Transcriptional repressor TCF25 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcriptional repressor TCF25 - putative

Species:

Leishmania infantum

UniProt:

A4HSA5_LEIIN

TriTrypDb:

LINF_040015900

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990112	RQC complex	2	1

Expansion

Sequence features

A4HSA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.684
CLV_C14_Caspase3-7	263	267	PF00656	0.605
CLV_C14_Caspase3-7	529	533	PF00656	0.513
CLV_C14_Caspase3-7	654	658	PF00656	0.436
CLV_C14_Caspase3-7	704	708	PF00656	0.436
CLV_NRD_NRD_1	121	123	PF00675	0.733
CLV_NRD_NRD_1	150	152	PF00675	0.627
CLV_NRD_NRD_1	158	160	PF00675	0.642
CLV_NRD_NRD_1	179	181	PF00675	0.657
CLV_NRD_NRD_1	272	274	PF00675	0.673
CLV_NRD_NRD_1	35	37	PF00675	0.792
CLV_NRD_NRD_1	411	413	PF00675	0.411
CLV_NRD_NRD_1	43	45	PF00675	0.692
CLV_NRD_NRD_1	503	505	PF00675	0.498
CLV_NRD_NRD_1	507	509	PF00675	0.463
CLV_NRD_NRD_1	690	692	PF00675	0.436
CLV_NRD_NRD_1	7	9	PF00675	0.632
CLV_NRD_NRD_1	806	808	PF00675	0.646
CLV_PCSK_FUR_1	482	486	PF00082	0.411
CLV_PCSK_KEX2_1	121	123	PF00082	0.757
CLV_PCSK_KEX2_1	148	150	PF00082	0.627
CLV_PCSK_KEX2_1	158	160	PF00082	0.638
CLV_PCSK_KEX2_1	179	181	PF00082	0.657
CLV_PCSK_KEX2_1	272	274	PF00082	0.673
CLV_PCSK_KEX2_1	411	413	PF00082	0.411
CLV_PCSK_KEX2_1	447	449	PF00082	0.411
CLV_PCSK_KEX2_1	484	486	PF00082	0.411
CLV_PCSK_KEX2_1	503	505	PF00082	0.411
CLV_PCSK_KEX2_1	507	509	PF00082	0.463
CLV_PCSK_KEX2_1	690	692	PF00082	0.436
CLV_PCSK_KEX2_1	7	9	PF00082	0.632
CLV_PCSK_KEX2_1	806	808	PF00082	0.646
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.627
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.411
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.411
CLV_PCSK_PC7_1	268	274	PF00082	0.679
CLV_PCSK_PC7_1	503	509	PF00082	0.397
CLV_PCSK_PC7_1	686	692	PF00082	0.436
CLV_PCSK_SKI1_1	412	416	PF00082	0.400
CLV_PCSK_SKI1_1	459	463	PF00082	0.443
CLV_PCSK_SKI1_1	520	524	PF00082	0.513
CLV_PCSK_SKI1_1	531	535	PF00082	0.332
CLV_PCSK_SKI1_1	580	584	PF00082	0.411
CLV_PCSK_SKI1_1	690	694	PF00082	0.436
CLV_PCSK_SKI1_1	728	732	PF00082	0.656
CLV_PCSK_SKI1_1	799	803	PF00082	0.703
DEG_APCC_DBOX_1	798	806	PF00400	0.700
DEG_SCF_TRCP1_1	704	709	PF00400	0.513
DEG_SPOP_SBC_1	187	191	PF00917	0.734
DEG_SPOP_SBC_1	210	214	PF00917	0.719
DEG_SPOP_SBC_1	95	99	PF00917	0.625
DOC_CKS1_1	301	306	PF01111	0.475
DOC_CYCLIN_RxL_1	456	465	PF00134	0.411
DOC_CYCLIN_RxL_1	796	804	PF00134	0.625
DOC_MAPK_gen_1	277	286	PF00069	0.613
DOC_MAPK_gen_1	457	464	PF00069	0.411
DOC_MAPK_gen_1	482	492	PF00069	0.411
DOC_MAPK_RevD_3	396	412	PF00069	0.424
DOC_MAPK_RevD_3	472	485	PF00069	0.411
DOC_PP2B_LxvP_1	540	543	PF13499	0.513
DOC_PP4_FxxP_1	301	304	PF00568	0.440
DOC_USP7_MATH_1	187	191	PF00917	0.757
DOC_USP7_MATH_1	210	214	PF00917	0.734
DOC_USP7_MATH_1	311	315	PF00917	0.587
DOC_USP7_MATH_1	347	351	PF00917	0.576
DOC_USP7_MATH_1	511	515	PF00917	0.524
DOC_USP7_MATH_1	592	596	PF00917	0.513
DOC_USP7_MATH_1	702	706	PF00917	0.429
DOC_USP7_MATH_1	87	91	PF00917	0.761
DOC_USP7_MATH_1	96	100	PF00917	0.816
DOC_USP7_UBL2_3	45	49	PF12436	0.723
DOC_WW_Pin1_4	124	129	PF00397	0.612
DOC_WW_Pin1_4	192	197	PF00397	0.800
DOC_WW_Pin1_4	266	271	PF00397	0.680
DOC_WW_Pin1_4	300	305	PF00397	0.467
DOC_WW_Pin1_4	590	595	PF00397	0.513
LIG_14-3-3_CanoR_1	346	352	PF00244	0.586
LIG_14-3-3_CanoR_1	428	434	PF00244	0.336
LIG_14-3-3_CanoR_1	459	465	PF00244	0.411
LIG_14-3-3_CanoR_1	587	591	PF00244	0.465
LIG_14-3-3_CanoR_1	690	696	PF00244	0.436
LIG_Actin_WH2_2	431	449	PF00022	0.411
LIG_Actin_WH2_2	516	533	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_2	27	31	PF00653	0.749
LIG_BIR_III_2	861	865	PF00653	0.644
LIG_BIR_III_4	616	620	PF00653	0.416
LIG_BRCT_BRCA1_1	282	286	PF00533	0.579
LIG_BRCT_BRCA1_1	340	344	PF00533	0.476
LIG_Clathr_ClatBox_1	461	465	PF01394	0.411
LIG_Clathr_ClatBox_1	473	477	PF01394	0.411
LIG_deltaCOP1_diTrp_1	326	332	PF00928	0.637
LIG_EH1_1	686	694	PF00400	0.513
LIG_eIF4E_1	374	380	PF01652	0.411
LIG_FHA_1	230	236	PF00498	0.553
LIG_FHA_1	279	285	PF00498	0.615
LIG_FHA_1	30	36	PF00498	0.777
LIG_FHA_1	456	462	PF00498	0.383
LIG_FHA_1	58	64	PF00498	0.738
LIG_FHA_2	125	131	PF00498	0.669
LIG_FHA_2	15	21	PF00498	0.679
LIG_FHA_2	246	252	PF00498	0.485
LIG_FHA_2	318	324	PF00498	0.553
LIG_FHA_2	451	457	PF00498	0.411
LIG_FHA_2	527	533	PF00498	0.411
LIG_FHA_2	789	795	PF00498	0.649
LIG_FHA_2	99	105	PF00498	0.714
LIG_LIR_Apic_2	299	304	PF02991	0.442
LIG_LIR_Gen_1	102	112	PF02991	0.732
LIG_LIR_Gen_1	231	240	PF02991	0.619
LIG_LIR_Gen_1	432	442	PF02991	0.389
LIG_LIR_Gen_1	477	483	PF02991	0.411
LIG_LIR_Gen_1	639	648	PF02991	0.411
LIG_LIR_Nem_3	102	108	PF02991	0.739
LIG_LIR_Nem_3	231	237	PF02991	0.634
LIG_LIR_Nem_3	326	331	PF02991	0.512
LIG_LIR_Nem_3	432	438	PF02991	0.389
LIG_LIR_Nem_3	477	481	PF02991	0.411
LIG_LIR_Nem_3	639	644	PF02991	0.411
LIG_LIR_Nem_3	725	730	PF02991	0.557
LIG_LIR_Nem_3	832	836	PF02991	0.742
LIG_LIR_Nem_3	844	850	PF02991	0.757
LIG_OCRL_FandH_1	667	679	PF00620	0.411
LIG_PCNA_yPIPBox_3	428	438	PF02747	0.411
LIG_PTAP_UEV_1	88	93	PF05743	0.624
LIG_PTB_Apo_2	541	548	PF02174	0.411
LIG_PTB_Apo_2	797	804	PF02174	0.489
LIG_PTB_Phospho_1	797	803	PF10480	0.489
LIG_SH2_CRK	312	316	PF00017	0.480
LIG_SH2_CRK	374	378	PF00017	0.411
LIG_SH2_CRK	478	482	PF00017	0.411
LIG_SH2_CRK	727	731	PF00017	0.641
LIG_SH2_NCK_1	848	852	PF00017	0.733
LIG_SH2_STAP1	384	388	PF00017	0.411
LIG_SH2_STAP1	545	549	PF00017	0.408
LIG_SH2_STAT5	335	338	PF00017	0.542
LIG_SH2_STAT5	478	481	PF00017	0.411
LIG_SH2_STAT5	797	800	PF00017	0.617
LIG_SH3_3	190	196	PF00018	0.843
LIG_SH3_3	463	469	PF00018	0.513
LIG_SH3_3	52	58	PF00018	0.731
LIG_SH3_3	86	92	PF00018	0.767
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.418
LIG_SUMO_SIM_anti_2	679	686	PF11976	0.416
LIG_SUMO_SIM_par_1	460	465	PF11976	0.411
LIG_SUMO_SIM_par_1	471	477	PF11976	0.411
LIG_TRAF2_1	167	170	PF00917	0.718
LIG_TRAF2_1	320	323	PF00917	0.609
LIG_TRAF2_1	353	356	PF00917	0.528
LIG_TRAF2_1	708	711	PF00917	0.586
LIG_TYR_ITIM	310	315	PF00017	0.490
LIG_TYR_ITIM	476	481	PF00017	0.411
LIG_WRC_WIRS_1	789	794	PF05994	0.654
MOD_CDK_SPxK_1	266	272	PF00069	0.682
MOD_CDK_SPxK_1	300	306	PF00069	0.476
MOD_CDK_SPxxK_3	266	273	PF00069	0.678
MOD_CK1_1	124	130	PF00069	0.657
MOD_CK1_1	213	219	PF00069	0.816
MOD_CK1_1	429	435	PF00069	0.436
MOD_CK1_1	47	53	PF00069	0.646
MOD_CK1_1	633	639	PF00069	0.421
MOD_CK1_1	70	76	PF00069	0.728
MOD_CK1_1	705	711	PF00069	0.670
MOD_CK1_1	717	723	PF00069	0.621
MOD_CK1_1	849	855	PF00069	0.726
MOD_CK1_1	99	105	PF00069	0.817
MOD_CK2_1	106	112	PF00069	0.753
MOD_CK2_1	124	130	PF00069	0.519
MOD_CK2_1	245	251	PF00069	0.480
MOD_CK2_1	317	323	PF00069	0.594
MOD_CK2_1	450	456	PF00069	0.411
MOD_CK2_1	531	537	PF00069	0.321
MOD_CK2_1	592	598	PF00069	0.436
MOD_CK2_1	69	75	PF00069	0.776
MOD_CK2_1	705	711	PF00069	0.632
MOD_CK2_1	788	794	PF00069	0.607
MOD_GlcNHglycan	190	193	PF01048	0.631
MOD_GlcNHglycan	298	301	PF01048	0.476
MOD_GlcNHglycan	391	394	PF01048	0.411
MOD_GlcNHglycan	415	418	PF01048	0.394
MOD_GlcNHglycan	428	431	PF01048	0.443
MOD_GlcNHglycan	566	571	PF01048	0.374
MOD_GlcNHglycan	594	597	PF01048	0.509
MOD_GlcNHglycan	600	603	PF01048	0.418
MOD_GlcNHglycan	638	641	PF01048	0.372
MOD_GlcNHglycan	653	656	PF01048	0.406
MOD_GlcNHglycan	704	707	PF01048	0.513
MOD_GlcNHglycan	819	823	PF01048	0.807
MOD_GlcNHglycan	851	854	PF01048	0.726
MOD_GlcNHglycan	89	92	PF01048	0.844
MOD_GSK3_1	112	119	PF00069	0.626
MOD_GSK3_1	188	195	PF00069	0.726
MOD_GSK3_1	209	216	PF00069	0.775
MOD_GSK3_1	278	285	PF00069	0.618
MOD_GSK3_1	296	303	PF00069	0.480
MOD_GSK3_1	562	569	PF00069	0.436
MOD_GSK3_1	586	593	PF00069	0.472
MOD_GSK3_1	624	631	PF00069	0.409
MOD_GSK3_1	632	639	PF00069	0.416
MOD_GSK3_1	65	72	PF00069	0.821
MOD_GSK3_1	676	683	PF00069	0.436
MOD_GSK3_1	691	698	PF00069	0.281
MOD_GSK3_1	702	709	PF00069	0.374
MOD_GSK3_1	94	101	PF00069	0.696
MOD_N-GLC_1	115	120	PF02516	0.733
MOD_N-GLC_1	728	733	PF02516	0.603
MOD_NEK2_1	296	301	PF00069	0.484
MOD_NEK2_1	337	342	PF00069	0.570
MOD_NEK2_1	413	418	PF00069	0.409
MOD_NEK2_1	476	481	PF00069	0.411
MOD_NEK2_1	632	637	PF00069	0.436
MOD_NEK2_1	69	74	PF00069	0.774
MOD_NEK2_1	736	741	PF00069	0.596
MOD_NEK2_2	282	287	PF00069	0.563
MOD_NEK2_2	526	531	PF00069	0.513
MOD_PIKK_1	633	639	PF00454	0.511
MOD_PKA_1	121	127	PF00069	0.663
MOD_PKA_1	154	160	PF00069	0.640
MOD_PKA_1	44	50	PF00069	0.739
MOD_PKA_2	121	127	PF00069	0.750
MOD_PKA_2	14	20	PF00069	0.667
MOD_PKA_2	278	284	PF00069	0.631
MOD_PKA_2	35	41	PF00069	0.770
MOD_PKA_2	573	579	PF00069	0.380
MOD_PKA_2	586	592	PF00069	0.313
MOD_PKA_2	731	737	PF00069	0.651
MOD_PKB_1	42	50	PF00069	0.628
MOD_PKB_1	726	734	PF00069	0.651
MOD_Plk_1	230	236	PF00069	0.661
MOD_Plk_1	476	482	PF00069	0.411
MOD_Plk_1	531	537	PF00069	0.367
MOD_Plk_1	714	720	PF00069	0.639
MOD_Plk_2-3	106	112	PF00069	0.739
MOD_Plk_4	203	209	PF00069	0.663
MOD_Plk_4	230	236	PF00069	0.622
MOD_Plk_4	282	288	PF00069	0.564
MOD_Plk_4	375	381	PF00069	0.411
MOD_Plk_4	415	421	PF00069	0.473
MOD_Plk_4	429	435	PF00069	0.289
MOD_Plk_4	731	737	PF00069	0.573
MOD_ProDKin_1	124	130	PF00069	0.610
MOD_ProDKin_1	192	198	PF00069	0.800
MOD_ProDKin_1	266	272	PF00069	0.682
MOD_ProDKin_1	300	306	PF00069	0.476
MOD_ProDKin_1	590	596	PF00069	0.513
MOD_SUMO_rev_2	513	522	PF00179	0.485
TRG_DiLeu_BaEn_1	168	173	PF01217	0.621
TRG_DiLeu_BaEn_1	680	685	PF01217	0.411
TRG_DiLeu_BaEn_4	168	174	PF01217	0.717
TRG_DiLeu_BaEn_4	673	679	PF01217	0.389
TRG_ENDOCYTIC_2	307	310	PF00928	0.520
TRG_ENDOCYTIC_2	312	315	PF00928	0.454
TRG_ENDOCYTIC_2	335	338	PF00928	0.548
TRG_ENDOCYTIC_2	478	481	PF00928	0.411
TRG_ENDOCYTIC_2	727	730	PF00928	0.546
TRG_ER_diArg_1	149	151	PF00400	0.657
TRG_ER_diArg_1	252	255	PF00400	0.533
TRG_ER_diArg_1	370	373	PF00400	0.436
TRG_ER_diArg_1	410	412	PF00400	0.411
TRG_ER_diArg_1	492	495	PF00400	0.411
TRG_ER_diArg_1	506	508	PF00400	0.411
TRG_ER_diArg_1	6	8	PF00400	0.625
TRG_ER_diArg_1	689	691	PF00400	0.436
TRG_ER_diArg_1	805	807	PF00400	0.636
TRG_NLS_MonoCore_2	146	151	PF00514	0.619
TRG_NLS_MonoExtC_3	146	151	PF00514	0.618
TRG_NLS_MonoExtC_3	154	159	PF00514	0.629
TRG_NLS_MonoExtC_3	43	48	PF00514	0.710
TRG_NLS_MonoExtC_3	77	83	PF00514	0.763
TRG_NLS_MonoExtN_4	147	152	PF00514	0.647
TRG_NLS_MonoExtN_4	154	159	PF00514	0.587
TRG_NLS_MonoExtN_4	42	49	PF00514	0.726
TRG_NLS_MonoExtN_4	76	82	PF00514	0.767
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	799	804	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q4	Leptomonas seymouri	49%	100%
A0A3S5H5E5	Leishmania donovani	100%	100%
A4H423	Leishmania braziliensis	78%	100%
E9AK89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9NF87	Leishmania major	91%	100%