LeishMANIAdb
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Nascent polypeptide associated complex subunit-like protein, copy 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nascent polypeptide associated complex subunit-like protein, copy 2
Gene product:
nascent polypeptide associated complex subunit- like protein - copy
Species:
Leishmania infantum
UniProt:
A4HS72_LEIIN
TriTrypDb:
LINF_040012700 *
Length:
266

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Nascent polypeptide associated complex subunit-like , copy 2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005854 nascent polypeptide-associated complex 2 8
GO:0032991 protein-containing complex 1 8
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HS72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS72

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0051082 unfolded protein binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 149 151 PF00675 0.296
CLV_NRD_NRD_1 32 34 PF00675 0.595
CLV_PCSK_KEX2_1 127 129 PF00082 0.264
CLV_PCSK_KEX2_1 32 34 PF00082 0.595
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.264
CLV_PCSK_SKI1_1 128 132 PF00082 0.266
CLV_PCSK_SKI1_1 245 249 PF00082 0.329
CLV_PCSK_SKI1_1 40 44 PF00082 0.544
DEG_APCC_DBOX_1 39 47 PF00400 0.523
DEG_Nend_UBRbox_1 1 4 PF02207 0.452
DOC_MAPK_gen_1 127 138 PF00069 0.478
DOC_MAPK_gen_1 150 157 PF00069 0.481
DOC_MAPK_RevD_3 136 151 PF00069 0.496
DOC_USP7_MATH_1 123 127 PF00917 0.613
DOC_USP7_MATH_1 195 199 PF00917 0.680
DOC_USP7_MATH_1 201 205 PF00917 0.642
DOC_USP7_MATH_1 207 211 PF00917 0.687
DOC_USP7_MATH_1 239 243 PF00917 0.589
DOC_USP7_UBL2_3 127 131 PF12436 0.467
DOC_USP7_UBL2_3 135 139 PF12436 0.469
LIG_14-3-3_CanoR_1 2 11 PF00244 0.441
LIG_14-3-3_CanoR_1 33 39 PF00244 0.605
LIG_14-3-3_CanoR_1 40 46 PF00244 0.425
LIG_APCC_ABBA_1 173 178 PF00400 0.478
LIG_BRCT_BRCA1_1 153 157 PF00533 0.518
LIG_BRCT_BRCA1_1 72 76 PF00533 0.511
LIG_FHA_1 170 176 PF00498 0.471
LIG_FHA_1 182 188 PF00498 0.441
LIG_FHA_1 88 94 PF00498 0.678
LIG_FHA_2 258 264 PF00498 0.589
LIG_LIR_Apic_2 163 168 PF02991 0.478
LIG_LIR_Gen_1 154 165 PF02991 0.555
LIG_LIR_Gen_1 170 181 PF02991 0.389
LIG_LIR_Gen_1 6 15 PF02991 0.436
LIG_LIR_Nem_3 154 160 PF02991 0.555
LIG_LIR_Nem_3 170 176 PF02991 0.383
LIG_LIR_Nem_3 6 11 PF02991 0.435
LIG_RPA_C_Fungi 238 250 PF08784 0.489
LIG_SH2_CRK 165 169 PF00017 0.334
LIG_SH2_STAP1 129 133 PF00017 0.334
LIG_SUMO_SIM_par_1 89 94 PF11976 0.648
LIG_TRAF2_1 107 110 PF00917 0.571
LIG_TRAF2_1 213 216 PF00917 0.645
LIG_TRAF2_1 96 99 PF00917 0.752
LIG_WW_3 33 37 PF00397 0.520
MOD_CK1_1 142 148 PF00069 0.472
MOD_CK1_1 202 208 PF00069 0.760
MOD_CK1_1 75 81 PF00069 0.538
MOD_CK2_1 257 263 PF00069 0.489
MOD_CK2_1 93 99 PF00069 0.736
MOD_GlcNHglycan 182 187 PF01048 0.565
MOD_GlcNHglycan 197 200 PF01048 0.440
MOD_GlcNHglycan 201 204 PF01048 0.419
MOD_GlcNHglycan 5 8 PF01048 0.562
MOD_GSK3_1 195 202 PF00069 0.611
MOD_GSK3_1 70 77 PF00069 0.671
MOD_GSK3_1 87 94 PF00069 0.419
MOD_N-GLC_1 142 147 PF02516 0.349
MOD_N-GLC_1 239 244 PF02516 0.489
MOD_NEK2_1 181 186 PF00069 0.472
MOD_NEK2_1 3 8 PF00069 0.440
MOD_NEK2_1 41 46 PF00069 0.546
MOD_NEK2_1 76 81 PF00069 0.744
MOD_NEK2_1 91 96 PF00069 0.413
MOD_NEK2_2 24 29 PF00069 0.449
MOD_PIKK_1 234 240 PF00454 0.389
MOD_Plk_1 182 188 PF00069 0.536
MOD_Plk_2-3 110 116 PF00069 0.604
MOD_Plk_4 169 175 PF00069 0.334
MOD_Plk_4 24 30 PF00069 0.451
MOD_Plk_4 257 263 PF00069 0.489
MOD_Plk_4 41 47 PF00069 0.612
MOD_SUMO_for_1 138 141 PF00179 0.334
MOD_SUMO_rev_2 226 232 PF00179 0.400
TRG_DiLeu_BaEn_4 109 115 PF01217 0.700
TRG_ER_diArg_1 32 34 PF00400 0.682

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NL03 Trypanosomatidae 61% 100%
A2R4V1 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 36% 100%
A5DGN9 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 34% 100%
A5DXK7 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 32% 100%
A6R641 Ajellomyces capsulatus (strain NAm1 / WU24) 36% 100%
C9ZY67 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
C9ZY68 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AK59 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O97212 Leishmania major 75% 95%
P0C2C7 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 37% 100%
P0CP06 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 28% 100%
P0CP07 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 28% 100%
Q5ANP2 Candida albicans (strain SC5314 / ATCC MYA-2876) 35% 100%
Q5AYK0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 36% 100%
Q6BSN9 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 36% 100%
Q6CDH0 Yarrowia lipolytica (strain CLIB 122 / E 150) 31% 100%
Q9BZK3 Homo sapiens 41% 100%
V5BDN6 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS