LeishMANIAdb
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Rhomboid-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Rhomboid-like protein
Gene product:
serine peptidase - Clan S- - family S54 - putative
Species:
Leishmania infantum
UniProt:
A4HS82_LEIIN
TriTrypDb:
LINF_040013500
Length:
396

Annotations

Annotations by Jardim et al.

Proteases, Rhomboid-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HS82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS82

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004175 endopeptidase activity 4 10
GO:0004252 serine-type endopeptidase activity 5 10
GO:0008233 peptidase activity 3 10
GO:0008236 serine-type peptidase activity 4 10
GO:0016787 hydrolase activity 2 10
GO:0017171 serine hydrolase activity 3 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 164 168 PF00656 0.656
CLV_NRD_NRD_1 73 75 PF00675 0.397
CLV_PCSK_SKI1_1 18 22 PF00082 0.405
CLV_PCSK_SKI1_1 357 361 PF00082 0.252
CLV_PCSK_SKI1_1 46 50 PF00082 0.584
DEG_Nend_UBRbox_3 1 3 PF02207 0.614
DEG_SPOP_SBC_1 37 41 PF00917 0.677
DEG_SPOP_SBC_1 66 70 PF00917 0.639
DOC_CYCLIN_RxL_1 382 393 PF00134 0.371
DOC_MAPK_gen_1 87 97 PF00069 0.752
DOC_PP1_RVXF_1 329 336 PF00149 0.290
DOC_PP4_FxxP_1 188 191 PF00568 0.600
DOC_USP7_MATH_1 115 119 PF00917 0.721
DOC_USP7_MATH_1 138 142 PF00917 0.759
DOC_USP7_MATH_1 25 29 PF00917 0.643
DOC_USP7_MATH_1 37 41 PF00917 0.724
DOC_USP7_MATH_1 59 63 PF00917 0.659
DOC_USP7_MATH_1 66 70 PF00917 0.617
DOC_USP7_MATH_1 99 103 PF00917 0.656
DOC_WW_Pin1_4 107 112 PF00397 0.668
DOC_WW_Pin1_4 134 139 PF00397 0.739
DOC_WW_Pin1_4 172 177 PF00397 0.609
DOC_WW_Pin1_4 27 32 PF00397 0.723
LIG_14-3-3_CanoR_1 100 104 PF00244 0.633
LIG_14-3-3_CanoR_1 18 27 PF00244 0.718
LIG_14-3-3_CanoR_1 275 279 PF00244 0.315
LIG_14-3-3_CanoR_1 46 51 PF00244 0.731
LIG_14-3-3_CanoR_1 74 83 PF00244 0.740
LIG_BRCT_BRCA1_1 116 120 PF00533 0.643
LIG_Clathr_ClatBox_1 322 326 PF01394 0.290
LIG_deltaCOP1_diTrp_1 217 222 PF00928 0.384
LIG_deltaCOP1_diTrp_1 232 241 PF00928 0.271
LIG_deltaCOP1_diTrp_1 256 263 PF00928 0.252
LIG_deltaCOP1_diTrp_1 354 359 PF00928 0.290
LIG_EH_1 315 319 PF12763 0.290
LIG_EVH1_1 186 190 PF00568 0.606
LIG_EVH1_2 339 343 PF00568 0.252
LIG_FHA_1 19 25 PF00498 0.516
LIG_FHA_1 192 198 PF00498 0.452
LIG_FHA_1 345 351 PF00498 0.313
LIG_FHA_1 382 388 PF00498 0.366
LIG_FHA_1 92 98 PF00498 0.667
LIG_FHA_2 359 365 PF00498 0.469
LIG_LIR_Gen_1 232 241 PF02991 0.334
LIG_LIR_Gen_1 277 285 PF02991 0.315
LIG_LIR_Gen_1 347 355 PF02991 0.290
LIG_LIR_Nem_3 217 222 PF02991 0.375
LIG_LIR_Nem_3 232 237 PF02991 0.280
LIG_LIR_Nem_3 277 282 PF02991 0.315
LIG_LIR_Nem_3 347 352 PF02991 0.290
LIG_LIR_Nem_3 354 359 PF02991 0.290
LIG_LYPXL_S_1 237 241 PF13949 0.452
LIG_Pex14_1 234 238 PF04695 0.334
LIG_Pex14_2 188 192 PF04695 0.599
LIG_Pex14_2 241 245 PF04695 0.294
LIG_PTB_Apo_2 240 247 PF02174 0.269
LIG_PTB_Phospho_1 240 246 PF10480 0.269
LIG_REV1ctd_RIR_1 4 14 PF16727 0.591
LIG_SH2_STAT5 185 188 PF00017 0.610
LIG_SH2_STAT5 209 212 PF00017 0.292
LIG_SH2_STAT5 377 380 PF00017 0.290
LIG_SH3_3 184 190 PF00018 0.610
LIG_SH3_3 336 342 PF00018 0.267
LIG_SUMO_SIM_par_1 321 326 PF11976 0.350
LIG_UBA3_1 386 391 PF00899 0.373
MOD_CDC14_SPxK_1 137 140 PF00782 0.731
MOD_CDK_SPK_2 134 139 PF00069 0.739
MOD_CDK_SPxK_1 134 140 PF00069 0.727
MOD_CK1_1 39 45 PF00069 0.725
MOD_CK1_1 69 75 PF00069 0.717
MOD_CK2_1 166 172 PF00069 0.631
MOD_CK2_1 358 364 PF00069 0.469
MOD_CMANNOS 258 261 PF00535 0.452
MOD_GlcNHglycan 167 171 PF01048 0.533
MOD_GlcNHglycan 180 183 PF01048 0.464
MOD_GlcNHglycan 52 55 PF01048 0.485
MOD_GlcNHglycan 61 64 PF01048 0.459
MOD_GlcNHglycan 76 79 PF01048 0.534
MOD_GSK3_1 107 114 PF00069 0.735
MOD_GSK3_1 134 141 PF00069 0.766
MOD_GSK3_1 14 21 PF00069 0.630
MOD_GSK3_1 281 288 PF00069 0.298
MOD_GSK3_1 36 43 PF00069 0.651
MOD_GSK3_1 46 53 PF00069 0.769
MOD_GSK3_1 61 68 PF00069 0.595
MOD_GSK3_1 74 81 PF00069 0.703
MOD_N-GLC_1 232 237 PF02516 0.598
MOD_NEK2_1 263 268 PF00069 0.252
MOD_NEK2_1 271 276 PF00069 0.252
MOD_NEK2_1 281 286 PF00069 0.290
MOD_NEK2_1 344 349 PF00069 0.290
MOD_NEK2_1 38 43 PF00069 0.695
MOD_NEK2_2 115 120 PF00069 0.645
MOD_NEK2_2 85 90 PF00069 0.756
MOD_NEK2_2 99 104 PF00069 0.637
MOD_PIKK_1 69 75 PF00454 0.641
MOD_PKA_1 139 145 PF00069 0.668
MOD_PKA_1 74 80 PF00069 0.601
MOD_PKA_2 129 135 PF00069 0.732
MOD_PKA_2 14 20 PF00069 0.694
MOD_PKA_2 25 31 PF00069 0.731
MOD_PKA_2 274 280 PF00069 0.315
MOD_PKA_2 99 105 PF00069 0.633
MOD_Plk_1 232 238 PF00069 0.397
MOD_Plk_4 115 121 PF00069 0.760
MOD_Plk_4 263 269 PF00069 0.269
MOD_Plk_4 274 280 PF00069 0.290
MOD_Plk_4 285 291 PF00069 0.269
MOD_Plk_4 91 97 PF00069 0.660
MOD_Plk_4 99 105 PF00069 0.615
MOD_ProDKin_1 107 113 PF00069 0.662
MOD_ProDKin_1 134 140 PF00069 0.741
MOD_ProDKin_1 172 178 PF00069 0.606
MOD_ProDKin_1 27 33 PF00069 0.726
TRG_DiLeu_BaLyEn_6 43 48 PF01217 0.596
TRG_ENDOCYTIC_2 185 188 PF00928 0.610
TRG_ENDOCYTIC_2 209 212 PF00928 0.290
TRG_ENDOCYTIC_2 238 241 PF00928 0.252
TRG_ENDOCYTIC_2 300 303 PF00928 0.469
TRG_ER_diArg_1 308 311 PF00400 0.452
TRG_Pf-PMV_PEXEL_1 385 390 PF00026 0.573

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA30 Leptomonas seymouri 81% 100%
A0A1X0NLI4 Trypanosomatidae 64% 100%
A0A3R7RFZ5 Trypanosoma rangeli 63% 100%
A0A3S7WNU2 Leishmania donovani 100% 100%
A4H3Z5 Leishmania braziliensis 92% 100%
C9ZY76 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9AK68 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 98%
Q9U0Z8 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS