G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ferrous iron transport protein B/50S ribosome-binding GTPase - putative

Species:

Leishmania infantum

UniProt:

A4HSD4_LEIIN

TriTrypDb:

LINF_050006900

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSD4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.449
CLV_C14_Caspase3-7	66	70	PF00656	0.509
CLV_NRD_NRD_1	147	149	PF00675	0.336
CLV_NRD_NRD_1	21	23	PF00675	0.483
CLV_NRD_NRD_1	233	235	PF00675	0.373
CLV_NRD_NRD_1	454	456	PF00675	0.218
CLV_NRD_NRD_1	499	501	PF00675	0.394
CLV_NRD_NRD_1	537	539	PF00675	0.391
CLV_NRD_NRD_1	704	706	PF00675	0.474
CLV_NRD_NRD_1	763	765	PF00675	0.480
CLV_NRD_NRD_1	779	781	PF00675	0.530
CLV_PCSK_FUR_1	11	15	PF00082	0.524
CLV_PCSK_FUR_1	705	709	PF00082	0.494
CLV_PCSK_KEX2_1	122	124	PF00082	0.353
CLV_PCSK_KEX2_1	13	15	PF00082	0.516
CLV_PCSK_KEX2_1	147	149	PF00082	0.374
CLV_PCSK_KEX2_1	21	23	PF00082	0.528
CLV_PCSK_KEX2_1	233	235	PF00082	0.373
CLV_PCSK_KEX2_1	343	345	PF00082	0.495
CLV_PCSK_KEX2_1	376	378	PF00082	0.538
CLV_PCSK_KEX2_1	454	456	PF00082	0.245
CLV_PCSK_KEX2_1	499	501	PF00082	0.394
CLV_PCSK_KEX2_1	536	538	PF00082	0.381
CLV_PCSK_KEX2_1	703	705	PF00082	0.489
CLV_PCSK_KEX2_1	707	709	PF00082	0.523
CLV_PCSK_KEX2_1	759	761	PF00082	0.484
CLV_PCSK_KEX2_1	763	765	PF00082	0.480
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.429
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.520
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.399
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.538
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.527
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.484
CLV_PCSK_PC7_1	339	345	PF00082	0.406
CLV_PCSK_PC7_1	703	709	PF00082	0.595
CLV_PCSK_SKI1_1	13	17	PF00082	0.580
CLV_PCSK_SKI1_1	140	144	PF00082	0.440
CLV_PCSK_SKI1_1	158	162	PF00082	0.479
CLV_PCSK_SKI1_1	217	221	PF00082	0.407
CLV_PCSK_SKI1_1	25	29	PF00082	0.423
CLV_PCSK_SKI1_1	302	306	PF00082	0.550
CLV_PCSK_SKI1_1	339	343	PF00082	0.626
CLV_PCSK_SKI1_1	355	359	PF00082	0.562
CLV_PCSK_SKI1_1	455	459	PF00082	0.218
CLV_PCSK_SKI1_1	503	507	PF00082	0.391
CLV_PCSK_SKI1_1	554	558	PF00082	0.328
CLV_PCSK_SKI1_1	749	753	PF00082	0.666
CLV_PCSK_SKI1_1	764	768	PF00082	0.480
DEG_APCC_DBOX_1	146	154	PF00400	0.354
DEG_APCC_DBOX_1	681	689	PF00400	0.466
DEG_APCC_DBOX_1	762	770	PF00400	0.575
DEG_SCF_FBW7_1	435	442	PF00400	0.418
DOC_AGCK_PIF_2	196	201	PF00069	0.283
DOC_CKS1_1	160	165	PF01111	0.351
DOC_CKS1_1	404	409	PF01111	0.458
DOC_CKS1_1	740	745	PF01111	0.657
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.516
