Acyltransferase-like protein, copy 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein - copy 2

Species:

Leishmania infantum

UniProt:

A4HSA2_LEIIN

TriTrypDb:

LINF_040015600

Length:

356

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Annotations by Jardim et al.

Phospholipid biosynthesis, Acyltransferase-like , copy 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4HSA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSA2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006654	phosphatidic acid biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	5
GO:0019637	organophosphate metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046473	phosphatidic acid metabolic process	6	5
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	30
GO:0016740	transferase activity	2	30
GO:0016746	acyltransferase activity	3	30
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	7
GO:0008374	O-acyltransferase activity	5	7
GO:0016411	acylglycerol O-acyltransferase activity	6	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0042171	lysophosphatidic acid acyltransferase activity	6	7
GO:0071617	lysophospholipid acyltransferase activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	175	181	PF00089	0.533
CLV_NRD_NRD_1	166	168	PF00675	0.522
CLV_NRD_NRD_1	324	326	PF00675	0.654
CLV_NRD_NRD_1	81	83	PF00675	0.297
CLV_PCSK_FUR_1	320	324	PF00082	0.598
CLV_PCSK_KEX2_1	320	322	PF00082	0.659
CLV_PCSK_KEX2_1	323	325	PF00082	0.689
CLV_PCSK_KEX2_1	81	83	PF00082	0.280
CLV_PCSK_PC7_1	320	326	PF00082	0.629
CLV_PCSK_SKI1_1	333	337	PF00082	0.759
CLV_PCSK_SKI1_1	51	55	PF00082	0.361
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.424
DOC_MAPK_gen_1	248	257	PF00069	0.321
DOC_MAPK_gen_1	81	89	PF00069	0.521
DOC_MAPK_MEF2A_6	293	301	PF00069	0.402
DOC_MAPK_MEF2A_6	82	91	PF00069	0.530
DOC_PP1_RVXF_1	95	102	PF00149	0.386
DOC_PP2B_LxvP_1	60	63	PF13499	0.414
DOC_PP2B_LxvP_1	77	80	PF13499	0.575
DOC_USP7_MATH_1	202	206	PF00917	0.207
DOC_WW_Pin1_4	147	152	PF00397	0.309
DOC_WW_Pin1_4	226	231	PF00397	0.271
LIG_14-3-3_CterR_2	353	356	PF00244	0.417
LIG_Actin_WH2_2	151	169	PF00022	0.351
LIG_AP2alpha_1	140	144	PF02296	0.268
LIG_BRCT_BRCA1_1	216	220	PF00533	0.331
LIG_CSL_BTD_1	262	265	PF09270	0.378
LIG_FHA_1	335	341	PF00498	0.412
LIG_FHA_1	56	62	PF00498	0.330
LIG_FHA_2	241	247	PF00498	0.251
LIG_FHA_2	343	349	PF00498	0.391
LIG_GBD_Chelix_1	295	303	PF00786	0.555
LIG_LIR_Gen_1	138	149	PF02991	0.277
LIG_LIR_Gen_1	240	249	PF02991	0.253
LIG_LIR_Gen_1	34	44	PF02991	0.472
LIG_LIR_Nem_3	138	144	PF02991	0.300
LIG_LIR_Nem_3	240	244	PF02991	0.271
LIG_LIR_Nem_3	34	39	PF02991	0.474
LIG_Pex14_2	140	144	PF04695	0.272
LIG_Pex14_2	172	176	PF04695	0.319
LIG_Pex14_2	182	186	PF04695	0.290
LIG_Pex14_2	92	96	PF04695	0.387
LIG_SH2_CRK	36	40	PF00017	0.321
LIG_SH2_STAT5	253	256	PF00017	0.280
LIG_SH2_STAT5	36	39	PF00017	0.295
LIG_SH2_STAT5	69	72	PF00017	0.382
LIG_SH2_STAT5	76	79	PF00017	0.582
LIG_SUMO_SIM_par_1	253	260	PF11976	0.369
LIG_TRAF2_1	316	319	PF00917	0.327
LIG_TYR_ITIM	74	79	PF00017	0.474
LIG_UBA3_1	155	163	PF00899	0.207
LIG_WRC_WIRS_1	238	243	PF05994	0.286
LIG_WW_3	263	267	PF00397	0.286
MOD_CK1_1	256	262	PF00069	0.410
MOD_CK2_1	240	246	PF00069	0.297
MOD_CK2_1	342	348	PF00069	0.394
MOD_GlcNHglycan	187	190	PF01048	0.587
MOD_GlcNHglycan	64	67	PF01048	0.338
MOD_GSK3_1	131	138	PF00069	0.243
MOD_GSK3_1	157	164	PF00069	0.315
MOD_N-GLC_1	135	140	PF02516	0.478
MOD_N-GLC_1	226	231	PF02516	0.471
MOD_NEK2_1	135	140	PF00069	0.255
MOD_NEK2_1	161	166	PF00069	0.304
MOD_NEK2_1	214	219	PF00069	0.311
MOD_NEK2_1	53	58	PF00069	0.335
MOD_NMyristoyl	1	7	PF02799	0.522
MOD_PIKK_1	202	208	PF00454	0.394
MOD_PKA_2	288	294	PF00069	0.288
MOD_Plk_1	135	141	PF00069	0.278
MOD_Plk_1	259	265	PF00069	0.362
MOD_Plk_4	136	142	PF00069	0.269
MOD_Plk_4	240	246	PF00069	0.325
MOD_Plk_4	34	40	PF00069	0.466
MOD_ProDKin_1	147	153	PF00069	0.309
MOD_ProDKin_1	226	232	PF00069	0.271
MOD_SUMO_rev_2	330	335	PF00179	0.447
TRG_ENDOCYTIC_2	238	241	PF00928	0.309
TRG_ENDOCYTIC_2	252	255	PF00928	0.269
TRG_ENDOCYTIC_2	36	39	PF00928	0.363
TRG_ENDOCYTIC_2	76	79	PF00928	0.480
TRG_ER_diArg_1	248	251	PF00400	0.321
TRG_ER_diArg_1	320	323	PF00400	0.457
TRG_ER_diArg_1	39	42	PF00400	0.394
TRG_ER_diArg_1	80	82	PF00400	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	64%	100%
A0A0N1HTP4	Leptomonas seymouri	53%	100%
A0A0N1I6V1	Leptomonas seymouri	34%	100%
A0A0N1IKX5	Leptomonas seymouri	33%	100%
A0A0S4IQ05	Bodo saltans	32%	100%
A0A0S4IR22	Bodo saltans	41%	100%
A0A1X0P9F0	Trypanosomatidae	34%	100%
A0A3R7NKA0	Trypanosoma rangeli	34%	100%
A0A3S5H5E4	Leishmania donovani	52%	82%
A0A3S5H7L8	Leishmania donovani	33%	100%
A0A3S7WNW6	Leishmania donovani	100%	100%
A4H419	Leishmania braziliensis	56%	100%
A4H420	Leishmania braziliensis	70%	100%
A4HHM7	Leishmania braziliensis	33%	100%
A4HKI5	Leishmania braziliensis	29%	100%
A4HSA1	Leishmania infantum	52%	100%
A4I4U1	Leishmania infantum	31%	100%
A4I4U2	Leishmania infantum	34%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AE89	Leishmania major	32%	100%
E9AE90	Leishmania major	33%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q582	Leishmania major	28%	100%
Q9NF90	Leishmania major	92%	100%
Q9NF91	Leishmania major	51%	100%
V5C201	Trypanosoma cruzi	35%	100%