LeishMANIAdb
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WASH_WAHD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WASH_WAHD domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HS70_LEIIN
TriTrypDb:
LINF_040012500
Length:
810

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS70
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS70

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 20 24 PF00656 0.647
CLV_C14_Caspase3-7 368 372 PF00656 0.577
CLV_C14_Caspase3-7 769 773 PF00656 0.732
CLV_NRD_NRD_1 113 115 PF00675 0.451
CLV_NRD_NRD_1 181 183 PF00675 0.817
CLV_NRD_NRD_1 463 465 PF00675 0.671
CLV_NRD_NRD_1 501 503 PF00675 0.867
CLV_NRD_NRD_1 505 507 PF00675 0.786
CLV_NRD_NRD_1 523 525 PF00675 0.513
CLV_NRD_NRD_1 527 529 PF00675 0.798
CLV_NRD_NRD_1 555 557 PF00675 0.737
CLV_NRD_NRD_1 739 741 PF00675 0.816
CLV_NRD_NRD_1 765 767 PF00675 0.734
CLV_NRD_NRD_1 91 93 PF00675 0.529
CLV_NRD_NRD_1 98 100 PF00675 0.413
CLV_PCSK_FUR_1 111 115 PF00082 0.529
CLV_PCSK_FUR_1 179 183 PF00082 0.817
CLV_PCSK_FUR_1 521 525 PF00082 0.704
CLV_PCSK_KEX2_1 113 115 PF00082 0.375
CLV_PCSK_KEX2_1 181 183 PF00082 0.817
CLV_PCSK_KEX2_1 463 465 PF00082 0.671
CLV_PCSK_KEX2_1 501 503 PF00082 0.865
CLV_PCSK_KEX2_1 505 507 PF00082 0.785
CLV_PCSK_KEX2_1 523 525 PF00082 0.513
CLV_PCSK_KEX2_1 526 528 PF00082 0.805
CLV_PCSK_KEX2_1 554 556 PF00082 0.743
CLV_PCSK_KEX2_1 738 740 PF00082 0.818
CLV_PCSK_KEX2_1 765 767 PF00082 0.775
CLV_PCSK_KEX2_1 91 93 PF00082 0.529
CLV_PCSK_KEX2_1 98 100 PF00082 0.413
CLV_PCSK_PC7_1 501 507 PF00082 0.858
CLV_PCSK_PC7_1 523 529 PF00082 0.827
CLV_PCSK_PC7_1 550 556 PF00082 0.739
CLV_PCSK_SKI1_1 143 147 PF00082 0.829
CLV_PCSK_SKI1_1 402 406 PF00082 0.581
CLV_PCSK_SKI1_1 444 448 PF00082 0.741
CLV_PCSK_SKI1_1 739 743 PF00082 0.817
DEG_APCC_DBOX_1 443 451 PF00400 0.786
DEG_Nend_UBRbox_2 1 3 PF02207 0.628
DEG_SPOP_SBC_1 315 319 PF00917 0.780
DEG_SPOP_SBC_1 365 369 PF00917 0.621
DOC_CDC14_PxL_1 39 47 PF14671 0.729
DOC_CKS1_1 421 426 PF01111 0.791
DOC_MAPK_gen_1 122 131 PF00069 0.749
DOC_PP2B_LxvP_1 45 48 PF13499 0.721
DOC_PP2B_LxvP_1 580 583 PF13499 0.700
DOC_PP2B_LxvP_1 590 593 PF13499 0.730
DOC_PP4_FxxP_1 177 180 PF00568 0.819
DOC_PP4_FxxP_1 421 424 PF00568 0.636
DOC_USP7_MATH_1 180 184 PF00917 0.813
DOC_USP7_MATH_1 223 227 PF00917 0.735
DOC_USP7_MATH_1 315 319 PF00917 0.697
DOC_USP7_MATH_1 349 353 PF00917 0.796
DOC_USP7_MATH_1 365 369 PF00917 0.511
DOC_USP7_MATH_1 377 381 PF00917 0.639
DOC_USP7_MATH_1 439 443 PF00917 0.622
DOC_USP7_MATH_1 48 52 PF00917 0.674
DOC_USP7_MATH_1 60 64 PF00917 0.311
DOC_USP7_MATH_1 626 630 PF00917 0.812
DOC_USP7_MATH_1 646 650 PF00917 0.658
DOC_USP7_MATH_1 676 680 PF00917 0.600
DOC_USP7_MATH_1 689 693 PF00917 0.666
DOC_USP7_MATH_1 730 734 PF00917 0.752
DOC_USP7_MATH_1 768 772 PF00917 0.769
DOC_USP7_MATH_1 799 803 PF00917 0.849
DOC_USP7_MATH_1 85 89 PF00917 0.529
DOC_WW_Pin1_4 181 186 PF00397 0.811
DOC_WW_Pin1_4 251 256 PF00397 0.710
DOC_WW_Pin1_4 382 387 PF00397 0.663
DOC_WW_Pin1_4 390 395 PF00397 0.701
DOC_WW_Pin1_4 420 425 PF00397 0.606
LIG_14-3-3_CanoR_1 111 119 PF00244 0.455
LIG_14-3-3_CanoR_1 141 146 PF00244 0.695
LIG_14-3-3_CanoR_1 179 185 PF00244 0.667
LIG_14-3-3_CanoR_1 18 23 PF00244 0.737
LIG_14-3-3_CanoR_1 233 242 PF00244 0.789
LIG_14-3-3_CanoR_1 600 605 PF00244 0.856
LIG_BRCT_BRCA1_1 173 177 PF00533 0.812
LIG_CtBP_PxDLS_1 587 591 PF00389 0.755
LIG_FHA_1 113 119 PF00498 0.529
LIG_FHA_1 273 279 PF00498 0.679
LIG_FHA_1 34 40 PF00498 0.721
LIG_FHA_1 410 416 PF00498 0.747
LIG_FHA_1 420 426 PF00498 0.545
LIG_FHA_1 611 617 PF00498 0.679
LIG_FHA_1 730 736 PF00498 0.799
LIG_FHA_2 115 121 PF00498 0.498
LIG_FHA_2 478 484 PF00498 0.811
LIG_FHA_2 534 540 PF00498 0.827
LIG_FHA_2 75 81 PF00498 0.343
LIG_LIR_Apic_2 174 180 PF02991 0.813
LIG_LIR_Apic_2 214 218 PF02991 0.834
LIG_LIR_Apic_2 385 391 PF02991 0.614
LIG_LIR_Apic_2 420 424 PF02991 0.613
LIG_LIR_Gen_1 510 516 PF02991 0.616
LIG_LIR_Nem_3 510 514 PF02991 0.626
LIG_LYPXL_yS_3 125 128 PF13949 0.565
LIG_MYND_1 126 130 PF01753 0.563
LIG_MYND_1 588 592 PF01753 0.753
LIG_MYND_1 608 612 PF01753 0.738
LIG_PROFILIN_1 605 611 PF00235 0.820
LIG_PROFILIN_1 663 669 PF00235 0.728
LIG_PROFILIN_1 683 689 PF00235 0.643
LIG_PROFILIN_1 714 720 PF00235 0.816
LIG_RPA_C_Fungi 21 33 PF08784 0.724
LIG_RPA_C_Fungi 550 562 PF08784 0.741
LIG_SH2_CRK 215 219 PF00017 0.833
LIG_SH2_CRK 430 434 PF00017 0.814
LIG_SH2_NCK_1 34 38 PF00017 0.727
LIG_SH2_SRC 215 218 PF00017 0.748
LIG_SH2_STAP1 34 38 PF00017 0.727
LIG_SH2_STAT5 657 660 PF00017 0.574
LIG_SH3_1 182 188 PF00018 0.803
LIG_SH3_1 388 394 PF00018 0.582
LIG_SH3_1 636 642 PF00018 0.819
LIG_SH3_1 662 668 PF00018 0.636
LIG_SH3_1 712 718 PF00018 0.823
LIG_SH3_3 120 126 PF00018 0.529
LIG_SH3_3 127 133 PF00018 0.682
LIG_SH3_3 182 188 PF00018 0.687
LIG_SH3_3 207 213 PF00018 0.727
LIG_SH3_3 249 255 PF00018 0.817
LIG_SH3_3 348 354 PF00018 0.794
LIG_SH3_3 388 394 PF00018 0.582
LIG_SH3_3 581 587 PF00018 0.737
LIG_SH3_3 589 595 PF00018 0.608
LIG_SH3_3 602 608 PF00018 0.675
LIG_SH3_3 617 623 PF00018 0.601
LIG_SH3_3 632 638 PF00018 0.613
LIG_SH3_3 639 645 PF00018 0.608
LIG_SH3_3 660 666 PF00018 0.824
LIG_SH3_3 680 686 PF00018 0.510
LIG_SH3_3 702 708 PF00018 0.852
LIG_SH3_3 710 716 PF00018 0.692
LIG_SUMO_SIM_par_1 274 279 PF11976 0.679
LIG_TRAF2_1 516 519 PF00917 0.724
LIG_UBA3_1 651 656 PF00899 0.752
LIG_WW_2 608 611 PF00397 0.818
LIG_WW_3 633 637 PF00397 0.765
LIG_WW_3 778 782 PF00397 0.668
MOD_CDK_SPxxK_3 382 389 PF00069 0.640
MOD_CK1_1 11 17 PF00069 0.751
MOD_CK1_1 167 173 PF00069 0.634
MOD_CK1_1 192 198 PF00069 0.835
MOD_CK1_1 21 27 PF00069 0.487
MOD_CK1_1 231 237 PF00069 0.575
MOD_CK1_1 250 256 PF00069 0.722
MOD_CK1_1 3 9 PF00069 0.797
MOD_CK1_1 309 315 PF00069 0.623
MOD_CK1_1 316 322 PF00069 0.668
MOD_CK1_1 411 417 PF00069 0.651
MOD_CK1_1 479 485 PF00069 0.851
MOD_CK1_1 51 57 PF00069 0.719
MOD_CK1_1 535 541 PF00069 0.832
MOD_CK1_1 677 683 PF00069 0.610
MOD_CK1_1 723 729 PF00069 0.803
MOD_CK1_1 747 753 PF00069 0.787
MOD_CK1_1 770 776 PF00069 0.787
MOD_CK1_1 802 808 PF00069 0.834
MOD_CK2_1 114 120 PF00069 0.529
MOD_CK2_1 477 483 PF00069 0.786
MOD_CK2_1 533 539 PF00069 0.853
MOD_Cter_Amidation 111 114 PF01082 0.529
MOD_GlcNHglycan 10 14 PF01048 0.815
MOD_GlcNHglycan 162 165 PF01048 0.785
MOD_GlcNHglycan 166 169 PF01048 0.724
MOD_GlcNHglycan 194 197 PF01048 0.814
MOD_GlcNHglycan 225 228 PF01048 0.736
MOD_GlcNHglycan 23 26 PF01048 0.541
MOD_GlcNHglycan 281 286 PF01048 0.740
MOD_GlcNHglycan 308 311 PF01048 0.596
MOD_GlcNHglycan 318 321 PF01048 0.737
MOD_GlcNHglycan 347 350 PF01048 0.804
MOD_GlcNHglycan 402 405 PF01048 0.645
MOD_GlcNHglycan 5 8 PF01048 0.794
MOD_GlcNHglycan 50 53 PF01048 0.725
MOD_GlcNHglycan 557 560 PF01048 0.732
MOD_GlcNHglycan 580 583 PF01048 0.776
MOD_GlcNHglycan 62 65 PF01048 0.331
MOD_GlcNHglycan 628 631 PF01048 0.814
MOD_GlcNHglycan 658 661 PF01048 0.795
MOD_GlcNHglycan 725 728 PF01048 0.828
MOD_GlcNHglycan 751 754 PF01048 0.848
MOD_GlcNHglycan 776 779 PF01048 0.674
MOD_GlcNHglycan 792 795 PF01048 0.772
MOD_GSK3_1 1 8 PF00069 0.717
MOD_GSK3_1 114 121 PF00069 0.481
MOD_GSK3_1 12 19 PF00069 0.669
MOD_GSK3_1 160 167 PF00069 0.642
MOD_GSK3_1 190 197 PF00069 0.831
MOD_GSK3_1 247 254 PF00069 0.649
MOD_GSK3_1 299 306 PF00069 0.635
MOD_GSK3_1 309 316 PF00069 0.646
MOD_GSK3_1 345 352 PF00069 0.785
MOD_GSK3_1 400 407 PF00069 0.719
MOD_GSK3_1 47 54 PF00069 0.716
MOD_GSK3_1 473 480 PF00069 0.778
MOD_GSK3_1 538 545 PF00069 0.743
MOD_GSK3_1 569 576 PF00069 0.843
MOD_GSK3_1 596 603 PF00069 0.699
MOD_GSK3_1 60 67 PF00069 0.315
MOD_GSK3_1 646 653 PF00069 0.728
MOD_GSK3_1 726 733 PF00069 0.817
MOD_GSK3_1 744 751 PF00069 0.565
MOD_GSK3_1 767 774 PF00069 0.797
MOD_GSK3_1 799 806 PF00069 0.839
MOD_N-GLC_1 250 255 PF02516 0.799
MOD_N-GLC_1 338 343 PF02516 0.744
MOD_NEK2_1 1 6 PF00069 0.670
MOD_NEK2_1 118 123 PF00069 0.529
MOD_NEK2_1 267 272 PF00069 0.779
MOD_NEK2_1 397 402 PF00069 0.718
MOD_NEK2_1 409 414 PF00069 0.618
MOD_NEK2_1 655 660 PF00069 0.571
MOD_NEK2_1 790 795 PF00069 0.790
MOD_NEK2_2 299 304 PF00069 0.590
MOD_PIKK_1 144 150 PF00454 0.644
MOD_PIKK_1 570 576 PF00454 0.860
MOD_PIKK_1 720 726 PF00454 0.722
MOD_PIKK_1 85 91 PF00454 0.529
MOD_PK_1 18 24 PF00069 0.733
MOD_PKA_1 113 119 PF00069 0.446
MOD_PKA_1 501 507 PF00069 0.858
MOD_PKA_1 555 561 PF00069 0.740
MOD_PKA_2 112 118 PF00069 0.500
MOD_PKA_2 17 23 PF00069 0.784
MOD_PKA_2 180 186 PF00069 0.811
MOD_PKA_2 303 309 PF00069 0.735
MOD_PKA_2 501 507 PF00069 0.854
MOD_PKA_2 555 561 PF00069 0.864
MOD_PKA_2 568 574 PF00069 0.648
MOD_PKA_2 599 605 PF00069 0.856
MOD_PKB_1 111 119 PF00069 0.446
MOD_Plk_1 1 7 PF00069 0.732
MOD_Plk_1 231 237 PF00069 0.555
MOD_Plk_1 281 287 PF00069 0.700
MOD_Plk_4 114 120 PF00069 0.529
MOD_Plk_4 272 278 PF00069 0.808
MOD_Plk_4 303 309 PF00069 0.685
MOD_Plk_4 730 736 PF00069 0.799
MOD_Plk_4 74 80 PF00069 0.446
MOD_ProDKin_1 181 187 PF00069 0.806
MOD_ProDKin_1 251 257 PF00069 0.708
MOD_ProDKin_1 382 388 PF00069 0.664
MOD_ProDKin_1 390 396 PF00069 0.700
MOD_ProDKin_1 420 426 PF00069 0.602
MOD_SUMO_rev_2 116 123 PF00179 0.446
MOD_SUMO_rev_2 649 658 PF00179 0.753
TRG_ENDOCYTIC_2 125 128 PF00928 0.565
TRG_ENDOCYTIC_2 360 363 PF00928 0.813
TRG_ENDOCYTIC_2 430 433 PF00928 0.818
TRG_ER_diArg_1 110 113 PF00400 0.216
TRG_ER_diArg_1 133 136 PF00400 0.685
TRG_ER_diArg_1 178 181 PF00400 0.821
TRG_ER_diArg_1 462 464 PF00400 0.664
TRG_ER_diArg_1 521 524 PF00400 0.808
TRG_ER_diArg_1 526 528 PF00400 0.756
TRG_ER_diArg_1 554 556 PF00400 0.867
TRG_ER_diArg_1 560 563 PF00400 0.776
TRG_ER_diArg_1 738 740 PF00400 0.816
TRG_ER_diArg_1 787 790 PF00400 0.861
TRG_ER_diArg_1 91 93 PF00400 0.529
TRG_ER_diArg_1 98 100 PF00400 0.413
TRG_Pf-PMV_PEXEL_1 444 449 PF00026 0.793
TRG_Pf-PMV_PEXEL_1 452 457 PF00026 0.649
TRG_Pf-PMV_PEXEL_1 650 654 PF00026 0.753
TRG_Pf-PMV_PEXEL_1 740 745 PF00026 0.828

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WNR6 Leishmania donovani 98% 99%
A4H408 Leishmania braziliensis 69% 100%
E9AK57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
O97214 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS