Putative cytochrome c oxidase assembly factor

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly factor - putative

Species:

Leishmania infantum

UniProt:

A4HSB1_LEIIN

TriTrypDb:

LINF_040016400

Length:

310

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase assembly factor

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	15
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	15
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HSB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSB1

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	10
GO:0006875	obsolete intracellular metal ion homeostasis	6	10
GO:0006878	intracellular copper ion homeostasis	8	10
GO:0008535	respiratory chain complex IV assembly	7	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0017004	cytochrome complex assembly	6	11
GO:0019725	cellular homeostasis	2	10
GO:0022607	cellular component assembly	4	11
GO:0030003	intracellular monoatomic cation homeostasis	5	10
GO:0042592	homeostatic process	3	10
GO:0043933	protein-containing complex organization	4	11
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	10
GO:0048878	chemical homeostasis	4	10
GO:0050801	monoatomic ion homeostasis	5	10
GO:0055065	obsolete metal ion homeostasis	7	10
GO:0055070	copper ion homeostasis	9	10
GO:0055076	obsolete transition metal ion homeostasis	8	10
GO:0055080	monoatomic cation homeostasis	6	10
GO:0055082	intracellular chemical homeostasis	3	10
GO:0065003	protein-containing complex assembly	5	11
GO:0065007	biological regulation	1	10
GO:0065008	regulation of biological quality	2	10
GO:0071840	cellular component organization or biogenesis	2	11
GO:0098771	inorganic ion homeostasis	6	10
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	10
GO:0005507	copper ion binding	6	10
GO:0016491	oxidoreductase activity	2	5
GO:0016530	metallochaperone activity	2	10
GO:0016531	copper chaperone activity	3	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0140104	molecular carrier activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.433
CLV_NRD_NRD_1	35	37	PF00675	0.415
CLV_NRD_NRD_1	62	64	PF00675	0.499
CLV_PCSK_KEX2_1	117	119	PF00082	0.564
CLV_PCSK_KEX2_1	208	210	PF00082	0.503
CLV_PCSK_KEX2_1	35	37	PF00082	0.415
CLV_PCSK_KEX2_1	62	64	PF00082	0.519
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.499
CLV_PCSK_PC7_1	113	119	PF00082	0.549
CLV_PCSK_SKI1_1	113	117	PF00082	0.609
CLV_PCSK_SKI1_1	135	139	PF00082	0.540
CLV_PCSK_SKI1_1	288	292	PF00082	0.559
CLV_PCSK_SKI1_1	3	7	PF00082	0.496
CLV_PCSK_SKI1_1	62	66	PF00082	0.469
DEG_APCC_DBOX_1	208	216	PF00400	0.222
DOC_CKS1_1	230	235	PF01111	0.222
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.222
DOC_MAPK_DCC_7	193	203	PF00069	0.222
DOC_PP1_RVXF_1	274	281	PF00149	0.270
DOC_USP7_MATH_1	122	126	PF00917	0.418
DOC_USP7_MATH_1	239	243	PF00917	0.222
DOC_USP7_MATH_1	39	43	PF00917	0.635
DOC_WW_Pin1_4	229	234	PF00397	0.249
DOC_WW_Pin1_4	35	40	PF00397	0.676
DOC_WW_Pin1_4	53	58	PF00397	0.721
LIG_14-3-3_CanoR_1	127	131	PF00244	0.437
LIG_14-3-3_CanoR_1	181	189	PF00244	0.317
LIG_AP2alpha_1	277	281	PF02296	0.251
LIG_BRCT_BRCA1_1	159	163	PF00533	0.253
LIG_deltaCOP1_diTrp_1	304	310	PF00928	0.292
LIG_eIF4E_1	19	25	PF01652	0.575
LIG_FHA_1	289	295	PF00498	0.275
LIG_FHA_2	145	151	PF00498	0.234
LIG_FHA_2	249	255	PF00498	0.313
LIG_LIR_Gen_1	160	168	PF02991	0.251
LIG_LIR_Gen_1	216	226	PF02991	0.256
LIG_LIR_Gen_1	85	96	PF02991	0.605
LIG_LIR_Nem_3	160	166	PF02991	0.224
LIG_LIR_Nem_3	216	221	PF02991	0.236
LIG_LIR_Nem_3	225	229	PF02991	0.204
LIG_LIR_Nem_3	242	246	PF02991	0.168
LIG_LIR_Nem_3	85	91	PF02991	0.622
LIG_LIR_Nem_3	93	97	PF02991	0.362
LIG_Pex14_1	161	165	PF04695	0.265
LIG_Pex14_2	157	161	PF04695	0.222
LIG_Pex14_2	164	168	PF04695	0.222
LIG_Pex14_2	222	226	PF04695	0.222
LIG_Pex14_2	277	281	PF04695	0.251
LIG_REV1ctd_RIR_1	278	288	PF16727	0.277
LIG_SH2_CRK	247	251	PF00017	0.222
LIG_SH2_CRK	94	98	PF00017	0.302
LIG_SH2_NCK_1	247	251	PF00017	0.222
LIG_SH2_STAT5	119	122	PF00017	0.342
LIG_SH2_STAT5	165	168	PF00017	0.262
LIG_SH2_STAT5	218	221	PF00017	0.265
LIG_SH2_STAT5	260	263	PF00017	0.238
LIG_SH3_3	218	224	PF00018	0.249
LIG_SH3_3	227	233	PF00018	0.196
LIG_SH3_3	70	76	PF00018	0.585
LIG_TRAF2_1	250	253	PF00917	0.297
LIG_TRAF2_1	255	258	PF00917	0.293
LIG_TRAF2_2	233	238	PF00917	0.222
MOD_CDK_SPK_2	229	234	PF00069	0.249
MOD_CK1_1	129	135	PF00069	0.418
MOD_CK1_1	18	24	PF00069	0.717
MOD_CK1_1	248	254	PF00069	0.215
MOD_CK1_1	42	48	PF00069	0.701
MOD_CK2_1	11	17	PF00069	0.554
MOD_CK2_1	144	150	PF00069	0.218
MOD_CMANNOS	307	310	PF00535	0.493
MOD_GlcNHglycan	123	127	PF01048	0.580
MOD_GlcNHglycan	41	44	PF01048	0.465
MOD_GSK3_1	11	18	PF00069	0.646
MOD_GSK3_1	122	129	PF00069	0.400
MOD_GSK3_1	35	42	PF00069	0.698
MOD_N-GLC_1	51	56	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	144	149	PF00069	0.292
MOD_NEK2_1	15	20	PF00069	0.627
MOD_NEK2_1	157	162	PF00069	0.233
MOD_NEK2_1	166	171	PF00069	0.271
MOD_NEK2_1	58	63	PF00069	0.653
MOD_PIKK_1	150	156	PF00454	0.227
MOD_PKA_1	208	214	PF00069	0.222
MOD_PKA_2	126	132	PF00069	0.401
MOD_PKA_2	180	186	PF00069	0.221
MOD_PKA_2	208	214	PF00069	0.218
MOD_Plk_1	262	268	PF00069	0.265
MOD_Plk_1	51	57	PF00069	0.542
MOD_Plk_4	104	110	PF00069	0.318
MOD_Plk_4	11	17	PF00069	0.554
MOD_Plk_4	217	223	PF00069	0.264
MOD_ProDKin_1	229	235	PF00069	0.249
MOD_ProDKin_1	35	41	PF00069	0.675
MOD_ProDKin_1	53	59	PF00069	0.722
TRG_DiLeu_BaEn_1	46	51	PF01217	0.554
TRG_ENDOCYTIC_2	165	168	PF00928	0.253
TRG_ENDOCYTIC_2	218	221	PF00928	0.253
TRG_ENDOCYTIC_2	246	249	PF00928	0.253
TRG_ENDOCYTIC_2	94	97	PF00928	0.277
TRG_ER_diArg_1	133	136	PF00400	0.335
TRG_ER_diArg_1	207	209	PF00400	0.222
TRG_ER_diArg_1	25	28	PF00400	0.623
TRG_ER_diArg_1	34	36	PF00400	0.600
TRG_NES_CRM1_1	210	225	PF08389	0.279
TRG_NLS_MonoExtN_4	113	120	PF00514	0.292
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G6	Leptomonas seymouri	36%	72%
A0A0N0P3R3	Leptomonas seymouri	76%	100%
A0A0N1I6S1	Leptomonas seymouri	30%	100%
A0A0S4J8R8	Bodo saltans	74%	100%
A0A0S4KH84	Bodo saltans	27%	95%
A0A1X0NLN8	Trypanosomatidae	74%	100%
A0A1X0NWD3	Trypanosomatidae	30%	100%
A0A3Q8ID19	Leishmania donovani	38%	72%
A0A3S5H5E9	Leishmania donovani	100%	100%
A0A3S5H786	Leishmania donovani	30%	100%
A4H427	Leishmania braziliensis	88%	100%
A4HF41	Leishmania braziliensis	38%	100%
A4HYS6	Leishmania infantum	30%	100%
A4I2C5	Leishmania infantum	39%	72%
A6H784	Bos taurus	36%	100%
C9ZYA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9AID5	Leishmania braziliensis	30%	100%
E9AK94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AUM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O43819	Homo sapiens	37%	100%
O97196	Leishmania major	92%	100%
Q4Q8Z5	Leishmania major	39%	100%
Q4QCW2	Leishmania major	30%	100%
Q5RH02	Danio rerio	34%	100%
Q8VCL2	Mus musculus	34%	100%
V5BI84	Trypanosoma cruzi	75%	100%