_Nem_3	91	97	PF02991	0.563
LIG_PALB2_WD40_1	543	551	PF16756	0.493
LIG_Pex14_1	161	165	PF04695	0.427
LIG_Pex14_2	157	161	PF04695	0.401
LIG_Pex14_2	523	527	PF04695	0.587
LIG_SH2_CRK	210	214	PF00017	0.450
LIG_SH2_NCK_1	210	214	PF00017	0.450
LIG_SH2_PTP2	148	151	PF00017	0.339
LIG_SH2_STAP1	50	54	PF00017	0.591
LIG_SH2_STAP1	897	901	PF00017	0.493
LIG_SH2_STAT3	815	818	PF00017	0.437
LIG_SH2_STAT3	897	900	PF00017	0.493
LIG_SH2_STAT5	148	151	PF00017	0.339
LIG_SH2_STAT5	50	53	PF00017	0.472
LIG_SH2_STAT5	815	818	PF00017	0.437
LIG_SH2_STAT5	870	873	PF00017	0.493
LIG_SH2_STAT5	992	995	PF00017	0.395
LIG_SH3_2	105	110	PF14604	0.722
LIG_SH3_3	102	108	PF00018	0.671
LIG_SH3_3	317	323	PF00018	0.513
LIG_SH3_3	58	64	PF00018	0.441
LIG_SH3_3	591	597	PF00018	0.497
LIG_SH3_3	848	854	PF00018	0.646
LIG_SUMO_SIM_par_1	149	155	PF11976	0.390
LIG_SUMO_SIM_par_1	360	365	PF11976	0.443
LIG_SUMO_SIM_par_1	590	596	PF11976	0.493
LIG_SUMO_SIM_par_1	670	676	PF11976	0.493
LIG_SUMO_SIM_par_1	72	78	PF11976	0.715
LIG_SUMO_SIM_par_1	958	965	PF11976	0.529
LIG_TRAF2_1	531	534	PF00917	0.466
LIG_UBA3_1	559	566	PF00899	0.493
LIG_WRC_WIRS_1	906	911	PF05994	0.458
MOD_CDC14_SPxK_1	245	248	PF00782	0.493
MOD_CDK_SPK_2	864	869	PF00069	0.493
MOD_CDK_SPxK_1	104	110	PF00069	0.652
MOD_CDK_SPxK_1	242	248	PF00069	0.493
MOD_CK1_1	198	204	PF00069	0.624
MOD_CK1_1	319	325	PF00069	0.791
MOD_CK1_1	327	333	PF00069	0.671
MOD_CK1_1	411	417	PF00069	0.583
MOD_CK1_1	418	424	PF00069	0.573
MOD_CK1_1	510	516	PF00069	0.629
MOD_CK1_1	522	528	PF00069	0.528
MOD_CK1_1	638	644	PF00069	0.493
MOD_CK2_1	149	155	PF00069	0.327
MOD_CK2_1	528	534	PF00069	0.477
MOD_CK2_1	54	60	PF00069	0.600
MOD_CK2_1	638	644	PF00069	0.493
MOD_Cter_Amidation	178	181	PF01082	0.594
MOD_Cter_Amidation	923	926	PF01082	0.746
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.677
MOD_GlcNHglycan	14	17	PF01048	0.608
MOD_GlcNHglycan	197	200	PF01048	0.738
MOD_GlcNHglycan	213	216	PF01048	0.367
MOD_GlcNHglycan	24	27	PF01048	0.501
MOD_GlcNHglycan	281	284	PF01048	0.378
MOD_GlcNHglycan	323	326	PF01048	0.695
MOD_GlcNHglycan	329	332	PF01048	0.739
MOD_GlcNHglycan	354	357	PF01048	0.587
MOD_GlcNHglycan	416	420	PF01048	0.627
MOD_GlcNHglycan	440	443	PF01048	0.653
MOD_GlcNHglycan	509	512	PF01048	0.738
MOD_GlcNHglycan	516	519	PF01048	0.617
MOD_GlcNHglycan	524	527	PF01048	0.469
MOD_GlcNHglycan	530	533	PF01048	0.391
MOD_GlcNHglycan	614	617	PF01048	0.285
MOD_GlcNHglycan	637	640	PF01048	0.293
MOD_GlcNHglycan	740	743	PF01048	0.268
MOD_GlcNHglycan	847	850	PF01048	0.720
MOD_GlcNHglycan	851	854	PF01048	0.597
MOD_GlcNHglycan	914	917	PF01048	0.601
MOD_GlcNHglycan	946	951	PF01048	0.529
MOD_GlcNHglycan	969	972	PF01048	0.445
MOD_GSK3_1	233	240	PF00069	0.493
MOD_GSK3_1	315	322	PF00069	0.576
MOD_GSK3_1	411	418	PF00069	0.668
MOD_GSK3_1	510	517	PF00069	0.604
MOD_GSK3_1	522	529	PF00069	0.710
MOD_GSK3_1	551	558	PF00069	0.495
MOD_GSK3_1	622	629	PF00069	0.510
MOD_GSK3_1	635	642	PF00069	0.566
MOD_GSK3_1	8	15	PF00069	0.649
MOD_GSK3_1	80	87	PF00069	0.587
MOD_GSK3_1	843	850	PF00069	0.629
MOD_GSK3_1	88	95	PF00069	0.612
MOD_GSK3_1	901	908	PF00069	0.493
MOD_N-GLC_1	718	723	PF02516	0.293
MOD_NEK2_1	170	175	PF00069	0.668
MOD_NEK2_1	314	319	PF00069	0.578
MOD_NEK2_1	440	445	PF00069	0.743
MOD_NEK2_1	551	556	PF00069	0.503
MOD_NEK2_1	569	574	PF00069	0.493
MOD_NEK2_1	599	604	PF00069	0.493
MOD_NEK2_1	628	633	PF00069	0.541
MOD_NEK2_1	687	692	PF00069	0.493
MOD_NEK2_1	794	799	PF00069	0.399
MOD_NEK2_1	845	850	PF00069	0.679
MOD_NEK2_1	862	867	PF00069	0.336
MOD_NEK2_1	901	906	PF00069	0.493
MOD_NEK2_1	912	917	PF00069	0.587
MOD_NEK2_2	408	413	PF00069	0.535
MOD_NMyristoyl	1	7	PF02799	0.690
MOD_OFUCOSY	619	626	PF10250	0.293
MOD_PIKK_1	170	176	PF00454	0.614
MOD_PIKK_1	266	272	PF00454	0.470
MOD_PIKK_1	330	336	PF00454	0.768
MOD_PIKK_1	347	353	PF00454	0.533
MOD_PIKK_1	411	417	PF00454	0.675
MOD_PIKK_1	599	605	PF00454	0.493
MOD_PIKK_1	794	800	PF00454	0.404
MOD_PKA_1	168	174	PF00069	0.610
MOD_PKA_1	265	271	PF00069	0.448
MOD_PKA_2	247	253	PF00069	0.488
MOD_PKA_2	48	54	PF00069	0.476
MOD_PKA_2	519	525	PF00069	0.697
MOD_PKA_2	549	555	PF00069	0.493
MOD_PKA_2	585	591	PF00069	0.493
MOD_PKA_2	693	699	PF00069	0.572
MOD_PKA_2	710	716	PF00069	0.412
MOD_PKB_1	190	198	PF00069	0.581
MOD_Plk_1	308	314	PF00069	0.493
MOD_Plk_1	639	645	PF00069	0.493
MOD_Plk_1	862	868	PF00069	0.457
MOD_Plk_2-3	309	315	PF00069	0.578
MOD_Plk_2-3	372	378	PF00069	0.424
MOD_Plk_4	149	155	PF00069	0.318
MOD_Plk_4	237	243	PF00069	0.493
MOD_Plk_4	309	315	PF00069	0.578
MOD_Plk_4	54	60	PF00069	0.558
MOD_Plk_4	555	561	PF00069	0.493
MOD_Plk_4	569	575	PF00069	0.493
MOD_Plk_4	693	699	PF00069	0.493
MOD_ProDKin_1	104	110	PF00069	0.652
MOD_ProDKin_1	190	196	PF00069	0.674
MOD_ProDKin_1	218	224	PF00069	0.624
MOD_ProDKin_1	242	248	PF00069	0.493
MOD_ProDKin_1	288	294	PF00069	0.535
MOD_ProDKin_1	316	322	PF00069	0.489
MOD_ProDKin_1	39	45	PF00069	0.588
MOD_ProDKin_1	418	424	PF00069	0.669
MOD_ProDKin_1	718	724	PF00069	0.493
MOD_ProDKin_1	864	870	PF00069	0.485
MOD_SUMO_for_1	882	885	PF00179	0.493
MOD_SUMO_rev_2	662	671	PF00179	0.493
TRG_DiLeu_BaEn_1	300	305	PF01217	0.578
TRG_DiLeu_BaEn_1	667	672	PF01217	0.493
TRG_DiLeu_BaEn_1	980	985	PF01217	0.429
TRG_DiLeu_BaEn_4	300	306	PF01217	0.578
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.448
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.569
TRG_ENDOCYTIC_2	148	151	PF00928	0.339
TRG_ENDOCYTIC_2	210	213	PF00928	0.448
TRG_ER_diArg_1	206	208	PF00400	0.514
TRG_ER_diArg_1	404	407	PF00400	0.425
TRG_ER_diArg_1	432	435	PF00400	0.644
TRG_ER_diArg_1	925	927	PF00400	0.683
TRG_NLS_Bipartite_1	168	184	PF00514	0.547
TRG_NLS_MonoExtC_3	179	185	PF00514	0.599
TRG_NLS_MonoExtN_4	177	184	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	976	980	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM6	Leptomonas seymouri	63%	99%
A0A3S5H5H2	Leishmania donovani	99%	100%
A4H477	Leishmania braziliensis	79%	99%
E9AKD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJG9	Leishmania major	91%	99%