LeishMANIAdb
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Peptide deformylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptide deformylase
Gene product:
Peptide deformylase 2 - putative
Species:
Leishmania infantum
UniProt:
A4HS79_LEIIN
TriTrypDb:
LINF_040013200 *
Length:
393

Annotations

Annotations by Jardim et al.

Translation, Peptide deformylase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HS79
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS79

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 11
GO:0006508 proteolysis 4 6
GO:0006518 peptide metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0019538 protein metabolic process 3 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 11
GO:0043043 peptide biosynthetic process 5 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043603 amide metabolic process 3 11
GO:0043604 amide biosynthetic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901566 organonitrogen compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018206 peptidyl-methionine modification 6 1
GO:0036211 protein modification process 4 1
GO:0043412 macromolecule modification 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0008233 peptidase activity 3 6
GO:0008237 metallopeptidase activity 4 6
GO:0016787 hydrolase activity 2 11
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 11
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 11
GO:0042586 peptide deformylase activity 5 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 87 91 PF00656 0.616
CLV_NRD_NRD_1 125 127 PF00675 0.314
CLV_NRD_NRD_1 271 273 PF00675 0.257
CLV_NRD_NRD_1 327 329 PF00675 0.399
CLV_NRD_NRD_1 359 361 PF00675 0.524
CLV_NRD_NRD_1 365 367 PF00675 0.603
CLV_PCSK_KEX2_1 125 127 PF00082 0.324
CLV_PCSK_KEX2_1 271 273 PF00082 0.270
CLV_PCSK_KEX2_1 365 367 PF00082 0.492
CLV_PCSK_PC1ET2_1 365 367 PF00082 0.495
CLV_PCSK_SKI1_1 229 233 PF00082 0.289
CLV_PCSK_SKI1_1 243 247 PF00082 0.139
CLV_PCSK_SKI1_1 255 259 PF00082 0.203
DEG_APCC_DBOX_1 254 262 PF00400 0.270
DEG_APCC_DBOX_1 344 352 PF00400 0.453
DEG_Nend_UBRbox_1 1 4 PF02207 0.683
DOC_ANK_TNKS_1 92 99 PF00023 0.584
DOC_CKS1_1 308 313 PF01111 0.471
DOC_MAPK_gen_1 251 258 PF00069 0.270
DOC_MAPK_RevD_3 256 272 PF00069 0.270
DOC_PP2B_LxvP_1 38 41 PF13499 0.578
DOC_PP4_FxxP_1 171 174 PF00568 0.270
DOC_PP4_FxxP_1 309 312 PF00568 0.379
DOC_USP7_MATH_1 11 15 PF00917 0.529
DOC_USP7_MATH_1 111 115 PF00917 0.337
DOC_USP7_MATH_1 149 153 PF00917 0.314
DOC_USP7_MATH_1 216 220 PF00917 0.266
DOC_USP7_MATH_1 89 93 PF00917 0.603
DOC_USP7_UBL2_3 361 365 PF12436 0.454
DOC_WW_Pin1_4 15 20 PF00397 0.690
DOC_WW_Pin1_4 307 312 PF00397 0.308
LIG_14-3-3_CanoR_1 2 10 PF00244 0.578
LIG_14-3-3_CanoR_1 229 234 PF00244 0.270
LIG_14-3-3_CanoR_1 301 305 PF00244 0.328
LIG_14-3-3_CanoR_1 45 53 PF00244 0.623
LIG_14-3-3_CanoR_1 56 61 PF00244 0.598
LIG_BIR_III_2 318 322 PF00653 0.399
LIG_BRCT_BRCA1_1 218 222 PF00533 0.256
LIG_BRCT_BRCA1_1 49 53 PF00533 0.563
LIG_EVH1_2 311 315 PF00568 0.359
LIG_FHA_1 102 108 PF00498 0.449
LIG_FHA_1 204 210 PF00498 0.342
LIG_FHA_1 230 236 PF00498 0.225
LIG_FHA_1 244 250 PF00498 0.202
LIG_FHA_1 268 274 PF00498 0.256
LIG_FHA_2 162 168 PF00498 0.270
LIG_FHA_2 285 291 PF00498 0.379
LIG_FHA_2 378 384 PF00498 0.641
LIG_Integrin_RGD_1 375 377 PF01839 0.739
LIG_LIR_Apic_2 169 174 PF02991 0.280
LIG_LIR_Apic_2 307 312 PF02991 0.360
LIG_LIR_Gen_1 192 201 PF02991 0.314
LIG_LIR_Gen_1 283 290 PF02991 0.394
LIG_LIR_Gen_1 303 313 PF02991 0.361
LIG_LIR_Nem_3 103 108 PF02991 0.520
LIG_LIR_Nem_3 131 135 PF02991 0.402
LIG_LIR_Nem_3 192 196 PF02991 0.447
LIG_LIR_Nem_3 292 298 PF02991 0.403
LIG_LIR_Nem_3 303 309 PF02991 0.331
LIG_LIR_Nem_3 310 316 PF02991 0.336
LIG_LYPXL_yS_3 105 108 PF13949 0.474
LIG_LYPXL_yS_3 148 151 PF13949 0.256
LIG_LYPXL_yS_3 295 298 PF13949 0.337
LIG_Pex14_1 116 120 PF04695 0.347
LIG_Pex14_1 291 295 PF04695 0.368
LIG_PTB_Apo_2 165 172 PF02174 0.397
LIG_Rb_pABgroove_1 160 168 PF01858 0.256
LIG_REV1ctd_RIR_1 40 49 PF16727 0.600
LIG_SH2_CRK 132 136 PF00017 0.354
LIG_SH2_CRK 146 150 PF00017 0.185
LIG_SH2_CRK 313 317 PF00017 0.372
LIG_SH2_SRC 146 149 PF00017 0.271
LIG_SH2_SRC 95 98 PF00017 0.536
LIG_SH2_STAP1 120 124 PF00017 0.397
LIG_SH2_STAP1 65 69 PF00017 0.442
LIG_SH2_STAT5 226 229 PF00017 0.296
LIG_SH2_STAT5 306 309 PF00017 0.294
LIG_SH2_STAT5 95 98 PF00017 0.520
LIG_SH3_3 27 33 PF00018 0.543
LIG_SH3_3 91 97 PF00018 0.498
LIG_SUMO_SIM_par_1 245 250 PF11976 0.409
LIG_TRAF2_1 100 103 PF00917 0.531
LIG_TRAF2_1 195 198 PF00917 0.302
LIG_TRAF2_1 350 353 PF00917 0.398
MOD_CK1_1 14 20 PF00069 0.662
MOD_CK1_1 289 295 PF00069 0.523
MOD_CK1_1 36 42 PF00069 0.647
MOD_CK1_1 82 88 PF00069 0.570
MOD_GlcNHglycan 151 154 PF01048 0.350
MOD_GlcNHglycan 219 222 PF01048 0.402
MOD_GlcNHglycan 24 27 PF01048 0.710
MOD_GlcNHglycan 35 38 PF01048 0.599
MOD_GlcNHglycan 383 389 PF01048 0.734
MOD_GlcNHglycan 49 52 PF01048 0.453
MOD_GlcNHglycan 84 87 PF01048 0.650
MOD_GSK3_1 11 18 PF00069 0.700
MOD_GSK3_1 149 156 PF00069 0.402
MOD_GSK3_1 203 210 PF00069 0.214
MOD_GSK3_1 300 307 PF00069 0.314
MOD_GSK3_1 386 393 PF00069 0.596
MOD_GSK3_1 47 54 PF00069 0.528
MOD_GSK3_1 81 88 PF00069 0.588
MOD_LATS_1 241 247 PF00433 0.302
MOD_N-GLC_1 82 87 PF02516 0.578
MOD_N-GLC_2 13 15 PF02516 0.574
MOD_NEK2_1 166 171 PF00069 0.296
MOD_NEK2_1 304 309 PF00069 0.321
MOD_NEK2_1 74 79 PF00069 0.540
MOD_PIKK_1 134 140 PF00454 0.402
MOD_PK_1 56 62 PF00069 0.642
MOD_PKA_2 300 306 PF00069 0.319
MOD_Plk_1 166 172 PF00069 0.402
MOD_Plk_2-3 294 300 PF00069 0.338
MOD_Plk_2-3 377 383 PF00069 0.604
MOD_Plk_4 166 172 PF00069 0.256
MOD_Plk_4 189 195 PF00069 0.402
MOD_Plk_4 300 306 PF00069 0.364
MOD_ProDKin_1 15 21 PF00069 0.689
MOD_ProDKin_1 307 313 PF00069 0.319
MOD_SUMO_rev_2 192 201 PF00179 0.473
MOD_SUMO_rev_2 322 330 PF00179 0.382
TRG_DiLeu_BaEn_1 131 136 PF01217 0.402
TRG_ENDOCYTIC_2 105 108 PF00928 0.474
TRG_ENDOCYTIC_2 132 135 PF00928 0.320
TRG_ENDOCYTIC_2 148 151 PF00928 0.181
TRG_ENDOCYTIC_2 295 298 PF00928 0.343
TRG_ENDOCYTIC_2 306 309 PF00928 0.357
TRG_ENDOCYTIC_2 313 316 PF00928 0.533
TRG_ER_diArg_1 125 127 PF00400 0.321
TRG_ER_diArg_1 233 236 PF00400 0.264
TRG_ER_diArg_1 252 255 PF00400 0.270
TRG_ER_diArg_1 271 273 PF00400 0.270
TRG_Pf-PMV_PEXEL_1 202 207 PF00026 0.302
TRG_Pf-PMV_PEXEL_1 236 240 PF00026 0.343

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P349 Leptomonas seymouri 79% 94%
A0A0S4JJP7 Bodo saltans 46% 100%
A0A1X0NLE7 Trypanosomatidae 59% 100%
A0A3S5IQR8 Trypanosoma rangeli 64% 100%
A0A3S7WNT3 Leishmania donovani 100% 96%
C9ZY73 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9AK65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q9U112 Leishmania major 92% 100%
V5BDN2 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS