Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HS60_LEIIN

TriTrypDb:

LINF_040011500

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HS60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS60

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.425
CLV_NRD_NRD_1	167	169	PF00675	0.312
CLV_NRD_NRD_1	75	77	PF00675	0.387
CLV_PCSK_KEX2_1	167	169	PF00082	0.312
CLV_PCSK_KEX2_1	75	77	PF00082	0.387
CLV_PCSK_SKI1_1	223	227	PF00082	0.357
CLV_PCSK_SKI1_1	324	328	PF00082	0.609
DEG_Nend_UBRbox_2	1	3	PF02207	0.529
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.532
DOC_MAPK_DCC_7	49	57	PF00069	0.286
DOC_MAPK_MEF2A_6	229	237	PF00069	0.497
DOC_MAPK_MEF2A_6	49	57	PF00069	0.303
DOC_SPAK_OSR1_1	66	70	PF12202	0.363
DOC_USP7_MATH_1	105	109	PF00917	0.706
DOC_USP7_MATH_1	282	286	PF00917	0.363
DOC_USP7_MATH_1	35	39	PF00917	0.439
DOC_WW_Pin1_4	113	118	PF00397	0.699
LIG_14-3-3_CanoR_1	223	232	PF00244	0.593
LIG_14-3-3_CanoR_1	78	88	PF00244	0.604
LIG_Actin_WH2_2	208	225	PF00022	0.574
LIG_APCC_ABBA_1	68	73	PF00400	0.433
LIG_BRCT_BRCA1_1	319	323	PF00533	0.329
LIG_FHA_1	207	213	PF00498	0.630
LIG_FHA_1	255	261	PF00498	0.430
LIG_FHA_1	289	295	PF00498	0.363
LIG_FHA_1	312	318	PF00498	0.302
LIG_FHA_2	133	139	PF00498	0.515
LIG_LIR_Gen_1	245	253	PF02991	0.363
LIG_LIR_Gen_1	89	98	PF02991	0.615
LIG_LIR_Nem_3	163	169	PF02991	0.512
LIG_LIR_Nem_3	302	307	PF02991	0.606
LIG_LIR_Nem_3	320	326	PF02991	0.292
LIG_LIR_Nem_3	82	87	PF02991	0.648
LIG_LIR_Nem_3	89	93	PF02991	0.570
LIG_PDZ_Class_2	323	328	PF00595	0.347
LIG_Pex14_1	63	67	PF04695	0.429
LIG_SH2_CRK	166	170	PF00017	0.468
LIG_SH2_CRK	283	287	PF00017	0.329
LIG_SH2_GRB2like	16	19	PF00017	0.436
LIG_SH2_NCK_1	90	94	PF00017	0.615
LIG_SH2_STAP1	283	287	PF00017	0.391
LIG_SH2_STAP1	300	304	PF00017	0.468
LIG_SH2_STAT5	16	19	PF00017	0.467
LIG_SH2_STAT5	295	298	PF00017	0.446
LIG_SH2_STAT5	90	93	PF00017	0.533
LIG_SH3_3	134	140	PF00018	0.488
LIG_SH3_3	14	20	PF00018	0.383
LIG_SH3_3	269	275	PF00018	0.476
LIG_SH3_3	47	53	PF00018	0.268
LIG_SH3_3	99	105	PF00018	0.646
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.527
LIG_SUMO_SIM_par_1	290	296	PF11976	0.321
LIG_SUMO_SIM_par_1	305	310	PF11976	0.270
LIG_TRAF2_1	107	110	PF00917	0.713
LIG_TRFH_1	249	253	PF08558	0.488
LIG_UBA3_1	322	327	PF00899	0.406
MOD_CK1_1	189	195	PF00069	0.548
MOD_CK1_1	36	42	PF00069	0.392
MOD_CK2_1	104	110	PF00069	0.613
MOD_CK2_1	252	258	PF00069	0.422
MOD_CK2_1	86	92	PF00069	0.633
MOD_GlcNHglycan	162	165	PF01048	0.296
MOD_GlcNHglycan	276	279	PF01048	0.512
MOD_GlcNHglycan	319	322	PF01048	0.329
MOD_GlcNHglycan	38	41	PF01048	0.652
MOD_GSK3_1	100	107	PF00069	0.657
MOD_GSK3_1	206	213	PF00069	0.613
MOD_GSK3_1	307	314	PF00069	0.363
MOD_GSK3_1	35	42	PF00069	0.414
MOD_GSK3_1	79	86	PF00069	0.640
MOD_NEK2_1	206	211	PF00069	0.620
MOD_NEK2_1	242	247	PF00069	0.302
MOD_NEK2_1	317	322	PF00069	0.303
MOD_PIKK_1	105	111	PF00454	0.734
MOD_PKA_1	210	216	PF00069	0.544
MOD_PKA_2	100	106	PF00069	0.651
MOD_PKB_1	221	229	PF00069	0.547
MOD_Plk_1	7	13	PF00069	0.478
MOD_Plk_4	132	138	PF00069	0.461
MOD_Plk_4	210	216	PF00069	0.564
MOD_Plk_4	242	248	PF00069	0.302
MOD_Plk_4	282	288	PF00069	0.320
MOD_Plk_4	307	313	PF00069	0.476
MOD_ProDKin_1	113	119	PF00069	0.697
MOD_SUMO_rev_2	320	328	PF00179	0.444
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.552
TRG_ENDOCYTIC_2	166	169	PF00928	0.468
TRG_ENDOCYTIC_2	249	252	PF00928	0.427
TRG_ENDOCYTIC_2	283	286	PF00928	0.329
TRG_ENDOCYTIC_2	90	93	PF00928	0.718
TRG_ER_diArg_1	166	168	PF00400	0.512
TRG_ER_diArg_1	220	223	PF00400	0.534
TRG_ER_diArg_1	4	7	PF00400	0.498
TRG_ER_diArg_1	75	78	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRM4	Leptomonas seymouri	52%	100%
A0A3S7WNQ6	Leishmania donovani	100%	100%
A4H3Y1	Leishmania braziliensis	77%	100%
E9AK47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q9NED8	Leishmania major	95%	100%