LeishMANIAdb
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Putative calpain-like cysteine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative calpain-like cysteine peptidase
Gene product:
cysteine peptidase - Clan CA - family C2 - putative
Species:
Leishmania infantum
UniProt:
A4HS39_LEIIN
TriTrypDb:
LINF_040009500
Length:
855

Annotations

Annotations by Jardim et al.

Proteases, calpain-like cysteine peptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) yes yes: 3
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 16
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 101
NetGPI no yes: 0, no: 103
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 5
GO:0005815 microtubule organizing center 2 1
GO:0005856 cytoskeleton 5 1
GO:0020016 ciliary pocket 2 1
GO:0020038 subpellicular network 2 1
GO:0030863 cortical cytoskeleton 6 1
GO:0036064 ciliary basal body 3 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0005930 axoneme 2 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HS39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS39

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 104
GO:0006807 nitrogen compound metabolic process 2 104
GO:0008152 metabolic process 1 104
GO:0019538 protein metabolic process 3 104
GO:0043170 macromolecule metabolic process 3 104
GO:0044238 primary metabolic process 2 104
GO:0071704 organic substance metabolic process 2 104
GO:1901564 organonitrogen compound metabolic process 3 104
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 104
GO:0004175 endopeptidase activity 4 104
GO:0004197 cysteine-type endopeptidase activity 5 104
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6 104
GO:0008233 peptidase activity 3 104
GO:0008234 cysteine-type peptidase activity 4 104
GO:0016787 hydrolase activity 2 104
GO:0140096 catalytic activity, acting on a protein 2 104

