Nascent polypeptide associated complex subunit-like protein, copy 1

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nascent polypeptide associated complex subunit- like protein - copy 2

Species:

Leishmania infantum

UniProt:

A4HS73_LEIIN

TriTrypDb:

LINF_040012800

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005854	nascent polypeptide-associated complex	2	13
GO:0032991	protein-containing complex	1	13
GO:0110165	cellular anatomical entity	1	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HS73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS73

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.514
CLV_NRD_NRD_1	55	57	PF00675	0.226
CLV_PCSK_KEX2_1	33	35	PF00082	0.213
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.213
CLV_PCSK_SKI1_1	151	155	PF00082	0.264
CLV_PCSK_SKI1_1	34	38	PF00082	0.213
DOC_MAPK_gen_1	33	44	PF00069	0.413
DOC_MAPK_gen_1	56	63	PF00069	0.426
DOC_MAPK_RevD_3	42	57	PF00069	0.426
DOC_USP7_MATH_1	101	105	PF00917	0.573

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRE4	Leptomonas seymouri	88%	98%
A0A1X0NL03	Trypanosomatidae	62%	94%
A0A3S5H5C5	Leishmania donovani	99%	100%
A0A3S5H5C6	Leishmania donovani	99%	100%
A1CMF8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	40%	84%
A1DLM0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	40%	84%
A2R4V1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	41%	85%
A3GHD3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	34%	98%
A4H3Y9	Leishmania braziliensis	88%	100%
A4RC89	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	41%	86%

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