LeishMANIAdb
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Putative huntingtin interacting protein (HIP)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative huntingtin interacting protein (HIP)
Gene product:
palmitoyl acyltransferase 1 - putative
Species:
Leishmania infantum
UniProt:
A4HS47_LEIIN
TriTrypDb:
LINF_040010200
Length:
1067

Annotations

LeishMANIAdb annotations

Very putatively could be a palmitoyltransferase.

Annotations by Jardim et al.

Metal Binding, huntingtin interacting (HIP)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HS47
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS47

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0018345 protein palmitoylation 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016409 palmitoyltransferase activity 5 9
GO:0016740 transferase activity 2 9
GO:0016746 acyltransferase activity 3 9
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9
GO:0008374 O-acyltransferase activity 5 1
GO:0016416 O-palmitoyltransferase activity 6 1
GO:0047965 glycoprotein O-fatty-acyltransferase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 3
GO:0140103 catalytic activity, acting on a glycoprotein 3 1
GO:0016417 S-acyltransferase activity 5 2
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 2
GO:0019707 protein-cysteine S-acyltransferase activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 208 212 PF00656 0.427
CLV_C14_Caspase3-7 327 331 PF00656 0.685
CLV_C14_Caspase3-7 882 886 PF00656 0.689
CLV_NRD_NRD_1 1020 1022 PF00675 0.527
CLV_NRD_NRD_1 306 308 PF00675 0.532
CLV_NRD_NRD_1 462 464 PF00675 0.450
CLV_NRD_NRD_1 50 52 PF00675 0.441
CLV_NRD_NRD_1 560 562 PF00675 0.493
CLV_NRD_NRD_1 638 640 PF00675 0.464
CLV_NRD_NRD_1 680 682 PF00675 0.303
CLV_NRD_NRD_1 727 729 PF00675 0.503
CLV_NRD_NRD_1 778 780 PF00675 0.519
CLV_PCSK_KEX2_1 1020 1022 PF00082 0.527
CLV_PCSK_KEX2_1 306 308 PF00082 0.532
CLV_PCSK_KEX2_1 461 463 PF00082 0.470
CLV_PCSK_KEX2_1 50 52 PF00082 0.441
CLV_PCSK_KEX2_1 559 561 PF00082 0.447
CLV_PCSK_KEX2_1 680 682 PF00082 0.303
CLV_PCSK_KEX2_1 727 729 PF00082 0.503
CLV_PCSK_KEX2_1 778 780 PF00082 0.519
CLV_PCSK_PC7_1 556 562 PF00082 0.437
CLV_PCSK_SKI1_1 195 199 PF00082 0.295
CLV_PCSK_SKI1_1 215 219 PF00082 0.272
CLV_PCSK_SKI1_1 405 409 PF00082 0.268
CLV_PCSK_SKI1_1 477 481 PF00082 0.456
CLV_PCSK_SKI1_1 51 55 PF00082 0.413
CLV_PCSK_SKI1_1 535 539 PF00082 0.393
CLV_PCSK_SKI1_1 565 569 PF00082 0.376
CLV_PCSK_SKI1_1 655 659 PF00082 0.527
CLV_PCSK_SKI1_1 681 685 PF00082 0.268
CLV_PCSK_SKI1_1 703 707 PF00082 0.319
CLV_PCSK_SKI1_1 809 813 PF00082 0.276
CLV_PCSK_SKI1_1 847 851 PF00082 0.351
CLV_Separin_Metazoa 1009 1013 PF03568 0.596
CLV_Separin_Metazoa 229 233 PF03568 0.478
DEG_APCC_DBOX_1 1052 1060 PF00400 0.601
DEG_APCC_DBOX_1 654 662 PF00400 0.628
DEG_Nend_UBRbox_1 1 4 PF02207 0.599
DEG_SPOP_SBC_1 146 150 PF00917 0.628
DEG_SPOP_SBC_1 913 917 PF00917 0.718
DOC_ANK_TNKS_1 312 319 PF00023 0.625
DOC_CYCLIN_RxL_1 402 409 PF00134 0.547
DOC_CYCLIN_RxL_1 474 484 PF00134 0.628
DOC_CYCLIN_RxL_1 652 662 PF00134 0.664
DOC_CYCLIN_RxL_1 805 817 PF00134 0.544
DOC_CYCLIN_yCln2_LP_2 507 513 PF00134 0.314
DOC_CYCLIN_yCln2_LP_2 610 616 PF00134 0.283
DOC_MAPK_gen_1 1020 1026 PF00069 0.701
DOC_MAPK_gen_1 494 504 PF00069 0.655
DOC_MAPK_MEF2A_6 157 164 PF00069 0.613
DOC_MAPK_MEF2A_6 443 450 PF00069 0.677
DOC_MAPK_MEF2A_6 497 504 PF00069 0.638
DOC_MAPK_MEF2A_6 506 515 PF00069 0.426
DOC_MAPK_MEF2A_6 535 543 PF00069 0.372
DOC_MAPK_MEF2A_6 703 712 PF00069 0.534
DOC_MAPK_NFAT4_5 703 711 PF00069 0.503
DOC_PP1_RVXF_1 807 814 PF00149 0.482
DOC_PP2B_LxvP_1 152 155 PF13499 0.687
DOC_PP2B_LxvP_1 507 510 PF13499 0.314
DOC_PP2B_LxvP_1 582 585 PF13499 0.316
DOC_PP2B_LxvP_1 940 943 PF13499 0.724
DOC_PP4_FxxP_1 361 364 PF00568 0.594
DOC_USP7_MATH_1 253 257 PF00917 0.617
DOC_USP7_MATH_1 326 330 PF00917 0.765
DOC_USP7_MATH_1 339 343 PF00917 0.729
DOC_USP7_MATH_1 417 421 PF00917 0.653
DOC_USP7_MATH_1 737 741 PF00917 0.303
DOC_USP7_MATH_1 747 751 PF00917 0.225
DOC_USP7_MATH_1 951 955 PF00917 0.701
DOC_USP7_UBL2_3 439 443 PF12436 0.680
DOC_WW_Pin1_4 180 185 PF00397 0.472
DOC_WW_Pin1_4 25 30 PF00397 0.742
DOC_WW_Pin1_4 285 290 PF00397 0.734
DOC_WW_Pin1_4 387 392 PF00397 0.468
DOC_WW_Pin1_4 420 425 PF00397 0.572
DOC_WW_Pin1_4 427 432 PF00397 0.642
DOC_WW_Pin1_4 469 474 PF00397 0.619
DOC_WW_Pin1_4 625 630 PF00397 0.476
LIG_14-3-3_CanoR_1 215 221 PF00244 0.519
LIG_14-3-3_CanoR_1 248 257 PF00244 0.587
LIG_14-3-3_CanoR_1 332 338 PF00244 0.691
LIG_14-3-3_CanoR_1 429 435 PF00244 0.678
LIG_14-3-3_CanoR_1 50 54 PF00244 0.633
LIG_14-3-3_CanoR_1 565 574 PF00244 0.534
LIG_14-3-3_CanoR_1 728 734 PF00244 0.344
LIG_14-3-3_CanoR_1 779 785 PF00244 0.303
LIG_14-3-3_CanoR_1 809 814 PF00244 0.476
LIG_14-3-3_CanoR_1 833 838 PF00244 0.550
LIG_APCC_ABBA_1 1 6 PF00400 0.660
LIG_APCC_ABBA_1 1004 1009 PF00400 0.644
LIG_BIR_III_4 211 215 PF00653 0.534
LIG_deltaCOP1_diTrp_1 569 576 PF00928 0.329
LIG_eIF4E_1 261 267 PF01652 0.565
LIG_eIF4E_1 441 447 PF01652 0.688
LIG_FHA_1 146 152 PF00498 0.726
LIG_FHA_1 517 523 PF00498 0.415
LIG_FHA_1 615 621 PF00498 0.381
LIG_FHA_1 65 71 PF00498 0.562
LIG_FHA_1 749 755 PF00498 0.393
LIG_FHA_1 768 774 PF00498 0.174
LIG_FHA_1 854 860 PF00498 0.700
LIG_FHA_1 93 99 PF00498 0.711
LIG_FHA_2 1035 1041 PF00498 0.694
LIG_FHA_2 44 50 PF00498 0.598
LIG_FHA_2 631 637 PF00498 0.673
LIG_FHA_2 77 83 PF00498 0.658
LIG_FHA_2 810 816 PF00498 0.471
LIG_FHA_2 880 886 PF00498 0.696
LIG_GBD_Chelix_1 1002 1010 PF00786 0.421
LIG_GBD_Chelix_1 796 804 PF00786 0.360
LIG_IBAR_NPY_1 866 868 PF08397 0.633
LIG_LIR_Apic_2 607 612 PF02991 0.340
LIG_LIR_Gen_1 52 61 PF02991 0.581
LIG_LIR_Gen_1 62 71 PF02991 0.547
LIG_LIR_Gen_1 783 792 PF02991 0.315
LIG_LIR_Gen_1 832 842 PF02991 0.570
LIG_LIR_Nem_3 437 441 PF02991 0.749
LIG_LIR_Nem_3 52 57 PF02991 0.566
LIG_LIR_Nem_3 588 593 PF02991 0.510
LIG_LIR_Nem_3 60 66 PF02991 0.538
LIG_LIR_Nem_3 607 611 PF02991 0.452
LIG_LIR_Nem_3 687 692 PF02991 0.536
LIG_LIR_Nem_3 725 729 PF02991 0.313
LIG_LIR_Nem_3 775 780 PF02991 0.282
LIG_LIR_Nem_3 783 787 PF02991 0.274
LIG_LIR_Nem_3 812 816 PF02991 0.489
LIG_LIR_Nem_3 832 838 PF02991 0.574
LIG_LYPXL_SIV_4 223 231 PF13949 0.602
LIG_LYPXL_yS_3 224 227 PF13949 0.600
LIG_PCNA_yPIPBox_3 157 165 PF02747 0.610
LIG_PCNA_yPIPBox_3 191 200 PF02747 0.503
LIG_PCNA_yPIPBox_3 703 716 PF02747 0.514
LIG_Pex14_1 572 576 PF04695 0.393
LIG_Rb_pABgroove_1 832 840 PF01858 0.613
LIG_SH2_CRK 261 265 PF00017 0.593
LIG_SH2_CRK 643 647 PF00017 0.594
LIG_SH2_CRK 726 730 PF00017 0.374
LIG_SH2_CRK 784 788 PF00017 0.346
LIG_SH2_CRK 860 864 PF00017 0.685
LIG_SH2_GRB2like 692 695 PF00017 0.503
LIG_SH2_NCK_1 220 224 PF00017 0.603
LIG_SH2_NCK_1 483 487 PF00017 0.585
LIG_SH2_PTP2 551 554 PF00017 0.356
LIG_SH2_PTP2 623 626 PF00017 0.497
LIG_SH2_STAP1 220 224 PF00017 0.597
LIG_SH2_STAP1 241 245 PF00017 0.630
LIG_SH2_STAP1 261 265 PF00017 0.591
LIG_SH2_STAP1 596 600 PF00017 0.465
LIG_SH2_STAP1 653 657 PF00017 0.623
LIG_SH2_STAP1 659 663 PF00017 0.506
LIG_SH2_STAP1 722 726 PF00017 0.346
LIG_SH2_STAP1 784 788 PF00017 0.346
LIG_SH2_STAT3 19 22 PF00017 0.710
LIG_SH2_STAT3 591 594 PF00017 0.420
LIG_SH2_STAT3 675 678 PF00017 0.527
LIG_SH2_STAT3 868 871 PF00017 0.639
LIG_SH2_STAT5 1055 1058 PF00017 0.602
LIG_SH2_STAT5 20 23 PF00017 0.683
LIG_SH2_STAT5 265 268 PF00017 0.583
LIG_SH2_STAT5 503 506 PF00017 0.659
LIG_SH2_STAT5 528 531 PF00017 0.472
LIG_SH2_STAT5 551 554 PF00017 0.499
LIG_SH2_STAT5 623 626 PF00017 0.421
LIG_SH2_STAT5 675 678 PF00017 0.507
LIG_SH2_STAT5 692 695 PF00017 0.400
LIG_SH2_STAT5 782 785 PF00017 0.297
LIG_SH2_STAT5 826 829 PF00017 0.628
LIG_SH2_STAT5 868 871 PF00017 0.626
LIG_SH3_2 302 307 PF14604 0.712
LIG_SH3_3 219 225 PF00018 0.607
LIG_SH3_3 288 294 PF00018 0.692
LIG_SH3_3 296 302 PF00018 0.659
LIG_SH3_3 664 670 PF00018 0.468
LIG_SH3_3 784 790 PF00018 0.421
LIG_SUMO_SIM_anti_2 1022 1028 PF11976 0.636
LIG_SUMO_SIM_anti_2 40 46 PF11976 0.653
LIG_SUMO_SIM_anti_2 400 405 PF11976 0.534
LIG_SUMO_SIM_anti_2 444 450 PF11976 0.661
LIG_SUMO_SIM_anti_2 512 519 PF11976 0.381
LIG_SUMO_SIM_anti_2 95 104 PF11976 0.706
LIG_SUMO_SIM_par_1 512 519 PF11976 0.397
LIG_TRAF2_1 1037 1040 PF00917 0.693
LIG_TRAF2_1 967 970 PF00917 0.752
LIG_TRFH_1 19 23 PF08558 0.649
LIG_TYR_ITIM 222 227 PF00017 0.511
LIG_WRC_WIRS_1 161 166 PF05994 0.487
LIG_WRC_WIRS_1 595 600 PF05994 0.541
LIG_WRC_WIRS_1 66 71 PF05994 0.524
MOD_CDC14_SPxK_1 472 475 PF00782 0.537
MOD_CDK_SPxK_1 469 475 PF00069 0.561
MOD_CK1_1 1013 1019 PF00069 0.590
MOD_CK1_1 144 150 PF00069 0.724
MOD_CK1_1 334 340 PF00069 0.714
MOD_CK1_1 387 393 PF00069 0.370
MOD_CK1_1 420 426 PF00069 0.536
MOD_CK1_1 430 436 PF00069 0.643
MOD_CK1_1 72 78 PF00069 0.500
MOD_CK1_1 853 859 PF00069 0.614
MOD_CK2_1 1034 1040 PF00069 0.646
MOD_CK2_1 49 55 PF00069 0.489
MOD_CK2_1 630 636 PF00069 0.593
MOD_CK2_1 76 82 PF00069 0.566
MOD_CK2_1 816 822 PF00069 0.585
MOD_CK2_1 972 978 PF00069 0.775
MOD_Cter_Amidation 1018 1021 PF01082 0.520
MOD_GlcNHglycan 1012 1015 PF01048 0.447
MOD_GlcNHglycan 109 112 PF01048 0.783
MOD_GlcNHglycan 114 117 PF01048 0.784
MOD_GlcNHglycan 32 35 PF01048 0.719
MOD_GlcNHglycan 333 336 PF01048 0.753
MOD_GlcNHglycan 341 344 PF01048 0.691
MOD_GlcNHglycan 386 389 PF01048 0.518
MOD_GlcNHglycan 396 399 PF01048 0.424
MOD_GlcNHglycan 419 422 PF01048 0.558
MOD_GlcNHglycan 453 456 PF01048 0.636
MOD_GlcNHglycan 71 74 PF01048 0.525
MOD_GlcNHglycan 739 742 PF01048 0.495
MOD_GlcNHglycan 85 88 PF01048 0.494
MOD_GlcNHglycan 901 904 PF01048 0.687
MOD_GlcNHglycan 907 910 PF01048 0.693
MOD_GlcNHglycan 953 956 PF01048 0.685
MOD_GlcNHglycan 972 975 PF01048 0.608
MOD_GlcNHglycan 998 1002 PF01048 0.636
MOD_GSK3_1 141 148 PF00069 0.756
MOD_GSK3_1 249 256 PF00069 0.473
MOD_GSK3_1 334 341 PF00069 0.757
MOD_GSK3_1 346 353 PF00069 0.756
MOD_GSK3_1 430 437 PF00069 0.629
MOD_GSK3_1 481 488 PF00069 0.483
MOD_GSK3_1 561 568 PF00069 0.568
MOD_GSK3_1 65 72 PF00069 0.518
MOD_GSK3_1 816 823 PF00069 0.616
MOD_GSK3_1 829 836 PF00069 0.449
MOD_GSK3_1 914 921 PF00069 0.673
MOD_LATS_1 35 41 PF00433 0.520
MOD_N-GLC_1 274 279 PF02516 0.591
MOD_N-GLC_1 311 316 PF02516 0.770
MOD_N-GLC_1 350 355 PF02516 0.725
MOD_N-GLC_1 417 422 PF02516 0.555
MOD_N-GLC_1 486 491 PF02516 0.540
MOD_N-GLC_1 76 81 PF02516 0.557
MOD_N-GLC_1 809 814 PF02516 0.403
MOD_N-GLC_1 99 104 PF02516 0.557
MOD_NEK2_1 1010 1015 PF00069 0.569
MOD_NEK2_1 160 165 PF00069 0.545
MOD_NEK2_1 187 192 PF00069 0.360
MOD_NEK2_1 249 254 PF00069 0.394
MOD_NEK2_1 338 343 PF00069 0.588
MOD_NEK2_1 43 48 PF00069 0.602
MOD_NEK2_1 434 439 PF00069 0.598
MOD_NEK2_1 516 521 PF00069 0.403
MOD_NEK2_1 586 591 PF00069 0.502
MOD_NEK2_1 69 74 PF00069 0.605
MOD_NEK2_1 729 734 PF00069 0.354
MOD_NEK2_1 736 741 PF00069 0.382
MOD_NEK2_1 772 777 PF00069 0.442
MOD_NEK2_1 780 785 PF00069 0.397
MOD_NEK2_1 850 855 PF00069 0.499
MOD_OFUCOSY 309 315 PF10250 0.522
MOD_PIKK_1 101 107 PF00454 0.662
MOD_PIKK_1 1034 1040 PF00454 0.653
MOD_PIKK_1 486 492 PF00454 0.504
MOD_PIKK_1 782 788 PF00454 0.403
MOD_PIKK_1 799 805 PF00454 0.403
MOD_PIKK_1 853 859 PF00454 0.632
MOD_PIKK_1 972 978 PF00454 0.775
MOD_PK_1 37 43 PF00069 0.629
MOD_PKA_2 331 337 PF00069 0.615
MOD_PKA_2 450 456 PF00069 0.686
MOD_PKA_2 49 55 PF00069 0.554
MOD_PKA_2 737 743 PF00069 0.360
MOD_PKA_2 970 976 PF00069 0.610
MOD_PKB_1 559 567 PF00069 0.586
MOD_Plk_1 141 147 PF00069 0.674
MOD_Plk_1 205 211 PF00069 0.253
MOD_Plk_1 37 43 PF00069 0.565
MOD_Plk_1 601 607 PF00069 0.476
MOD_Plk_1 809 815 PF00069 0.421
MOD_Plk_1 820 826 PF00069 0.587
MOD_Plk_2-3 49 55 PF00069 0.535
MOD_Plk_4 147 153 PF00069 0.657
MOD_Plk_4 586 592 PF00069 0.474
MOD_Plk_4 65 71 PF00069 0.455
MOD_Plk_4 711 717 PF00069 0.422
MOD_Plk_4 729 735 PF00069 0.187
MOD_Plk_4 809 815 PF00069 0.432
MOD_Plk_4 821 827 PF00069 0.529
MOD_Plk_4 833 839 PF00069 0.375
MOD_ProDKin_1 180 186 PF00069 0.316
MOD_ProDKin_1 25 31 PF00069 0.698
MOD_ProDKin_1 285 291 PF00069 0.682
MOD_ProDKin_1 387 393 PF00069 0.311
MOD_ProDKin_1 420 426 PF00069 0.460
MOD_ProDKin_1 427 433 PF00069 0.563
MOD_ProDKin_1 469 475 PF00069 0.516
MOD_ProDKin_1 625 631 PF00069 0.483
TRG_DiLeu_BaEn_1 725 730 PF01217 0.421
TRG_DiLeu_BaLyEn_6 13 18 PF01217 0.632
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.479
TRG_DiLeu_BaLyEn_6 542 547 PF01217 0.382
TRG_ENDOCYTIC_2 224 227 PF00928 0.509
TRG_ENDOCYTIC_2 261 264 PF00928 0.489
TRG_ENDOCYTIC_2 508 511 PF00928 0.365
TRG_ENDOCYTIC_2 551 554 PF00928 0.508
TRG_ENDOCYTIC_2 595 598 PF00928 0.582
TRG_ENDOCYTIC_2 623 626 PF00928 0.421
TRG_ENDOCYTIC_2 643 646 PF00928 0.487
TRG_ENDOCYTIC_2 686 689 PF00928 0.497
TRG_ENDOCYTIC_2 726 729 PF00928 0.365
TRG_ENDOCYTIC_2 784 787 PF00928 0.311
TRG_ENDOCYTIC_2 835 838 PF00928 0.445
TRG_ER_diArg_1 305 307 PF00400 0.663
TRG_ER_diArg_1 461 463 PF00400 0.647
TRG_ER_diArg_1 559 561 PF00400 0.604
TRG_ER_diArg_1 679 681 PF00400 0.421
TRG_ER_diArg_1 726 728 PF00400 0.360
TRG_ER_diArg_1 777 779 PF00400 0.382
TRG_Pf-PMV_PEXEL_1 465 470 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 565 569 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 762 766 PF00026 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9Z8 Leptomonas seymouri 50% 100%
A0A1X0NKY1 Trypanosomatidae 30% 100%
A0A3S5H5B0 Leishmania donovani 100% 100%
A0A422N9R9 Trypanosoma rangeli 30% 100%
A4H3X2 Leishmania braziliensis 68% 96%
E9AK34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 98%
O97203 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS