Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (and similar) - putative

Species:

Leishmania infantum

UniProt:

A4HSD3_LEIIN

TriTrypDb:

LINF_050006800

Length:

361

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HSD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSD3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006379	mRNA cleavage	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.583
CLV_C14_Caspase3-7	333	337	PF00656	0.673
CLV_PCSK_KEX2_1	347	349	PF00082	0.632
CLV_PCSK_KEX2_1	72	74	PF00082	0.326
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.632
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.325
CLV_PCSK_PC7_1	343	349	PF00082	0.631
DEG_Nend_UBRbox_2	1	3	PF02207	0.540
DOC_ANK_TNKS_1	349	356	PF00023	0.545
DOC_CKS1_1	286	291	PF01111	0.688
DOC_CYCLIN_yCln2_LP_2	310	313	PF00134	0.653
DOC_PP2B_LxvP_1	310	313	PF13499	0.653
DOC_PP4_FxxP_1	342	345	PF00568	0.636
DOC_USP7_MATH_1	38	42	PF00917	0.456
DOC_WW_Pin1_4	285	290	PF00397	0.688
LIG_14-3-3_CanoR_1	210	216	PF00244	0.320
LIG_BIR_III_2	24	28	PF00653	0.637
LIG_BRCT_BRCA1_1	59	63	PF00533	0.598
LIG_BRCT_BRCA1_1	82	86	PF00533	0.303
LIG_FHA_1	112	118	PF00498	0.552
LIG_FHA_2	32	38	PF00498	0.630
LIG_Integrin_RGD_1	222	224	PF01839	0.356
LIG_LIR_Apic_2	285	290	PF02991	0.520
LIG_LIR_Apic_2	340	345	PF02991	0.698
LIG_LIR_Nem_3	83	88	PF02991	0.292
LIG_LIR_Nem_3	92	98	PF02991	0.290
LIG_MLH1_MIPbox_1	82	86	PF16413	0.303
LIG_Pex14_2	86	90	PF04695	0.291
LIG_PTB_Apo_2	201	208	PF02174	0.493
LIG_PTB_Apo_2	84	91	PF02174	0.291
LIG_PTB_Phospho_1	201	207	PF10480	0.506
LIG_SH2_CRK	182	186	PF00017	0.653
LIG_SH2_CRK	287	291	PF00017	0.673
LIG_SH2_GRB2like	85	88	PF00017	0.291
LIG_SH2_NCK_1	287	291	PF00017	0.651
LIG_SH2_SRC	65	68	PF00017	0.325
LIG_SH2_STAP1	65	69	PF00017	0.367
LIG_SH2_STAT3	170	173	PF00017	0.659
LIG_SH2_STAT3	357	360	PF00017	0.670
LIG_SH2_STAT5	163	166	PF00017	0.498
LIG_SH2_STAT5	287	290	PF00017	0.652
LIG_SH2_STAT5	309	312	PF00017	0.686
LIG_SH2_STAT5	85	88	PF00017	0.291
LIG_SH2_STAT5	98	101	PF00017	0.291
LIG_SH3_1	182	188	PF00018	0.646
LIG_SH3_1	286	292	PF00018	0.652
LIG_SH3_1	343	349	PF00018	0.672
LIG_SH3_2	301	306	PF14604	0.705
LIG_SH3_3	139	145	PF00018	0.550
LIG_SH3_3	182	188	PF00018	0.646
LIG_SH3_3	240	246	PF00018	0.754
LIG_SH3_3	286	292	PF00018	0.702
LIG_SH3_3	298	304	PF00018	0.653
LIG_SH3_3	324	330	PF00018	0.760
LIG_SH3_3	343	349	PF00018	0.746
LIG_SH3_3	353	359	PF00018	0.631
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.367
LIG_TRAF2_1	100	103	PF00917	0.367
LIG_TRAF2_2	349	354	PF00917	0.545
MOD_CK1_1	285	291	PF00069	0.612
MOD_CK1_1	59	65	PF00069	0.614
MOD_CK2_1	211	217	PF00069	0.320
MOD_CK2_1	31	37	PF00069	0.562
MOD_GlcNHglycan	266	269	PF01048	0.756
MOD_GlcNHglycan	295	298	PF01048	0.644
MOD_GlcNHglycan	333	336	PF01048	0.665
MOD_GlcNHglycan	339	342	PF01048	0.622
MOD_GlcNHglycan	59	62	PF01048	0.601
MOD_N-GLC_1	111	116	PF02516	0.581
MOD_NEK2_1	211	216	PF00069	0.253
MOD_NEK2_2	38	43	PF00069	0.461
MOD_Plk_1	105	111	PF00069	0.512
MOD_Plk_1	91	97	PF00069	0.293
MOD_Plk_4	105	111	PF00069	0.516
MOD_Plk_4	282	288	PF00069	0.523
MOD_ProDKin_1	285	291	PF00069	0.687
TRG_DiLeu_BaEn_1	144	149	PF01217	0.485
TRG_ENDOCYTIC_2	98	101	PF00928	0.291
TRG_NES_CRM1_1	37	51	PF08389	0.589
TRG_NLS_MonoCore_2	346	351	PF00514	0.675
TRG_NLS_MonoExtC_3	346	352	PF00514	0.694
TRG_NLS_MonoExtN_4	345	351	PF00514	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N7	Leptomonas seymouri	53%	100%
A0A0S4JNN9	Bodo saltans	33%	100%
A0A3S5H5G4	Leishmania donovani	99%	100%
A4H465	Leishmania braziliensis	79%	97%
C9ZPW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AKC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QJI4	Leishmania major	89%	100%