CHCH domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS62_LEIIN

TriTrypDb:

LINF_040011700

Length:

140

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HS62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS62

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.529
CLV_NRD_NRD_1	19	21	PF00675	0.531
CLV_NRD_NRD_1	4	6	PF00675	0.527
CLV_PCSK_KEX2_1	19	21	PF00082	0.530
CLV_PCSK_KEX2_1	3	5	PF00082	0.517
DEG_SPOP_SBC_1	21	25	PF00917	0.554
DOC_CKS1_1	98	103	PF01111	0.440
DOC_PP4_MxPP_1	136	139	PF00568	0.668
DOC_USP7_MATH_1	58	62	PF00917	0.553
DOC_WW_Pin1_4	97	102	PF00397	0.489
LIG_14-3-3_CanoR_1	20	30	PF00244	0.564
LIG_FHA_1	98	104	PF00498	0.520
LIG_LIR_Nem_3	11	15	PF02991	0.515
LIG_Pex14_1	122	126	PF04695	0.439
LIG_PTB_Apo_2	66	73	PF02174	0.606
LIG_PTB_Phospho_1	66	72	PF10480	0.635
LIG_SH2_SRC	72	75	PF00017	0.627
LIG_SH2_STAP1	106	110	PF00017	0.401
LIG_SH2_STAT3	126	129	PF00017	0.439
LIG_SH2_STAT5	126	129	PF00017	0.439
LIG_SH2_STAT5	37	40	PF00017	0.570
LIG_SH2_STAT5	70	73	PF00017	0.641
LIG_SH3_1	132	138	PF00018	0.583
LIG_SH3_3	132	138	PF00018	0.620
LIG_SH3_3	24	30	PF00018	0.707
LIG_SH3_3	35	41	PF00018	0.615
LIG_SH3_3	76	82	PF00018	0.517
LIG_SH3_3	95	101	PF00018	0.644
LIG_TRAF2_1	92	95	PF00917	0.634
MOD_CK1_1	116	122	PF00069	0.477
MOD_GlcNHglycan	115	118	PF01048	0.532
MOD_GlcNHglycan	12	15	PF01048	0.608
MOD_GSK3_1	10	17	PF00069	0.705
MOD_PIKK_1	125	131	PF00454	0.534
MOD_PIKK_1	77	83	PF00454	0.578
MOD_Plk_4	58	64	PF00069	0.551
MOD_ProDKin_1	97	103	PF00069	0.482
TRG_ER_diArg_1	19	21	PF00400	0.557
TRG_ER_diArg_1	2	5	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKW3	Trypanosomatidae	57%	95%
A0A3R7REF5	Trypanosoma rangeli	61%	100%
A0A3S5H5B8	Leishmania donovani	99%	100%
A0A3S5H5B9	Leishmania donovani	97%	92%
A4H401	Leishmania braziliensis	86%	100%
A4HS63	Leishmania infantum	97%	92%
C9ZY60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	95%
E9AK49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AK50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q9NED5	Leishmania major	96%	100%
Q9NED6	Leishmania major	96%	100%
V5BMV1	Trypanosoma cruzi	61%	95%