Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSD2_LEIIN

TriTrypDb:

LINF_050006600

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HSD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	713	717	PF00656	0.714
CLV_NRD_NRD_1	139	141	PF00675	0.533
CLV_NRD_NRD_1	15	17	PF00675	0.593
CLV_NRD_NRD_1	219	221	PF00675	0.711
CLV_NRD_NRD_1	369	371	PF00675	0.761
CLV_NRD_NRD_1	414	416	PF00675	0.727
CLV_NRD_NRD_1	645	647	PF00675	0.764
CLV_NRD_NRD_1	675	677	PF00675	0.766
CLV_PCSK_FUR_1	673	677	PF00082	0.670
CLV_PCSK_KEX2_1	139	141	PF00082	0.561
CLV_PCSK_KEX2_1	15	17	PF00082	0.560
CLV_PCSK_KEX2_1	219	221	PF00082	0.711
CLV_PCSK_KEX2_1	369	371	PF00082	0.761
CLV_PCSK_KEX2_1	414	416	PF00082	0.727
CLV_PCSK_KEX2_1	42	44	PF00082	0.527
CLV_PCSK_KEX2_1	645	647	PF00082	0.764
CLV_PCSK_KEX2_1	675	677	PF00082	0.761
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.527
CLV_PCSK_SKI1_1	395	399	PF00082	0.706
CLV_PCSK_SKI1_1	423	427	PF00082	0.646
CLV_PCSK_SKI1_1	576	580	PF00082	0.619
CLV_PCSK_SKI1_1	645	649	PF00082	0.841
CLV_PCSK_SKI1_1	676	680	PF00082	0.755
CLV_PCSK_SKI1_1	744	748	PF00082	0.584
CLV_Separin_Metazoa	193	197	PF03568	0.590
CLV_Separin_Metazoa	411	415	PF03568	0.732
CLV_Separin_Metazoa	420	424	PF03568	0.622
DEG_APCC_DBOX_1	188	196	PF00400	0.690
DEG_APCC_DBOX_1	314	322	PF00400	0.702
DEG_APCC_DBOX_1	414	422	PF00400	0.776
DEG_SPOP_SBC_1	717	721	PF00917	0.672
DOC_CDC14_PxL_1	398	406	PF14671	0.691
DOC_CKS1_1	374	379	PF01111	0.729
DOC_CKS1_1	444	449	PF01111	0.724
DOC_CKS1_1	588	593	PF01111	0.808
DOC_CYCLIN_RxL_1	485	496	PF00134	0.797
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.635
DOC_MAPK_DCC_7	478	487	PF00069	0.707
DOC_MAPK_gen_1	139	145	PF00069	0.683
DOC_MAPK_gen_1	478	487	PF00069	0.707
DOC_MAPK_MEF2A_6	478	487	PF00069	0.707
DOC_PP2B_LxvP_1	526	529	PF13499	0.792
DOC_PP2B_LxvP_1	559	562	PF13499	0.655
DOC_PP2B_LxvP_1	639	642	PF13499	0.712
DOC_USP7_MATH_1	181	185	PF00917	0.789
DOC_USP7_MATH_1	188	192	PF00917	0.731
DOC_USP7_MATH_1	473	477	PF00917	0.807
DOC_USP7_MATH_1	516	520	PF00917	0.785
DOC_USP7_MATH_1	533	537	PF00917	0.676
DOC_USP7_MATH_1	540	544	PF00917	0.709
DOC_USP7_MATH_1	548	552	PF00917	0.832
DOC_USP7_MATH_1	656	660	PF00917	0.797
DOC_USP7_MATH_1	698	702	PF00917	0.716
DOC_USP7_MATH_1	717	721	PF00917	0.740
DOC_USP7_MATH_1	725	729	PF00917	0.652
DOC_WW_Pin1_4	213	218	PF00397	0.712
