Putative paraflagellar rod component par4

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component par4 - putative

Species:

Leishmania infantum

UniProt:

A4HSC7_LEIIN

TriTrypDb:

LINF_050005300

Length:

581

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod component par4

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4HSC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.439
CLV_C14_Caspase3-7	539	543	PF00656	0.542
CLV_NRD_NRD_1	220	222	PF00675	0.558
CLV_NRD_NRD_1	239	241	PF00675	0.447
CLV_NRD_NRD_1	348	350	PF00675	0.435
CLV_NRD_NRD_1	359	361	PF00675	0.389
CLV_NRD_NRD_1	43	45	PF00675	0.470
CLV_NRD_NRD_1	569	571	PF00675	0.585
CLV_NRD_NRD_1	69	71	PF00675	0.578
CLV_PCSK_KEX2_1	171	173	PF00082	0.630
CLV_PCSK_KEX2_1	238	240	PF00082	0.469
CLV_PCSK_KEX2_1	325	327	PF00082	0.637
CLV_PCSK_KEX2_1	43	45	PF00082	0.486
CLV_PCSK_KEX2_1	549	551	PF00082	0.472
CLV_PCSK_KEX2_1	69	71	PF00082	0.572
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.624
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.490
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.637
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.482
CLV_PCSK_SKI1_1	103	107	PF00082	0.554
CLV_PCSK_SKI1_1	201	205	PF00082	0.606
CLV_PCSK_SKI1_1	222	226	PF00082	0.532
CLV_PCSK_SKI1_1	295	299	PF00082	0.537
CLV_PCSK_SKI1_1	465	469	PF00082	0.639
CLV_PCSK_SKI1_1	476	480	PF00082	0.524
CLV_PCSK_SKI1_1	510	514	PF00082	0.630
CLV_PCSK_SKI1_1	560	564	PF00082	0.451
CLV_PCSK_SKI1_1	9	13	PF00082	0.553
CLV_Separin_Metazoa	491	495	PF03568	0.537
DOC_MAPK_gen_1	15	23	PF00069	0.470
DOC_MAPK_gen_1	221	229	PF00069	0.570
DOC_MAPK_gen_1	510	518	PF00069	0.492
DOC_MAPK_gen_1	531	540	PF00069	0.437
DOC_MAPK_gen_1	568	575	PF00069	0.453
DOC_PP1_RVXF_1	366	372	PF00149	0.444
DOC_USP7_MATH_1	283	287	PF00917	0.528
DOC_USP7_MATH_1	493	497	PF00917	0.639
DOC_USP7_UBL2_3	302	306	PF12436	0.540
DOC_USP7_UBL2_3	392	396	PF12436	0.595
DOC_USP7_UBL2_3	5	9	PF12436	0.588
LIG_14-3-3_CanoR_1	221	227	PF00244	0.533
LIG_14-3-3_CanoR_1	251	260	PF00244	0.441
LIG_14-3-3_CanoR_1	284	291	PF00244	0.533
LIG_14-3-3_CanoR_1	568	574	PF00244	0.458
LIG_Actin_WH2_2	460	478	PF00022	0.503
LIG_Actin_WH2_2	505	521	PF00022	0.489
LIG_Actin_WH2_2	534	551	PF00022	0.548
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_CaM_IQ_9	541	557	PF13499	0.560
LIG_Clathr_ClatBox_1	112	116	PF01394	0.458
LIG_FHA_1	296	302	PF00498	0.552
LIG_FHA_1	450	456	PF00498	0.415
LIG_FHA_1	570	576	PF00498	0.446
LIG_FHA_2	253	259	PF00498	0.579
LIG_FHA_2	267	273	PF00498	0.600
LIG_FHA_2	379	385	PF00498	0.393
LIG_FHA_2	436	442	PF00498	0.634
LIG_FHA_2	444	450	PF00498	0.411
LIG_FHA_2	559	565	PF00498	0.604
LIG_FHA_2	99	105	PF00498	0.623
LIG_Integrin_isoDGR_2	378	380	PF01839	0.614
LIG_LIR_Gen_1	364	374	PF02991	0.428
LIG_LIR_Gen_1	458	467	PF02991	0.507
LIG_LIR_Nem_3	364	369	PF02991	0.427
LIG_LIR_Nem_3	458	464	PF02991	0.591
LIG_NRBOX	225	231	PF00104	0.543
LIG_NRBOX	353	359	PF00104	0.448
LIG_PCNA_yPIPBox_3	216	230	PF02747	0.583
LIG_PCNA_yPIPBox_3	349	358	PF02747	0.585
LIG_SH2_STAP1	134	138	PF00017	0.391
LIG_SH2_STAP1	241	245	PF00017	0.494
LIG_SH2_STAP1	432	436	PF00017	0.537
LIG_SH2_STAP1	92	96	PF00017	0.589
LIG_SH2_STAT3	134	137	PF00017	0.506
LIG_SH2_STAT3	432	435	PF00017	0.460
LIG_SH2_STAT3	92	95	PF00017	0.588
LIG_SH2_STAT5	307	310	PF00017	0.423
LIG_SH3_3	487	493	PF00018	0.515
LIG_SUMO_SIM_anti_2	536	543	PF11976	0.432
LIG_TRAF2_1	255	258	PF00917	0.469
LIG_TRAF2_1	411	414	PF00917	0.623
LIG_UBA3_1	436	444	PF00899	0.453
LIG_WRC_WIRS_1	273	278	PF05994	0.448
MOD_CK1_1	420	426	PF00069	0.570
MOD_CK1_1	91	97	PF00069	0.618
MOD_CK2_1	252	258	PF00069	0.562
MOD_CK2_1	266	272	PF00069	0.483
MOD_CK2_1	307	313	PF00069	0.496
MOD_CK2_1	36	42	PF00069	0.528
MOD_CK2_1	378	384	PF00069	0.390
MOD_CK2_1	408	414	PF00069	0.509
MOD_CK2_1	551	557	PF00069	0.504
MOD_CK2_1	87	93	PF00069	0.507
MOD_Cter_Amidation	7	10	PF01082	0.595
MOD_GlcNHglycan	12	15	PF01048	0.461
MOD_GlcNHglycan	182	185	PF01048	0.569
MOD_GlcNHglycan	419	422	PF01048	0.600
MOD_GlcNHglycan	82	85	PF01048	0.462
MOD_GSK3_1	279	286	PF00069	0.377
MOD_GSK3_1	307	314	PF00069	0.446
MOD_GSK3_1	404	411	PF00069	0.491
MOD_GSK3_1	76	83	PF00069	0.596
MOD_GSK3_1	87	94	PF00069	0.626
MOD_N-GLC_1	222	227	PF02516	0.583
MOD_N-GLC_1	404	409	PF02516	0.474
MOD_NEK2_1	167	172	PF00069	0.544
MOD_NEK2_1	266	271	PF00069	0.494
MOD_NEK2_1	344	349	PF00069	0.483
MOD_NEK2_1	443	448	PF00069	0.442
MOD_NEK2_1	518	523	PF00069	0.554
MOD_NEK2_2	558	563	PF00069	0.444
MOD_PIKK_1	155	161	PF00454	0.629
MOD_PIKK_1	252	258	PF00454	0.639
MOD_PIKK_1	266	272	PF00454	0.631
MOD_PIKK_1	344	350	PF00454	0.593
MOD_PIKK_1	91	97	PF00454	0.523
MOD_PKA_1	9	15	PF00069	0.633
MOD_PKA_2	127	133	PF00069	0.585
MOD_PKA_2	138	144	PF00069	0.592
MOD_PKA_2	180	186	PF00069	0.549
MOD_PKA_2	250	256	PF00069	0.540
MOD_PKA_2	283	289	PF00069	0.500
MOD_PKA_2	493	499	PF00069	0.613
MOD_PKA_2	569	575	PF00069	0.622
MOD_PKA_2	79	85	PF00069	0.594
MOD_Plk_1	144	150	PF00069	0.478
MOD_Plk_1	222	228	PF00069	0.580
MOD_Plk_1	404	410	PF00069	0.603
MOD_Plk_1	494	500	PF00069	0.569
MOD_Plk_1	76	82	PF00069	0.468
MOD_Plk_1	87	93	PF00069	0.411
MOD_Plk_2-3	272	278	PF00069	0.622
MOD_Plk_2-3	88	94	PF00069	0.460
MOD_Plk_4	222	228	PF00069	0.524
MOD_Plk_4	353	359	PF00069	0.501
MOD_Plk_4	367	373	PF00069	0.494
MOD_SUMO_for_1	113	116	PF00179	0.485
MOD_SUMO_for_1	276	279	PF00179	0.445
MOD_SUMO_for_1	456	459	PF00179	0.558
MOD_SUMO_for_1	512	515	PF00179	0.493
MOD_SUMO_for_1	562	565	PF00179	0.491
MOD_SUMO_rev_2	182	190	PF00179	0.504
MOD_SUMO_rev_2	214	224	PF00179	0.581
MOD_SUMO_rev_2	257	266	PF00179	0.529
MOD_SUMO_rev_2	289	297	PF00179	0.455
MOD_SUMO_rev_2	299	308	PF00179	0.574
MOD_SUMO_rev_2	542	551	PF00179	0.597
MOD_SUMO_rev_2	83	91	PF00179	0.572
TRG_DiLeu_BaEn_1	353	358	PF01217	0.458
TRG_DiLeu_BaEn_3	118	124	PF01217	0.500
TRG_DiLeu_BaEn_3	50	56	PF01217	0.521
TRG_DiLeu_BaEn_4	151	157	PF01217	0.511
TRG_DiLeu_BaEn_4	257	263	PF01217	0.484
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.437
TRG_ENDOCYTIC_2	461	464	PF00928	0.591
TRG_ER_diArg_1	239	241	PF00400	0.484
TRG_ER_diArg_1	450	453	PF00400	0.601
TRG_ER_diArg_1	530	533	PF00400	0.554
TRG_ER_diArg_1	69	71	PF00400	0.585
TRG_NES_CRM1_1	507	520	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW9	Leptomonas seymouri	48%	100%
A0A0S4JPX7	Bodo saltans	35%	99%
A0A1X0P3Y1	Trypanosomatidae	40%	100%
A0A3R7MZM3	Trypanosoma rangeli	40%	100%
A0A3S5H5F5	Leishmania donovani	100%	100%
A4H450	Leishmania braziliensis	80%	100%
C9ZPY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QJJ9	Leishmania major	95%	100%
V5BJE7	Trypanosoma cruzi	40%	100%