LeishMANIAdb
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Spindle assembly checkpoint component MAD1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Spindle assembly checkpoint component MAD1
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSC8_LEIIN
TriTrypDb:
LINF_050005400
Length:
833

Annotations

Annotations by Jardim et al.

Intracellular signaling, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HSC8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSC8

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006163 purine nucleotide metabolic process 5 10
GO:0006164 purine nucleotide biosynthetic process 6 10
GO:0006171 cAMP biosynthetic process 8 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006753 nucleoside phosphate metabolic process 4 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009058 biosynthetic process 2 10
GO:0009117 nucleotide metabolic process 5 10
GO:0009150 purine ribonucleotide metabolic process 6 10
GO:0009152 purine ribonucleotide biosynthetic process 7 10
GO:0009165 nucleotide biosynthetic process 6 10
GO:0009187 cyclic nucleotide metabolic process 6 10
GO:0009190 cyclic nucleotide biosynthetic process 7 10
GO:0009259 ribonucleotide metabolic process 5 10
GO:0009260 ribonucleotide biosynthetic process 6 10
GO:0009987 cellular process 1 10
GO:0018130 heterocycle biosynthetic process 4 10
GO:0019438 aromatic compound biosynthetic process 4 10
GO:0019637 organophosphate metabolic process 3 10
GO:0019693 ribose phosphate metabolic process 4 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0034654 nucleobase-containing compound biosynthetic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044249 cellular biosynthetic process 3 10
GO:0044271 cellular nitrogen compound biosynthetic process 4 10
GO:0044281 small molecule metabolic process 2 10
GO:0046058 cAMP metabolic process 7 10
GO:0046390 ribose phosphate biosynthetic process 5 10
GO:0046483 heterocycle metabolic process 3 10
GO:0052652 cyclic purine nucleotide metabolic process 6 10
GO:0055086 nucleobase-containing small molecule metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:0072521 purine-containing compound metabolic process 4 10
GO:0072522 purine-containing compound biosynthetic process 5 10
GO:0090407 organophosphate biosynthetic process 4 10
GO:1901135 carbohydrate derivative metabolic process 3 10
GO:1901137 carbohydrate derivative biosynthetic process 4 10
GO:1901293 nucleoside phosphate biosynthetic process 5 10
GO:1901360 organic cyclic compound metabolic process 3 10
GO:1901362 organic cyclic compound biosynthetic process 4 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:1901576 organic substance biosynthetic process 3 10
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 528 532 PF00656 0.426
CLV_C14_Caspase3-7 81 85 PF00656 0.627
CLV_NRD_NRD_1 112 114 PF00675 0.614
CLV_NRD_NRD_1 367 369 PF00675 0.762
CLV_NRD_NRD_1 425 427 PF00675 0.616
CLV_NRD_NRD_1 600 602 PF00675 0.521
CLV_NRD_NRD_1 791 793 PF00675 0.618
CLV_NRD_NRD_1 823 825 PF00675 0.493
CLV_PCSK_KEX2_1 112 114 PF00082 0.595
CLV_PCSK_KEX2_1 266 268 PF00082 0.612
CLV_PCSK_KEX2_1 367 369 PF00082 0.669
CLV_PCSK_KEX2_1 425 427 PF00082 0.616
CLV_PCSK_KEX2_1 600 602 PF00082 0.557
CLV_PCSK_KEX2_1 791 793 PF00082 0.620
CLV_PCSK_PC1ET2_1 266 268 PF00082 0.612
CLV_PCSK_SKI1_1 151 155 PF00082 0.498
CLV_PCSK_SKI1_1 204 208 PF00082 0.617
CLV_PCSK_SKI1_1 24 28 PF00082 0.608
CLV_PCSK_SKI1_1 330 334 PF00082 0.546
CLV_PCSK_SKI1_1 353 357 PF00082 0.573
CLV_PCSK_SKI1_1 368 372 PF00082 0.716
CLV_PCSK_SKI1_1 407 411 PF00082 0.612
CLV_PCSK_SKI1_1 646 650 PF00082 0.530
CLV_PCSK_SKI1_1 710 714 PF00082 0.519
CLV_Separin_Metazoa 457 461 PF03568 0.559
CLV_Separin_Metazoa 66 70 PF03568 0.550
DEG_Nend_UBRbox_3 1 3 PF02207 0.797
DEG_SPOP_SBC_1 216 220 PF00917 0.409
DOC_CDC14_PxL_1 305 313 PF14671 0.582
DOC_CDC14_PxL_1 320 328 PF14671 0.566
DOC_CYCLIN_yClb5_NLxxxL_5 415 424 PF00134 0.648
DOC_CYCLIN_yCln2_LP_2 513 519 PF00134 0.458
DOC_CYCLIN_yCln2_LP_2 718 721 PF00134 0.541
DOC_MAPK_gen_1 266 274 PF00069 0.582
DOC_MAPK_gen_1 50 59 PF00069 0.633
DOC_MAPK_gen_1 538 546 PF00069 0.373
DOC_MAPK_gen_1 681 690 PF00069 0.560
DOC_MAPK_MEF2A_6 267 276 PF00069 0.555
DOC_MAPK_MEF2A_6 436 445 PF00069 0.432
DOC_PP1_RVXF_1 175 182 PF00149 0.560
DOC_PP1_RVXF_1 230 236 PF00149 0.347
DOC_PP1_RVXF_1 410 416 PF00149 0.513
DOC_PP1_RVXF_1 434 441 PF00149 0.448
DOC_PP1_RVXF_1 447 453 PF00149 0.389
DOC_PP2B_LxvP_1 326 329 PF13499 0.478
DOC_PP2B_LxvP_1 443 446 PF13499 0.476
DOC_PP2B_LxvP_1 520 523 PF13499 0.544
DOC_PP2B_LxvP_1 718 721 PF13499 0.519
DOC_PP4_FxxP_1 36 39 PF00568 0.586
DOC_PP4_FxxP_1 648 651 PF00568 0.604
DOC_USP7_MATH_1 127 131 PF00917 0.555
DOC_USP7_MATH_1 216 220 PF00917 0.584
DOC_USP7_MATH_1 44 48 PF00917 0.645
DOC_USP7_MATH_1 617 621 PF00917 0.481
DOC_USP7_MATH_1 658 662 PF00917 0.585
DOC_USP7_UBL2_3 162 166 PF12436 0.609
DOC_WW_Pin1_4 1 6 PF00397 0.673
DOC_WW_Pin1_4 646 651 PF00397 0.562
LIG_14-3-3_CanoR_1 151 160 PF00244 0.537
LIG_14-3-3_CanoR_1 267 275 PF00244 0.522
LIG_14-3-3_CanoR_1 407 416 PF00244 0.550
LIG_14-3-3_CanoR_1 460 464 PF00244 0.456
LIG_14-3-3_CanoR_1 501 510 PF00244 0.427
LIG_14-3-3_CanoR_1 541 545 PF00244 0.409
LIG_14-3-3_CanoR_1 6 13 PF00244 0.784
LIG_14-3-3_CanoR_1 791 795 PF00244 0.656
LIG_Actin_WH2_2 183 200 PF00022 0.569
LIG_Actin_WH2_2 459 475 PF00022 0.520
LIG_deltaCOP1_diTrp_1 508 515 PF00928 0.442
LIG_FHA_1 192 198 PF00498 0.507
LIG_FHA_1 25 31 PF00498 0.475
LIG_FHA_1 267 273 PF00498 0.505
LIG_FHA_1 408 414 PF00498 0.629
LIG_FHA_1 467 473 PF00498 0.557
LIG_FHA_1 54 60 PF00498 0.587
LIG_FHA_1 613 619 PF00498 0.526
LIG_FHA_1 7 13 PF00498 0.712
LIG_FHA_1 785 791 PF00498 0.603
LIG_FHA_1 795 801 PF00498 0.597
LIG_FHA_1 807 813 PF00498 0.533
LIG_FHA_2 783 789 PF00498 0.547
LIG_FHA_2 79 85 PF00498 0.549
LIG_Integrin_isoDGR_2 447 449 PF01839 0.452
LIG_LIR_Apic_2 33 39 PF02991 0.584
LIG_LIR_Apic_2 550 555 PF02991 0.458
LIG_LIR_Apic_2 645 651 PF02991 0.570
LIG_LIR_Gen_1 298 309 PF02991 0.447
LIG_LIR_Gen_1 437 446 PF02991 0.433
LIG_LIR_Gen_1 730 740 PF02991 0.551
LIG_LIR_Gen_1 743 753 PF02991 0.546
LIG_LIR_Nem_3 208 214 PF02991 0.620
LIG_LIR_Nem_3 298 304 PF02991 0.440
LIG_LIR_Nem_3 386 392 PF02991 0.497
LIG_LIR_Nem_3 437 443 PF02991 0.435
LIG_LIR_Nem_3 476 480 PF02991 0.406
LIG_LIR_Nem_3 743 749 PF02991 0.571
LIG_LIR_Nem_3 84 90 PF02991 0.522
LIG_LYPXL_SIV_4 346 354 PF13949 0.537
LIG_PCNA_yPIPBox_3 600 609 PF02747 0.454
LIG_PCNA_yPIPBox_3 699 710 PF02747 0.565
LIG_Pex14_2 300 304 PF04695 0.454
LIG_PTB_Apo_2 563 570 PF02174 0.575
LIG_PTB_Phospho_1 563 569 PF10480 0.583
LIG_SH2_CRK 467 471 PF00017 0.516
LIG_SH2_CRK 537 541 PF00017 0.455
LIG_SH2_PTP2 552 555 PF00017 0.564
LIG_SH2_SRC 552 555 PF00017 0.564
LIG_SH2_STAP1 247 251 PF00017 0.593
LIG_SH2_STAP1 483 487 PF00017 0.517
LIG_SH2_STAT3 247 250 PF00017 0.591
LIG_SH2_STAT3 769 772 PF00017 0.560
LIG_SH2_STAT5 22 25 PF00017 0.613
LIG_SH2_STAT5 292 295 PF00017 0.428
LIG_SH2_STAT5 414 417 PF00017 0.568
LIG_SH2_STAT5 552 555 PF00017 0.558
LIG_SH2_STAT5 746 749 PF00017 0.598
LIG_SH2_STAT5 769 772 PF00017 0.527
LIG_SH3_3 427 433 PF00018 0.507
LIG_SH3_3 652 658 PF00018 0.632
LIG_SUMO_SIM_anti_2 268 276 PF11976 0.616
LIG_SUMO_SIM_anti_2 686 694 PF11976 0.573
LIG_SUMO_SIM_par_1 272 278 PF11976 0.528
LIG_SUMO_SIM_par_1 55 61 PF11976 0.570
LIG_SUMO_SIM_par_1 639 645 PF11976 0.476
LIG_TRAF2_1 206 209 PF00917 0.476
LIG_TRAF2_1 525 528 PF00917 0.512
LIG_TRAF2_1 755 758 PF00917 0.595
LIG_TRFH_1 716 720 PF08558 0.514
LIG_TYR_ITIM 465 470 PF00017 0.504
LIG_TYR_ITIM 535 540 PF00017 0.463
LIG_WRC_WIRS_1 297 302 PF05994 0.559
LIG_WRC_WIRS_1 618 623 PF05994 0.502
MOD_CDK_SPK_2 1 6 PF00069 0.668
MOD_CDK_SPxxK_3 1 8 PF00069 0.670
MOD_CDK_SPxxK_3 646 653 PF00069 0.501
MOD_CK1_1 218 224 PF00069 0.604
MOD_CK1_1 53 59 PF00069 0.639
MOD_CK1_1 612 618 PF00069 0.537
MOD_CK1_1 620 626 PF00069 0.600
MOD_CK1_1 660 666 PF00069 0.473
MOD_CK1_1 697 703 PF00069 0.581
MOD_CK2_1 134 140 PF00069 0.482
MOD_CK2_1 196 202 PF00069 0.558
MOD_CK2_1 390 396 PF00069 0.516
MOD_CK2_1 397 403 PF00069 0.557
MOD_CK2_1 730 736 PF00069 0.540
MOD_CK2_1 782 788 PF00069 0.536
MOD_CK2_1 88 94 PF00069 0.565
MOD_GlcNHglycan 46 49 PF01048 0.602
MOD_GlcNHglycan 52 55 PF01048 0.557
MOD_GlcNHglycan 554 558 PF01048 0.544
MOD_GlcNHglycan 624 627 PF01048 0.650
MOD_GlcNHglycan 774 778 PF01048 0.627
MOD_GSK3_1 192 199 PF00069 0.537
MOD_GSK3_1 288 295 PF00069 0.512
MOD_GSK3_1 296 303 PF00069 0.470
MOD_GSK3_1 481 488 PF00069 0.386
MOD_GSK3_1 69 76 PF00069 0.498
MOD_GSK3_1 694 701 PF00069 0.569
MOD_GSK3_1 719 726 PF00069 0.508
MOD_GSK3_1 78 85 PF00069 0.487
MOD_GSK3_1 790 797 PF00069 0.539
MOD_N-GLC_1 407 412 PF02516 0.606
MOD_N-GLC_1 794 799 PF02516 0.577
MOD_N-GLC_2 596 598 PF02516 0.515
MOD_NEK2_1 134 139 PF00069 0.487
MOD_NEK2_1 288 293 PF00069 0.525
MOD_NEK2_1 300 305 PF00069 0.417
MOD_NEK2_1 402 407 PF00069 0.578
MOD_NEK2_1 420 425 PF00069 0.683
MOD_NEK2_1 458 463 PF00069 0.449
MOD_NEK2_1 465 470 PF00069 0.393
MOD_NEK2_1 540 545 PF00069 0.411
MOD_NEK2_1 78 83 PF00069 0.609
MOD_NEK2_1 794 799 PF00069 0.587
MOD_NEK2_1 88 93 PF00069 0.563
MOD_PIKK_1 127 133 PF00454 0.496
MOD_PIKK_1 134 140 PF00454 0.451
MOD_PIKK_1 381 387 PF00454 0.570
MOD_PIKK_1 503 509 PF00454 0.373
MOD_PIKK_1 571 577 PF00454 0.403
MOD_PIKK_1 580 586 PF00454 0.410
MOD_PIKK_1 620 626 PF00454 0.627
MOD_PIKK_1 723 729 PF00454 0.492
MOD_PIKK_1 95 101 PF00454 0.544
MOD_PKA_1 266 272 PF00069 0.536
MOD_PKA_2 200 206 PF00069 0.553
MOD_PKA_2 266 272 PF00069 0.599
MOD_PKA_2 459 465 PF00069 0.452
MOD_PKA_2 540 546 PF00069 0.381
MOD_PKA_2 790 796 PF00069 0.629
MOD_PKB_1 804 812 PF00069 0.554
MOD_Plk_1 402 408 PF00069 0.527
MOD_Plk_1 420 426 PF00069 0.701
MOD_Plk_1 485 491 PF00069 0.466
MOD_Plk_1 644 650 PF00069 0.452
MOD_Plk_1 794 800 PF00069 0.621
MOD_Plk_1 88 94 PF00069 0.565
MOD_Plk_2-3 196 202 PF00069 0.554
MOD_Plk_2-3 397 403 PF00069 0.593
MOD_Plk_2-3 481 487 PF00069 0.477
MOD_Plk_2-3 730 736 PF00069 0.572
MOD_Plk_4 288 294 PF00069 0.478
MOD_Plk_4 296 302 PF00069 0.489
MOD_Plk_4 485 491 PF00069 0.369
MOD_Plk_4 665 671 PF00069 0.531
MOD_Plk_4 701 707 PF00069 0.562
MOD_Plk_4 730 736 PF00069 0.537
MOD_Plk_4 82 88 PF00069 0.629
MOD_ProDKin_1 1 7 PF00069 0.672
MOD_ProDKin_1 646 652 PF00069 0.575
MOD_SUMO_for_1 146 149 PF00179 0.556
MOD_SUMO_rev_2 115 124 PF00179 0.496
MOD_SUMO_rev_2 169 174 PF00179 0.439
MOD_SUMO_rev_2 191 200 PF00179 0.539
MOD_SUMO_rev_2 259 268 PF00179 0.575
MOD_SUMO_rev_2 334 340 PF00179 0.539
TRG_DiLeu_BaEn_1 63 68 PF01217 0.509
TRG_DiLeu_BaEn_2 230 236 PF01217 0.347
TRG_DiLeu_BaEn_4 65 71 PF01217 0.615
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.501
TRG_ENDOCYTIC_2 211 214 PF00928 0.623
TRG_ENDOCYTIC_2 301 304 PF00928 0.441
TRG_ENDOCYTIC_2 467 470 PF00928 0.489
TRG_ENDOCYTIC_2 537 540 PF00928 0.454
TRG_ENDOCYTIC_2 732 735 PF00928 0.523
TRG_ENDOCYTIC_2 746 749 PF00928 0.467
TRG_ER_diArg_1 112 114 PF00400 0.614
TRG_ER_diArg_1 232 235 PF00400 0.408
TRG_ER_diArg_1 366 368 PF00400 0.566
TRG_ER_diArg_1 424 426 PF00400 0.618
TRG_ER_diArg_1 599 601 PF00400 0.551
TRG_ER_diArg_1 790 792 PF00400 0.598
TRG_NES_CRM1_1 631 645 PF08389 0.523
TRG_NES_CRM1_1 730 744 PF08389 0.571
TRG_Pf-PMV_PEXEL_1 133 138 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 205 209 PF00026 0.533
TRG_Pf-PMV_PEXEL_1 234 238 PF00026 0.579
TRG_Pf-PMV_PEXEL_1 390 394 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 824 828 PF00026 0.578

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC98 Leptomonas seymouri 68% 100%
A0A0S4JP59 Bodo saltans 30% 88%
A0A1X0P3L6 Trypanosomatidae 46% 99%
A0A3S5H5F6 Leishmania donovani 100% 100%
A0A422NYC2 Trypanosoma rangeli 46% 98%
A4H451 Leishmania braziliensis 85% 100%
C9ZPY3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 99%
E9AKA9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QJJ8 Leishmania major 94% 100%
V5BAC3 Trypanosoma cruzi 44% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS