LeishMANIAdb
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Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Gene product:
protein tyrosine phosphatase - putative
Species:
Leishmania infantum
UniProt:
A4HSE7_LEIIN
TriTrypDb:
LINF_050007700
Length:
224

Annotations

Annotations by Jardim et al.

Phosphatase, tyrosine phosphatase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HSE7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSE7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006629 lipid metabolic process 3 11
GO:0006631 fatty acid metabolic process 4 11
GO:0006633 fatty acid biosynthetic process 5 11
GO:0008152 metabolic process 1 11
GO:0008610 lipid biosynthetic process 4 11
GO:0009058 biosynthetic process 2 11
GO:0009987 cellular process 1 11
GO:0016053 organic acid biosynthetic process 4 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0032787 monocarboxylic acid metabolic process 6 11
GO:0043436 oxoacid metabolic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0044281 small molecule metabolic process 2 11
GO:0044283 small molecule biosynthetic process 3 11
GO:0046394 carboxylic acid biosynthetic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:0072330 monocarboxylic acid biosynthetic process 6 11
GO:1901576 organic substance biosynthetic process 3 11
GO:0000038 very long-chain fatty acid metabolic process 5 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0030497 fatty acid elongation 6 1
GO:0042761 very long-chain fatty acid biosynthetic process 6 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016787 hydrolase activity 2 5
GO:0016829 lyase activity 2 11
GO:0016835 carbon-oxygen lyase activity 3 11
GO:0016836 hydro-lyase activity 4 11
GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity 5 11
GO:0102343 obsolete 3-hydroxy-arachidoyl-CoA dehydratase activity 5 11
GO:0102344 obsolete 3-hydroxy-behenoyl-CoA dehydratase activity 5 11
GO:0102345 obsolete 3-hydroxy-lignoceroyl-CoA dehydratase activity 5 11
GO:0018812 3-hydroxyacyl-CoA dehydratase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 208 210 PF00675 0.253
CLV_PCSK_KEX2_1 208 210 PF00082 0.253
DEG_APCC_DBOX_1 124 132 PF00400 0.399
DEG_MDM2_SWIB_1 177 185 PF02201 0.296
DOC_CYCLIN_yClb1_LxF_4 172 177 PF00134 0.296
DOC_MAPK_gen_1 162 171 PF00069 0.278
DOC_MAPK_MEF2A_6 97 104 PF00069 0.320
DOC_PP1_RVXF_1 172 178 PF00149 0.296
DOC_PP1_RVXF_1 95 102 PF00149 0.288
DOC_USP7_MATH_1 194 198 PF00917 0.293
DOC_USP7_UBL2_3 210 214 PF12436 0.499
DOC_WW_Pin1_4 65 70 PF00397 0.362
LIG_14-3-3_CanoR_1 115 119 PF00244 0.293
LIG_14-3-3_CanoR_1 135 143 PF00244 0.444
LIG_14-3-3_CanoR_1 208 213 PF00244 0.456
LIG_14-3-3_CterR_2 219 224 PF00244 0.613
LIG_Actin_WH2_2 119 137 PF00022 0.273
LIG_BRCT_BRCA1_1 97 101 PF00533 0.253
LIG_FHA_1 146 152 PF00498 0.318
LIG_FHA_1 166 172 PF00498 0.151
LIG_FHA_1 19 25 PF00498 0.337
LIG_FHA_1 50 56 PF00498 0.390
LIG_FHA_1 70 76 PF00498 0.151
LIG_FHA_1 94 100 PF00498 0.278
LIG_LIR_Gen_1 137 147 PF02991 0.309
LIG_LIR_Gen_1 180 190 PF02991 0.277
LIG_LIR_Gen_1 72 82 PF02991 0.332
LIG_LIR_Gen_1 98 107 PF02991 0.286
LIG_LIR_Nem_3 130 136 PF02991 0.448
LIG_LIR_Nem_3 137 142 PF02991 0.260
LIG_LIR_Nem_3 178 182 PF02991 0.242
LIG_LIR_Nem_3 184 190 PF02991 0.269
LIG_LIR_Nem_3 197 201 PF02991 0.226
LIG_LIR_Nem_3 38 43 PF02991 0.296
LIG_LIR_Nem_3 72 77 PF02991 0.359
LIG_LYPXL_S_1 39 43 PF13949 0.511
LIG_LYPXL_yS_3 40 43 PF13949 0.298
LIG_PALB2_WD40_1 182 190 PF16756 0.318
LIG_Pex14_2 177 181 PF04695 0.270
LIG_SH2_CRK 155 159 PF00017 0.318
LIG_SH2_CRK 85 89 PF00017 0.407
LIG_SH2_STAP1 136 140 PF00017 0.529
LIG_SH2_STAP1 201 205 PF00017 0.451
LIG_SH2_STAT5 160 163 PF00017 0.270
LIG_SH2_STAT5 198 201 PF00017 0.288
LIG_SH2_STAT5 7 10 PF00017 0.275
LIG_SH3_3 138 144 PF00018 0.293
LIG_SH3_3 166 172 PF00018 0.253
LIG_SH3_3 63 69 PF00018 0.327
LIG_SUMO_SIM_anti_2 79 85 PF11976 0.317
LIG_TYR_ITIM 83 88 PF00017 0.318
MOD_CK1_1 217 223 PF00069 0.625
MOD_CK1_1 95 101 PF00069 0.320
MOD_CK2_1 212 218 PF00069 0.484
MOD_GlcNHglycan 136 139 PF01048 0.253
MOD_GlcNHglycan 214 217 PF01048 0.338
MOD_GSK3_1 177 184 PF00069 0.292
MOD_GSK3_1 208 215 PF00069 0.522
MOD_GSK3_1 65 72 PF00069 0.293
MOD_N-GLC_1 175 180 PF02516 0.476
MOD_NEK2_1 134 139 PF00069 0.441
MOD_NEK2_1 175 180 PF00069 0.278
MOD_NEK2_1 212 217 PF00069 0.569
MOD_PKA_1 208 214 PF00069 0.456
MOD_PKA_2 114 120 PF00069 0.293
MOD_PKA_2 134 140 PF00069 0.440
MOD_PKA_2 208 214 PF00069 0.456
MOD_Plk_1 175 181 PF00069 0.271
MOD_Plk_4 114 120 PF00069 0.220
MOD_Plk_4 129 135 PF00069 0.459
MOD_Plk_4 18 24 PF00069 0.329
MOD_Plk_4 181 187 PF00069 0.323
MOD_Plk_4 194 200 PF00069 0.319
MOD_Plk_4 35 41 PF00069 0.305
MOD_Plk_4 70 76 PF00069 0.293
MOD_Plk_4 95 101 PF00069 0.313
MOD_ProDKin_1 65 71 PF00069 0.362
TRG_DiLeu_BaLyEn_6 42 47 PF01217 0.276
TRG_DiLeu_BaLyEn_6 77 82 PF01217 0.318
TRG_ENDOCYTIC_2 136 139 PF00928 0.440
TRG_ENDOCYTIC_2 155 158 PF00928 0.275
TRG_ENDOCYTIC_2 182 185 PF00928 0.292
TRG_ENDOCYTIC_2 201 204 PF00928 0.377
TRG_ENDOCYTIC_2 40 43 PF00928 0.298
TRG_ENDOCYTIC_2 85 88 PF00928 0.318
TRG_ER_diLys_1 221 224 PF00400 0.637
TRG_NLS_MonoExtC_3 161 166 PF00514 0.272
TRG_NLS_MonoExtN_4 159 166 PF00514 0.272

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT96 Leptomonas seymouri 77% 100%
A0A0S4J5C4 Bodo saltans 53% 100%
A0A1X0P0I0 Trypanosomatidae 63% 94%
A0A3R7K8T2 Trypanosoma rangeli 61% 93%
A0A3S5H5H0 Leishmania donovani 100% 100%
A2AKM2 Mus musculus 27% 97%
A4H472 Leishmania braziliensis 85% 100%
B0YJ81 Homo sapiens 35% 78%
D0A4J7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 80%
E9AKD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O14346 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
O17040 Caenorhabditis elegans 37% 100%
P40857 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 100%
Q0P5C7 Bos taurus 23% 97%
Q2KIP8 Bos taurus 39% 88%
Q4QJH5 Leishmania major 96% 100%
Q4W1W1 Canis lupus familiaris 36% 90%
Q5RBK3 Pongo abelii 39% 88%
Q5VWC8 Homo sapiens 25% 97%
Q5ZEJ0 Oryza sativa subsp. japonica 39% 100%
Q6GNB5 Xenopus laevis 26% 100%
Q6Y1H2 Homo sapiens 39% 88%
Q7XSZ4 Oryza sativa subsp. japonica 40% 100%
Q8VZB2 Arabidopsis thaliana 41% 100%
Q9D3B1 Mus musculus 39% 88%
Q9N1R5 Ovis aries 36% 78%
Q9QY80 Mus musculus 36% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS