Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSF0_LEIIN

TriTrypDb:

LINF_050008000

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.607
CLV_C14_Caspase3-7	581	585	PF00656	0.619
CLV_C14_Caspase3-7	698	702	PF00656	0.592
CLV_C14_Caspase3-7	757	761	PF00656	0.477
CLV_NRD_NRD_1	167	169	PF00675	0.616
CLV_NRD_NRD_1	367	369	PF00675	0.683
CLV_NRD_NRD_1	418	420	PF00675	0.609
CLV_NRD_NRD_1	428	430	PF00675	0.616
CLV_NRD_NRD_1	475	477	PF00675	0.513
CLV_NRD_NRD_1	561	563	PF00675	0.700
CLV_NRD_NRD_1	659	661	PF00675	0.598
CLV_PCSK_FUR_1	558	562	PF00082	0.598
CLV_PCSK_KEX2_1	167	169	PF00082	0.745
CLV_PCSK_KEX2_1	367	369	PF00082	0.683
CLV_PCSK_KEX2_1	418	420	PF00082	0.609
CLV_PCSK_KEX2_1	427	429	PF00082	0.602
CLV_PCSK_KEX2_1	475	477	PF00082	0.513
CLV_PCSK_KEX2_1	560	562	PF00082	0.693
CLV_PCSK_KEX2_1	659	661	PF00082	0.599
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.564
CLV_PCSK_PC7_1	414	420	PF00082	0.656
CLV_PCSK_SKI1_1	200	204	PF00082	0.566
CLV_PCSK_SKI1_1	733	737	PF00082	0.571
CLV_PCSK_SKI1_1	754	758	PF00082	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.517
DEG_SPOP_SBC_1	508	512	PF00917	0.556
DEG_SPOP_SBC_1	597	601	PF00917	0.490
DOC_ANK_TNKS_1	176	183	PF00023	0.556
DOC_CYCLIN_RxL_1	730	739	PF00134	0.574
DOC_CYCLIN_RxL_1	749	760	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	530	536	PF00134	0.643
DOC_MAPK_gen_1	367	375	PF00069	0.619
DOC_MAPK_gen_1	749	758	PF00069	0.553
DOC_PP1_RVXF_1	30	36	PF00149	0.503
DOC_PP1_RVXF_1	752	759	PF00149	0.546
DOC_PP2B_LxvP_1	102	105	PF13499	0.612
DOC_PP2B_LxvP_1	146	149	PF13499	0.676
DOC_PP2B_LxvP_1	388	391	PF13499	0.607
DOC_PP2B_LxvP_1	530	533	PF13499	0.606
DOC_PP2B_LxvP_1	625	628	PF13499	0.665
DOC_PP2B_LxvP_1	729	732	PF13499	0.534
DOC_PP4_FxxP_1	492	495	PF00568	0.479
DOC_USP7_MATH_1	10	14	PF00917	0.541
DOC_USP7_MATH_1	111	115	PF00917	0.690
DOC_USP7_MATH_1	155	159	PF00917	0.609
DOC_USP7_MATH_1	181	185	PF00917	0.642
DOC_USP7_MATH_1	222	226	PF00917	0.650
DOC_USP7_MATH_1	333	337	PF00917	0.609
DOC_USP7_MATH_1	406	410	PF00917	0.693
DOC_USP7_MATH_1	508	512	PF00917	0.621
DOC_USP7_MATH_1	537	541	PF00917	0.709
DOC_USP7_MATH_1	570	574	PF00917	0.603
DOC_USP7_MATH_1	597	601	PF00917	0.541
DOC_USP7_MATH_1	65	69	PF00917	0.622
DOC_USP7_MATH_1	671	675	PF00917	0.694
DOC_USP7_MATH_1	90	94	PF00917	0.557
DOC_WW_Pin1_4	11	16	PF00397	0.568
DOC_WW_Pin1_4	119	124	PF00397	0.657
DOC_WW_Pin1_4	20	25	PF00397	0.535
DOC_WW_Pin1_4	246	251	PF00397	0.598
DOC_WW_Pin1_4	253	258	PF00397	0.616
DOC_WW_Pin1_4	280	285	PF00397	0.604
DOC_WW_Pin1_4	310	315	PF00397	0.597
DOC_WW_Pin1_4	417	422	PF00397	0.679
DOC_WW_Pin1_4	45	50	PF00397	0.535
DOC_WW_Pin1_4	484	489	PF00397	0.611
DOC_WW_Pin1_4	509	514	PF00397	0.607
DOC_WW_Pin1_4	593	598	PF00397	0.575
DOC_WW_Pin1_4	648	653	PF00397	0.648
DOC_WW_Pin1_4	658	663	PF00397	0.510
DOC_WW_Pin1_4	727	732	PF00397	0.573
DOC_WW_Pin1_4	734	739	PF00397	0.510
LIG_14-3-3_CanoR_1	115	120	PF00244	0.681
LIG_14-3-3_CanoR_1	125	129	PF00244	0.534
LIG_14-3-3_CanoR_1	167	171	PF00244	0.563
LIG_14-3-3_CanoR_1	22	28	PF00244	0.499
LIG_14-3-3_CanoR_1	754	759	PF00244	0.493
LIG_14-3-3_CanoR_1	9	15	PF00244	0.540
LIG_FHA_1	266	272	PF00498	0.612
LIG_FHA_1	311	317	PF00498	0.799
LIG_FHA_1	485	491	PF00498	0.541
LIG_FHA_1	520	526	PF00498	0.515
LIG_FHA_1	642	648	PF00498	0.552
LIG_FHA_1	757	763	PF00498	0.506
LIG_FHA_2	212	218	PF00498	0.661
LIG_FHA_2	65	71	PF00498	0.574
LIG_FHA_2	671	677	PF00498	0.657
LIG_FHA_2	696	702	PF00498	0.617
LIG_FHA_2	755	761	PF00498	0.551
LIG_LIR_Apic_2	381	387	PF02991	0.531
LIG_LIR_Apic_2	489	495	PF02991	0.570
LIG_LIR_Apic_2	592	597	PF02991	0.518
LIG_LIR_Gen_1	114	123	PF02991	0.618
LIG_LIR_Gen_1	545	554	PF02991	0.553
LIG_LIR_Nem_3	114	119	PF02991	0.629
LIG_LIR_Nem_3	489	494	PF02991	0.638
LIG_LIR_Nem_3	545	550	PF02991	0.566
LIG_LIR_Nem_3	603	609	PF02991	0.434
LIG_LIR_Nem_3	666	670	PF02991	0.626
LIG_LIR_Nem_3	720	725	PF02991	0.672
LIG_MYND_1	107	111	PF01753	0.597
LIG_MYND_1	314	318	PF01753	0.544
LIG_PDZ_Class_3	766	771	PF00595	0.542
LIG_Pex14_1	605	609	PF04695	0.445
LIG_Pex14_2	470	474	PF04695	0.583
LIG_SH2_CRK	547	551	PF00017	0.501
LIG_SH2_CRK	594	598	PF00017	0.510
LIG_SH2_NCK_1	481	485	PF00017	0.588
LIG_SH2_PTP2	667	670	PF00017	0.572
LIG_SH2_SRC	331	334	PF00017	0.650
LIG_SH2_STAP1	547	551	PF00017	0.501
LIG_SH2_STAP1	86	90	PF00017	0.583
LIG_SH2_STAT5	331	334	PF00017	0.762
LIG_SH2_STAT5	481	484	PF00017	0.585
LIG_SH2_STAT5	549	552	PF00017	0.495
LIG_SH2_STAT5	594	597	PF00017	0.515
LIG_SH2_STAT5	667	670	PF00017	0.557
LIG_SH3_1	312	318	PF00018	0.682
LIG_SH3_3	18	24	PF00018	0.529
LIG_SH3_3	312	318	PF00018	0.682
LIG_SH3_3	436	442	PF00018	0.686
LIG_SH3_3	522	528	PF00018	0.523
LIG_SH3_3	611	617	PF00018	0.506
LIG_SH3_3	718	724	PF00018	0.737
LIG_SH3_3	9	15	PF00018	0.577
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.489
LIG_SUMO_SIM_par_1	137	143	PF11976	0.636
LIG_TRAF2_1	392	395	PF00917	0.571
LIG_TRAF2_1	67	70	PF00917	0.621
LIG_TRAF2_1	766	769	PF00917	0.550
LIG_TRFH_1	727	731	PF08558	0.548
LIG_WRC_WIRS_1	141	146	PF05994	0.653
LIG_WW_3	19	23	PF00397	0.548
LIG_WW_3	730	734	PF00397	0.613
LIG_WW_3	749	753	PF00397	0.415
MOD_CDC14_SPxK_1	122	125	PF00782	0.585
MOD_CDC14_SPxK_1	730	733	PF00782	0.574
MOD_CDK_SPK_2	417	422	PF00069	0.679
MOD_CDK_SPxK_1	119	125	PF00069	0.595
MOD_CDK_SPxK_1	727	733	PF00069	0.582
MOD_CDK_SPxxK_3	246	253	PF00069	0.555
MOD_CK1_1	13	19	PF00069	0.549
MOD_CK1_1	140	146	PF00069	0.536
MOD_CK1_1	23	29	PF00069	0.502
MOD_CK1_1	241	247	PF00069	0.489
MOD_CK1_1	249	255	PF00069	0.566
MOD_CK1_1	334	340	PF00069	0.658
MOD_CK1_1	496	502	PF00069	0.731
MOD_CK1_1	511	517	PF00069	0.476
MOD_CK1_1	545	551	PF00069	0.632
MOD_CK1_1	578	584	PF00069	0.814
MOD_CK1_1	596	602	PF00069	0.430
MOD_CK1_1	651	657	PF00069	0.653
MOD_CK1_1	734	740	PF00069	0.534
MOD_CK1_1	81	87	PF00069	0.578
MOD_CK2_1	157	163	PF00069	0.677
MOD_CK2_1	211	217	PF00069	0.607
MOD_CK2_1	406	412	PF00069	0.688
MOD_CK2_1	520	526	PF00069	0.533
MOD_CK2_1	64	70	PF00069	0.563
MOD_CK2_1	670	676	PF00069	0.523
MOD_Cter_Amidation	558	561	PF01082	0.544
MOD_DYRK1A_RPxSP_1	253	257	PF00069	0.607
MOD_GlcNHglycan	178	181	PF01048	0.639
MOD_GlcNHglycan	183	186	PF01048	0.657
MOD_GlcNHglycan	208	211	PF01048	0.651
MOD_GlcNHglycan	336	339	PF01048	0.586
MOD_GlcNHglycan	355	359	PF01048	0.481
MOD_GlcNHglycan	364	367	PF01048	0.703
MOD_GlcNHglycan	370	373	PF01048	0.462
MOD_GlcNHglycan	381	384	PF01048	0.533
MOD_GlcNHglycan	399	402	PF01048	0.523
MOD_GlcNHglycan	544	547	PF01048	0.703
MOD_GlcNHglycan	587	590	PF01048	0.600
MOD_GlcNHglycan	600	603	PF01048	0.480
MOD_GlcNHglycan	673	676	PF01048	0.724
MOD_GlcNHglycan	678	681	PF01048	0.592
MOD_GlcNHglycan	684	687	PF01048	0.539
MOD_GlcNHglycan	740	743	PF01048	0.511
MOD_GlcNHglycan	92	95	PF01048	0.581
MOD_GSK3_1	10	17	PF00069	0.549
MOD_GSK3_1	111	118	PF00069	0.619
MOD_GSK3_1	202	209	PF00069	0.542
MOD_GSK3_1	23	30	PF00069	0.511
MOD_GSK3_1	249	256	PF00069	0.599
MOD_GSK3_1	327	334	PF00069	0.564
MOD_GSK3_1	45	52	PF00069	0.534
MOD_GSK3_1	456	463	PF00069	0.671
MOD_GSK3_1	482	489	PF00069	0.596
MOD_GSK3_1	507	514	PF00069	0.806
MOD_GSK3_1	515	522	PF00069	0.534
MOD_GSK3_1	545	552	PF00069	0.565
MOD_GSK3_1	585	592	PF00069	0.598
MOD_GSK3_1	593	600	PF00069	0.537
MOD_GSK3_1	647	654	PF00069	0.649
MOD_GSK3_1	671	678	PF00069	0.692
MOD_GSK3_1	72	79	PF00069	0.599
MOD_GSK3_1	727	734	PF00069	0.666
MOD_GSK3_1	92	99	PF00069	0.539
MOD_N-GLC_1	585	590	PF02516	0.675
MOD_NEK2_1	139	144	PF00069	0.645
MOD_NEK2_1	202	207	PF00069	0.540
MOD_NEK2_1	265	270	PF00069	0.711
MOD_NEK2_1	27	32	PF00069	0.503
MOD_NEK2_1	598	603	PF00069	0.458
MOD_NEK2_1	647	652	PF00069	0.647
MOD_NEK2_1	670	675	PF00069	0.689
MOD_NEK2_1	80	85	PF00069	0.565
MOD_NEK2_2	157	162	PF00069	0.555
MOD_NEK2_2	589	594	PF00069	0.535
MOD_PIKK_1	511	517	PF00454	0.602
MOD_PIKK_1	53	59	PF00454	0.549
MOD_PIKK_1	65	71	PF00454	0.588
MOD_PIKK_1	78	84	PF00454	0.516
MOD_PK_1	115	121	PF00069	0.694
MOD_PKA_1	560	566	PF00069	0.611
MOD_PKA_2	111	117	PF00069	0.689
MOD_PKA_2	124	130	PF00069	0.539
MOD_PKA_2	166	172	PF00069	0.675
MOD_PKA_2	176	182	PF00069	0.660
MOD_PKA_2	379	385	PF00069	0.596
MOD_PKA_2	456	462	PF00069	0.686
MOD_PKA_2	560	566	PF00069	0.639
MOD_PKB_1	752	760	PF00069	0.503
MOD_Plk_1	575	581	PF00069	0.644
MOD_Plk_4	124	130	PF00069	0.585
MOD_Plk_4	23	29	PF00069	0.523
MOD_Plk_4	238	244	PF00069	0.547
MOD_Plk_4	265	271	PF00069	0.517
MOD_Plk_4	327	333	PF00069	0.551
MOD_Plk_4	486	492	PF00069	0.648
MOD_Plk_4	493	499	PF00069	0.480
MOD_Plk_4	520	526	PF00069	0.533
MOD_Plk_4	545	551	PF00069	0.595
MOD_Plk_4	663	669	PF00069	0.550
MOD_ProDKin_1	11	17	PF00069	0.567
MOD_ProDKin_1	119	125	PF00069	0.656
MOD_ProDKin_1	20	26	PF00069	0.532
MOD_ProDKin_1	246	252	PF00069	0.598
MOD_ProDKin_1	253	259	PF00069	0.612
MOD_ProDKin_1	280	286	PF00069	0.605
MOD_ProDKin_1	310	316	PF00069	0.597
MOD_ProDKin_1	417	423	PF00069	0.675
MOD_ProDKin_1	45	51	PF00069	0.537
MOD_ProDKin_1	484	490	PF00069	0.605
MOD_ProDKin_1	509	515	PF00069	0.606
MOD_ProDKin_1	593	599	PF00069	0.572
MOD_ProDKin_1	648	654	PF00069	0.651
MOD_ProDKin_1	658	664	PF00069	0.502
MOD_ProDKin_1	727	733	PF00069	0.574
MOD_ProDKin_1	734	740	PF00069	0.513
MOD_SUMO_for_1	271	274	PF00179	0.535
TRG_DiLeu_BaEn_1	526	531	PF01217	0.586
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.599
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.514
TRG_ENDOCYTIC_2	547	550	PF00928	0.546
TRG_ENDOCYTIC_2	667	670	PF00928	0.633
TRG_ER_diArg_1	367	369	PF00400	0.598
TRG_ER_diArg_1	417	419	PF00400	0.686
TRG_ER_diArg_1	426	429	PF00400	0.574
TRG_ER_diArg_1	474	476	PF00400	0.594
TRG_ER_diArg_1	561	564	PF00400	0.692
TRG_ER_diArg_1	658	660	PF00400	0.610
TRG_ER_diArg_1	751	754	PF00400	0.601
TRG_NLS_MonoExtC_3	559	564	PF00514	0.557
TRG_NLS_MonoExtN_4	558	564	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ8	Leptomonas seymouri	34%	100%
A0A3S7WP11	Leishmania donovani	100%	82%
A4H475	Leishmania braziliensis	70%	98%
E9AKD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%
Q4QJH2	Leishmania major	83%	100%