DOC_WW_Pin1_4	360	365	PF00397	0.717
DOC_WW_Pin1_4	373	378	PF00397	0.680
DOC_WW_Pin1_4	440	445	PF00397	0.690
DOC_WW_Pin1_4	457	462	PF00397	0.817
DOC_WW_Pin1_4	512	517	PF00397	0.751
DOC_WW_Pin1_4	552	557	PF00397	0.796
DOC_WW_Pin1_4	568	573	PF00397	0.766
DOC_WW_Pin1_4	584	589	PF00397	0.595
DOC_WW_Pin1_4	600	605	PF00397	0.719
DOC_WW_Pin1_4	654	659	PF00397	0.779
DOC_WW_Pin1_4	665	670	PF00397	0.638
DOC_WW_Pin1_4	676	681	PF00397	0.788
DOC_WW_Pin1_4	700	705	PF00397	0.751
LIG_14-3-3_CanoR_1	123	132	PF00244	0.559
LIG_14-3-3_CanoR_1	139	145	PF00244	0.519
LIG_14-3-3_CanoR_1	182	186	PF00244	0.786
LIG_14-3-3_CanoR_1	220	230	PF00244	0.702
LIG_14-3-3_CanoR_1	292	297	PF00244	0.680
LIG_14-3-3_CanoR_1	415	425	PF00244	0.688
LIG_14-3-3_CanoR_1	510	516	PF00244	0.680
LIG_14-3-3_CanoR_1	541	545	PF00244	0.629
LIG_14-3-3_CanoR_1	645	655	PF00244	0.703
LIG_14-3-3_CanoR_1	673	681	PF00244	0.756
LIG_APCC_ABBA_1	232	237	PF00400	0.707
LIG_BIR_III_2	209	213	PF00653	0.626
LIG_BIR_III_2	258	262	PF00653	0.688
LIG_BRCT_BRCA1_1	459	463	PF00533	0.820
LIG_EVH1_1	526	530	PF00568	0.730
LIG_FHA_1	144	150	PF00498	0.647
LIG_FHA_1	237	243	PF00498	0.729
LIG_FHA_1	464	470	PF00498	0.728
LIG_FHA_1	512	518	PF00498	0.611
LIG_FHA_2	241	247	PF00498	0.694
LIG_FHA_2	311	317	PF00498	0.607
LIG_FHA_2	577	583	PF00498	0.619
LIG_FHA_2	688	694	PF00498	0.830
LIG_LIR_Apic_2	323	328	PF02991	0.548
LIG_MYND_1	190	194	PF01753	0.590
LIG_Pex14_2	394	398	PF04695	0.600
LIG_SH2_NCK_1	432	436	PF00017	0.638
LIG_SH2_NCK_1	722	726	PF00017	0.714
LIG_SH2_STAP1	89	93	PF00017	0.580
LIG_SH2_STAT3	38	41	PF00017	0.543
LIG_SH2_STAT3	634	637	PF00017	0.831
LIG_SH2_STAT5	121	124	PF00017	0.578
LIG_SH2_STAT5	387	390	PF00017	0.683
LIG_SH3_1	480	486	PF00018	0.676
LIG_SH3_2	483	488	PF14604	0.678
LIG_SH3_3	182	188	PF00018	0.708
LIG_SH3_3	396	402	PF00018	0.634
LIG_SH3_3	436	442	PF00018	0.685
LIG_SH3_3	458	464	PF00018	0.810
LIG_SH3_3	480	486	PF00018	0.676
LIG_SH3_3	524	530	PF00018	0.717
LIG_SH3_3	585	591	PF00018	0.715
LIG_SH3_3	598	604	PF00018	0.729
LIG_SH3_3	652	658	PF00018	0.699
LIG_SH3_4	131	138	PF00018	0.486
LIG_SH3_CIN85_PxpxPR_1	529	534	PF14604	0.808
LIG_SUMO_SIM_par_1	581	587	PF11976	0.827
LIG_TRAF2_1	244	247	PF00917	0.759
LIG_TRAF2_1	328	331	PF00917	0.705
LIG_TRAF2_1	519	522	PF00917	0.716
LIG_TRAF2_1	579	582	PF00917	0.719
LIG_TRAF2_1	97	100	PF00917	0.663
LIG_WW_3	411	415	PF00397	0.688
MOD_CDC14_SPxK_1	216	219	PF00782	0.674
MOD_CDC14_SPxK_1	555	558	PF00782	0.829
MOD_CDC14_SPxK_1	573	576	PF00782	0.808
MOD_CDK_SPxK_1	213	219	PF00069	0.675
MOD_CDK_SPxK_1	373	379	PF00069	0.740
MOD_CDK_SPxK_1	552	558	PF00069	0.828
MOD_CDK_SPxK_1	570	576	PF00069	0.810
MOD_CDK_SPxxK_3	213	220	PF00069	0.677
MOD_CK1_1	163	169	PF00069	0.654
MOD_CK1_1	357	363	PF00069	0.774
MOD_CK1_1	564	570	PF00069	0.706
MOD_CK1_1	587	593	PF00069	0.809
MOD_CK1_1	628	634	PF00069	0.788
MOD_CK1_1	659	665	PF00069	0.742
MOD_CK1_1	682	688	PF00069	0.786
MOD_CK1_1	699	705	PF00069	0.620
MOD_CK1_1	710	716	PF00069	0.685
MOD_CK1_1	718	724	PF00069	0.769
MOD_CK1_1	728	734	PF00069	0.623
MOD_CK2_1	240	246	PF00069	0.702
MOD_CK2_1	310	316	PF00069	0.479
MOD_CK2_1	502	508	PF00069	0.767
MOD_CK2_1	515	521	PF00069	0.671
MOD_CK2_1	576	582	PF00069	0.704
MOD_CK2_1	646	652	PF00069	0.690
MOD_CK2_1	660	666	PF00069	0.756
MOD_CK2_1	687	693	PF00069	0.831
MOD_Cter_Amidation	336	339	PF01082	0.652
MOD_Cter_Amidation	643	646	PF01082	0.765
MOD_DYRK1A_RPxSP_1	568	572	PF00069	0.735
MOD_DYRK1A_RPxSP_1	676	680	PF00069	0.755
MOD_GlcNHglycan	249	253	PF01048	0.662
MOD_GlcNHglycan	262	265	PF01048	0.641
MOD_GlcNHglycan	334	337	PF01048	0.822
MOD_GlcNHglycan	357	360	PF01048	0.721
MOD_GlcNHglycan	452	455	PF01048	0.712
MOD_GlcNHglycan	471	474	PF01048	0.636
MOD_GlcNHglycan	475	478	PF01048	0.724
MOD_GlcNHglycan	496	499	PF01048	0.782
MOD_GlcNHglycan	504	507	PF01048	0.785
MOD_GlcNHglycan	518	521	PF01048	0.614
MOD_GlcNHglycan	536	539	PF01048	0.812
MOD_GlcNHglycan	546	549	PF01048	0.557
MOD_GlcNHglycan	648	651	PF01048	0.810
MOD_GlcNHglycan	658	661	PF01048	0.691
MOD_GlcNHglycan	676	679	PF01048	0.827
MOD_GlcNHglycan	698	701	PF01048	0.717
MOD_GlcNHglycan	712	715	PF01048	0.723
MOD_GlcNHglycan	723	726	PF01048	0.638
MOD_GlcNHglycan	727	730	PF01048	0.611
MOD_GlcNHglycan	755	758	PF01048	0.633
MOD_GSK3_1	119	126	PF00069	0.496
MOD_GSK3_1	163	170	PF00069	0.620
MOD_GSK3_1	236	243	PF00069	0.711
MOD_GSK3_1	344	351	PF00069	0.689
MOD_GSK3_1	353	360	PF00069	0.692
MOD_GSK3_1	430	437	PF00069	0.562
MOD_GSK3_1	459	466	PF00069	0.828
MOD_GSK3_1	469	476	PF00069	0.755
MOD_GSK3_1	511	518	PF00069	0.793
MOD_GSK3_1	540	547	PF00069	0.776
MOD_GSK3_1	548	555	PF00069	0.802
MOD_GSK3_1	564	571	PF00069	0.745
MOD_GSK3_1	656	663	PF00069	0.746
MOD_GSK3_1	676	683	PF00069	0.845
MOD_GSK3_1	684	691	PF00069	0.786
MOD_GSK3_1	696	703	PF00069	0.762
MOD_GSK3_1	708	715	PF00069	0.712
MOD_GSK3_1	717	724	PF00069	0.653
MOD_GSK3_1	749	756	PF00069	0.588
MOD_N-GLC_1	360	365	PF02516	0.836
MOD_NEK2_1	162	167	PF00069	0.621
MOD_NEK2_1	430	435	PF00069	0.569
MOD_NEK2_1	618	623	PF00069	0.673
MOD_NEK2_1	684	689	PF00069	0.733
MOD_NEK2_2	540	545	PF00069	0.628
MOD_PIKK_1	121	127	PF00454	0.563
MOD_PIKK_1	310	316	PF00454	0.479
MOD_PKA_1	645	651	PF00069	0.763
MOD_PKA_2	138	144	PF00069	0.668
MOD_PKA_2	181	187	PF00069	0.782
MOD_PKA_2	188	194	PF00069	0.704
MOD_PKA_2	221	227	PF00069	0.690
MOD_PKA_2	240	246	PF00069	0.678
MOD_PKA_2	494	500	PF00069	0.746
MOD_PKA_2	533	539	PF00069	0.756
MOD_PKA_2	540	546	PF00069	0.674
MOD_PKA_2	564	570	PF00069	0.776
MOD_PKA_2	645	651	PF00069	0.790
MOD_PKA_2	674	680	PF00069	0.732
MOD_PKA_2	73	79	PF00069	0.558
MOD_PKB_1	751	759	PF00069	0.611
MOD_Plk_1	248	254	PF00069	0.646
MOD_Plk_1	628	634	PF00069	0.788
MOD_Plk_4	163	169	PF00069	0.660
MOD_Plk_4	292	298	PF00069	0.688
MOD_Plk_4	660	666	PF00069	0.760
MOD_ProDKin_1	213	219	PF00069	0.714
MOD_ProDKin_1	360	366	PF00069	0.719
MOD_ProDKin_1	373	379	PF00069	0.676
MOD_ProDKin_1	440	446	PF00069	0.693
MOD_ProDKin_1	457	463	PF00069	0.819
MOD_ProDKin_1	512	518	PF00069	0.750
MOD_ProDKin_1	552	558	PF00069	0.798
MOD_ProDKin_1	568	574	PF00069	0.763
MOD_ProDKin_1	584	590	PF00069	0.592
MOD_ProDKin_1	600	606	PF00069	0.716
MOD_ProDKin_1	654	660	PF00069	0.780
MOD_ProDKin_1	665	671	PF00069	0.640
MOD_ProDKin_1	676	682	PF00069	0.788
MOD_ProDKin_1	700	706	PF00069	0.752
MOD_SUMO_for_1	388	391	PF00179	0.676
MOD_SUMO_for_1	501	504	PF00179	0.629
TRG_DiLeu_BaEn_4	521	527	PF01217	0.715
TRG_DiLeu_BaEn_4	581	587	PF01217	0.831
TRG_ER_diArg_1	114	117	PF00400	0.526
TRG_ER_diArg_1	218	220	PF00400	0.804
TRG_ER_diArg_1	369	371	PF00400	0.761
TRG_ER_diArg_1	413	415	PF00400	0.744
TRG_ER_diArg_1	478	481	PF00400	0.723
TRG_ER_diArg_1	673	676	PF00400	0.831
TRG_ER_diArg_1	748	751	PF00400	0.586
TRG_NES_CRM1_1	429	441	PF08389	0.663
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.797
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.750

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW2	Leptomonas seymouri	41%	100%
A0A3S7WNZ4	Leishmania donovani	99%	100%
A4H463	Leishmania braziliensis	68%	98%
E9AKC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJI6	Leishmania major	88%	99%