Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS84_LEIIN

TriTrypDb:

LINF_040014100

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.559
CLV_PCSK_KEX2_1	36	38	PF00082	0.412
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.412
CLV_PCSK_SKI1_1	37	41	PF00082	0.393
DEG_APCC_DBOX_1	230	238	PF00400	0.413
DEG_SPOP_SBC_1	98	102	PF00917	0.588
DOC_CKS1_1	173	178	PF01111	0.584
DOC_MAPK_gen_1	36	42	PF00069	0.401
DOC_MAPK_MEF2A_6	179	188	PF00069	0.443
DOC_MAPK_MEF2A_6	198	207	PF00069	0.345
DOC_PP2B_LxvP_1	184	187	PF13499	0.447
DOC_PP2B_LxvP_1	93	96	PF13499	0.655
DOC_USP7_MATH_1	111	115	PF00917	0.569
DOC_USP7_MATH_1	145	149	PF00917	0.626
DOC_USP7_MATH_1	15	19	PF00917	0.531
DOC_USP7_MATH_1	187	191	PF00917	0.474
DOC_USP7_MATH_1	45	49	PF00917	0.522
DOC_USP7_MATH_1	98	102	PF00917	0.653
DOC_WW_Pin1_4	168	173	PF00397	0.642
DOC_WW_Pin1_4	174	179	PF00397	0.641
DOC_WW_Pin1_4	65	70	PF00397	0.746
LIG_14-3-3_CanoR_1	227	235	PF00244	0.445
LIG_14-3-3_CanoR_1	5	10	PF00244	0.560
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_FHA_1	17	23	PF00498	0.599
LIG_LIR_Gen_1	148	157	PF02991	0.643
LIG_LIR_Gen_1	201	210	PF02991	0.388
LIG_LIR_Gen_1	26	34	PF02991	0.387
LIG_LIR_LC3C_4	201	205	PF02991	0.382
LIG_LIR_Nem_3	148	152	PF02991	0.619
LIG_LIR_Nem_3	201	205	PF02991	0.367
LIG_LIR_Nem_3	26	30	PF02991	0.388
LIG_PDZ_Class_2	243	248	PF00595	0.386
LIG_PROFILIN_1	161	167	PF00235	0.542
LIG_SH2_CRK	149	153	PF00017	0.629
LIG_SH2_NCK_1	149	153	PF00017	0.629
LIG_SH2_PTP2	27	30	PF00017	0.370
LIG_SH2_STAP1	149	153	PF00017	0.533
LIG_SH2_STAT5	215	218	PF00017	0.573
LIG_SH2_STAT5	27	30	PF00017	0.370
LIG_SH2_STAT5	59	62	PF00017	0.535
LIG_SH3_3	116	122	PF00018	0.631
LIG_SH3_3	157	163	PF00018	0.594
LIG_SH3_3	170	176	PF00018	0.499
LIG_TYR_ITIM	25	30	PF00017	0.398
MOD_CDK_SPK_2	174	179	PF00069	0.551
MOD_CDK_SPxxK_3	172	179	PF00069	0.556
MOD_CK1_1	100	106	PF00069	0.623
MOD_CK1_1	190	196	PF00069	0.395
MOD_CK1_1	26	32	PF00069	0.457
MOD_CK1_1	4	10	PF00069	0.554
MOD_CK2_1	152	158	PF00069	0.536
MOD_Cter_Amidation	34	37	PF01082	0.369
MOD_GlcNHglycan	102	105	PF01048	0.641
MOD_GlcNHglycan	113	116	PF01048	0.543
MOD_GSK3_1	1	8	PF00069	0.618
MOD_GSK3_1	168	175	PF00069	0.659
MOD_GSK3_1	187	194	PF00069	0.405
MOD_GSK3_1	98	105	PF00069	0.640
MOD_NEK2_1	1	6	PF00069	0.562
MOD_NEK2_1	167	172	PF00069	0.673
MOD_NEK2_1	191	196	PF00069	0.402
MOD_PKA_2	226	232	PF00069	0.452
MOD_PKA_2	4	10	PF00069	0.554
MOD_Plk_1	191	197	PF00069	0.392
MOD_Plk_2-3	226	232	PF00069	0.482
MOD_Plk_4	192	198	PF00069	0.489
MOD_Plk_4	23	29	PF00069	0.439
MOD_ProDKin_1	168	174	PF00069	0.640
MOD_ProDKin_1	65	71	PF00069	0.755
MOD_SUMO_rev_2	114	119	PF00179	0.666
MOD_SUMO_rev_2	29	38	PF00179	0.401
TRG_DiLeu_BaEn_1	192	197	PF01217	0.490
TRG_DiLeu_BaEn_1	230	235	PF01217	0.535
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.632
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.633
TRG_ENDOCYTIC_2	149	152	PF00928	0.629
TRG_ENDOCYTIC_2	27	30	PF00928	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P497	Leptomonas seymouri	48%	100%
A0A3S7WNU9	Leishmania donovani	99%	100%
A4H3Y4	Leishmania braziliensis	73%	100%
E9AK72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O97008	Leishmania major	91%	100%