LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HS54_LEIIN
TriTrypDb:
LINF_040010900
Length:
267

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4HS54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 53 57 PF00656 0.454
CLV_NRD_NRD_1 118 120 PF00675 0.523
CLV_NRD_NRD_1 162 164 PF00675 0.469
CLV_NRD_NRD_1 170 172 PF00675 0.491
CLV_NRD_NRD_1 19 21 PF00675 0.407
CLV_NRD_NRD_1 5 7 PF00675 0.523
CLV_NRD_NRD_1 66 68 PF00675 0.707
CLV_PCSK_KEX2_1 118 120 PF00082 0.523
CLV_PCSK_KEX2_1 162 164 PF00082 0.469
CLV_PCSK_KEX2_1 170 172 PF00082 0.491
CLV_PCSK_KEX2_1 19 21 PF00082 0.458
CLV_PCSK_KEX2_1 7 9 PF00082 0.512
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.512
CLV_PCSK_SKI1_1 141 145 PF00082 0.460
DEG_Nend_UBRbox_1 1 4 PF02207 0.647
DOC_CKS1_1 9 14 PF01111 0.719
DOC_MAPK_gen_1 170 179 PF00069 0.710
DOC_MAPK_gen_1 19 26 PF00069 0.646
DOC_MAPK_gen_1 6 15 PF00069 0.720
DOC_MAPK_MEF2A_6 81 90 PF00069 0.422
DOC_PP1_RVXF_1 150 156 PF00149 0.671
DOC_PP2B_LxvP_1 13 16 PF13499 0.707
DOC_PP4_MxPP_1 206 209 PF00568 0.453
DOC_USP7_MATH_1 101 105 PF00917 0.490
DOC_USP7_MATH_1 107 111 PF00917 0.562
DOC_USP7_MATH_1 130 134 PF00917 0.653
DOC_USP7_MATH_1 260 264 PF00917 0.465
DOC_WW_Pin1_4 26 31 PF00397 0.567
DOC_WW_Pin1_4 8 13 PF00397 0.730
LIG_14-3-3_CanoR_1 235 241 PF00244 0.722
LIG_14-3-3_CanoR_1 261 265 PF00244 0.411
LIG_BRCT_BRCA1_1 21 25 PF00533 0.708
LIG_BRCT_BRCA1_1 41 45 PF00533 0.222
LIG_FHA_1 184 190 PF00498 0.546
LIG_FHA_1 8 14 PF00498 0.773
LIG_FHA_2 135 141 PF00498 0.741
LIG_FHA_2 26 32 PF00498 0.712
LIG_FHA_2 51 57 PF00498 0.455
LIG_IRF3_LxIS_1 82 89 PF10401 0.520
LIG_LIR_Gen_1 42 49 PF02991 0.416
LIG_LIR_Gen_1 89 97 PF02991 0.513
LIG_LIR_Nem_3 42 48 PF02991 0.416
LIG_LIR_Nem_3 89 93 PF02991 0.513
LIG_MLH1_MIPbox_1 41 45 PF16413 0.513
LIG_NRBOX 33 39 PF00104 0.397
LIG_SH2_CRK 202 206 PF00017 0.436
LIG_SH2_GRB2like 246 249 PF00017 0.402
LIG_SH2_PTP2 246 249 PF00017 0.411
LIG_SH2_STAP1 202 206 PF00017 0.436
LIG_SH2_STAT5 14 17 PF00017 0.677
LIG_SH2_STAT5 236 239 PF00017 0.675
LIG_SH2_STAT5 243 246 PF00017 0.609
LIG_SH2_STAT5 44 47 PF00017 0.513
LIG_SH3_1 6 12 PF00018 0.770
LIG_SH3_3 129 135 PF00018 0.713
LIG_SH3_3 15 21 PF00018 0.677
LIG_SH3_3 6 12 PF00018 0.718
LIG_SH3_3 79 85 PF00018 0.570
LIG_Sin3_3 253 260 PF02671 0.474
LIG_SUMO_SIM_anti_2 186 193 PF11976 0.433
LIG_SUMO_SIM_anti_2 254 259 PF11976 0.513
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.417
LIG_SUMO_SIM_par_1 186 193 PF11976 0.420
LIG_SUMO_SIM_par_1 83 89 PF11976 0.514
MOD_CK1_1 75 81 PF00069 0.589
MOD_CK2_1 130 136 PF00069 0.745
MOD_CK2_1 25 31 PF00069 0.719
MOD_Cter_Amidation 65 68 PF01082 0.779
MOD_DYRK1A_RPxSP_1 8 12 PF00069 0.717
MOD_GlcNHglycan 34 37 PF01048 0.458
MOD_GSK3_1 130 137 PF00069 0.743
MOD_GSK3_1 190 197 PF00069 0.411
MOD_GSK3_1 47 54 PF00069 0.552
MOD_NEK2_1 25 30 PF00069 0.681
MOD_NEK2_1 39 44 PF00069 0.358
MOD_NEK2_2 236 241 PF00069 0.664
MOD_PK_1 19 25 PF00069 0.658
MOD_PKA_1 19 25 PF00069 0.680
MOD_PKA_1 7 13 PF00069 0.710
MOD_PKA_2 19 25 PF00069 0.662
MOD_PKA_2 260 266 PF00069 0.411
MOD_PKA_2 66 72 PF00069 0.508
MOD_PKA_2 7 13 PF00069 0.720
MOD_PKA_2 75 81 PF00069 0.531
MOD_PKB_1 70 78 PF00069 0.595
MOD_Plk_4 101 107 PF00069 0.513
MOD_Plk_4 19 25 PF00069 0.660
MOD_Plk_4 190 196 PF00069 0.353
MOD_Plk_4 200 206 PF00069 0.407
MOD_Plk_4 260 266 PF00069 0.343
MOD_Plk_4 44 50 PF00069 0.317
MOD_ProDKin_1 26 32 PF00069 0.562
MOD_ProDKin_1 8 14 PF00069 0.730
TRG_ENDOCYTIC_2 202 205 PF00928 0.500
TRG_ENDOCYTIC_2 246 249 PF00928 0.355
TRG_ER_diArg_1 118 120 PF00400 0.723
TRG_ER_diArg_1 18 20 PF00400 0.641
TRG_ER_diArg_1 6 9 PF00400 0.732
TRG_ER_diArg_1 70 73 PF00400 0.588
TRG_Pf-PMV_PEXEL_1 111 116 PF00026 0.441

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB33 Leptomonas seymouri 52% 100%
A0A3S7WNS4 Leishmania donovani 100% 100%
A4H3X9 Leishmania braziliensis 75% 100%
E9AK41 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q95Z83 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS