LeishMANIAdb
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PDZ domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PDZ domain-containing protein
Gene product:
Tir chaperone protein (CesT) family/PDZ domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HS67_LEIIN
TriTrypDb:
LINF_040012200
Length:
794

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS67
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS67

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0008104 protein localization 4 11
GO:0009306 protein secretion 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0030254 protein secretion by the type III secretion system 4 11
GO:0032940 secretion by cell 3 11
GO:0033036 macromolecule localization 2 11
GO:0035592 establishment of protein localization to extracellular region 4 11
GO:0045184 establishment of protein localization 3 11
GO:0046903 secretion 4 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0055085 transmembrane transport 2 11
GO:0070727 cellular macromolecule localization 3 11
GO:0071692 protein localization to extracellular region 5 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
GO:0071806 protein transmembrane transport 3 11
GO:0140352 export from cell 2 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 2 6 PF00656 0.651
CLV_C14_Caspase3-7 446 450 PF00656 0.663
CLV_NRD_NRD_1 152 154 PF00675 0.551
CLV_NRD_NRD_1 167 169 PF00675 0.471
CLV_NRD_NRD_1 196 198 PF00675 0.468
CLV_NRD_NRD_1 248 250 PF00675 0.443
CLV_NRD_NRD_1 333 335 PF00675 0.446
CLV_NRD_NRD_1 408 410 PF00675 0.661
CLV_NRD_NRD_1 464 466 PF00675 0.336
CLV_NRD_NRD_1 758 760 PF00675 0.410
CLV_PCSK_FUR_1 150 154 PF00082 0.529
CLV_PCSK_KEX2_1 152 154 PF00082 0.555
CLV_PCSK_KEX2_1 195 197 PF00082 0.501
CLV_PCSK_KEX2_1 248 250 PF00082 0.470
CLV_PCSK_KEX2_1 27 29 PF00082 0.420
CLV_PCSK_KEX2_1 333 335 PF00082 0.464
CLV_PCSK_KEX2_1 464 466 PF00082 0.336
CLV_PCSK_KEX2_1 696 698 PF00082 0.524
CLV_PCSK_KEX2_1 758 760 PF00082 0.378
CLV_PCSK_PC1ET2_1 27 29 PF00082 0.420
CLV_PCSK_PC1ET2_1 696 698 PF00082 0.524
CLV_PCSK_SKI1_1 152 156 PF00082 0.486
CLV_PCSK_SKI1_1 241 245 PF00082 0.468
CLV_PCSK_SKI1_1 272 276 PF00082 0.415
CLV_Separin_Metazoa 165 169 PF03568 0.498
DEG_APCC_DBOX_1 14 22 PF00400 0.476
DEG_APCC_DBOX_1 223 231 PF00400 0.447
DEG_SPOP_SBC_1 137 141 PF00917 0.591
DEG_SPOP_SBC_1 686 690 PF00917 0.560
DOC_CKS1_1 33 38 PF01111 0.424
DOC_CKS1_1 614 619 PF01111 0.603
DOC_CKS1_1 764 769 PF01111 0.277
DOC_CYCLIN_RxL_1 149 159 PF00134 0.623
DOC_CYCLIN_RxL_1 301 312 PF00134 0.536
DOC_CYCLIN_yCln2_LP_2 142 148 PF00134 0.561
DOC_MAPK_DCC_7 696 704 PF00069 0.446
DOC_MAPK_gen_1 150 157 PF00069 0.519
DOC_MAPK_gen_1 222 229 PF00069 0.447
DOC_MAPK_gen_1 27 33 PF00069 0.419
DOC_MAPK_gen_1 464 472 PF00069 0.536
DOC_MAPK_gen_1 696 704 PF00069 0.446
DOC_MAPK_gen_1 774 784 PF00069 0.386
DOC_MAPK_MEF2A_6 696 704 PF00069 0.535
DOC_MAPK_MEF2A_6 777 786 PF00069 0.344
DOC_PP2B_LxvP_1 563 566 PF13499 0.536
DOC_PP2B_LxvP_1 670 673 PF13499 0.525
DOC_PP2B_LxvP_1 683 686 PF13499 0.569
DOC_USP7_MATH_1 137 141 PF00917 0.603
DOC_USP7_MATH_1 437 441 PF00917 0.528
DOC_USP7_MATH_1 50 54 PF00917 0.475
DOC_USP7_MATH_1 633 637 PF00917 0.667
DOC_USP7_MATH_1 651 655 PF00917 0.561
DOC_USP7_MATH_1 660 664 PF00917 0.612
DOC_USP7_MATH_1 686 690 PF00917 0.619
DOC_USP7_MATH_1 729 733 PF00917 0.410
DOC_USP7_MATH_1 9 13 PF00917 0.589
DOC_WW_Pin1_4 113 118 PF00397 0.761
DOC_WW_Pin1_4 124 129 PF00397 0.750
DOC_WW_Pin1_4 133 138 PF00397 0.517
DOC_WW_Pin1_4 141 146 PF00397 0.541
DOC_WW_Pin1_4 32 37 PF00397 0.564
DOC_WW_Pin1_4 429 434 PF00397 0.692
DOC_WW_Pin1_4 613 618 PF00397 0.704
DOC_WW_Pin1_4 635 640 PF00397 0.718
DOC_WW_Pin1_4 654 659 PF00397 0.486
DOC_WW_Pin1_4 663 668 PF00397 0.761
DOC_WW_Pin1_4 678 683 PF00397 0.547
DOC_WW_Pin1_4 763 768 PF00397 0.337
LIG_14-3-3_CanoR_1 179 183 PF00244 0.598
LIG_14-3-3_CanoR_1 237 245 PF00244 0.586
LIG_14-3-3_CanoR_1 28 34 PF00244 0.543
LIG_14-3-3_CanoR_1 409 413 PF00244 0.732
LIG_14-3-3_CanoR_1 427 433 PF00244 0.762
LIG_14-3-3_CanoR_1 588 598 PF00244 0.561
LIG_Actin_WH2_2 459 475 PF00022 0.270
LIG_BIR_II_1 1 5 PF00653 0.696
LIG_BRCT_BRCA1_1 142 146 PF00533 0.578
LIG_eIF4E_1 506 512 PF01652 0.473
LIG_eIF4E_1 719 725 PF01652 0.322
LIG_FHA_1 481 487 PF00498 0.464
LIG_FHA_1 491 497 PF00498 0.483
LIG_FHA_1 500 506 PF00498 0.444
LIG_FHA_1 590 596 PF00498 0.567
LIG_FHA_1 608 614 PF00498 0.762
LIG_FHA_1 673 679 PF00498 0.522
LIG_FHA_1 705 711 PF00498 0.405
LIG_FHA_1 783 789 PF00498 0.369
LIG_FHA_1 86 92 PF00498 0.427
LIG_FHA_2 444 450 PF00498 0.660
LIG_LIR_Gen_1 489 500 PF02991 0.442
LIG_LIR_Gen_1 555 564 PF02991 0.464
LIG_LIR_LC3C_4 721 726 PF02991 0.357
LIG_LIR_Nem_3 489 495 PF02991 0.442
LIG_LIR_Nem_3 756 760 PF02991 0.410
LIG_Rb_pABgroove_1 492 500 PF01858 0.496
LIG_SH2_CRK 344 348 PF00017 0.501
LIG_SH2_CRK 492 496 PF00017 0.442
LIG_SH2_CRK 508 512 PF00017 0.442
LIG_SH2_NCK_1 498 502 PF00017 0.536
LIG_SH2_NCK_1 630 634 PF00017 0.564
LIG_SH2_SRC 506 509 PF00017 0.473
LIG_SH2_SRC 719 722 PF00017 0.410
LIG_SH2_STAP1 492 496 PF00017 0.452
LIG_SH2_STAP1 508 512 PF00017 0.411
LIG_SH2_STAP1 530 534 PF00017 0.442
LIG_SH2_STAP1 630 634 PF00017 0.588
LIG_SH2_STAP1 687 691 PF00017 0.487
LIG_SH2_STAT3 343 346 PF00017 0.485
LIG_SH2_STAT5 492 495 PF00017 0.451
LIG_SH2_STAT5 506 509 PF00017 0.421
LIG_SH2_STAT5 630 633 PF00017 0.693
LIG_SH2_STAT5 687 690 PF00017 0.532
LIG_SH3_2 93 98 PF14604 0.573
LIG_SH3_3 346 352 PF00018 0.456
LIG_SH3_3 611 617 PF00018 0.656
LIG_SH3_3 8 14 PF00018 0.618
LIG_SH3_3 90 96 PF00018 0.615
LIG_SUMO_SIM_anti_2 225 231 PF11976 0.444
LIG_SUMO_SIM_anti_2 493 499 PF11976 0.543
LIG_SUMO_SIM_anti_2 721 727 PF11976 0.300
LIG_SUMO_SIM_par_1 153 159 PF11976 0.639
LIG_SUMO_SIM_par_1 483 489 PF11976 0.441
LIG_SUMO_SIM_par_1 87 92 PF11976 0.403
LIG_TRAF2_1 205 208 PF00917 0.567
LIG_TRAF2_1 254 257 PF00917 0.468
LIG_TYR_ITAM 489 511 PF00017 0.442
LIG_UBA3_1 264 272 PF00899 0.528
LIG_WW_3 95 99 PF00397 0.698
MOD_CDK_SPK_2 113 118 PF00069 0.631
MOD_CDK_SPxxK_3 113 120 PF00069 0.738
MOD_CDK_SPxxK_3 32 39 PF00069 0.431
MOD_CDK_SPxxK_3 654 661 PF00069 0.644
MOD_CK1_1 136 142 PF00069 0.680
MOD_CK1_1 32 38 PF00069 0.609
MOD_CK1_1 397 403 PF00069 0.703
MOD_CK1_1 411 417 PF00069 0.652
MOD_CK1_1 432 438 PF00069 0.654
MOD_CK1_1 572 578 PF00069 0.451
MOD_CK1_1 607 613 PF00069 0.705
MOD_CK1_1 632 638 PF00069 0.726
MOD_CK1_1 650 656 PF00069 0.592
MOD_CK1_1 663 669 PF00069 0.635
MOD_CK2_1 202 208 PF00069 0.518
MOD_Cter_Amidation 25 28 PF01082 0.439
MOD_GlcNHglycan 1 4 PF01048 0.725
MOD_GlcNHglycan 204 207 PF01048 0.624
MOD_GlcNHglycan 388 391 PF01048 0.677
MOD_GlcNHglycan 413 416 PF01048 0.664
MOD_GlcNHglycan 559 562 PF01048 0.328
MOD_GlcNHglycan 606 609 PF01048 0.752
MOD_GlcNHglycan 631 634 PF01048 0.708
MOD_GlcNHglycan 643 646 PF01048 0.766
MOD_GlcNHglycan 649 652 PF01048 0.518
MOD_GlcNHglycan 662 665 PF01048 0.602
MOD_GlcNHglycan 693 696 PF01048 0.650
MOD_GSK3_1 133 140 PF00069 0.728
MOD_GSK3_1 382 389 PF00069 0.681
MOD_GSK3_1 399 406 PF00069 0.587
MOD_GSK3_1 411 418 PF00069 0.643
MOD_GSK3_1 423 430 PF00069 0.629
MOD_GSK3_1 480 487 PF00069 0.446
MOD_GSK3_1 507 514 PF00069 0.542
MOD_GSK3_1 565 572 PF00069 0.461
MOD_GSK3_1 628 635 PF00069 0.698
MOD_GSK3_1 637 644 PF00069 0.729
MOD_GSK3_1 647 654 PF00069 0.455
MOD_GSK3_1 659 666 PF00069 0.511
MOD_GSK3_1 687 694 PF00069 0.643
MOD_N-GLC_1 746 751 PF02516 0.282
MOD_N-GLC_2 482 484 PF02516 0.239
MOD_NEK2_1 178 183 PF00069 0.552
MOD_NEK2_1 297 302 PF00069 0.491
MOD_NEK2_1 399 404 PF00069 0.774
MOD_NEK2_1 423 428 PF00069 0.656
MOD_NEK2_1 478 483 PF00069 0.461
MOD_NEK2_1 507 512 PF00069 0.469
MOD_NEK2_1 534 539 PF00069 0.544
MOD_NEK2_1 559 564 PF00069 0.467
MOD_NEK2_1 641 646 PF00069 0.651
MOD_NEK2_1 691 696 PF00069 0.543
MOD_NEK2_1 704 709 PF00069 0.427
MOD_NEK2_1 746 751 PF00069 0.282
MOD_NEK2_1 77 82 PF00069 0.501
MOD_NEK2_1 782 787 PF00069 0.322
MOD_NEK2_2 29 34 PF00069 0.433
MOD_OFUCOSY 48 55 PF10250 0.454
MOD_PIKK_1 122 128 PF00454 0.527
MOD_PIKK_1 565 571 PF00454 0.536
MOD_PIKK_1 9 15 PF00454 0.566
MOD_PKA_2 122 128 PF00069 0.556
MOD_PKA_2 178 184 PF00069 0.640
MOD_PKA_2 202 208 PF00069 0.511
MOD_PKA_2 236 242 PF00069 0.460
MOD_PKA_2 38 44 PF00069 0.379
MOD_PKA_2 408 414 PF00069 0.639
MOD_PKB_1 425 433 PF00069 0.623
MOD_Plk_1 490 496 PF00069 0.482
MOD_Plk_1 534 540 PF00069 0.536
MOD_Plk_4 490 496 PF00069 0.477
MOD_Plk_4 507 513 PF00069 0.377
MOD_Plk_4 534 540 PF00069 0.513
MOD_Plk_4 559 565 PF00069 0.461
MOD_Plk_4 706 712 PF00069 0.445
MOD_Plk_4 729 735 PF00069 0.416
MOD_ProDKin_1 113 119 PF00069 0.760
MOD_ProDKin_1 124 130 PF00069 0.750
MOD_ProDKin_1 133 139 PF00069 0.516
MOD_ProDKin_1 141 147 PF00069 0.537
MOD_ProDKin_1 32 38 PF00069 0.562
MOD_ProDKin_1 429 435 PF00069 0.689
MOD_ProDKin_1 613 619 PF00069 0.706
MOD_ProDKin_1 635 641 PF00069 0.719
MOD_ProDKin_1 654 660 PF00069 0.486
MOD_ProDKin_1 663 669 PF00069 0.759
MOD_ProDKin_1 678 684 PF00069 0.547
MOD_ProDKin_1 763 769 PF00069 0.337
MOD_SUMO_for_1 265 268 PF00179 0.527
MOD_SUMO_rev_2 268 274 PF00179 0.462
TRG_DiLeu_BaEn_1 358 363 PF01217 0.528
TRG_DiLeu_BaEn_1 491 496 PF01217 0.536
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.651
TRG_ENDOCYTIC_2 344 347 PF00928 0.461
TRG_ENDOCYTIC_2 492 495 PF00928 0.442
TRG_ENDOCYTIC_2 508 511 PF00928 0.442
TRG_ENDOCYTIC_2 530 533 PF00928 0.442
TRG_ER_diArg_1 117 120 PF00400 0.640
TRG_ER_diArg_1 150 153 PF00400 0.567
TRG_ER_diArg_1 194 197 PF00400 0.507
TRG_ER_diArg_1 308 311 PF00400 0.460
TRG_ER_diArg_1 333 335 PF00400 0.517
TRG_ER_diArg_1 424 427 PF00400 0.714
TRG_ER_diArg_1 463 465 PF00400 0.536
TRG_ER_diArg_1 757 759 PF00400 0.423
TRG_NES_CRM1_1 461 474 PF08389 0.336
TRG_NES_CRM1_1 60 74 PF08389 0.513
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.567
TRG_Pf-PMV_PEXEL_1 197 202 PF00026 0.554
TRG_Pf-PMV_PEXEL_1 327 332 PF00026 0.484
TRG_Pf-PMV_PEXEL_1 353 358 PF00026 0.462
TRG_Pf-PMV_PEXEL_1 464 468 PF00026 0.304
TRG_Pf-PMV_PEXEL_1 574 579 PF00026 0.296
TRG_Pf-PMV_PEXEL_1 759 763 PF00026 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I193 Leptomonas seymouri 58% 100%
A0A0S4ILT7 Bodo saltans 35% 100%
A0A1X0NMQ4 Trypanosomatidae 36% 100%
A0A3R7NDD0 Trypanosoma rangeli 36% 100%
A0A3S5H5C1 Leishmania donovani 100% 100%
A4H405 Leishmania braziliensis 78% 98%
E9AK54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q9U110 Leishmania major 93% 100%
V5BIA8 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS