Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSE1_LEIIN

TriTrypDb:

LINF_050006100

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	7	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.566
CLV_NRD_NRD_1	112	114	PF00675	0.448
CLV_NRD_NRD_1	160	162	PF00675	0.313
CLV_NRD_NRD_1	201	203	PF00675	0.406
CLV_NRD_NRD_1	255	257	PF00675	0.422
CLV_NRD_NRD_1	284	286	PF00675	0.607
CLV_NRD_NRD_1	3	5	PF00675	0.651
CLV_NRD_NRD_1	311	313	PF00675	0.497
CLV_NRD_NRD_1	320	322	PF00675	0.400
CLV_PCSK_FUR_1	282	286	PF00082	0.655
CLV_PCSK_KEX2_1	112	114	PF00082	0.472
CLV_PCSK_KEX2_1	126	128	PF00082	0.347
CLV_PCSK_KEX2_1	160	162	PF00082	0.313
CLV_PCSK_KEX2_1	201	203	PF00082	0.401
CLV_PCSK_KEX2_1	282	284	PF00082	0.668
CLV_PCSK_KEX2_1	3	5	PF00082	0.651
CLV_PCSK_KEX2_1	311	313	PF00082	0.486
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.524
CLV_PCSK_SKI1_1	127	131	PF00082	0.446
CLV_PCSK_SKI1_1	160	164	PF00082	0.465
CLV_PCSK_SKI1_1	311	315	PF00082	0.561
CLV_PCSK_SKI1_1	82	86	PF00082	0.481
DEG_APCC_DBOX_1	28	36	PF00400	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DEG_ODPH_VHL_1	103	116	PF01847	0.542
DOC_CYCLIN_RxL_1	124	134	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.545
DOC_MAPK_gen_1	289	298	PF00069	0.578
DOC_MAPK_gen_1	7	17	PF00069	0.537
DOC_MAPK_MEF2A_6	10	19	PF00069	0.596
DOC_PP1_RVXF_1	111	118	PF00149	0.486
DOC_PP1_RVXF_1	158	165	PF00149	0.388
DOC_PP1_RVXF_1	200	207	PF00149	0.486
DOC_PP2B_LxvP_1	102	105	PF13499	0.544
DOC_PP2B_LxvP_1	250	253	PF13499	0.414
DOC_USP7_MATH_1	211	215	PF00917	0.472
DOC_USP7_MATH_1	300	304	PF00917	0.429
DOC_USP7_MATH_1	74	78	PF00917	0.524
DOC_WW_Pin1_4	152	157	PF00397	0.544
DOC_WW_Pin1_4	304	309	PF00397	0.503
LIG_14-3-3_CanoR_1	27	33	PF00244	0.539
LIG_14-3-3_CanoR_1	3	11	PF00244	0.700
LIG_14-3-3_CanoR_1	311	319	PF00244	0.582
LIG_APCC_ABBA_1	228	233	PF00400	0.513
LIG_APCC_ABBAyCdc20_2	201	207	PF00400	0.483
LIG_Clathr_ClatBox_1	203	207	PF01394	0.474
LIG_eIF4E_1	124	130	PF01652	0.487
LIG_FHA_1	179	185	PF00498	0.418
LIG_FHA_1	48	54	PF00498	0.576
LIG_FHA_2	230	236	PF00498	0.384
LIG_FHA_2	304	310	PF00498	0.500
LIG_LIR_Gen_1	134	144	PF02991	0.415
LIG_LIR_Gen_1	168	179	PF02991	0.483
LIG_LIR_Gen_1	235	245	PF02991	0.460
LIG_LIR_LC3C_4	247	252	PF02991	0.480
LIG_LIR_Nem_3	134	140	PF02991	0.405
LIG_LIR_Nem_3	168	174	PF02991	0.403
LIG_LIR_Nem_3	235	240	PF02991	0.463
LIG_NRBOX	31	37	PF00104	0.564
LIG_OCRL_FandH_1	192	204	PF00620	0.545
LIG_REV1ctd_RIR_1	161	170	PF16727	0.463
LIG_SH2_STAP1	237	241	PF00017	0.480
LIG_SH2_STAP1	319	323	PF00017	0.538
LIG_SH2_STAT3	64	67	PF00017	0.528
LIG_SH2_STAT5	124	127	PF00017	0.374
LIG_SH2_STAT5	209	212	PF00017	0.489
LIG_SH2_STAT5	254	257	PF00017	0.523
LIG_SH3_1	219	225	PF00018	0.454
LIG_SH3_3	173	179	PF00018	0.443
LIG_SH3_3	184	190	PF00018	0.334
LIG_SH3_3	219	225	PF00018	0.454
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.475
LIG_SUMO_SIM_par_1	49	56	PF11976	0.601
LIG_UBA3_1	241	249	PF00899	0.460
MOD_CDK_SPxxK_3	304	311	PF00069	0.455
MOD_CK1_1	169	175	PF00069	0.427
MOD_CK1_1	303	309	PF00069	0.450
MOD_CK2_1	140	146	PF00069	0.497
MOD_CK2_1	229	235	PF00069	0.488
MOD_GlcNHglycan	302	305	PF01048	0.446
MOD_GlcNHglycan	314	317	PF01048	0.423
MOD_GlcNHglycan	60	63	PF01048	0.522
MOD_GlcNHglycan	76	79	PF01048	0.334
MOD_GlcNHglycan	91	94	PF01048	0.429
MOD_GSK3_1	192	199	PF00069	0.421
MOD_GSK3_1	300	307	PF00069	0.432
MOD_GSK3_1	47	54	PF00069	0.536
MOD_N-GLC_1	317	322	PF02516	0.393
MOD_NEK2_1	130	135	PF00069	0.524
MOD_NEK2_1	2	7	PF00069	0.635
MOD_NEK2_1	89	94	PF00069	0.467
MOD_OFUCOSY	167	173	PF10250	0.420
MOD_PKA_1	3	9	PF00069	0.664
MOD_PKA_2	2	8	PF00069	0.636
MOD_PKA_2	28	34	PF00069	0.522
MOD_Plk_4	133	139	PF00069	0.399
MOD_Plk_4	166	172	PF00069	0.456
MOD_Plk_4	211	217	PF00069	0.450
MOD_ProDKin_1	152	158	PF00069	0.538
MOD_ProDKin_1	304	310	PF00069	0.497
MOD_SUMO_rev_2	243	251	PF00179	0.474
TRG_DiLeu_BaEn_1	246	251	PF01217	0.432
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.540
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.559
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.464
TRG_ENDOCYTIC_2	237	240	PF00928	0.483
TRG_ENDOCYTIC_2	324	327	PF00928	0.400
TRG_ER_diArg_1	112	114	PF00400	0.472
TRG_ER_diArg_1	160	162	PF00400	0.313
TRG_ER_diArg_1	2	4	PF00400	0.687
TRG_ER_diArg_1	201	203	PF00400	0.411
TRG_ER_diArg_1	216	219	PF00400	0.432
TRG_ER_diArg_1	282	285	PF00400	0.658
TRG_ER_diArg_1	311	313	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N8	Leptomonas seymouri	67%	100%
A0A1X0P3K8	Trypanosomatidae	42%	98%
A0A3S5H5F9	Leishmania donovani	100%	100%
A0A3S5ISB0	Trypanosoma rangeli	48%	100%
A4H458	Leishmania braziliensis	88%	100%
C9ZPX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AKB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QJJ1	Leishmania major	97%	100%
V5AUY0	Trypanosoma cruzi	43%	100%