LeishMANIAdb
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Adenylosuccinate lyase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Adenylosuccinate lyase
Gene product:
adenylosuccinate lyase - putative
Species:
Leishmania infantum
UniProt:
A4HS40_LEIIN
TriTrypDb:
LINF_040009600
Length:
479

Annotations

Annotations by Jardim et al.

Purine metabolism, Adenylosuccinate lyase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HS40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS40

PDB structure(s): 4mx2_A , 4mx2_B , 4mx2_C , 4mx2_D , 4mx2_E , 4mx2_F , 4mx2_G , 4mx2_H

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006163 purine nucleotide metabolic process 5 12
GO:0006164 purine nucleotide biosynthetic process 6 12
GO:0006167 AMP biosynthetic process 8 11
GO:0006188 IMP biosynthetic process 8 12
GO:0006189 'de novo' IMP biosynthetic process 9 11
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006753 nucleoside phosphate metabolic process 4 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009117 nucleotide metabolic process 5 12
GO:0009123 nucleoside monophosphate metabolic process 5 12
GO:0009124 nucleoside monophosphate biosynthetic process 6 12
GO:0009126 purine nucleoside monophosphate metabolic process 6 12
GO:0009127 purine nucleoside monophosphate biosynthetic process 7 12
GO:0009150 purine ribonucleotide metabolic process 6 12
GO:0009152 purine ribonucleotide biosynthetic process 7 12
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 12
GO:0009161 ribonucleoside monophosphate metabolic process 6 12
GO:0009165 nucleotide biosynthetic process 6 12
GO:0009167 purine ribonucleoside monophosphate metabolic process 7 12
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 8 12
GO:0009259 ribonucleotide metabolic process 5 12
GO:0009260 ribonucleotide biosynthetic process 6 12
GO:0009987 cellular process 1 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0019637 organophosphate metabolic process 3 12
GO:0019693 ribose phosphate metabolic process 4 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034654 nucleobase-containing compound biosynthetic process 4 12
GO:0044208 'de novo' AMP biosynthetic process 9 11
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0044281 small molecule metabolic process 2 12
GO:0046033 AMP metabolic process 7 11
GO:0046040 IMP metabolic process 7 12
GO:0046390 ribose phosphate biosynthetic process 5 12
GO:0046483 heterocycle metabolic process 3 12
GO:0055086 nucleobase-containing small molecule metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0072521 purine-containing compound metabolic process 4 12
GO:0072522 purine-containing compound biosynthetic process 5 12
GO:0090407 organophosphate biosynthetic process 4 12
GO:1901135 carbohydrate derivative metabolic process 3 12
GO:1901137 carbohydrate derivative biosynthetic process 4 12
GO:1901293 nucleoside phosphate biosynthetic process 5 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity 5 12
GO:0016829 lyase activity 2 12
GO:0016840 carbon-nitrogen lyase activity 3 12
GO:0016842 amidine-lyase activity 4 12
GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity 5 11
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 1
GO:0036094 small molecule binding 2 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 362 366 PF00656 0.301
CLV_NRD_NRD_1 266 268 PF00675 0.335
CLV_NRD_NRD_1 387 389 PF00675 0.378
CLV_NRD_NRD_1 420 422 PF00675 0.301
CLV_PCSK_FUR_1 40 44 PF00082 0.274
CLV_PCSK_KEX2_1 266 268 PF00082 0.260
CLV_PCSK_KEX2_1 387 389 PF00082 0.378
CLV_PCSK_KEX2_1 42 44 PF00082 0.274
CLV_PCSK_KEX2_1 420 422 PF00082 0.301
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.274
CLV_PCSK_SKI1_1 107 111 PF00082 0.340
CLV_PCSK_SKI1_1 162 166 PF00082 0.310
CLV_PCSK_SKI1_1 220 224 PF00082 0.303
CLV_PCSK_SKI1_1 361 365 PF00082 0.317
CLV_PCSK_SKI1_1 392 396 PF00082 0.427
CLV_PCSK_SKI1_1 432 436 PF00082 0.301
CLV_PCSK_SKI1_1 83 87 PF00082 0.274
DEG_APCC_DBOX_1 219 227 PF00400 0.474
DEG_APCC_DBOX_1 460 468 PF00400 0.301
DEG_SPOP_SBC_1 13 17 PF00917 0.428
DOC_CYCLIN_yClb5_NLxxxL_5 370 376 PF00134 0.422
DOC_CYCLIN_yCln2_LP_2 372 378 PF00134 0.301
DOC_MAPK_gen_1 387 395 PF00069 0.378
DOC_MAPK_gen_1 59 66 PF00069 0.460
DOC_MAPK_MEF2A_6 59 66 PF00069 0.460
DOC_PP2B_LxvP_1 224 227 PF13499 0.510
DOC_PP2B_LxvP_1 372 375 PF13499 0.301
DOC_USP7_MATH_1 382 386 PF00917 0.290
DOC_WW_Pin1_4 198 203 PF00397 0.449
DOC_WW_Pin1_4 26 31 PF00397 0.479
DOC_WW_Pin1_4 32 37 PF00397 0.433
DOC_WW_Pin1_4 43 48 PF00397 0.440
DOC_WW_Pin1_4 465 470 PF00397 0.301
LIG_14-3-3_CanoR_1 267 277 PF00244 0.445
LIG_14-3-3_CanoR_1 49 58 PF00244 0.475
LIG_14-3-3_CanoR_1 83 90 PF00244 0.461
LIG_14-3-3_CanoR_1 94 99 PF00244 0.459
LIG_Actin_RPEL_3 381 400 PF02755 0.324
LIG_Actin_WH2_2 373 389 PF00022 0.405
LIG_Actin_WH2_2 69 85 PF00022 0.462
LIG_BIR_II_1 1 5 PF00653 0.689
LIG_FHA_1 219 225 PF00498 0.562
LIG_FHA_1 269 275 PF00498 0.455
LIG_FHA_1 43 49 PF00498 0.457
LIG_FHA_1 455 461 PF00498 0.441
LIG_FHA_2 114 120 PF00498 0.340
LIG_FHA_2 146 152 PF00498 0.452
LIG_FHA_2 270 276 PF00498 0.449
LIG_FHA_2 94 100 PF00498 0.536
LIG_GBD_Chelix_1 411 419 PF00786 0.301
LIG_IRF3_LxIS_1 350 357 PF10401 0.364
LIG_LIR_Apic_2 186 190 PF02991 0.462
LIG_LIR_Apic_2 422 427 PF02991 0.301
LIG_LIR_Gen_1 139 147 PF02991 0.463
LIG_LIR_Gen_1 275 283 PF02991 0.460
LIG_LIR_Gen_1 300 310 PF02991 0.449
LIG_LIR_Gen_1 405 415 PF02991 0.288
LIG_LIR_Gen_1 468 477 PF02991 0.306
LIG_LIR_Gen_1 53 62 PF02991 0.474
LIG_LIR_Gen_1 96 106 PF02991 0.536
LIG_LIR_Nem_3 139 145 PF02991 0.462
LIG_LIR_Nem_3 253 257 PF02991 0.474
LIG_LIR_Nem_3 260 265 PF02991 0.491
LIG_LIR_Nem_3 275 280 PF02991 0.334
LIG_LIR_Nem_3 300 305 PF02991 0.449
LIG_LIR_Nem_3 405 411 PF02991 0.288
LIG_LIR_Nem_3 468 473 PF02991 0.293
LIG_LIR_Nem_3 53 58 PF02991 0.460
LIG_LIR_Nem_3 96 101 PF02991 0.536
LIG_LYPXL_yS_3 246 249 PF13949 0.449
LIG_NRBOX 175 181 PF00104 0.528
LIG_Pex14_2 254 258 PF04695 0.449
LIG_SH2_CRK 277 281 PF00017 0.474
LIG_SH2_GRB2like 277 280 PF00017 0.489
LIG_SH2_PTP2 304 307 PF00017 0.553
LIG_SH2_STAP1 270 274 PF00017 0.459
LIG_SH2_STAP1 277 281 PF00017 0.434
LIG_SH2_STAT3 270 273 PF00017 0.474
LIG_SH2_STAT3 309 312 PF00017 0.510
LIG_SH2_STAT3 60 63 PF00017 0.535
LIG_SH2_STAT5 126 129 PF00017 0.463
LIG_SH2_STAT5 169 172 PF00017 0.440
LIG_SH2_STAT5 262 265 PF00017 0.454
LIG_SH2_STAT5 270 273 PF00017 0.430
LIG_SH2_STAT5 304 307 PF00017 0.449
LIG_SH2_STAT5 309 312 PF00017 0.449
LIG_SH2_STAT5 472 475 PF00017 0.383
LIG_SH2_STAT5 51 54 PF00017 0.474
LIG_SH2_STAT5 68 71 PF00017 0.460
LIG_SH3_3 196 202 PF00018 0.449
LIG_SUMO_SIM_par_1 463 468 PF11976 0.318
LIG_TRAF2_1 5 8 PF00917 0.696
LIG_TRFH_1 32 36 PF08558 0.453
LIG_UBA3_1 176 183 PF00899 0.474
LIG_UBA3_1 222 231 PF00899 0.511
LIG_UBA3_1 293 299 PF00899 0.511
MOD_CDK_SPxK_1 43 49 PF00069 0.486
MOD_CK1_1 2 8 PF00069 0.684
MOD_CK1_1 26 32 PF00069 0.560
MOD_CK2_1 2 8 PF00069 0.700
MOD_CK2_1 269 275 PF00069 0.449
MOD_CK2_1 399 405 PF00069 0.221
MOD_CK2_1 93 99 PF00069 0.541
MOD_GlcNHglycan 131 134 PF01048 0.353
MOD_GlcNHglycan 321 324 PF01048 0.260
MOD_GlcNHglycan 350 353 PF01048 0.428
MOD_GlcNHglycan 4 7 PF01048 0.678
MOD_GSK3_1 218 225 PF00069 0.558
MOD_GSK3_1 26 33 PF00069 0.464
MOD_N-GLC_1 152 157 PF02516 0.253
MOD_NEK2_1 145 150 PF00069 0.460
MOD_NEK2_1 179 184 PF00069 0.493
MOD_NEK2_1 192 197 PF00069 0.434
MOD_NEK2_1 222 227 PF00069 0.553
MOD_NEK2_1 257 262 PF00069 0.497
MOD_NEK2_1 340 345 PF00069 0.384
MOD_NEK2_1 363 368 PF00069 0.324
MOD_NEK2_1 93 98 PF00069 0.491
MOD_NEK2_2 382 387 PF00069 0.354
MOD_PIKK_1 146 152 PF00454 0.460
MOD_PIKK_1 23 29 PF00454 0.558
MOD_PIKK_1 269 275 PF00454 0.449
MOD_PIKK_1 77 83 PF00454 0.553
MOD_PKA_1 42 48 PF00069 0.474
MOD_PKA_2 268 274 PF00069 0.538
MOD_PKA_2 42 48 PF00069 0.457
MOD_PKA_2 93 99 PF00069 0.504
MOD_PKB_1 267 275 PF00069 0.553
MOD_Plk_1 152 158 PF00069 0.447
MOD_Plk_1 364 370 PF00069 0.301
MOD_Plk_1 442 448 PF00069 0.340
MOD_Plk_2-3 454 460 PF00069 0.447
MOD_Plk_4 289 295 PF00069 0.553
MOD_Plk_4 364 370 PF00069 0.316
MOD_Plk_4 414 420 PF00069 0.301
MOD_ProDKin_1 198 204 PF00069 0.449
MOD_ProDKin_1 26 32 PF00069 0.475
MOD_ProDKin_1 43 49 PF00069 0.440
MOD_ProDKin_1 465 471 PF00069 0.301
MOD_SUMO_rev_2 113 123 PF00179 0.460
MOD_SUMO_rev_2 306 314 PF00179 0.465
MOD_SUMO_rev_2 99 109 PF00179 0.460
TRG_DiLeu_BaEn_3 217 223 PF01217 0.553
TRG_ENDOCYTIC_2 246 249 PF00928 0.449
TRG_ENDOCYTIC_2 262 265 PF00928 0.460
TRG_ENDOCYTIC_2 277 280 PF00928 0.370
TRG_ENDOCYTIC_2 304 307 PF00928 0.449
TRG_ENDOCYTIC_2 428 431 PF00928 0.301
TRG_ENDOCYTIC_2 55 58 PF00928 0.460
TRG_ER_diArg_1 265 267 PF00400 0.535
TRG_ER_diArg_1 386 388 PF00400 0.378
TRG_ER_diArg_1 419 421 PF00400 0.301
TRG_Pf-PMV_PEXEL_1 361 365 PF00026 0.301

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H3AL67 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) 48% 100%
A0A0N1I0W7 Leptomonas seymouri 84% 100%
A0A0S4JC64 Bodo saltans 70% 100%
A0A1X0NMR7 Trypanosomatidae 72% 100%
A0A3R7N1M2 Trypanosoma rangeli 73% 100%
A3KN12 Bos taurus 23% 98%
A4H3W5 Leishmania braziliensis 91% 100%
A5IGB3 Legionella pneumophila (strain Corby) 47% 100%
A7LBL3 Leishmania donovani 100% 100%
C9ZY37 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9AK27 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O28041 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 30% 100%
P0AB89 Escherichia coli (strain K12) 50% 100%
P0AB90 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 50% 100%
P12047 Bacillus subtilis (strain 168) 25% 100%
P21265 Gallus gallus 24% 99%
P30566 Homo sapiens 26% 99%
P44797 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 49% 100%
P57351 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 43% 100%
P72478 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 28% 100%
Q2FFI7 Staphylococcus aureus (strain USA300) 24% 100%
Q2G2S0 Staphylococcus aureus (strain NCTC 8325 / PS 47) 24% 100%
Q2YU66 Staphylococcus aureus (strain bovine RF122 / ET3-1) 24% 100%
Q49YV3 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 24% 100%
Q4L7M3 Staphylococcus haemolyticus (strain JCSC1435) 25% 100%
Q54J34 Dictyostelium discoideum 55% 100%
Q58339 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 28% 100%
Q5HEL4 Staphylococcus aureus (strain COL) 24% 100%
Q5HN26 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 24% 100%
Q5ZXD1 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 47% 100%
Q6G825 Staphylococcus aureus (strain MSSA476) 24% 100%
Q6GFE9 Staphylococcus aureus (strain MRSA252) 24% 100%
Q7A0G9 Staphylococcus aureus (strain MW2) 24% 100%
Q7A4Q3 Staphylococcus aureus (strain N315) 24% 100%
Q89AM3 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 41% 100%
Q8CRT6 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 24% 100%
Q8HXY5 Macaca fascicularis 26% 99%
Q8K9Q7 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 42% 100%
Q99SX9 Staphylococcus aureus (strain Mu50 / ATCC 700699) 24% 100%
Q9I0K9 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 50% 100%
Q9RSE6 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 26% 100%
Q9U0T7 Leishmania major 96% 100%
Q9X0I0 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 27% 100%
V5BE01 Trypanosoma cruzi 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS