Acyltransferase-like protein, copy 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein - copy 1

Species:

Leishmania infantum

UniProt:

A4HSA1_LEIIN

TriTrypDb:

LINF_040015500

Length:

308

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Annotations by Jardim et al.

Phospholipid biosynthesis, Acyltransferase-like , copy 1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

A4HSA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HSA1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046473	phosphatidic acid metabolic process	6	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	31
GO:0016740	transferase activity	2	31
GO:0016746	acyltransferase activity	3	31
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016411	acylglycerol O-acyltransferase activity	6	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0042171	lysophosphatidic acid acyltransferase activity	6	6
GO:0071617	lysophospholipid acyltransferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.310
CLV_MEL_PAP_1	156	162	PF00089	0.536
CLV_NRD_NRD_1	147	149	PF00675	0.524
CLV_NRD_NRD_1	278	280	PF00675	0.553
CLV_PCSK_KEX2_1	278	280	PF00082	0.555
CLV_PCSK_SKI1_1	134	138	PF00082	0.517
DEG_APCC_DBOX_1	20	28	PF00400	0.431
DOC_CYCLIN_RxL_1	131	141	PF00134	0.325
DOC_MAPK_DCC_7	21	29	PF00069	0.350
DOC_MAPK_DCC_7	67	75	PF00069	0.400
DOC_MAPK_gen_1	21	29	PF00069	0.311
DOC_MAPK_MEF2A_6	21	29	PF00069	0.316
DOC_MAPK_MEF2A_6	31	39	PF00069	0.278
DOC_MAPK_MEF2A_6	67	75	PF00069	0.380
DOC_PP1_RVXF_1	76	83	PF00149	0.346
DOC_PP1_RVXF_1	99	105	PF00149	0.436
DOC_PP2B_LxvP_1	58	61	PF13499	0.572
DOC_USP7_MATH_1	2	6	PF00917	0.204
DOC_WW_Pin1_4	128	133	PF00397	0.313
LIG_14-3-3_CanoR_1	101	105	PF00244	0.388
LIG_APCC_ABBA_1	199	204	PF00400	0.313
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BRCT_BRCA1_1	4	8	PF00533	0.457
LIG_deltaCOP1_diTrp_1	241	247	PF00928	0.296
LIG_EH1_1	33	41	PF00400	0.256
LIG_FHA_1	47	53	PF00498	0.331
LIG_FHA_1	60	66	PF00498	0.496
LIG_GBD_Chelix_1	11	19	PF00786	0.375
LIG_LIR_Gen_1	123	133	PF02991	0.285
LIG_LIR_Gen_1	5	15	PF02991	0.431
LIG_LIR_LC3C_4	49	53	PF02991	0.341
LIG_LIR_Nem_3	103	107	PF02991	0.344
LIG_LIR_Nem_3	120	125	PF02991	0.301
LIG_LIR_Nem_3	131	136	PF02991	0.297
LIG_LIR_Nem_3	231	236	PF02991	0.274
LIG_LIR_Nem_3	5	11	PF02991	0.452
LIG_Pex14_2	153	157	PF04695	0.318
LIG_Pex14_2	163	167	PF04695	0.285
LIG_Pex14_2	222	226	PF04695	0.310
LIG_Pex14_2	77	81	PF04695	0.377
LIG_SH2_CRK	125	129	PF00017	0.341
LIG_SH2_PTP2	17	20	PF00017	0.243
LIG_SH2_STAT3	63	66	PF00017	0.431
LIG_SH2_STAT5	114	117	PF00017	0.395
LIG_SH2_STAT5	166	169	PF00017	0.252
LIG_SH2_STAT5	17	20	PF00017	0.295
LIG_SH2_STAT5	64	67	PF00017	0.537
LIG_SH3_3	210	216	PF00018	0.387
LIG_TYR_ITIM	15	20	PF00017	0.377
LIG_UBA3_1	221	227	PF00899	0.291
MOD_CDK_SPxK_1	128	134	PF00069	0.336
MOD_CK1_1	46	52	PF00069	0.375
MOD_CMANNOS	244	247	PF00535	0.586
MOD_GlcNHglycan	168	171	PF01048	0.588
MOD_GlcNHglycan	194	197	PF01048	0.528
MOD_GlcNHglycan	301	304	PF01048	0.645
MOD_GlcNHglycan	45	48	PF01048	0.341
MOD_GSK3_1	138	145	PF00069	0.307
MOD_GSK3_1	270	277	PF00069	0.331
MOD_NEK2_1	136	141	PF00069	0.262
MOD_NEK2_1	142	147	PF00069	0.294
MOD_PIKK_1	105	111	PF00454	0.258
MOD_PKA_2	100	106	PF00069	0.359
MOD_Plk_1	240	246	PF00069	0.356
MOD_Plk_4	117	123	PF00069	0.270
MOD_Plk_4	2	8	PF00069	0.474
MOD_Plk_4	221	227	PF00069	0.325
MOD_Plk_4	229	235	PF00069	0.336
MOD_Plk_4	38	44	PF00069	0.337
MOD_Plk_4	59	65	PF00069	0.616
MOD_ProDKin_1	128	134	PF00069	0.313
MOD_SUMO_rev_2	267	276	PF00179	0.332
MOD_SUMO_rev_2	290	300	PF00179	0.292
MOD_SUMO_rev_2	302	308	PF00179	0.376
TRG_ENDOCYTIC_2	125	128	PF00928	0.363
TRG_ENDOCYTIC_2	17	20	PF00928	0.363
TRG_ENDOCYTIC_2	219	222	PF00928	0.310
TRG_ENDOCYTIC_2	233	236	PF00928	0.279
TRG_ENDOCYTIC_2	288	291	PF00928	0.388
TRG_ER_diArg_1	20	23	PF00400	0.386
TRG_ER_diArg_1	278	280	PF00400	0.375
TRG_NES_CRM1_1	256	269	PF08389	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	55%	90%
A0A0N1HTP4	Leptomonas seymouri	66%	100%
A0A0N1I6V1	Leptomonas seymouri	35%	100%
A0A0N1IKX5	Leptomonas seymouri	34%	100%
A0A0S4IQ05	Bodo saltans	31%	91%
A0A0S4IR22	Bodo saltans	42%	100%
A0A0S4JRB2	Bodo saltans	31%	97%
A0A1X0P9F0	Trypanosomatidae	33%	100%
A0A3Q8IFY7	Leishmania donovani	24%	100%
A0A3R7NKA0	Trypanosoma rangeli	33%	100%
A0A3S5H5E4	Leishmania donovani	99%	71%
A0A3S5H7L8	Leishmania donovani	34%	95%
A0A3S7WNW6	Leishmania donovani	52%	87%
A4H418	Leishmania braziliensis	72%	100%
A4H419	Leishmania braziliensis	65%	100%
A4H420	Leishmania braziliensis	53%	100%
A4HHM7	Leishmania braziliensis	32%	100%
A4HSA2	Leishmania infantum	52%	87%
A4I4U1	Leishmania infantum	30%	95%
A4I4U2	Leishmania infantum	34%	100%
A4I816	Leishmania infantum	24%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AE89	Leishmania major	31%	100%
E9AE90	Leishmania major	33%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q9NF90	Leishmania major	52%	100%
Q9NF91	Leishmania major	93%	100%
V5C201	Trypanosoma cruzi	31%	100%