Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS68_LEIIN

TriTrypDb:

LINF_040012300

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.779
CLV_NRD_NRD_1	206	208	PF00675	0.781
CLV_NRD_NRD_1	331	333	PF00675	0.783
CLV_NRD_NRD_1	498	500	PF00675	0.618
CLV_NRD_NRD_1	614	616	PF00675	0.825
CLV_NRD_NRD_1	96	98	PF00675	0.614
CLV_PCSK_FUR_1	612	616	PF00082	0.825
CLV_PCSK_KEX2_1	331	333	PF00082	0.623
CLV_PCSK_KEX2_1	498	500	PF00082	0.667
CLV_PCSK_KEX2_1	614	616	PF00082	0.825
CLV_PCSK_KEX2_1	96	98	PF00082	0.618
CLV_PCSK_SKI1_1	208	212	PF00082	0.860
CLV_PCSK_SKI1_1	262	266	PF00082	0.634
CLV_PCSK_SKI1_1	334	338	PF00082	0.560
CLV_PCSK_SKI1_1	482	486	PF00082	0.737
CLV_PCSK_SKI1_1	68	72	PF00082	0.627
CLV_PCSK_SKI1_1	96	100	PF00082	0.650
DEG_APCC_DBOX_1	116	124	PF00400	0.694
DEG_APCC_DBOX_1	95	103	PF00400	0.697
DEG_Nend_UBRbox_2	1	3	PF02207	0.695
DEG_SPOP_SBC_1	372	376	PF00917	0.751
DOC_CKS1_1	173	178	PF01111	0.766
DOC_CKS1_1	186	191	PF01111	0.677
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.665
DOC_PP2B_LxvP_1	525	528	PF13499	0.737
DOC_SPAK_OSR1_1	491	495	PF12202	0.798
DOC_USP7_MATH_1	174	178	PF00917	0.807
DOC_USP7_MATH_1	195	199	PF00917	0.809
DOC_USP7_MATH_1	215	219	PF00917	0.761
DOC_USP7_MATH_1	372	376	PF00917	0.813
DOC_USP7_MATH_1	377	381	PF00917	0.779
DOC_USP7_MATH_1	385	389	PF00917	0.643
DOC_USP7_MATH_1	403	407	PF00917	0.555
DOC_USP7_MATH_1	463	467	PF00917	0.715
DOC_USP7_MATH_1	528	532	PF00917	0.728
DOC_USP7_MATH_1	70	74	PF00917	0.748
DOC_USP7_MATH_1	705	709	PF00917	0.792
DOC_USP7_MATH_2	246	252	PF00917	0.622
DOC_WW_Pin1_4	167	172	PF00397	0.849
DOC_WW_Pin1_4	185	190	PF00397	0.555
DOC_WW_Pin1_4	246	251	PF00397	0.762
DOC_WW_Pin1_4	381	386	PF00397	0.754
DOC_WW_Pin1_4	469	474	PF00397	0.782
DOC_WW_Pin1_4	576	581	PF00397	0.620
DOC_WW_Pin1_4	685	690	PF00397	0.790
DOC_WW_Pin1_4	97	102	PF00397	0.702
LIG_14-3-3_CanoR_1	207	213	PF00244	0.782
LIG_14-3-3_CanoR_1	282	290	PF00244	0.765
LIG_14-3-3_CanoR_1	321	329	PF00244	0.681
LIG_14-3-3_CanoR_1	334	343	PF00244	0.555
LIG_14-3-3_CanoR_1	394	399	PF00244	0.799
LIG_14-3-3_CanoR_1	404	411	PF00244	0.652
LIG_14-3-3_CanoR_1	482	492	PF00244	0.740
LIG_14-3-3_CanoR_1	529	536	PF00244	0.633
LIG_14-3-3_CanoR_1	54	59	PF00244	0.751
LIG_14-3-3_CanoR_1	658	663	PF00244	0.830
LIG_14-3-3_CanoR_1	68	75	PF00244	0.596
LIG_BIR_III_4	38	42	PF00653	0.738
LIG_BRCT_BRCA1_1	386	390	PF00533	0.703
LIG_BRCT_BRCA1_1	488	492	PF00533	0.744
LIG_deltaCOP1_diTrp_1	584	588	PF00928	0.752
LIG_FHA_1	173	179	PF00498	0.863
LIG_FHA_1	285	291	PF00498	0.788
LIG_FHA_1	374	380	PF00498	0.839
LIG_FHA_1	547	553	PF00498	0.727
LIG_FHA_1	668	674	PF00498	0.805
LIG_FHA_2	14	20	PF00498	0.811
LIG_FHA_2	333	339	PF00498	0.656
LIG_FHA_2	630	636	PF00498	0.738
LIG_HCF-1_HBM_1	45	48	PF13415	0.609
LIG_Integrin_RGD_1	349	351	PF01839	0.707
LIG_LIR_Apic_2	193	197	PF02991	0.856
LIG_LIR_Gen_1	582	593	PF02991	0.668
LIG_LIR_Nem_3	222	228	PF02991	0.716
LIG_LIR_Nem_3	582	588	PF02991	0.811
LIG_MYND_1	474	478	PF01753	0.692
LIG_SH2_CRK	161	165	PF00017	0.595
LIG_SH2_CRK	333	337	PF00017	0.725
LIG_SH2_CRK	370	374	PF00017	0.740
LIG_SH2_NCK_1	411	415	PF00017	0.699
LIG_SH2_STAP1	133	137	PF00017	0.613
LIG_SH2_STAP1	322	326	PF00017	0.602
LIG_SH2_STAT5	700	703	PF00017	0.804
LIG_SH3_2	422	427	PF14604	0.576
LIG_SH3_3	168	174	PF00018	0.771
LIG_SH3_3	244	250	PF00018	0.680
LIG_SH3_3	415	421	PF00018	0.705
LIG_SH3_3	468	474	PF00018	0.694
LIG_SH3_3	513	519	PF00018	0.733
LIG_SH3_3	575	581	PF00018	0.592
LIG_SH3_3	625	631	PF00018	0.718
LIG_SH3_3	683	689	PF00018	0.788
LIG_SH3_3	87	93	PF00018	0.747
LIG_SUMO_SIM_par_1	645	651	PF11976	0.764
MOD_CK1_1	100	106	PF00069	0.737
MOD_CK1_1	110	116	PF00069	0.726
MOD_CK1_1	172	178	PF00069	0.842
MOD_CK1_1	203	209	PF00069	0.770
MOD_CK1_1	230	236	PF00069	0.788
MOD_CK1_1	249	255	PF00069	0.616
MOD_CK1_1	25	31	PF00069	0.766
MOD_CK1_1	272	278	PF00069	0.769
MOD_CK1_1	3	9	PF00069	0.771
MOD_CK1_1	359	365	PF00069	0.785
MOD_CK1_1	384	390	PF00069	0.758
MOD_CK1_1	465	471	PF00069	0.712
MOD_CK1_1	472	478	PF00069	0.610
MOD_CK1_1	532	538	PF00069	0.783
MOD_CK1_1	553	559	PF00069	0.687
MOD_CK1_1	56	62	PF00069	0.736
MOD_CK1_1	587	593	PF00069	0.832
MOD_CK1_1	622	628	PF00069	0.838
MOD_CK1_1	685	691	PF00069	0.831
MOD_CK1_1	703	709	PF00069	0.497
MOD_CK2_1	119	125	PF00069	0.617
MOD_CK2_1	249	255	PF00069	0.625
MOD_CK2_1	394	400	PF00069	0.697
MOD_CK2_1	629	635	PF00069	0.743
MOD_CK2_1	658	664	PF00069	0.673
MOD_DYRK1A_RPxSP_1	167	171	PF00069	0.621
MOD_DYRK1A_RPxSP_1	97	101	PF00069	0.719
MOD_GlcNHglycan	202	205	PF01048	0.762
MOD_GlcNHglycan	230	233	PF01048	0.738
MOD_GlcNHglycan	266	269	PF01048	0.731
MOD_GlcNHglycan	324	327	PF01048	0.632
MOD_GlcNHglycan	358	361	PF01048	0.737
MOD_GlcNHglycan	379	382	PF01048	0.696
MOD_GlcNHglycan	387	390	PF01048	0.625
MOD_GlcNHglycan	405	408	PF01048	0.586
MOD_GlcNHglycan	434	437	PF01048	0.698
MOD_GlcNHglycan	465	468	PF01048	0.837
MOD_GlcNHglycan	486	489	PF01048	0.799
MOD_GlcNHglycan	494	497	PF01048	0.687
MOD_GlcNHglycan	536	539	PF01048	0.809
MOD_GlcNHglycan	541	544	PF01048	0.720
MOD_GlcNHglycan	553	556	PF01048	0.516
MOD_GlcNHglycan	581	584	PF01048	0.629
MOD_GlcNHglycan	653	656	PF01048	0.784
MOD_GlcNHglycan	702	705	PF01048	0.715
MOD_GlcNHglycan	72	75	PF01048	0.817
MOD_GSK3_1	107	114	PF00069	0.749
MOD_GSK3_1	22	29	PF00069	0.752
MOD_GSK3_1	226	233	PF00069	0.767
MOD_GSK3_1	260	267	PF00069	0.620
MOD_GSK3_1	282	289	PF00069	0.676
MOD_GSK3_1	312	319	PF00069	0.663
MOD_GSK3_1	320	327	PF00069	0.538
MOD_GSK3_1	373	380	PF00069	0.842
MOD_GSK3_1	381	388	PF00069	0.696
MOD_GSK3_1	390	397	PF00069	0.552
MOD_GSK3_1	465	472	PF00069	0.679
MOD_GSK3_1	482	489	PF00069	0.599
MOD_GSK3_1	528	535	PF00069	0.784
MOD_GSK3_1	539	546	PF00069	0.604
MOD_GSK3_1	54	61	PF00069	0.676
MOD_GSK3_1	547	554	PF00069	0.735
MOD_GSK3_1	565	572	PF00069	0.548
MOD_GSK3_1	587	594	PF00069	0.787
MOD_GSK3_1	619	626	PF00069	0.816
MOD_GSK3_1	653	660	PF00069	0.780
MOD_GSK3_1	66	73	PF00069	0.673
MOD_GSK3_1	667	674	PF00069	0.759
MOD_GSK3_1	678	685	PF00069	0.685
MOD_GSK3_1	688	695	PF00069	0.641
MOD_GSK3_1	703	710	PF00069	0.555
MOD_LATS_1	107	113	PF00433	0.722
MOD_N-GLC_1	25	30	PF02516	0.662
MOD_N-GLC_1	547	552	PF02516	0.650
MOD_N-GLC_1	622	627	PF02516	0.764
MOD_N-GLC_2	699	701	PF02516	0.809
MOD_NEK2_1	264	269	PF00069	0.678
MOD_NEK2_1	324	329	PF00069	0.772
MOD_NEK2_1	373	378	PF00069	0.808
MOD_NEK2_1	390	395	PF00069	0.558
MOD_NEK2_1	492	497	PF00069	0.720
MOD_NEK2_1	521	526	PF00069	0.821
MOD_NEK2_1	534	539	PF00069	0.668
MOD_NEK2_1	591	596	PF00069	0.823
MOD_NEK2_1	694	699	PF00069	0.741
MOD_NEK2_2	286	291	PF00069	0.711
MOD_PIKK_1	159	165	PF00454	0.692
MOD_PIKK_1	312	318	PF00454	0.682
MOD_PIKK_1	394	400	PF00454	0.833
MOD_PIKK_1	91	97	PF00454	0.758
MOD_PKA_2	22	28	PF00069	0.686
MOD_PKA_2	281	287	PF00069	0.857
MOD_PKA_2	301	307	PF00069	0.658
MOD_PKA_2	320	326	PF00069	0.508
MOD_PKA_2	403	409	PF00069	0.716
MOD_PKA_2	490	496	PF00069	0.753
MOD_PKA_2	528	534	PF00069	0.813
MOD_PKA_2	53	59	PF00069	0.707
MOD_PKA_2	657	663	PF00069	0.827
MOD_PKB_1	280	288	PF00069	0.775
MOD_PKB_1	300	308	PF00069	0.598
MOD_PKB_1	332	340	PF00069	0.564
MOD_Plk_1	25	31	PF00069	0.622
MOD_Plk_1	457	463	PF00069	0.744
MOD_Plk_1	547	553	PF00069	0.634
MOD_Plk_2-3	119	125	PF00069	0.568
MOD_Plk_4	119	125	PF00069	0.671
MOD_Plk_4	465	471	PF00069	0.679
MOD_Plk_4	472	478	PF00069	0.642
MOD_Plk_4	547	553	PF00069	0.707
MOD_Plk_4	624	630	PF00069	0.725
MOD_Plk_4	671	677	PF00069	0.726
MOD_ProDKin_1	167	173	PF00069	0.851
MOD_ProDKin_1	185	191	PF00069	0.555
MOD_ProDKin_1	246	252	PF00069	0.766
MOD_ProDKin_1	381	387	PF00069	0.754
MOD_ProDKin_1	469	475	PF00069	0.781
MOD_ProDKin_1	576	582	PF00069	0.619
MOD_ProDKin_1	685	691	PF00069	0.789
MOD_ProDKin_1	97	103	PF00069	0.704
MOD_SUMO_rev_2	505	511	PF00179	0.604
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.708
TRG_ENDOCYTIC_2	161	164	PF00928	0.589
TRG_ENDOCYTIC_2	333	336	PF00928	0.754
TRG_ENDOCYTIC_2	370	373	PF00928	0.737
TRG_ENDOCYTIC_2	662	665	PF00928	0.744
TRG_ER_diArg_1	280	283	PF00400	0.861
TRG_ER_diArg_1	331	333	PF00400	0.700
TRG_ER_diArg_1	498	500	PF00400	0.682
TRG_ER_diArg_1	613	615	PF00400	0.830
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5C2	Leishmania donovani	99%	100%
A4H406	Leishmania braziliensis	47%	93%
E9AK55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	93%
O97216	Leishmania major	79%	98%