Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS95_LEIIN

TriTrypDb:

LINF_040014800

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.635
CLV_NRD_NRD_1	34	36	PF00675	0.571
CLV_NRD_NRD_1	62	64	PF00675	0.714
CLV_NRD_NRD_1	72	74	PF00675	0.645
CLV_PCSK_FUR_1	32	36	PF00082	0.578
CLV_PCSK_KEX2_1	34	36	PF00082	0.571
CLV_PCSK_KEX2_1	61	63	PF00082	0.706
CLV_PCSK_PC7_1	30	36	PF00082	0.578
CLV_PCSK_SKI1_1	412	416	PF00082	0.557
DEG_SPOP_SBC_1	137	141	PF00917	0.726
DOC_CKS1_1	266	271	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	119	122	PF00134	0.696
DOC_MAPK_DCC_7	115	125	PF00069	0.711
DOC_PP2B_LxvP_1	119	122	PF13499	0.712
DOC_PP2B_LxvP_1	46	49	PF13499	0.668
DOC_USP7_MATH_1	100	104	PF00917	0.672
DOC_USP7_MATH_1	105	109	PF00917	0.643
DOC_USP7_MATH_1	124	128	PF00917	0.615
DOC_USP7_MATH_1	217	221	PF00917	0.616
DOC_USP7_MATH_1	227	231	PF00917	0.625
DOC_USP7_MATH_1	235	239	PF00917	0.743
DOC_USP7_MATH_1	267	271	PF00917	0.679
DOC_USP7_MATH_1	322	326	PF00917	0.660
DOC_USP7_MATH_1	371	375	PF00917	0.694
DOC_WW_Pin1_4	191	196	PF00397	0.751
DOC_WW_Pin1_4	225	230	PF00397	0.653
DOC_WW_Pin1_4	236	241	PF00397	0.767
DOC_WW_Pin1_4	265	270	PF00397	0.568
DOC_WW_Pin1_4	329	334	PF00397	0.826
DOC_WW_Pin1_4	36	41	PF00397	0.535
DOC_WW_Pin1_4	374	379	PF00397	0.793
DOC_WW_Pin1_4	388	393	PF00397	0.580
DOC_WW_Pin1_4	443	448	PF00397	0.705
DOC_WW_Pin1_4	466	471	PF00397	0.607
LIG_14-3-3_CanoR_1	299	305	PF00244	0.679
LIG_14-3-3_CanoR_1	357	361	PF00244	0.587
LIG_14-3-3_CanoR_1	412	421	PF00244	0.553
LIG_Actin_WH2_2	396	414	PF00022	0.501
LIG_APCC_ABBAyCdc20_2	10	16	PF00400	0.512
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_EVH1_2	121	125	PF00568	0.644
LIG_FHA_1	175	181	PF00498	0.738
LIG_FHA_2	138	144	PF00498	0.730
LIG_FHA_2	165	171	PF00498	0.677
LIG_FHA_2	348	354	PF00498	0.696
LIG_FHA_2	400	406	PF00498	0.578
LIG_FHA_2	81	87	PF00498	0.552
LIG_LIR_Apic_2	448	453	PF02991	0.651
LIG_LIR_Nem_3	131	136	PF02991	0.733
LIG_LIR_Nem_3	147	153	PF02991	0.485
LIG_MYND_1	41	45	PF01753	0.528
LIG_PCNA_PIPBox_1	248	257	PF02747	0.458
LIG_Pex14_1	92	96	PF04695	0.636
LIG_SH2_CRK	96	100	PF00017	0.574
LIG_SH2_STAT5	136	139	PF00017	0.796
LIG_SH2_STAT5	8	11	PF00017	0.517
LIG_SH3_1	54	60	PF00018	0.650
LIG_SH3_2	57	62	PF14604	0.763
LIG_SH3_3	115	121	PF00018	0.569
LIG_SH3_3	146	152	PF00018	0.639
LIG_SH3_3	193	199	PF00018	0.804
LIG_SH3_3	231	237	PF00018	0.760
LIG_SH3_3	263	269	PF00018	0.706
LIG_SH3_3	280	286	PF00018	0.591
LIG_SH3_3	323	329	PF00018	0.803
LIG_SH3_3	375	381	PF00018	0.789
LIG_SH3_3	418	424	PF00018	0.521
LIG_SH3_3	52	58	PF00018	0.733
LIG_SH3_CIN85_PxpxPR_1	49	54	PF14604	0.605
LIG_SUMO_SIM_par_1	44	50	PF11976	0.552
LIG_TRAF2_1	200	203	PF00917	0.581
LIG_TRAF2_1	350	353	PF00917	0.592
LIG_WW_2	328	331	PF00397	0.621
LIG_WW_3	39	43	PF00397	0.544
LIG_WW_3	58	62	PF00397	0.505
LIG_WW_3	70	74	PF00397	0.502
MOD_CDK_SPxK_1	36	42	PF00069	0.560
MOD_CDK_SPxK_1	443	449	PF00069	0.542
MOD_CK1_1	138	144	PF00069	0.730
MOD_CK1_1	174	180	PF00069	0.640
MOD_CK1_1	239	245	PF00069	0.590
MOD_CK1_1	374	380	PF00069	0.766
MOD_CK2_1	267	273	PF00069	0.669
MOD_CK2_1	347	353	PF00069	0.674
MOD_CK2_1	399	405	PF00069	0.548
MOD_CK2_1	80	86	PF00069	0.550
MOD_GlcNHglycan	107	110	PF01048	0.802
MOD_GlcNHglycan	126	129	PF01048	0.568
MOD_GlcNHglycan	173	176	PF01048	0.661
MOD_GlcNHglycan	213	216	PF01048	0.655
MOD_GlcNHglycan	219	222	PF01048	0.620
MOD_GlcNHglycan	229	232	PF01048	0.613
MOD_GlcNHglycan	269	272	PF01048	0.649
MOD_GlcNHglycan	373	376	PF01048	0.769
MOD_GlcNHglycan	434	438	PF01048	0.595
MOD_GlcNHglycan	64	67	PF01048	0.581
MOD_GSK3_1	181	188	PF00069	0.695
MOD_GSK3_1	235	242	PF00069	0.722
MOD_GSK3_1	338	345	PF00069	0.809
MOD_GSK3_1	379	386	PF00069	0.677
MOD_GSK3_1	62	69	PF00069	0.606
MOD_N-GLC_1	412	417	PF02516	0.589
MOD_NEK2_1	1	6	PF00069	0.662
MOD_NEK2_1	111	116	PF00069	0.658
MOD_NEK2_1	201	206	PF00069	0.580
MOD_PIKK_1	201	207	PF00454	0.616
MOD_PIKK_1	293	299	PF00454	0.740
MOD_PKA_1	62	68	PF00069	0.585
MOD_PKA_2	356	362	PF00069	0.616
MOD_PKA_2	62	68	PF00069	0.625
MOD_Plk_1	100	106	PF00069	0.655
MOD_Plk_1	111	117	PF00069	0.566
MOD_Plk_1	322	328	PF00069	0.779
MOD_Plk_2-3	399	405	PF00069	0.548
MOD_Plk_4	23	29	PF00069	0.680
MOD_ProDKin_1	191	197	PF00069	0.752
MOD_ProDKin_1	225	231	PF00069	0.655
MOD_ProDKin_1	236	242	PF00069	0.572
MOD_ProDKin_1	265	271	PF00069	0.571
MOD_ProDKin_1	329	335	PF00069	0.829
MOD_ProDKin_1	36	42	PF00069	0.545
MOD_ProDKin_1	374	380	PF00069	0.793
MOD_ProDKin_1	388	394	PF00069	0.580
MOD_ProDKin_1	443	449	PF00069	0.705
MOD_ProDKin_1	466	472	PF00069	0.607
TRG_ENDOCYTIC_2	96	99	PF00928	0.573
TRG_ER_diArg_1	29	32	PF00400	0.534
TRG_ER_diArg_1	420	423	PF00400	0.561
TRG_ER_diArg_1	60	63	PF00400	0.658
TRG_ER_diArg_1	77	80	PF00400	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B3	Leptomonas seymouri	30%	100%
A0A3S5H5D9	Leishmania donovani	100%	100%
A4H412	Leishmania braziliensis	63%	93%
E9ACP9	Leishmania major	85%	100%
E9AK79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	93%