Axonemal_dynein_light_chain_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Axonemal dynein light chain - putative

Species:

Leishmania infantum

UniProt:

A4HS65_LEIIN

TriTrypDb:

LINF_040012000

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HS65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.564
CLV_C14_Caspase3-7	20	24	PF00656	0.565
CLV_C14_Caspase3-7	275	279	PF00656	0.590
CLV_C14_Caspase3-7	320	324	PF00656	0.491
CLV_C14_Caspase3-7	381	385	PF00656	0.587
CLV_NRD_NRD_1	289	291	PF00675	0.550
CLV_NRD_NRD_1	316	318	PF00675	0.457
CLV_NRD_NRD_1	325	327	PF00675	0.491
CLV_NRD_NRD_1	420	422	PF00675	0.504
CLV_NRD_NRD_1	606	608	PF00675	0.304
CLV_NRD_NRD_1	667	669	PF00675	0.284
CLV_NRD_NRD_1	716	718	PF00675	0.549
CLV_PCSK_FUR_1	418	422	PF00082	0.456
CLV_PCSK_KEX2_1	289	291	PF00082	0.550
CLV_PCSK_KEX2_1	316	318	PF00082	0.457
CLV_PCSK_KEX2_1	325	327	PF00082	0.491
CLV_PCSK_KEX2_1	420	422	PF00082	0.504
CLV_PCSK_KEX2_1	606	608	PF00082	0.304
CLV_PCSK_KEX2_1	716	718	PF00082	0.549
CLV_PCSK_PC7_1	285	291	PF00082	0.565
CLV_PCSK_SKI1_1	111	115	PF00082	0.533
CLV_PCSK_SKI1_1	126	130	PF00082	0.464
CLV_PCSK_SKI1_1	2	6	PF00082	0.660
CLV_PCSK_SKI1_1	290	294	PF00082	0.547
CLV_PCSK_SKI1_1	316	320	PF00082	0.458
CLV_PCSK_SKI1_1	346	350	PF00082	0.495
CLV_PCSK_SKI1_1	390	394	PF00082	0.473
CLV_PCSK_SKI1_1	440	444	PF00082	0.474
CLV_PCSK_SKI1_1	592	596	PF00082	0.304
CLV_PCSK_SKI1_1	601	605	PF00082	0.304
CLV_PCSK_SKI1_1	606	610	PF00082	0.304
CLV_PCSK_SKI1_1	619	623	PF00082	0.304
CLV_PCSK_SKI1_1	641	645	PF00082	0.304
CLV_PCSK_SKI1_1	669	673	PF00082	0.347
CLV_PCSK_SKI1_1	682	686	PF00082	0.248
CLV_PCSK_SKI1_1	690	694	PF00082	0.357
CLV_Separin_Metazoa	313	317	PF03568	0.467
CLV_Separin_Metazoa	589	593	PF03568	0.284
DEG_APCC_DBOX_1	345	353	PF00400	0.567
DEG_APCC_DBOX_1	379	387	PF00400	0.525
DEG_APCC_DBOX_1	389	397	PF00400	0.476
DEG_APCC_DBOX_1	468	476	PF00400	0.494
DEG_APCC_DBOX_1	658	666	PF00400	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DEG_SPOP_SBC_1	374	378	PF00917	0.626
DOC_CKS1_1	533	538	PF01111	0.623
DOC_CYCLIN_RxL_1	314	324	PF00134	0.467
DOC_CYCLIN_RxL_1	487	501	PF00134	0.535
DOC_CYCLIN_RxL_1	601	611	PF00134	0.369
DOC_CYCLIN_RxL_1	687	694	PF00134	0.373
DOC_CYCLIN_yClb5_NLxxxL_5	692	701	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.567
DOC_MAPK_gen_1	576	585	PF00069	0.466
DOC_MAPK_MEF2A_6	101	110	PF00069	0.518
DOC_MAPK_MEF2A_6	576	585	PF00069	0.531
DOC_MAPK_RevD_3	594	607	PF00069	0.304
DOC_PP2B_LxvP_1	245	248	PF13499	0.587
DOC_PP2B_LxvP_1	88	91	PF13499	0.564
DOC_USP7_MATH_1	194	198	PF00917	0.633
DOC_USP7_MATH_1	288	292	PF00917	0.640
DOC_USP7_MATH_1	3	7	PF00917	0.640
DOC_USP7_MATH_1	442	446	PF00917	0.461
DOC_USP7_MATH_1	503	507	PF00917	0.617
DOC_USP7_MATH_1	517	521	PF00917	0.669
DOC_WW_Pin1_4	145	150	PF00397	0.690
DOC_WW_Pin1_4	270	275	PF00397	0.495
DOC_WW_Pin1_4	532	537	PF00397	0.627
LIG_14-3-3_CanoR_1	126	134	PF00244	0.611
LIG_14-3-3_CanoR_1	185	194	PF00244	0.686
LIG_14-3-3_CanoR_1	289	295	PF00244	0.553
LIG_14-3-3_CanoR_1	316	322	PF00244	0.431
LIG_14-3-3_CanoR_1	380	384	PF00244	0.599
LIG_14-3-3_CanoR_1	461	468	PF00244	0.507
LIG_14-3-3_CanoR_1	499	505	PF00244	0.584
LIG_14-3-3_CanoR_1	509	517	PF00244	0.634
LIG_14-3-3_CanoR_1	592	597	PF00244	0.304
LIG_14-3-3_CanoR_1	626	635	PF00244	0.394
LIG_14-3-3_CanoR_1	661	666	PF00244	0.248
LIG_14-3-3_CanoR_1	716	721	PF00244	0.620
LIG_Actin_RPEL_3	585	604	PF02755	0.394
LIG_Actin_WH2_2	365	382	PF00022	0.595
LIG_Actin_WH2_2	426	442	PF00022	0.473
LIG_Actin_WH2_2	576	594	PF00022	0.476
LIG_BIR_III_4	48	52	PF00653	0.593
LIG_CaM_IQ_9	118	133	PF13499	0.593
LIG_Clathr_ClatBox_1	456	460	PF01394	0.471
LIG_Clathr_ClatBox_1	472	476	PF01394	0.475
LIG_eIF4E_1	344	350	PF01652	0.549
LIG_EVH1_2	388	392	PF00568	0.533
LIG_FHA_1	37	43	PF00498	0.618
LIG_FHA_1	374	380	PF00498	0.624
LIG_FHA_1	460	466	PF00498	0.510
LIG_FHA_1	540	546	PF00498	0.647
LIG_FHA_1	566	572	PF00498	0.517
LIG_FHA_1	593	599	PF00498	0.304
LIG_FHA_1	61	67	PF00498	0.689
LIG_FHA_2	130	136	PF00498	0.627
LIG_FHA_2	273	279	PF00498	0.587
LIG_FHA_2	423	429	PF00498	0.469
LIG_FHA_2	436	442	PF00498	0.355
LIG_FHA_2	476	482	PF00498	0.526
LIG_FHA_2	50	56	PF00498	0.688
LIG_FHA_2	68	74	PF00498	0.514
LIG_FHA_2	93	99	PF00498	0.571
LIG_LIR_Apic_2	157	162	PF02991	0.639
LIG_LIR_Gen_1	308	319	PF02991	0.530
LIG_LIR_Gen_1	445	455	PF02991	0.475
LIG_LIR_Nem_3	308	314	PF02991	0.475
LIG_LIR_Nem_3	445	450	PF02991	0.465
LIG_MYND_3	251	255	PF01753	0.549
LIG_NRBOX	604	610	PF00104	0.369
LIG_PCNA_PIPBox_1	416	425	PF02747	0.470
LIG_RPA_C_Fungi	17	29	PF08784	0.535
LIG_SH2_CRK	159	163	PF00017	0.613
LIG_SH2_NCK_1	159	163	PF00017	0.635
LIG_SH2_NCK_1	447	451	PF00017	0.466
LIG_SH2_PTP2	311	314	PF00017	0.521
LIG_SH2_SRC	164	167	PF00017	0.636
LIG_SH2_SRC	395	398	PF00017	0.458
LIG_SH2_STAT5	139	142	PF00017	0.558
LIG_SH2_STAT5	270	273	PF00017	0.475
LIG_SH2_STAT5	311	314	PF00017	0.521
LIG_SH2_STAT5	344	347	PF00017	0.547
LIG_SH2_STAT5	395	398	PF00017	0.458
LIG_SH2_STAT5	447	450	PF00017	0.401
LIG_SH2_STAT5	471	474	PF00017	0.493
LIG_SH3_1	546	552	PF00018	0.586
LIG_SH3_3	146	152	PF00018	0.787
LIG_SH3_3	336	342	PF00018	0.542
LIG_SH3_3	383	389	PF00018	0.628
LIG_SH3_3	462	468	PF00018	0.503
LIG_SH3_3	546	552	PF00018	0.586
LIG_SH3_3	593	599	PF00018	0.304
LIG_SH3_3	75	81	PF00018	0.641
LIG_SUMO_SIM_anti_2	310	316	PF11976	0.526
LIG_SUMO_SIM_anti_2	428	435	PF11976	0.455
LIG_SUMO_SIM_par_1	317	324	PF11976	0.540
LIG_SUMO_SIM_par_1	454	460	PF11976	0.467
LIG_SUMO_SIM_par_1	594	600	PF11976	0.304
LIG_SUMO_SIM_par_1	60	67	PF11976	0.628
LIG_TYR_ITIM	309	314	PF00017	0.474
LIG_WW_3	387	391	PF00397	0.471
MOD_CDK_SPxK_1	532	538	PF00069	0.625
MOD_CK1_1	138	144	PF00069	0.640
MOD_CK1_1	186	192	PF00069	0.686
MOD_CK1_1	273	279	PF00069	0.527
MOD_CK1_1	445	451	PF00069	0.417
MOD_CK1_1	47	53	PF00069	0.810
MOD_CK1_1	67	73	PF00069	0.565
MOD_CK2_1	192	198	PF00069	0.593
MOD_CK2_1	364	370	PF00069	0.612
MOD_CK2_1	428	434	PF00069	0.418
MOD_CK2_1	435	441	PF00069	0.405
MOD_CK2_1	475	481	PF00069	0.458
MOD_CK2_1	49	55	PF00069	0.650
MOD_CK2_1	67	73	PF00069	0.514
MOD_GlcNHglycan	230	233	PF01048	0.645
MOD_GlcNHglycan	275	278	PF01048	0.556
MOD_GlcNHglycan	298	301	PF01048	0.487
MOD_GlcNHglycan	366	369	PF01048	0.611
MOD_GlcNHglycan	48	52	PF01048	0.593
MOD_GlcNHglycan	514	517	PF01048	0.749
MOD_GlcNHglycan	519	522	PF01048	0.710
MOD_GlcNHglycan	555	558	PF01048	0.588
MOD_GlcNHglycan	561	564	PF01048	0.523
MOD_GSK3_1	126	133	PF00069	0.579
MOD_GSK3_1	140	147	PF00069	0.511
MOD_GSK3_1	150	157	PF00069	0.786
MOD_GSK3_1	199	206	PF00069	0.599
MOD_GSK3_1	317	324	PF00069	0.485
MOD_GSK3_1	374	381	PF00069	0.544
MOD_GSK3_1	47	54	PF00069	0.588
MOD_GSK3_1	499	506	PF00069	0.602
MOD_GSK3_1	555	562	PF00069	0.565
MOD_GSK3_1	60	67	PF00069	0.754
MOD_GSK3_1	637	644	PF00069	0.248
MOD_GSK3_1	657	664	PF00069	0.183
MOD_N-GLC_1	627	632	PF02516	0.248
MOD_NEK2_1	228	233	PF00069	0.546
MOD_NEK2_1	258	263	PF00069	0.494
MOD_NEK2_1	321	326	PF00069	0.573
MOD_NEK2_1	475	480	PF00069	0.403
MOD_NEK2_1	497	502	PF00069	0.569
MOD_NEK2_1	64	69	PF00069	0.763
MOD_NEK2_1	92	97	PF00069	0.597
MOD_NEK2_2	11	16	PF00069	0.644
MOD_NEK2_2	541	546	PF00069	0.637
MOD_PIKK_1	627	633	PF00454	0.304
MOD_PK_1	661	667	PF00069	0.248
MOD_PKA_1	716	722	PF00069	0.581
MOD_PKA_2	288	294	PF00069	0.555
MOD_PKA_2	379	385	PF00069	0.596
MOD_PKA_2	460	466	PF00069	0.510
MOD_PKA_2	498	504	PF00069	0.576
MOD_PKA_2	715	721	PF00069	0.616
MOD_PKB_1	124	132	PF00069	0.607
MOD_PKB_1	659	667	PF00069	0.248
MOD_Plk_1	154	160	PF00069	0.635
MOD_Plk_1	428	434	PF00069	0.482
MOD_Plk_1	475	481	PF00069	0.462
MOD_Plk_1	576	582	PF00069	0.531
MOD_Plk_1	60	66	PF00069	0.638
MOD_Plk_2-3	428	434	PF00069	0.459
MOD_Plk_2-3	435	441	PF00069	0.391
MOD_Plk_2-3	60	66	PF00069	0.573
MOD_Plk_4	428	434	PF00069	0.474
MOD_Plk_4	581	587	PF00069	0.480
MOD_ProDKin_1	145	151	PF00069	0.688
MOD_ProDKin_1	270	276	PF00069	0.502
MOD_ProDKin_1	532	538	PF00069	0.625
MOD_SUMO_for_1	473	476	PF00179	0.534
MOD_SUMO_rev_2	677	681	PF00179	0.304
TRG_DiLeu_BaEn_1	310	315	PF01217	0.523
TRG_DiLeu_BaEn_1	600	605	PF01217	0.304
TRG_DiLeu_BaEn_4	434	440	PF01217	0.486
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.613
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.369
TRG_ENDOCYTIC_2	311	314	PF00928	0.456
TRG_ENDOCYTIC_2	394	397	PF00928	0.483
TRG_ENDOCYTIC_2	447	450	PF00928	0.456
TRG_ER_diArg_1	123	126	PF00400	0.536
TRG_ER_diArg_1	315	317	PF00400	0.454
TRG_ER_diArg_1	418	421	PF00400	0.501
TRG_ER_diArg_1	605	607	PF00400	0.304
TRG_ER_diArg_1	658	661	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA8	Leptomonas seymouri	46%	96%
A0A3S7WNS6	Leishmania donovani	100%	100%
A4H403	Leishmania braziliensis	68%	96%
E9AK52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q9NED3	Leishmania major	88%	100%