Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin - putative

Species:

Leishmania infantum

UniProt:

A4HSA6_LEIIN

TriTrypDb:

LINF_300036200

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSA6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0016787	hydrolase activity	2	2
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.358
CLV_NRD_NRD_1	327	329	PF00675	0.475
CLV_NRD_NRD_1	436	438	PF00675	0.633
CLV_NRD_NRD_1	62	64	PF00675	0.777
CLV_PCSK_FUR_1	434	438	PF00082	0.623
CLV_PCSK_KEX2_1	110	112	PF00082	0.358
CLV_PCSK_KEX2_1	265	267	PF00082	0.358
CLV_PCSK_KEX2_1	436	438	PF00082	0.642
CLV_PCSK_KEX2_1	62	64	PF00082	0.777
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.358
CLV_PCSK_SKI1_1	182	186	PF00082	0.451
CLV_PCSK_SKI1_1	359	363	PF00082	0.475
CLV_PCSK_SKI1_1	54	58	PF00082	0.787
DEG_APCC_DBOX_1	213	221	PF00400	0.358
DEG_SPOP_SBC_1	41	45	PF00917	0.771
DOC_CYCLIN_yCln2_LP_2	443	446	PF00134	0.756
DOC_MAPK_gen_1	298	307	PF00069	0.366
DOC_MAPK_gen_1	374	383	PF00069	0.358
DOC_MAPK_HePTP_8	371	383	PF00069	0.358
DOC_MAPK_MEF2A_6	279	288	PF00069	0.358
DOC_MAPK_MEF2A_6	374	383	PF00069	0.358
DOC_MAPK_MEF2A_6	411	419	PF00069	0.534
DOC_MAPK_NFAT4_5	376	384	PF00069	0.358
DOC_PP1_RVXF_1	302	308	PF00149	0.358
DOC_PP1_RVXF_1	460	466	PF00149	0.737
DOC_PP2B_LxvP_1	443	446	PF13499	0.756
DOC_PP4_MxPP_1	444	447	PF00568	0.746
DOC_USP7_MATH_1	10	14	PF00917	0.759
DOC_USP7_MATH_1	130	134	PF00917	0.475
DOC_USP7_MATH_1	248	252	PF00917	0.384
DOC_USP7_MATH_1	275	279	PF00917	0.358
DOC_USP7_UBL2_3	300	304	PF12436	0.358
DOC_USP7_UBL2_3	329	333	PF12436	0.358
DOC_USP7_UBL2_3	407	411	PF12436	0.470
DOC_USP7_UBL2_3	50	54	PF12436	0.791
DOC_USP7_UBL2_3	94	98	PF12436	0.610
DOC_WW_Pin1_4	37	42	PF00397	0.783
DOC_WW_Pin1_4	467	472	PF00397	0.691
DOC_WW_Pin1_4	55	60	PF00397	0.465
LIG_14-3-3_CanoR_1	279	288	PF00244	0.358
LIG_14-3-3_CanoR_1	302	308	PF00244	0.358
LIG_14-3-3_CanoR_1	374	383	PF00244	0.358
LIG_14-3-3_CanoR_1	436	446	PF00244	0.640
LIG_14-3-3_CanoR_1	462	466	PF00244	0.732
LIG_14-3-3_CanoR_1	62	69	PF00244	0.775
LIG_Actin_WH2_2	77	92	PF00022	0.571
LIG_APCC_ABBA_1	210	215	PF00400	0.358
LIG_APCC_ABBA_1	229	234	PF00400	0.358
LIG_APCC_ABBAyCdc20_2	228	234	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_BRCT_BRCA1_1	132	136	PF00533	0.475
LIG_BRCT_BRCA1_1	251	255	PF00533	0.475
LIG_CaM_IQ_9	394	409	PF13499	0.358
LIG_Clathr_ClatBox_1	104	108	PF01394	0.358
LIG_FHA_1	200	206	PF00498	0.475
LIG_FHA_1	280	286	PF00498	0.475
LIG_FHA_1	351	357	PF00498	0.411
LIG_FHA_1	362	368	PF00498	0.291
LIG_FHA_1	375	381	PF00498	0.358
LIG_FHA_1	392	398	PF00498	0.358
LIG_FHA_2	104	110	PF00498	0.475
LIG_FHA_2	287	293	PF00498	0.451
LIG_FHA_2	304	310	PF00498	0.206
LIG_FHA_2	320	326	PF00498	0.358
LIG_FXI_DFP_1	119	123	PF00024	0.358
LIG_HCF-1_HBM_1	388	391	PF13415	0.475
LIG_LIR_Gen_1	133	144	PF02991	0.362
LIG_LIR_Gen_1	206	217	PF02991	0.475
LIG_LIR_Gen_1	252	259	PF02991	0.358
LIG_LIR_Gen_1	306	313	PF02991	0.358
LIG_LIR_Nem_3	123	129	PF02991	0.411
LIG_LIR_Nem_3	133	139	PF02991	0.304
LIG_LIR_Nem_3	145	151	PF02991	0.349
LIG_LIR_Nem_3	206	212	PF02991	0.475
LIG_LIR_Nem_3	252	258	PF02991	0.358
LIG_LIR_Nem_3	306	310	PF02991	0.358
LIG_LIR_Nem_3	464	468	PF02991	0.711
LIG_Pex14_2	122	126	PF04695	0.358
LIG_SH2_CRK	86	90	PF00017	0.510
LIG_SH2_STAT5	167	170	PF00017	0.466
LIG_SH2_STAT5	186	189	PF00017	0.157
LIG_SH2_STAT5	203	206	PF00017	0.358
LIG_SH2_STAT5	287	290	PF00017	0.475
LIG_SH2_STAT5	86	89	PF00017	0.507
LIG_SH3_2	445	450	PF14604	0.756
LIG_SH3_3	136	142	PF00018	0.358
LIG_SH3_3	442	448	PF00018	0.755
LIG_SH3_3	463	469	PF00018	0.711
LIG_SUMO_SIM_par_1	103	109	PF11976	0.362
LIG_TYR_ITIM	84	89	PF00017	0.508
MOD_CDK_SPxxK_3	55	62	PF00069	0.780
MOD_CK1_1	197	203	PF00069	0.475
MOD_CK1_1	347	353	PF00069	0.400
MOD_CK1_1	375	381	PF00069	0.429
MOD_CK1_1	40	46	PF00069	0.772
MOD_CK1_1	429	435	PF00069	0.703
MOD_CK1_1	464	470	PF00069	0.704
MOD_CK1_1	55	61	PF00069	0.575
MOD_CK2_1	10	16	PF00069	0.758
MOD_GlcNHglycan	12	15	PF01048	0.582
MOD_GlcNHglycan	152	155	PF01048	0.358
MOD_GlcNHglycan	2	5	PF01048	0.745
MOD_GlcNHglycan	32	37	PF01048	0.428
MOD_GlcNHglycan	349	352	PF01048	0.400
MOD_GlcNHglycan	45	48	PF01048	0.564
MOD_GlcNHglycan	457	460	PF01048	0.655
MOD_GlcNHglycan	54	57	PF01048	0.670
MOD_GlcNHglycan	64	67	PF01048	0.658
MOD_GSK3_1	165	172	PF00069	0.358
MOD_GSK3_1	199	206	PF00069	0.475
MOD_GSK3_1	239	246	PF00069	0.475
MOD_GSK3_1	275	282	PF00069	0.358
MOD_GSK3_1	331	338	PF00069	0.358
MOD_GSK3_1	37	44	PF00069	0.778
MOD_GSK3_1	375	382	PF00069	0.358
MOD_GSK3_1	413	420	PF00069	0.654
MOD_GSK3_1	57	64	PF00069	0.427
MOD_LATS_1	435	441	PF00433	0.746
MOD_N-GLC_1	335	340	PF02516	0.358
MOD_NEK2_1	122	127	PF00069	0.475
MOD_NEK2_1	316	321	PF00069	0.358
MOD_NEK2_1	367	372	PF00069	0.358
MOD_NEK2_1	390	395	PF00069	0.358
MOD_NEK2_1	415	420	PF00069	0.675
MOD_OFUCOSY	424	430	PF10250	0.704
MOD_PKA_1	52	58	PF00069	0.790
MOD_PKA_1	62	68	PF00069	0.600
MOD_PKA_2	314	320	PF00069	0.358
MOD_PKA_2	375	381	PF00069	0.389
MOD_PKA_2	438	444	PF00069	0.653
MOD_PKA_2	461	467	PF00069	0.729
MOD_PKA_2	61	67	PF00069	0.777
MOD_PKA_2	89	95	PF00069	0.575
MOD_Plk_1	17	23	PF00069	0.553
MOD_Plk_1	335	341	PF00069	0.358
MOD_Plk_1	5	11	PF00069	0.752
MOD_Plk_4	335	341	PF00069	0.358
MOD_Plk_4	375	381	PF00069	0.358
MOD_ProDKin_1	37	43	PF00069	0.780
MOD_ProDKin_1	467	473	PF00069	0.694
MOD_ProDKin_1	55	61	PF00069	0.464
MOD_SUMO_for_1	114	117	PF00179	0.358
MOD_SUMO_for_1	406	409	PF00179	0.447
MOD_SUMO_rev_2	325	335	PF00179	0.380
TRG_ENDOCYTIC_2	313	316	PF00928	0.358
TRG_ENDOCYTIC_2	86	89	PF00928	0.507
TRG_ER_diArg_1	21	24	PF00400	0.768
TRG_ER_diArg_1	265	267	PF00400	0.358
TRG_ER_diArg_1	434	437	PF00400	0.617
TRG_ER_diArg_1	88	91	PF00400	0.411
TRG_NLS_MonoExtN_4	50	56	PF00514	0.789
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	33%	73%
A0A0N1HY56	Leptomonas seymouri	25%	70%
A0A0N1I0Y5	Leptomonas seymouri	34%	79%
A0A0S4J971	Bodo saltans	23%	87%
A0A0S4JBJ4	Bodo saltans	29%	89%
A0A0S4JEF6	Bodo saltans	32%	72%
A0A0S4JJ54	Bodo saltans	26%	69%
A0A0S4JLC6	Bodo saltans	26%	86%
A0A0S4JLW3	Bodo saltans	30%	82%
A0A0S4JMJ1	Bodo saltans	65%	79%
A0A1X0NIJ1	Trypanosomatidae	30%	82%
A0A1X0NJN6	Trypanosomatidae	29%	98%
A0A1X0NL76	Trypanosomatidae	31%	67%
A0A1X0NMI8	Trypanosomatidae	31%	74%
A0A1X0NNQ8	Trypanosomatidae	27%	75%
A0A1X0P2B6	Trypanosomatidae	32%	79%
A0A1X0P537	Trypanosomatidae	26%	100%
A0A1X0P5Y8	Trypanosomatidae	27%	72%
A0A1X0P9T0	Trypanosomatidae	29%	100%
A0A3Q8IAZ2	Leishmania donovani	30%	74%
A0A3Q8IBS7	Leishmania donovani	35%	79%
A0A3Q8IEL2	Leishmania donovani	33%	82%
A0A3Q8IHG6	Leishmania donovani	33%	82%
A0A3R7MC35	Trypanosoma rangeli	29%	96%
A0A3R7MDH9	Trypanosoma rangeli	23%	68%
A0A3R7NVF2	Trypanosoma rangeli	32%	88%
A0A3R7R330	Trypanosoma rangeli	33%	93%
A0A3S5H4S8	Leishmania donovani	32%	72%
A0A3S5IRH3	Trypanosoma rangeli	33%	79%
A0A3S5ISI5	Trypanosoma rangeli	27%	100%
A0A3S7WST0	Leishmania donovani	30%	66%
A0A3S7X2P9	Leishmania donovani	33%	82%
A0A3S7X9Y1	Leishmania donovani	25%	100%
A0A422P055	Trypanosoma rangeli	29%	68%
A0A422P4C5	Trypanosoma rangeli	29%	67%
A4H337	Leishmania braziliensis	33%	73%
A4H4I4	Leishmania braziliensis	26%	73%
A4H7F1	Leishmania braziliensis	30%	66%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HCT2	Leishmania braziliensis	28%	67%
A4HHN8	Leishmania braziliensis	33%	82%
A4HHY2	Leishmania braziliensis	35%	80%
A4HND6	Leishmania braziliensis	24%	100%
A4HRC5	Leishmania infantum	32%	72%
A4HVT9	Leishmania infantum	30%	66%
A4I0A6	Leishmania infantum	30%	74%
A4I4V2	Leishmania infantum	33%	82%
A4I4V3	Leishmania infantum	33%	82%
A4I562	Leishmania infantum	35%	79%
A4IC09	Leishmania infantum	25%	100%
A6H750	Bos taurus	28%	71%
A8WFU8	Danio rerio	31%	76%
B9EY52	Oryza sativa subsp. japonica	30%	68%
B9G2X9	Oryza sativa subsp. japonica	31%	80%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	82%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	84%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	77%
C9ZTA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
C9ZTM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	70%
D0A6E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	67%
D0A6W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	70%
D0A729	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
E9ABZ2	Leishmania major	34%	72%
E9AEA0	Leishmania major	34%	82%
E9AEA1	Leishmania major	34%	82%
E9AFU7	Leishmania major	24%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	72%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	73%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	82%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	82%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	67%
E9AW71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	74%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	79%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F4ICA0	Arabidopsis thaliana	33%	67%
F9W301	Oryza sativa subsp. japonica	36%	100%
O00139	Homo sapiens	31%	68%
P17119	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	66%
P20480	Drosophila melanogaster	30%	69%
P28740	Mus musculus	31%	69%
P28743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	68%
P32364	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	74%
P46872	Strongylocentrotus purpuratus	34%	69%
P46874	Bombyx mori	34%	100%
P70096	Cricetulus griseus	31%	67%
P79955	Xenopus laevis	30%	75%
Q2NL05	Bos taurus	31%	73%
Q3V300	Mus musculus	31%	73%
Q4Q7S4	Leishmania major	35%	80%
Q4QFZ3	Leishmania major	30%	66%
Q4QJ61	Leishmania major	24%	72%
Q4R918	Macaca fascicularis	30%	82%
Q5E913	Arabidopsis thaliana	31%	77%
Q5XI51	Rattus norvegicus	29%	73%
Q5ZKV8	Gallus gallus	30%	68%
Q6P3R1	Xenopus tropicalis	30%	76%
Q7Y1C8	Oryza sativa subsp. japonica	28%	66%
Q7ZYL5	Xenopus laevis	28%	74%
Q8C0N1	Mus musculus	28%	72%
Q8GW44	Arabidopsis thaliana	34%	100%
Q8J1G1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	71%
Q8W0Y9	Arabidopsis thaliana	34%	77%
Q91636	Xenopus laevis	29%	66%
Q91637	Xenopus laevis	31%	71%
Q940Y8	Arabidopsis thaliana	28%	71%
Q965T6	Caenorhabditis elegans	35%	75%
Q96FN5	Homo sapiens	27%	75%
Q9D2Z8	Mus musculus	27%	75%
Q9I869	Xenopus laevis	29%	74%
Q9NF78	Leishmania major	30%	74%
Q9QWT9	Mus musculus	30%	72%
Q9UIL4	Homo sapiens	29%	100%
Q9US60	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	87%
Q9UTL2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	95%
Q9W1U4	Drosophila melanogaster	30%	77%
Q9WV63	Rattus norvegicus	31%	69%
V5B8M1	Trypanosoma cruzi	32%	79%
V5B8X9	Trypanosoma cruzi	25%	69%
V5BHI2	Trypanosoma cruzi	29%	67%
V5BIC1	Trypanosoma cruzi	28%	76%
V5BK25	Trypanosoma cruzi	25%	67%
V5BNJ8	Trypanosoma cruzi	31%	80%
V5D7H9	Trypanosoma cruzi	26%	100%
V5DFA7	Trypanosoma cruzi	29%	86%
V5DMS2	Trypanosoma cruzi	33%	90%
V5DSJ9	Trypanosoma cruzi	32%	90%
V5DTU1	Trypanosoma cruzi	33%	84%