LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HSA3_LEIIN
TriTrypDb:
LINF_040015700
Length:
485

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HSA3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSA3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 91 95 PF00656 0.601
CLV_NRD_NRD_1 174 176 PF00675 0.506
CLV_NRD_NRD_1 278 280 PF00675 0.620
CLV_NRD_NRD_1 465 467 PF00675 0.649
CLV_PCSK_KEX2_1 174 176 PF00082 0.506
CLV_PCSK_KEX2_1 278 280 PF00082 0.620
CLV_PCSK_KEX2_1 465 467 PF00082 0.649
CLV_PCSK_SKI1_1 303 307 PF00082 0.626
DEG_APCC_DBOX_1 277 285 PF00400 0.539
DEG_SCF_FBW7_1 109 116 PF00400 0.518
DEG_SCF_FBW7_1 234 241 PF00400 0.659
DEG_SPOP_SBC_1 305 309 PF00917 0.627
DOC_CKS1_1 110 115 PF01111 0.520
DOC_CKS1_1 235 240 PF01111 0.611
DOC_MAPK_gen_1 49 58 PF00069 0.493
DOC_MAPK_HePTP_8 46 58 PF00069 0.505
DOC_MAPK_MEF2A_6 49 58 PF00069 0.557
DOC_MAPK_NFAT4_5 51 59 PF00069 0.492
DOC_PP2B_LxvP_1 153 156 PF13499 0.470
DOC_PP2B_LxvP_1 203 206 PF13499 0.564
DOC_USP7_MATH_1 113 117 PF00917 0.524
DOC_USP7_MATH_1 143 147 PF00917 0.512
DOC_USP7_MATH_1 184 188 PF00917 0.677
DOC_USP7_MATH_1 238 242 PF00917 0.632
DOC_USP7_MATH_1 370 374 PF00917 0.611
DOC_USP7_MATH_1 8 12 PF00917 0.748
DOC_WW_Pin1_4 109 114 PF00397 0.636
DOC_WW_Pin1_4 12 17 PF00397 0.551
DOC_WW_Pin1_4 218 223 PF00397 0.617
DOC_WW_Pin1_4 234 239 PF00397 0.567
DOC_WW_Pin1_4 246 251 PF00397 0.596
DOC_WW_Pin1_4 257 262 PF00397 0.579
DOC_WW_Pin1_4 306 311 PF00397 0.636
DOC_WW_Pin1_4 332 337 PF00397 0.779
DOC_WW_Pin1_4 4 9 PF00397 0.701
DOC_WW_Pin1_4 56 61 PF00397 0.526
LIG_14-3-3_CanoR_1 178 183 PF00244 0.563
LIG_14-3-3_CanoR_1 303 312 PF00244 0.632
LIG_14-3-3_CanoR_1 406 416 PF00244 0.612
LIG_14-3-3_CanoR_1 465 472 PF00244 0.671
LIG_Actin_WH2_2 182 199 PF00022 0.554
LIG_APCC_ABBA_1 447 452 PF00400 0.604
LIG_BIR_II_1 1 5 PF00653 0.733
LIG_BRCT_BRCA1_1 14 18 PF00533 0.635
LIG_BRCT_BRCA1_1 148 152 PF00533 0.522
LIG_BRCT_BRCA1_1 410 414 PF00533 0.642
LIG_FHA_1 283 289 PF00498 0.542
LIG_FHA_1 307 313 PF00498 0.665
LIG_FHA_2 17 23 PF00498 0.570
LIG_FHA_2 438 444 PF00498 0.646
LIG_LIR_Gen_1 149 160 PF02991 0.591
LIG_LIR_Gen_1 167 176 PF02991 0.485
LIG_LIR_Nem_3 103 109 PF02991 0.701
LIG_LIR_Nem_3 149 155 PF02991 0.605
LIG_LIR_Nem_3 167 172 PF02991 0.521
LIG_LYPXL_yS_3 106 109 PF13949 0.552
LIG_NRBOX 29 35 PF00104 0.495
LIG_PCNA_yPIPBox_3 21 34 PF02747 0.515
LIG_SH2_STAT5 23 26 PF00017 0.639
LIG_SH3_3 104 110 PF00018 0.572
LIG_SH3_3 250 256 PF00018 0.699
LIG_SH3_3 342 348 PF00018 0.681
LIG_SH3_3 420 426 PF00018 0.699
LIG_SH3_3 475 481 PF00018 0.711
LIG_TRAF2_1 341 344 PF00917 0.733
LIG_WW_3 182 186 PF00397 0.631
MOD_CDK_SPK_2 56 61 PF00069 0.487
MOD_CK1_1 146 152 PF00069 0.543
MOD_CK1_1 2 8 PF00069 0.701
MOD_CK1_1 241 247 PF00069 0.652
MOD_CK1_1 311 317 PF00069 0.652
MOD_CK1_1 322 328 PF00069 0.583
MOD_CK1_1 407 413 PF00069 0.629
MOD_CK1_1 417 423 PF00069 0.609
MOD_CK1_1 459 465 PF00069 0.701
MOD_CK1_1 467 473 PF00069 0.628
MOD_CK1_1 474 480 PF00069 0.555
MOD_CK1_1 76 82 PF00069 0.666
MOD_CK1_1 97 103 PF00069 0.568
MOD_CK2_1 388 394 PF00069 0.697
MOD_GlcNHglycan 145 148 PF01048 0.521
MOD_GlcNHglycan 164 167 PF01048 0.515
MOD_GlcNHglycan 180 183 PF01048 0.487
MOD_GlcNHglycan 186 189 PF01048 0.531
MOD_GlcNHglycan 203 206 PF01048 0.517
MOD_GlcNHglycan 212 215 PF01048 0.613
MOD_GlcNHglycan 222 225 PF01048 0.577
MOD_GlcNHglycan 243 246 PF01048 0.587
MOD_GlcNHglycan 3 7 PF01048 0.701
MOD_GlcNHglycan 313 316 PF01048 0.686
MOD_GlcNHglycan 324 327 PF01048 0.592
MOD_GlcNHglycan 355 358 PF01048 0.715
MOD_GlcNHglycan 378 384 PF01048 0.679
MOD_GlcNHglycan 391 394 PF01048 0.591
MOD_GlcNHglycan 410 413 PF01048 0.501
MOD_GlcNHglycan 418 422 PF01048 0.640
MOD_GlcNHglycan 427 430 PF01048 0.551
MOD_GlcNHglycan 473 476 PF01048 0.693
MOD_GlcNHglycan 99 102 PF01048 0.658
MOD_GSK3_1 109 116 PF00069 0.576
MOD_GSK3_1 12 19 PF00069 0.505
MOD_GSK3_1 164 171 PF00069 0.499
MOD_GSK3_1 2 9 PF00069 0.701
MOD_GSK3_1 234 241 PF00069 0.660
MOD_GSK3_1 304 311 PF00069 0.673
MOD_GSK3_1 328 335 PF00069 0.705
MOD_GSK3_1 404 411 PF00069 0.580
MOD_GSK3_1 433 440 PF00069 0.682
MOD_GSK3_1 455 462 PF00069 0.675
MOD_GSK3_1 464 471 PF00069 0.619
MOD_GSK3_1 76 83 PF00069 0.711
MOD_N-GLC_1 407 412 PF02516 0.573
MOD_NEK2_1 33 38 PF00069 0.495
MOD_NEK2_2 16 21 PF00069 0.527
MOD_PIKK_1 33 39 PF00454 0.490
MOD_PIKK_1 94 100 PF00454 0.630
MOD_PKA_1 465 471 PF00069 0.646
MOD_PKA_2 177 183 PF00069 0.583
MOD_PKA_2 184 190 PF00069 0.621
MOD_PKA_2 282 288 PF00069 0.542
MOD_PKA_2 394 400 PF00069 0.615
MOD_PKA_2 464 470 PF00069 0.672
MOD_PKA_2 80 86 PF00069 0.677
MOD_Plk_1 16 22 PF00069 0.545
MOD_Plk_2-3 371 377 PF00069 0.725
MOD_Plk_2-3 73 79 PF00069 0.651
MOD_Plk_4 148 154 PF00069 0.583
MOD_Plk_4 168 174 PF00069 0.496
MOD_ProDKin_1 109 115 PF00069 0.632
MOD_ProDKin_1 12 18 PF00069 0.538
MOD_ProDKin_1 218 224 PF00069 0.616
MOD_ProDKin_1 234 240 PF00069 0.564
MOD_ProDKin_1 246 252 PF00069 0.591
MOD_ProDKin_1 257 263 PF00069 0.578
MOD_ProDKin_1 306 312 PF00069 0.641
MOD_ProDKin_1 332 338 PF00069 0.779
MOD_ProDKin_1 4 10 PF00069 0.699
MOD_ProDKin_1 56 62 PF00069 0.521
MOD_SUMO_rev_2 294 300 PF00179 0.656
TRG_ENDOCYTIC_2 106 109 PF00928 0.668
TRG_ENDOCYTIC_2 450 453 PF00928 0.601
TRG_ER_diArg_1 131 134 PF00400 0.425
TRG_ER_diArg_1 173 175 PF00400 0.498
TRG_ER_diArg_1 288 291 PF00400 0.589
TRG_ER_diArg_1 50 53 PF00400 0.493
TRG_Pf-PMV_PEXEL_1 28 32 PF00026 0.498

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WNX2 Leishmania donovani 100% 100%
A4H421 Leishmania braziliensis 63% 100%
E9AK87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q9NF89 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS