Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS59_LEIIN

TriTrypDb:

LINF_040011400

Length:

200

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HS59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	48	50	PF00675	0.382
CLV_PCSK_KEX2_1	108	110	PF00082	0.377
CLV_PCSK_KEX2_1	48	50	PF00082	0.382
CLV_PCSK_KEX2_1	69	71	PF00082	0.491
CLV_PCSK_KEX2_1	79	81	PF00082	0.451
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.455
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.491
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.451
CLV_PCSK_SKI1_1	108	112	PF00082	0.361
CLV_PCSK_SKI1_1	133	137	PF00082	0.357
CLV_PCSK_SKI1_1	49	53	PF00082	0.363
CLV_PCSK_SKI1_1	70	74	PF00082	0.406
DOC_MAPK_gen_1	55	64	PF00069	0.576
DOC_MAPK_gen_1	69	78	PF00069	0.553
DOC_PP1_RVXF_1	131	137	PF00149	0.535
DOC_USP7_UBL2_3	34	38	PF12436	0.558
DOC_USP7_UBL2_3	69	73	PF12436	0.574
DOC_USP7_UBL2_3	75	79	PF12436	0.583
DOC_WW_Pin1_4	26	31	PF00397	0.606
LIG_14-3-3_CanoR_1	109	114	PF00244	0.571
LIG_APCC_ABBAyCdc20_2	33	39	PF00400	0.555
LIG_deltaCOP1_diTrp_1	129	136	PF00928	0.546
LIG_FHA_1	130	136	PF00498	0.531
LIG_FHA_1	139	145	PF00498	0.564
LIG_FHA_1	180	186	PF00498	0.276
LIG_FHA_1	26	32	PF00498	0.585
LIG_FHA_1	86	92	PF00498	0.577
LIG_FHA_2	157	163	PF00498	0.603
LIG_FHA_2	56	62	PF00498	0.555
LIG_LIR_Gen_1	129	137	PF02991	0.547
LIG_LIR_Gen_1	160	169	PF02991	0.581
LIG_LIR_Gen_1	61	72	PF02991	0.592
LIG_LIR_Nem_3	129	134	PF02991	0.558
LIG_LIR_Nem_3	160	166	PF02991	0.594
LIG_LIR_Nem_3	61	67	PF02991	0.577
LIG_PCNA_yPIPBox_3	63	72	PF02747	0.591
LIG_Pex14_1	168	172	PF04695	0.291
LIG_Pex14_1	186	190	PF04695	0.423
LIG_SH2_CRK	27	31	PF00017	0.599
LIG_SH2_STAP1	169	173	PF00017	0.310
LIG_SH2_STAP1	83	87	PF00017	0.592
LIG_SH2_STAT5	27	30	PF00017	0.591
LIG_SH3_3	40	46	PF00018	0.562
LIG_SUMO_SIM_par_1	88	94	PF11976	0.580
LIG_TRAF2_1	159	162	PF00917	0.598
LIG_WRC_WIRS_1	14	19	PF05994	0.690
LIG_WRC_WIRS_1	169	174	PF05994	0.299
MOD_CDK_SPxxK_3	26	33	PF00069	0.597
MOD_CK1_1	112	118	PF00069	0.587
MOD_CK1_1	171	177	PF00069	0.412
MOD_CK2_1	156	162	PF00069	0.611
MOD_CK2_1	55	61	PF00069	0.554
MOD_GSK3_1	108	115	PF00069	0.563
MOD_GSK3_1	152	159	PF00069	0.635
MOD_GSK3_1	167	174	PF00069	0.436
MOD_GSK3_1	51	58	PF00069	0.649
MOD_GSK3_1	83	90	PF00069	0.578
MOD_N-GLC_1	25	30	PF02516	0.398
MOD_N-GLC_1	6	11	PF02516	0.425
MOD_NEK2_1	172	177	PF00069	0.312
MOD_NEK2_1	179	184	PF00069	0.324
MOD_PKA_1	108	114	PF00069	0.558
MOD_PKA_1	117	123	PF00069	0.577
MOD_PKA_2	108	114	PF00069	0.572
MOD_Plk_1	6	12	PF00069	0.632
MOD_Plk_4	109	115	PF00069	0.561
MOD_Plk_4	162	168	PF00069	0.484
MOD_Plk_4	172	178	PF00069	0.262
MOD_Plk_4	95	101	PF00069	0.563
MOD_ProDKin_1	26	32	PF00069	0.599
MOD_SUMO_for_1	101	104	PF00179	0.575
MOD_SUMO_rev_2	103	110	PF00179	0.624
TRG_DiLeu_BaEn_1	139	144	PF01217	0.587
TRG_DiLeu_BaEn_3	161	167	PF01217	0.584
TRG_ENDOCYTIC_2	169	172	PF00928	0.291
TRG_ENDOCYTIC_2	196	199	PF00928	0.400
TRG_ENDOCYTIC_2	37	40	PF00928	0.548
TRG_ENDOCYTIC_2	44	47	PF00928	0.574
TRG_ER_diArg_1	47	49	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGR9	Leptomonas seymouri	96%	100%
A0A0S4IMJ1	Bodo saltans	80%	100%
A0A1X0NKX0	Trypanosomatidae	90%	100%
A0A3S7WNT5	Leishmania donovani	100%	100%
A0A422ND00	Trypanosoma rangeli	87%	100%
A4H3Y0	Leishmania braziliensis	95%	100%
C9ZY55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
E9AK46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q9NED9	Leishmania major	100%	100%