DOC_MAPK_gen_1	216	222	PF00069	0.333
DOC_MAPK_gen_1	320	329	PF00069	0.529
DOC_MAPK_gen_1	441	450	PF00069	0.418
DOC_MAPK_gen_1	551	561	PF00069	0.329
DOC_MAPK_gen_1	763	771	PF00069	0.538
DOC_MAPK_MEF2A_6	180	188	PF00069	0.298
DOC_MAPK_MEF2A_6	554	561	PF00069	0.323
DOC_MAPK_MEF2A_6	723	731	PF00069	0.611
DOC_MAPK_NFAT4_5	554	562	PF00069	0.330
DOC_PP2B_LxvP_1	118	121	PF13499	0.327
DOC_PP2B_LxvP_1	323	326	PF13499	0.561
DOC_PP2B_LxvP_1	448	451	PF13499	0.418
DOC_USP7_MATH_1	266	270	PF00917	0.674
DOC_USP7_MATH_1	272	276	PF00917	0.466
DOC_USP7_MATH_1	289	293	PF00917	0.517
DOC_USP7_MATH_1	363	367	PF00917	0.558
DOC_USP7_MATH_1	370	374	PF00917	0.557
DOC_USP7_MATH_1	596	600	PF00917	0.617
DOC_USP7_MATH_1	675	679	PF00917	0.485
DOC_USP7_UBL2_3	212	216	PF12436	0.493
DOC_USP7_UBL2_3	49	53	PF12436	0.555
DOC_USP7_UBL2_3	554	558	PF12436	0.422
DOC_USP7_UBL2_3	753	757	PF12436	0.549
DOC_WW_Pin1_4	159	164	PF00397	0.361
DOC_WW_Pin1_4	403	408	PF00397	0.395
DOC_WW_Pin1_4	435	440	PF00397	0.418
DOC_WW_Pin1_4	591	596	PF00397	0.588
DOC_WW_Pin1_4	739	744	PF00397	0.568
LIG_14-3-3_CanoR_1	147	151	PF00244	0.446
LIG_14-3-3_CanoR_1	355	362	PF00244	0.589
LIG_14-3-3_CanoR_1	47	56	PF00244	0.522
LIG_14-3-3_CanoR_1	644	649	PF00244	0.510
LIG_14-3-3_CanoR_1	677	681	PF00244	0.480
LIG_14-3-3_CanoR_1	694	698	PF00244	0.306
LIG_APCC_ABBA_1	557	562	PF00400	0.330
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_2	663	667	PF00653	0.548
LIG_BIR_III_4	620	624	PF00653	0.711
LIG_BRCT_BRCA1_1	197	201	PF00533	0.386
LIG_BRCT_BRCA1_2	197	203	PF00533	0.394
LIG_Clathr_ClatBox_1	685	689	PF01394	0.453
LIG_deltaCOP1_diTrp_1	169	175	PF00928	0.299
LIG_FHA_1	445	451	PF00498	0.418
LIG_FHA_1	486	492	PF00498	0.412
LIG_FHA_1	56	62	PF00498	0.419
LIG_FHA_2	160	166	PF00498	0.348
LIG_FHA_2	272	278	PF00498	0.639
LIG_FHA_2	356	362	PF00498	0.477
LIG_FHA_2	379	385	PF00498	0.430
LIG_FHA_2	484	490	PF00498	0.372
LIG_FHA_2	679	685	PF00498	0.383
LIG_GBD_Chelix_1	526	534	PF00786	0.428
LIG_IBAR_NPY_1	331	333	PF08397	0.445
LIG_Integrin_RGD_1	243	245	PF01839	0.430
LIG_IRF3_LxIS_1	506	513	PF10401	0.379
LIG_LIR_Gen_1	110	118	PF02991	0.406
LIG_LIR_Gen_1	378	388	PF02991	0.451
LIG_LIR_Gen_1	390	399	PF02991	0.435
LIG_LIR_Gen_1	442	451	PF02991	0.418
LIG_LIR_Gen_1	562	572	PF02991	0.432
LIG_LIR_Gen_1	62	70	PF02991	0.402
LIG_LIR_Gen_1	631	640	PF02991	0.501
LIG_LIR_Gen_1	681	690	PF02991	0.464
LIG_LIR_Nem_3	110	114	PF02991	0.416
LIG_LIR_Nem_3	169	174	PF02991	0.312
LIG_LIR_Nem_3	198	204	PF02991	0.369
LIG_LIR_Nem_3	245	250	PF02991	0.367
LIG_LIR_Nem_3	378	383	PF02991	0.453
LIG_LIR_Nem_3	390	395	PF02991	0.367
LIG_LIR_Nem_3	442	448	PF02991	0.418
LIG_LIR_Nem_3	562	568	PF02991	0.431
LIG_LIR_Nem_3	62	67	PF02991	0.401
LIG_LIR_Nem_3	631	637	PF02991	0.506
LIG_LIR_Nem_3	678	683	PF02991	0.489
LIG_LIR_Nem_3	716	721	PF02991	0.557
LIG_LYPXL_yS_3	415	418	PF13949	0.418
LIG_NRBOX	113	119	PF00104	0.392
LIG_Pex14_1	236	240	PF04695	0.304
LIG_REV1ctd_RIR_1	247	253	PF16727	0.416
LIG_RPA_C_Fungi	689	701	PF08784	0.478
LIG_SH2_CRK	670	674	PF00017	0.481
LIG_SH2_CRK	718	722	PF00017	0.552
LIG_SH2_PTP2	567	570	PF00017	0.357
LIG_SH2_SRC	560	563	PF00017	0.332
LIG_SH2_SRC	567	570	PF00017	0.323
LIG_SH2_STAP1	164	168	PF00017	0.314
LIG_SH2_STAP1	333	337	PF00017	0.514
LIG_SH2_STAP1	655	659	PF00017	0.647
LIG_SH2_STAT3	239	242	PF00017	0.337
LIG_SH2_STAT3	586	589	PF00017	0.550
LIG_SH2_STAT5	204	207	PF00017	0.388
LIG_SH2_STAT5	239	242	PF00017	0.322
LIG_SH2_STAT5	560	563	PF00017	0.426
LIG_SH2_STAT5	564	567	PF00017	0.334
LIG_SH2_STAT5	586	589	PF00017	0.562
LIG_SH2_STAT5	718	721	PF00017	0.552
LIG_SH2_STAT5	75	78	PF00017	0.547
LIG_SH3_3	118	124	PF00018	0.338
LIG_SH3_3	251	257	PF00018	0.482
LIG_SH3_3	326	332	PF00018	0.482
LIG_SH3_3	379	385	PF00018	0.428
LIG_SH3_3	410	416	PF00018	0.264
LIG_SH3_3	565	571	PF00018	0.354
LIG_SH3_3	744	750	PF00018	0.660
LIG_SH3_4	755	762	PF00018	0.572
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.290
LIG_SUMO_SIM_par_1	732	742	PF11976	0.643
LIG_TRAF2_1	358	361	PF00917	0.532
LIG_TRAF2_1	607	610	PF00917	0.660
LIG_TRAF2_1	628	631	PF00917	0.561
LIG_TRAF2_1	70	73	PF00917	0.498
LIG_TRAF2_2	385	390	PF00917	0.340
LIG_TYR_ITIM	413	418	PF00017	0.255
LIG_UBA3_1	117	122	PF00899	0.353
LIG_WRC_WIRS_1	196	201	PF05994	0.283
LIG_WRC_WIRS_1	466	471	PF05994	0.352
LIG_WW_1	571	574	PF00397	0.365
MOD_CDK_SPxK_1	435	441	PF00069	0.255
MOD_CDK_SPxxK_3	159	166	PF00069	0.350
MOD_CK1_1	468	474	PF00069	0.364
MOD_CK1_1	678	684	PF00069	0.446
MOD_CK2_1	128	134	PF00069	0.369
MOD_CK2_1	159	165	PF00069	0.369
MOD_CK2_1	208	214	PF00069	0.481
MOD_CK2_1	355	361	PF00069	0.483
MOD_CK2_1	51	57	PF00069	0.425
MOD_CK2_1	522	528	PF00069	0.382
MOD_CK2_1	619	625	PF00069	0.685
MOD_CK2_1	678	684	PF00069	0.391
MOD_Cter_Amidation	19	22	PF01082	0.512
MOD_GlcNHglycan	130	133	PF01048	0.415
MOD_GlcNHglycan	250	253	PF01048	0.340
MOD_GlcNHglycan	334	338	PF01048	0.454
MOD_GlcNHglycan	372	375	PF01048	0.490
MOD_GlcNHglycan	435	438	PF01048	0.275
MOD_GlcNHglycan	591	594	PF01048	0.579
MOD_GlcNHglycan	599	602	PF01048	0.633
MOD_GlcNHglycan	618	624	PF01048	0.460
MOD_GlcNHglycan	638	641	PF01048	0.520
MOD_GSK3_1	112	119	PF00069	0.428
MOD_GSK3_1	204	211	PF00069	0.414
MOD_GSK3_1	222	229	PF00069	0.209
MOD_GSK3_1	267	274	PF00069	0.626
MOD_GSK3_1	399	406	PF00069	0.454
MOD_GSK3_1	435	442	PF00069	0.260
MOD_GSK3_1	465	472	PF00069	0.350
MOD_GSK3_1	47	54	PF00069	0.476
MOD_GSK3_1	483	490	PF00069	0.369
MOD_GSK3_1	9	16	PF00069	0.441
MOD_LATS_1	311	317	PF00433	0.631
MOD_N-GLC_1	222	227	PF02516	0.316
MOD_N-GLC_1	510	515	PF02516	0.369
MOD_NEK2_1	1	6	PF00069	0.472
MOD_NEK2_1	248	253	PF00069	0.421
MOD_NEK2_1	469	474	PF00069	0.399
MOD_NEK2_1	491	496	PF00069	0.542
MOD_NEK2_1	510	515	PF00069	0.249
MOD_NEK2_1	676	681	PF00069	0.464
MOD_NEK2_1	9	14	PF00069	0.418
MOD_PIKK_1	47	53	PF00454	0.541
MOD_PKA_1	13	19	PF00069	0.463
MOD_PKA_1	706	712	PF00069	0.509
MOD_PKA_2	13	19	PF00069	0.467
MOD_PKA_2	146	152	PF00069	0.448
MOD_PKA_2	205	211	PF00069	0.362
MOD_PKA_2	363	369	PF00069	0.467
MOD_PKA_2	584	590	PF00069	0.396
MOD_PKA_2	676	682	PF00069	0.500
MOD_PKA_2	693	699	PF00069	0.401
MOD_Plk_1	333	339	PF00069	0.376
MOD_Plk_1	510	516	PF00069	0.379
MOD_Plk_2-3	378	384	PF00069	0.438
MOD_Plk_2-3	522	528	PF00069	0.416
MOD_Plk_2-3	625	631	PF00069	0.591
MOD_Plk_2-3	653	659	PF00069	0.638
MOD_Plk_4	182	188	PF00069	0.406
MOD_Plk_4	444	450	PF00069	0.267
MOD_Plk_4	51	57	PF00069	0.425
MOD_Plk_4	716	722	PF00069	0.561
MOD_ProDKin_1	159	165	PF00069	0.352
MOD_ProDKin_1	403	409	PF00069	0.389
MOD_ProDKin_1	435	441	PF00069	0.255
MOD_ProDKin_1	591	597	PF00069	0.592
MOD_ProDKin_1	739	745	PF00069	0.570
MOD_SUMO_for_1	351	354	PF00179	0.630
MOD_SUMO_for_1	375	378	PF00179	0.534
MOD_SUMO_rev_2	125	131	PF00179	0.435
MOD_SUMO_rev_2	133	143	PF00179	0.557
MOD_SUMO_rev_2	154	160	PF00179	0.510
MOD_SUMO_rev_2	211	218	PF00179	0.486
TRG_DiLeu_BaEn_1	156	161	PF01217	0.491
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.372
TRG_ENDOCYTIC_2	415	418	PF00928	0.255
TRG_ENDOCYTIC_2	683	686	PF00928	0.460
TRG_ENDOCYTIC_2	718	721	PF00928	0.552
TRG_ER_diArg_1	146	148	PF00400	0.318
TRG_ER_diArg_1	454	456	PF00400	0.255
TRG_ER_diArg_1	499	501	PF00400	0.394
TRG_ER_diArg_1	536	538	PF00400	0.381
TRG_ER_diArg_1	703	705	PF00400	0.462
TRG_NLS_MonoCore_2	704	709	PF00514	0.503
TRG_NLS_MonoExtN_4	703	710	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S3	Leptomonas seymouri	76%	99%
A0A3S5H5G5	Leishmania donovani	100%	100%
A0A422NYH3	Trypanosoma rangeli	53%	100%
A4H466	Leishmania braziliensis	86%	100%
C9ZPW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9AKC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QJI3	Leishmania major	94%	100%
Q5BJT6	Rattus norvegicus	36%	100%
Q6NY89	Danio rerio	37%	100%