Putative ubiquitin-conjugating enzyme e2

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme E2 - putative

Species:

Leishmania infantum

UniProt:

A4HS64_LEIIN

TriTrypDb:

LINF_040011900

Length:

148

Annotations

Annotations by Jardim et al.

Protein modification, ubiquitin-conjugating enzyme e2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 8
Forrest at al. (procyclic)	yes	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HS64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS64

PDB structure(s): 6zm3_AAA , 6zm3_CCC

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	7
GO:0017076	purine nucleotide binding	4	12
GO:0019787	ubiquitin-like protein transferase activity	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.489
CLV_PCSK_SKI1_1	101	105	PF00082	0.279
CLV_PCSK_SKI1_1	144	148	PF00082	0.508
CLV_PCSK_SKI1_1	5	9	PF00082	0.263
CLV_PCSK_SKI1_1	68	72	PF00082	0.263
DEG_APCC_DBOX_1	82	90	PF00400	0.263
DEG_APCC_KENBOX_2	26	30	PF00400	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SCF_FBW7_2	21	28	PF00400	0.357
DOC_CYCLIN_RxL_1	98	105	PF00134	0.279

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R4	Leptomonas seymouri	35%	81%
A0A0N1I1Z1	Leptomonas seymouri	39%	95%
A0A0N1I707	Leptomonas seymouri	52%	100%
A0A0N1IA93	Leptomonas seymouri	27%	77%
A0A0N1IA94	Leptomonas seymouri	31%	90%
A0A0N1PB60	Leptomonas seymouri	95%	99%
A0A0S4IJE0	Bodo saltans	45%	67%
A0A0S4IWQ9	Bodo saltans	34%	77%
A0A0S4J8W6	Bodo saltans	81%	99%
A0A0S4JGV6	Bodo saltans	44%	100%

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