LeishMANIAdb
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Putative RNA-binding protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative RNA-binding protein
Gene product:
RNA-binding protein - putative
Species:
Leishmania infantum
UniProt:
A4HSB6_LEIIN
TriTrypDb:
LINF_040016900
Length:
311

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 127

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HSB6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSB6

Function

Biological processes
Term Name Level Count
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003729 mRNA binding 5 1
GO:0003730 mRNA 3'-UTR binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 151 157 PF00089 0.469
CLV_NRD_NRD_1 149 151 PF00675 0.328
CLV_PCSK_KEX2_1 149 151 PF00082 0.328
CLV_PCSK_SKI1_1 169 173 PF00082 0.328
CLV_PCSK_SKI1_1 238 242 PF00082 0.253
CLV_PCSK_SKI1_1 88 92 PF00082 0.196
DEG_APCC_DBOX_1 168 176 PF00400 0.431
DEG_Nend_Nbox_1 1 3 PF02207 0.506
DEG_SCF_FBW7_1 90 95 PF00400 0.396
DEG_SPOP_SBC_1 298 302 PF00917 0.550
DOC_CYCLIN_RxL_1 166 174 PF00134 0.305
DOC_MAPK_gen_1 149 155 PF00069 0.467
DOC_PP2B_LxvP_1 25 28 PF13499 0.525
DOC_PP4_FxxP_1 138 141 PF00568 0.441
DOC_PP4_MxPP_1 304 307 PF00568 0.652
DOC_USP7_MATH_1 230 234 PF00917 0.442
DOC_USP7_MATH_1 271 275 PF00917 0.445
DOC_WW_Pin1_4 124 129 PF00397 0.442
DOC_WW_Pin1_4 186 191 PF00397 0.248
DOC_WW_Pin1_4 23 28 PF00397 0.577
DOC_WW_Pin1_4 88 93 PF00397 0.400
LIG_14-3-3_CanoR_1 154 161 PF00244 0.428
LIG_Clathr_ClatBox_1 225 229 PF01394 0.396
LIG_FHA_1 166 172 PF00498 0.338
LIG_FHA_1 187 193 PF00498 0.361
LIG_FHA_1 251 257 PF00498 0.309
LIG_FHA_1 270 276 PF00498 0.352
LIG_FHA_1 79 85 PF00498 0.443
LIG_FHA_1 89 95 PF00498 0.365
LIG_FHA_2 176 182 PF00498 0.321
LIG_FHA_2 245 251 PF00498 0.386
LIG_LIR_Apic_2 136 141 PF02991 0.446
LIG_LIR_Gen_1 140 151 PF02991 0.331
LIG_LIR_Gen_1 191 200 PF02991 0.463
LIG_LIR_Gen_1 257 266 PF02991 0.334
LIG_LIR_LC3C_4 272 277 PF02991 0.450
LIG_LIR_Nem_3 140 146 PF02991 0.322
LIG_LIR_Nem_3 191 197 PF02991 0.474
LIG_LIR_Nem_3 199 203 PF02991 0.454
LIG_LYPXL_S_1 304 308 PF13949 0.569
LIG_LYPXL_yS_3 305 308 PF13949 0.543
LIG_PTB_Apo_2 174 181 PF02174 0.314
LIG_PTB_Phospho_1 174 180 PF10480 0.312
LIG_REV1ctd_RIR_1 135 140 PF16727 0.344
LIG_SH2_CRK 12 16 PF00017 0.536
LIG_SH2_CRK 39 43 PF00017 0.623
LIG_SH2_GRB2like 43 46 PF00017 0.593
LIG_SH2_NCK_1 143 147 PF00017 0.326
LIG_SH2_NCK_1 39 43 PF00017 0.623
LIG_SH2_SRC 143 146 PF00017 0.314
LIG_SH2_SRC 20 23 PF00017 0.583
LIG_SH2_SRC 39 42 PF00017 0.567
LIG_SH2_SRC 43 46 PF00017 0.537
LIG_SH2_STAP1 180 184 PF00017 0.308
LIG_SH2_STAT3 2 5 PF00017 0.517
LIG_SH2_STAT5 152 155 PF00017 0.317
LIG_SH3_3 16 22 PF00018 0.570
LIG_SH3_3 204 210 PF00018 0.396
LIG_SUMO_SIM_anti_2 204 210 PF11976 0.463
LIG_SUMO_SIM_anti_2 30 37 PF11976 0.673
LIG_SUMO_SIM_par_1 168 174 PF11976 0.292
LIG_SUMO_SIM_par_1 244 251 PF11976 0.486
LIG_UBA3_1 122 129 PF00899 0.503
MOD_CDK_SPK_2 124 129 PF00069 0.442
MOD_CK1_1 127 133 PF00069 0.407
MOD_CK1_1 199 205 PF00069 0.457
MOD_CK2_1 244 250 PF00069 0.544
MOD_Cter_Amidation 147 150 PF01082 0.357
MOD_GlcNHglycan 129 132 PF01048 0.196
MOD_GlcNHglycan 181 185 PF01048 0.375
MOD_GlcNHglycan 232 235 PF01048 0.298
MOD_GSK3_1 161 168 PF00069 0.393
MOD_GSK3_1 171 178 PF00069 0.292
MOD_GSK3_1 23 30 PF00069 0.607
MOD_GSK3_1 244 251 PF00069 0.494
MOD_GSK3_1 265 272 PF00069 0.462
MOD_GSK3_1 88 95 PF00069 0.396
MOD_N-GLC_1 159 164 PF02516 0.469
MOD_N-GLC_1 211 216 PF02516 0.196
MOD_N-GLC_1 79 84 PF02516 0.462
MOD_N-GLC_1 88 93 PF02516 0.166
MOD_NEK2_1 161 166 PF00069 0.405
MOD_NEK2_1 171 176 PF00069 0.280
MOD_NEK2_1 248 253 PF00069 0.474
MOD_NEK2_1 299 304 PF00069 0.573
MOD_PIKK_1 161 167 PF00454 0.393
MOD_PIKK_1 175 181 PF00454 0.320
MOD_PIKK_1 212 218 PF00454 0.420
MOD_PIKK_1 66 72 PF00454 0.720
MOD_PIKK_1 92 98 PF00454 0.396
MOD_PKA_2 153 159 PF00069 0.435
MOD_PKA_2 230 236 PF00069 0.500
MOD_Plk_1 212 218 PF00069 0.500
MOD_Plk_1 79 85 PF00069 0.407
MOD_Plk_1 92 98 PF00069 0.381
MOD_Plk_4 171 177 PF00069 0.323
MOD_Plk_4 271 277 PF00069 0.443
MOD_Plk_4 31 37 PF00069 0.656
MOD_Plk_4 80 86 PF00069 0.597
MOD_ProDKin_1 124 130 PF00069 0.442
MOD_ProDKin_1 186 192 PF00069 0.248
MOD_ProDKin_1 23 29 PF00069 0.577
MOD_ProDKin_1 88 94 PF00069 0.400
MOD_SUMO_for_1 210 213 PF00179 0.407
MOD_SUMO_rev_2 261 269 PF00179 0.382
TRG_ENDOCYTIC_2 143 146 PF00928 0.306
TRG_ENDOCYTIC_2 152 155 PF00928 0.307
TRG_ENDOCYTIC_2 194 197 PF00928 0.430
TRG_ENDOCYTIC_2 200 203 PF00928 0.430
TRG_ENDOCYTIC_2 305 308 PF00928 0.543
TRG_ER_diArg_1 149 151 PF00400 0.328
TRG_ER_diArg_1 71 74 PF00400 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I013 Leptomonas seymouri 76% 96%
A0A0S4JUP2 Bodo saltans 68% 77%
A0A1X0NMJ6 Trypanosomatidae 67% 98%
A0A3R7NIY6 Trypanosoma rangeli 66% 97%
A0A3S7WNY0 Leishmania donovani 100% 100%
A4H432 Leishmania braziliensis 95% 100%
C9ZYA9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 95%
E9AK98 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O97003 Leishmania major 99% 100%
V5BDL5 Trypanosoma cruzi 65% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS