Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSB2_LEIIN

TriTrypDb:

LINF_040016500

Length:

300

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.544
CLV_NRD_NRD_1	32	34	PF00675	0.655
CLV_PCSK_KEX2_1	14	16	PF00082	0.586
CLV_PCSK_KEX2_1	193	195	PF00082	0.500
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.658
CLV_PCSK_SKI1_1	168	172	PF00082	0.551
CLV_PCSK_SKI1_1	181	185	PF00082	0.509
DOC_USP7_MATH_1	125	129	PF00917	0.682
DOC_USP7_MATH_1	141	145	PF00917	0.608
DOC_USP7_MATH_1	238	242	PF00917	0.646
DOC_USP7_MATH_1	272	276	PF00917	0.691
DOC_USP7_MATH_1	67	71	PF00917	0.766
DOC_USP7_MATH_1	72	76	PF00917	0.757
DOC_USP7_UBL2_3	34	38	PF12436	0.606
DOC_WW_Pin1_4	1	6	PF00397	0.587
DOC_WW_Pin1_4	102	107	PF00397	0.721
DOC_WW_Pin1_4	268	273	PF00397	0.757
LIG_14-3-3_CanoR_1	193	199	PF00244	0.501
LIG_14-3-3_CanoR_1	94	98	PF00244	0.764
LIG_14-3-3_CanoR_1	99	106	PF00244	0.623
LIG_AP2alpha_2	55	57	PF02296	0.553
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_deltaCOP1_diTrp_1	55	60	PF00928	0.588
LIG_FHA_1	194	200	PF00498	0.463
LIG_FHA_1	290	296	PF00498	0.586
LIG_FXI_DFP_1	57	61	PF00024	0.577
LIG_LIR_Gen_1	55	62	PF02991	0.717
LIG_LIR_Nem_3	148	154	PF02991	0.595
LIG_LIR_Nem_3	55	60	PF02991	0.703
LIG_PTAP_UEV_1	254	259	PF05743	0.629
LIG_SH2_NCK_1	245	249	PF00017	0.569
LIG_SH2_STAT5	152	155	PF00017	0.597
LIG_SH3_1	252	258	PF00018	0.652
LIG_SH3_3	2	8	PF00018	0.623
LIG_SH3_3	252	258	PF00018	0.667
LIG_SH3_3	266	272	PF00018	0.623
LIG_SH3_3	50	56	PF00018	0.613
LIG_TRAF2_1	217	220	PF00917	0.619
LIG_TRAF2_1	63	66	PF00917	0.597
LIG_WW_3	51	55	PF00397	0.644
MOD_CDK_SPK_2	268	273	PF00069	0.649
MOD_CDK_SPxxK_3	102	109	PF00069	0.702
MOD_CK1_1	105	111	PF00069	0.583
MOD_CK1_1	282	288	PF00069	0.607
MOD_CK1_1	98	104	PF00069	0.640
MOD_CK2_1	141	147	PF00069	0.657
MOD_CK2_1	159	165	PF00069	0.463
MOD_CK2_1	60	66	PF00069	0.587
MOD_GlcNHglycan	161	164	PF01048	0.518
MOD_GlcNHglycan	232	235	PF01048	0.746
MOD_GlcNHglycan	255	258	PF01048	0.691
MOD_GlcNHglycan	40	43	PF01048	0.655
MOD_GlcNHglycan	70	73	PF01048	0.777
MOD_GlcNHglycan	74	77	PF01048	0.710
MOD_GlcNHglycan	91	94	PF01048	0.665
MOD_GSK3_1	105	112	PF00069	0.740
MOD_GSK3_1	268	275	PF00069	0.753
MOD_GSK3_1	279	286	PF00069	0.566
MOD_GSK3_1	68	75	PF00069	0.678
MOD_GSK3_1	89	96	PF00069	0.693
MOD_GSK3_1	97	104	PF00069	0.588
MOD_LATS_1	107	113	PF00433	0.644
MOD_LATS_1	27	33	PF00433	0.634
MOD_NEK2_1	279	284	PF00069	0.591
MOD_PIKK_1	184	190	PF00454	0.524
MOD_PIKK_1	74	80	PF00454	0.718
MOD_PK_1	109	115	PF00069	0.648
MOD_PKA_1	193	199	PF00069	0.469
MOD_PKA_2	193	199	PF00069	0.469
MOD_PKA_2	243	249	PF00069	0.603
MOD_PKA_2	272	278	PF00069	0.616
MOD_PKA_2	67	73	PF00069	0.702
MOD_PKA_2	93	99	PF00069	0.754
MOD_Plk_1	238	244	PF00069	0.682
MOD_Plk_2-3	61	67	PF00069	0.593
MOD_Plk_4	194	200	PF00069	0.510
MOD_ProDKin_1	1	7	PF00069	0.585
MOD_ProDKin_1	102	108	PF00069	0.721
MOD_ProDKin_1	268	274	PF00069	0.754
TRG_ENDOCYTIC_2	151	154	PF00928	0.599
TRG_ER_diArg_1	193	195	PF00400	0.515
TRG_ER_diArg_1	199	202	PF00400	0.485
TRG_ER_diArg_1	242	245	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIT4	Leptomonas seymouri	36%	93%
A0A3S5H5F0	Leishmania donovani	99%	100%
A4H428	Leishmania braziliensis	55%	100%
E9AK95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O97195	Leishmania major	90%	100%