Zinc_finger_-_C3HC4_type_(RING_finger )_containing_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HS49_LEIIN

TriTrypDb:

LINF_040010400

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HS49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS49

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.479
CLV_C14_Caspase3-7	347	351	PF00656	0.396
CLV_NRD_NRD_1	170	172	PF00675	0.557
CLV_NRD_NRD_1	259	261	PF00675	0.411
CLV_NRD_NRD_1	460	462	PF00675	0.599
CLV_PCSK_KEX2_1	170	172	PF00082	0.557
CLV_PCSK_KEX2_1	259	261	PF00082	0.411
CLV_PCSK_KEX2_1	46	48	PF00082	0.262
CLV_PCSK_KEX2_1	460	462	PF00082	0.585
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.260
CLV_PCSK_PC7_1	166	172	PF00082	0.538
CLV_PCSK_SKI1_1	405	409	PF00082	0.434
CLV_PCSK_SKI1_1	412	416	PF00082	0.434
CLV_PCSK_SKI1_1	8	12	PF00082	0.358
CLV_PCSK_SKI1_1	83	87	PF00082	0.459
DEG_APCC_DBOX_1	259	267	PF00400	0.407
DEG_APCC_DBOX_1	404	412	PF00400	0.403
DEG_APCC_DBOX_1	82	90	PF00400	0.396
DEG_Nend_UBRbox_2	1	3	PF02207	0.448
DEG_SPOP_SBC_1	433	437	PF00917	0.510
DEG_SPOP_SBC_1	450	454	PF00917	0.500
DOC_CKS1_1	228	233	PF01111	0.555
DOC_CKS1_1	422	427	PF01111	0.497
DOC_CYCLIN_RxL_1	386	396	PF00134	0.376
DOC_CYCLIN_RxL_1	79	88	PF00134	0.405
DOC_MAPK_gen_1	79	86	PF00069	0.362
DOC_MAPK_MEF2A_6	302	310	PF00069	0.365
DOC_PP1_RVXF_1	289	296	PF00149	0.405
DOC_PP2B_LxvP_1	525	528	PF13499	0.586
DOC_PP2B_PxIxI_1	426	432	PF00149	0.540
DOC_PP4_FxxP_1	22	25	PF00568	0.355
DOC_PP4_FxxP_1	66	69	PF00568	0.302
DOC_USP7_MATH_1	120	124	PF00917	0.644
DOC_USP7_MATH_1	249	253	PF00917	0.629
DOC_USP7_MATH_1	335	339	PF00917	0.438
DOC_USP7_MATH_1	450	454	PF00917	0.550
DOC_USP7_MATH_1	462	466	PF00917	0.493
DOC_USP7_MATH_1	494	498	PF00917	0.524
DOC_USP7_MATH_2	212	218	PF00917	0.546
DOC_WW_Pin1_4	137	142	PF00397	0.642
DOC_WW_Pin1_4	152	157	PF00397	0.791
DOC_WW_Pin1_4	159	164	PF00397	0.625
DOC_WW_Pin1_4	195	200	PF00397	0.615
DOC_WW_Pin1_4	223	228	PF00397	0.576
DOC_WW_Pin1_4	247	252	PF00397	0.597
DOC_WW_Pin1_4	380	385	PF00397	0.369
DOC_WW_Pin1_4	421	426	PF00397	0.505
DOC_WW_Pin1_4	451	456	PF00397	0.584
DOC_WW_Pin1_4	520	525	PF00397	0.654
DOC_WW_Pin1_4	550	555	PF00397	0.537
DOC_WW_Pin1_4	561	566	PF00397	0.548
LIG_14-3-3_CanoR_1	193	200	PF00244	0.578
LIG_14-3-3_CanoR_1	260	268	PF00244	0.468
LIG_14-3-3_CanoR_1	284	290	PF00244	0.288
LIG_14-3-3_CanoR_1	328	334	PF00244	0.432
LIG_14-3-3_CanoR_1	8	13	PF00244	0.368
LIG_BIR_III_4	367	371	PF00653	0.283
LIG_BRCT_BRCA1_1	337	341	PF00533	0.445
LIG_BRCT_BRCA1_1	485	489	PF00533	0.539
LIG_CtBP_PxDLS_1	34	38	PF00389	0.279
LIG_FHA_1	223	229	PF00498	0.566
LIG_FHA_1	347	353	PF00498	0.373
LIG_FHA_1	397	403	PF00498	0.402
LIG_FHA_2	113	119	PF00498	0.520
LIG_FHA_2	138	144	PF00498	0.646
LIG_FHA_2	414	420	PF00498	0.443
LIG_Integrin_isoDGR_2	579	581	PF01839	0.569
LIG_Integrin_RGD_1	584	586	PF01839	0.527
LIG_LIR_Apic_2	19	25	PF02991	0.384
LIG_LIR_Apic_2	29	34	PF02991	0.310
LIG_LIR_Gen_1	267	276	PF02991	0.412
LIG_LIR_Gen_1	399	408	PF02991	0.438
LIG_LIR_Gen_1	512	522	PF02991	0.552
LIG_LIR_Nem_3	177	183	PF02991	0.590
LIG_LIR_Nem_3	256	261	PF02991	0.435
LIG_LIR_Nem_3	267	271	PF02991	0.466
LIG_LIR_Nem_3	359	365	PF02991	0.445
LIG_LIR_Nem_3	369	374	PF02991	0.373
LIG_LIR_Nem_3	399	404	PF02991	0.437
LIG_LIR_Nem_3	512	517	PF02991	0.552
LIG_Pex14_2	295	299	PF04695	0.400
LIG_Rb_pABgroove_1	272	280	PF01858	0.389
LIG_SH2_CRK	268	272	PF00017	0.379
LIG_SH2_CRK	362	366	PF00017	0.532
LIG_SH2_CRK	501	505	PF00017	0.661
LIG_SH2_CRK	514	518	PF00017	0.571
LIG_SH2_PTP2	180	183	PF00017	0.573
LIG_SH2_PTP2	401	404	PF00017	0.377
LIG_SH2_SRC	180	183	PF00017	0.573
LIG_SH2_STAP1	268	272	PF00017	0.379
LIG_SH2_STAP1	348	352	PF00017	0.411
LIG_SH2_STAP1	514	518	PF00017	0.556
LIG_SH2_STAT3	320	323	PF00017	0.357
LIG_SH2_STAT5	180	183	PF00017	0.573
LIG_SH2_STAT5	320	323	PF00017	0.357
LIG_SH2_STAT5	348	351	PF00017	0.363
LIG_SH2_STAT5	373	376	PF00017	0.368
LIG_SH2_STAT5	401	404	PF00017	0.377
LIG_SH2_STAT5	501	504	PF00017	0.525
LIG_SH2_STAT5	514	517	PF00017	0.505
LIG_SH2_STAT5	98	101	PF00017	0.406
LIG_SH3_2	521	526	PF14604	0.579
LIG_SH3_3	153	159	PF00018	0.824
LIG_SH3_3	331	337	PF00018	0.378
LIG_SH3_3	444	450	PF00018	0.510
LIG_SH3_3	518	524	PF00018	0.690
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.289
LIG_SUMO_SIM_par_1	88	93	PF11976	0.350
LIG_TRAF2_2	14	19	PF00917	0.414
LIG_TYR_ITIM	266	271	PF00017	0.379
LIG_UBA3_1	309	318	PF00899	0.388
MOD_CAAXbox	589	592	PF01239	0.577
MOD_CDC14_SPxK_1	198	201	PF00782	0.572
MOD_CDC14_SPxK_1	523	526	PF00782	0.569
MOD_CDK_SPxK_1	195	201	PF00069	0.574
MOD_CDK_SPxK_1	520	526	PF00069	0.561
MOD_CDK_SPxxK_3	159	166	PF00069	0.549
MOD_CDK_SPxxK_3	561	568	PF00069	0.574
MOD_CK1_1	136	142	PF00069	0.622
MOD_CK1_1	188	194	PF00069	0.674
MOD_CK1_1	195	201	PF00069	0.667
MOD_CK1_1	217	223	PF00069	0.732
MOD_CK1_1	413	419	PF00069	0.498
MOD_CK1_1	434	440	PF00069	0.769
MOD_CK1_1	472	478	PF00069	0.520
MOD_CK1_1	512	518	PF00069	0.521
MOD_CK2_1	137	143	PF00069	0.698
MOD_CK2_1	261	267	PF00069	0.393
MOD_CK2_1	341	347	PF00069	0.404
MOD_CK2_1	413	419	PF00069	0.430
MOD_GlcNHglycan	188	191	PF01048	0.662
MOD_GlcNHglycan	238	241	PF01048	0.610
MOD_GlcNHglycan	247	250	PF01048	0.531
MOD_GlcNHglycan	285	288	PF01048	0.365
MOD_GlcNHglycan	336	340	PF01048	0.441
MOD_GlcNHglycan	367	371	PF01048	0.287
MOD_GlcNHglycan	438	441	PF01048	0.635
MOD_GlcNHglycan	474	477	PF01048	0.547
MOD_GlcNHglycan	479	482	PF01048	0.516
MOD_GlcNHglycan	541	544	PF01048	0.540
MOD_GSK3_1	101	108	PF00069	0.403
MOD_GSK3_1	120	127	PF00069	0.605
MOD_GSK3_1	133	140	PF00069	0.591
MOD_GSK3_1	154	161	PF00069	0.689
MOD_GSK3_1	188	195	PF00069	0.626
MOD_GSK3_1	200	207	PF00069	0.686
MOD_GSK3_1	214	221	PF00069	0.451
MOD_GSK3_1	223	230	PF00069	0.671
MOD_GSK3_1	236	243	PF00069	0.662
MOD_GSK3_1	245	252	PF00069	0.585
MOD_GSK3_1	396	403	PF00069	0.453
MOD_GSK3_1	427	434	PF00069	0.563
MOD_GSK3_1	470	477	PF00069	0.545
MOD_GSK3_1	479	486	PF00069	0.497
MOD_GSK3_1	490	497	PF00069	0.442
MOD_GSK3_1	509	516	PF00069	0.647
MOD_GSK3_1	539	546	PF00069	0.531
MOD_GSK3_1	70	77	PF00069	0.470
MOD_N-GLC_1	218	223	PF02516	0.590
MOD_N-GLC_1	236	241	PF02516	0.607
MOD_NEK2_1	245	250	PF00069	0.565
MOD_NEK2_1	341	346	PF00069	0.472
MOD_NEK2_1	407	412	PF00069	0.426
MOD_NEK2_1	490	495	PF00069	0.538
MOD_NEK2_1	539	544	PF00069	0.557
MOD_NEK2_1	70	75	PF00069	0.410
MOD_NEK2_1	85	90	PF00069	0.512
MOD_NEK2_2	400	405	PF00069	0.478
MOD_NEK2_2	494	499	PF00069	0.492
MOD_PIKK_1	261	267	PF00454	0.412
MOD_PIKK_1	319	325	PF00454	0.333
MOD_PIKK_1	499	505	PF00454	0.768
MOD_PIKK_1	526	532	PF00454	0.554
MOD_PKA_2	101	107	PF00069	0.421
MOD_PKA_2	192	198	PF00069	0.579
MOD_PKA_2	200	206	PF00069	0.565
MOD_PKA_2	283	289	PF00069	0.350
MOD_PKA_2	580	586	PF00069	0.601
MOD_Plk_1	218	224	PF00069	0.679
MOD_Plk_4	70	76	PF00069	0.409
MOD_Plk_4	85	91	PF00069	0.435
MOD_ProDKin_1	137	143	PF00069	0.644
MOD_ProDKin_1	152	158	PF00069	0.787
MOD_ProDKin_1	159	165	PF00069	0.625
MOD_ProDKin_1	195	201	PF00069	0.614
MOD_ProDKin_1	223	229	PF00069	0.578
MOD_ProDKin_1	247	253	PF00069	0.592
MOD_ProDKin_1	380	386	PF00069	0.368
MOD_ProDKin_1	421	427	PF00069	0.505
MOD_ProDKin_1	451	457	PF00069	0.583
MOD_ProDKin_1	520	526	PF00069	0.657
MOD_ProDKin_1	550	556	PF00069	0.539
MOD_ProDKin_1	561	567	PF00069	0.547
MOD_SUMO_rev_2	77	81	PF00179	0.405
TRG_DiLeu_BaEn_1	267	272	PF01217	0.428
TRG_ENDOCYTIC_2	180	183	PF00928	0.573
TRG_ENDOCYTIC_2	268	271	PF00928	0.405
TRG_ENDOCYTIC_2	362	365	PF00928	0.558
TRG_ENDOCYTIC_2	373	376	PF00928	0.275
TRG_ENDOCYTIC_2	401	404	PF00928	0.389
TRG_ENDOCYTIC_2	501	504	PF00928	0.550
TRG_ENDOCYTIC_2	514	517	PF00928	0.556
TRG_ER_diArg_1	169	171	PF00400	0.590
TRG_ER_diArg_1	258	260	PF00400	0.417
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV78	Leptomonas seymouri	51%	94%
A0A3R7KFH5	Trypanosoma rangeli	27%	100%
A0A3S5H5B1	Leishmania donovani	99%	100%
A4HDK3	Leishmania braziliensis	27%	93%
A4HDK4	Leishmania braziliensis	27%	93%
E9AK36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
O97201	Leishmania major	90%	99%
Q4QAJ3	Leishmania major	29%	97%
Q4QBX6	Leishmania major	22%	100%