Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HSA4_LEIIN

TriTrypDb:

LINF_040015800

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	25	27	PF00675	0.499
CLV_PCSK_KEX2_1	25	27	PF00082	0.499
CLV_PCSK_KEX2_1	44	46	PF00082	0.532
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.557
DOC_USP7_MATH_1	111	115	PF00917	0.530
DOC_USP7_MATH_1	120	124	PF00917	0.424
DOC_USP7_MATH_1	3	7	PF00917	0.601
DOC_USP7_MATH_1	73	77	PF00917	0.438
LIG_14-3-3_CanoR_1	102	106	PF00244	0.468
LIG_14-3-3_CanoR_1	12	21	PF00244	0.571
LIG_14-3-3_CanoR_1	37	43	PF00244	0.441
LIG_14-3-3_CanoR_1	91	99	PF00244	0.525
LIG_BRCT_BRCA1_1	113	117	PF00533	0.522
LIG_FHA_1	54	60	PF00498	0.519
LIG_FHA_1	63	69	PF00498	0.449
LIG_FHA_2	37	43	PF00498	0.467
LIG_FHA_2	49	55	PF00498	0.460
LIG_LIR_Gen_1	104	113	PF02991	0.526
LIG_LIR_Nem_3	104	110	PF02991	0.526
LIG_SH2_CRK	107	111	PF00017	0.420
LIG_SH2_STAT5	112	115	PF00017	0.524
LIG_TYR_ITIM	105	110	PF00017	0.529
MOD_CK1_1	123	129	PF00069	0.574
MOD_CK1_1	13	19	PF00069	0.647
MOD_CK1_1	36	42	PF00069	0.599
MOD_CK1_1	74	80	PF00069	0.458
MOD_CK2_1	48	54	PF00069	0.545
MOD_GlcNHglycan	118	121	PF01048	0.414
MOD_GlcNHglycan	46	49	PF01048	0.612
MOD_GlcNHglycan	5	8	PF01048	0.568
MOD_GlcNHglycan	73	76	PF01048	0.483
MOD_GlcNHglycan	77	80	PF01048	0.433
MOD_GSK3_1	116	123	PF00069	0.543
MOD_GSK3_1	44	51	PF00069	0.503
MOD_GSK3_1	71	78	PF00069	0.473
MOD_GSK3_1	8	15	PF00069	0.567
MOD_NEK2_1	121	126	PF00069	0.545
MOD_NEK2_1	55	60	PF00069	0.578
MOD_NEK2_1	62	67	PF00069	0.549
MOD_NEK2_1	92	97	PF00069	0.502
MOD_PKA_1	44	50	PF00069	0.504
MOD_PKA_2	101	107	PF00069	0.504
MOD_PKA_2	11	17	PF00069	0.644
MOD_PKA_2	28	34	PF00069	0.419
MOD_PKA_2	36	42	PF00069	0.410
MOD_PKA_2	44	50	PF00069	0.276
MOD_Plk_1	33	39	PF00069	0.489
MOD_Plk_4	101	107	PF00069	0.511
MOD_SUMO_rev_2	36	46	PF00179	0.588
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.533
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.490
TRG_ENDOCYTIC_2	107	110	PF00928	0.419
TRG_ER_diArg_1	25	27	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB6	Leptomonas seymouri	49%	91%
A0A1X0NLC3	Trypanosomatidae	35%	92%
A0A3S7WNY1	Leishmania donovani	99%	100%
A4H422	Leishmania braziliensis	74%	100%
C9ZY96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9AK88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9NF88	Leishmania major	98%	100%
V5AYA9	Trypanosoma cruzi	31%	96%