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 274 278 PF00656 0.498
CLV_C14_Caspase3-7 797 801 PF00656 0.335
CLV_NRD_NRD_1 489 491 PF00675 0.442
CLV_NRD_NRD_1 85 87 PF00675 0.582
CLV_PCSK_KEX2_1 313 315 PF00082 0.375
CLV_PCSK_PC1ET2_1 313 315 PF00082 0.405
CLV_PCSK_SKI1_1 310 314 PF00082 0.455
CLV_PCSK_SKI1_1 401 405 PF00082 0.401
CLV_PCSK_SKI1_1 87 91 PF00082 0.631
DEG_Kelch_Keap1_1 207 212 PF01344 0.454
DEG_SCF_FBW7_1 125 131 PF00400 0.549
DOC_CDC14_PxL_1 735 743 PF14671 0.470
DOC_CKS1_1 125 130 PF01111 0.789
DOC_CKS1_1 497 502 PF01111 0.549
DOC_CYCLIN_yClb1_LxF_4 287 293 PF00134 0.511
DOC_CYCLIN_yCln2_LP_2 555 561 PF00134 0.624
DOC_MAPK_gen_1 782 790 PF00069 0.490
DOC_MAPK_gen_1 91 101 PF00069 0.423
DOC_MAPK_MEF2A_6 644 651 PF00069 0.467
DOC_MAPK_MEF2A_6 782 790 PF00069 0.528
DOC_MAPK_MEF2A_6 94 103 PF00069 0.430
DOC_PP1_RVXF_1 136 142 PF00149 0.710
DOC_PP1_RVXF_1 389 395 PF00149 0.556
DOC_PP2B_LxvP_1 101 104 PF13499 0.571
DOC_PP2B_LxvP_1 685 688 PF13499 0.316
DOC_PP2B_LxvP_1 736 739 PF13499 0.450
DOC_PP4_FxxP_1 156 159 PF00568 0.373
DOC_PP4_FxxP_1 372 375 PF00568 0.559
DOC_PP4_FxxP_1 616 619 PF00568 0.460
DOC_PP4_FxxP_1 761 764 PF00568 0.349
DOC_PP4_FxxP_1 82 85 PF00568 0.562
DOC_USP7_MATH_1 299 303 PF00917 0.532
DOC_USP7_MATH_1 668 672 PF00917 0.552
DOC_USP7_UBL2_3 434 438 PF12436 0.553
DOC_USP7_UBL2_3 543 547 PF12436 0.622
DOC_USP7_UBL2_3 87 91 PF12436 0.625
DOC_WW_Pin1_4 121 126 PF00397 0.669
DOC_WW_Pin1_4 194 199 PF00397 0.431
DOC_WW_Pin1_4 496 501 PF00397 0.561
DOC_WW_Pin1_4 510 515 PF00397 0.554
LIG_14-3-3_CanoR_1 168 174 PF00244 0.455
LIG_14-3-3_CanoR_1 391 395 PF00244 0.532
LIG_14-3-3_CanoR_1 625 631 PF00244 0.482
LIG_14-3-3_CanoR_1 86 93 PF00244 0.637
LIG_APCC_ABBA_1 827 832 PF00400 0.385
LIG_BIR_II_1 1 5 PF00653 0.796
LIG_BRCT_BRCA1_1 178 182 PF00533 0.393
LIG_BRCT_BRCA1_1 19 23 PF00533 0.802
LIG_BRCT_BRCA1_1 512 516 PF00533 0.675
LIG_deltaCOP1_diTrp_1 711 716 PF00928 0.519
LIG_FHA_1 527 533 PF00498 0.566
LIG_FHA_1 593 599 PF00498 0.590
LIG_FHA_1 648 654 PF00498 0.536
LIG_FHA_1 723 729 PF00498 0.551
LIG_FHA_1 822 828 PF00498 0.534
LIG_FHA_2 195 201 PF00498 0.416
LIG_FHA_2 203 209 PF00498 0.287
LIG_FHA_2 274 280 PF00498 0.489
LIG_FHA_2 358 364 PF00498 0.507
LIG_FHA_2 4 10 PF00498 0.627
LIG_FHA_2 599 605 PF00498 0.589
LIG_FHA_2 627 633 PF00498 0.492
LIG_Integrin_isoDGR_2 477 479 PF01839 0.240
LIG_LIR_Apic_2 153 159 PF02991 0.368
LIG_LIR_Apic_2 760 764 PF02991 0.360
LIG_LIR_Apic_2 79 85 PF02991 0.616
LIG_LIR_Gen_1 433 444 PF02991 0.558
LIG_LIR_Gen_1 596 606 PF02991 0.561
LIG_LIR_Gen_1 711 722 PF02991 0.503
LIG_LIR_Gen_1 770 779 PF02991 0.346
LIG_LIR_Nem_3 172 176 PF02991 0.385
LIG_LIR_Nem_3 294 300 PF02991 0.515
LIG_LIR_Nem_3 406 412 PF02991 0.579
LIG_LIR_Nem_3 426 431 PF02991 0.550
LIG_LIR_Nem_3 442 446 PF02991 0.545
LIG_LIR_Nem_3 596 602 PF02991 0.552
LIG_LIR_Nem_3 677 681 PF02991 0.510
LIG_LIR_Nem_3 693 699 PF02991 0.553
LIG_LIR_Nem_3 711 717 PF02991 0.518
LIG_LIR_Nem_3 770 774 PF02991 0.640
LIG_LIR_Nem_3 817 822 PF02991 0.586
LIG_LIR_Nem_3 95 99 PF02991 0.548
LIG_LYPXL_yS_3 678 681 PF13949 0.428
LIG_Pex14_2 227 231 PF04695 0.449
LIG_SH2_CRK 443 447 PF00017 0.548
LIG_SH2_CRK 493 497 PF00017 0.564
LIG_SH2_CRK 696 700 PF00017 0.595
LIG_SH2_GRB2like 767 770 PF00017 0.298
LIG_SH2_NCK_1 122 126 PF00017 0.746
LIG_SH2_NCK_1 443 447 PF00017 0.571
LIG_SH2_PTP2 323 326 PF00017 0.599
LIG_SH2_PTP2 771 774 PF00017 0.309
LIG_SH2_STAT5 213 216 PF00017 0.430
LIG_SH2_STAT5 248 251 PF00017 0.499
LIG_SH2_STAT5 323 326 PF00017 0.537
LIG_SH2_STAT5 408 411 PF00017 0.556
LIG_SH2_STAT5 608 611 PF00017 0.572
LIG_SH2_STAT5 735 738 PF00017 0.438
LIG_SH2_STAT5 767 770 PF00017 0.602
LIG_SH2_STAT5 771 774 PF00017 0.533
LIG_SH2_STAT5 835 838 PF00017 0.542
LIG_SH3_1 122 128 PF00018 0.754
LIG_SH3_3 122 128 PF00018 0.698
LIG_SH3_3 163 169 PF00018 0.578
LIG_SH3_3 501 507 PF00018 0.553
LIG_SH3_3 640 646 PF00018 0.468
LIG_SH3_3 68 74 PF00018 0.721
LIG_SH3_3 817 823 PF00018 0.576
LIG_SUMO_SIM_anti_2 800 806 PF11976 0.529
LIG_SUMO_SIM_par_1 538 544 PF11976 0.650
LIG_SUMO_SIM_par_1 679 684 PF11976 0.469
LIG_TRAF2_1 67 70 PF00917 0.846
LIG_TRAF2_1 794 797 PF00917 0.344
LIG_TRAF2_1 829 832 PF00917 0.619
LIG_TRFH_1 735 739 PF08558 0.441
LIG_TYR_ITIM 161 166 PF00017 0.417
LIG_TYR_ITIM 676 681 PF00017 0.569
LIG_WRC_WIRS_1 187 192 PF05994 0.497
LIG_WW_3 91 95 PF00397 0.705
MOD_CDK_SPxK_1 496 502 PF00069 0.567
MOD_CK1_1 12 18 PF00069 0.679
MOD_CK1_1 124 130 PF00069 0.757
MOD_CK1_1 194 200 PF00069 0.394
MOD_CK1_1 237 243 PF00069 0.428
MOD_CK1_1 303 309 PF00069 0.551
MOD_CK1_1 563 569 PF00069 0.589
MOD_CK2_1 194 200 PF00069 0.392
MOD_CK2_1 202 208 PF00069 0.352
MOD_CK2_1 273 279 PF00069 0.524
MOD_CK2_1 299 305 PF00069 0.553
MOD_CK2_1 357 363 PF00069 0.545
MOD_GlcNHglycan 239 242 PF01048 0.460
MOD_GlcNHglycan 305 308 PF01048 0.372
MOD_GlcNHglycan 379 382 PF01048 0.373
MOD_GlcNHglycan 447 450 PF01048 0.357
MOD_GlcNHglycan 562 565 PF01048 0.404
MOD_GlcNHglycan 729 733 PF01048 0.453
MOD_GSK3_1 124 131 PF00069 0.751
MOD_GSK3_1 202 209 PF00069 0.415
MOD_GSK3_1 233 240 PF00069 0.429
MOD_GSK3_1 299 306 PF00069 0.545
MOD_GSK3_1 510 517 PF00069 0.569
MOD_GSK3_1 647 654 PF00069 0.522
MOD_GSK3_1 700 707 PF00069 0.481
MOD_N-GLC_1 12 17 PF02516 0.660
MOD_N-GLC_1 169 174 PF02516 0.401
MOD_N-GLC_1 176 181 PF02516 0.399
MOD_N-GLC_1 700 705 PF02516 0.500
MOD_NEK2_1 199 204 PF00069 0.349
MOD_NEK2_1 215 220 PF00069 0.470
MOD_NEK2_1 399 404 PF00069 0.577
MOD_NEK2_1 439 444 PF00069 0.559
MOD_NEK2_1 526 531 PF00069 0.554
MOD_NEK2_1 639 644 PF00069 0.455
MOD_NEK2_1 647 652 PF00069 0.441
MOD_PIKK_1 242 248 PF00454 0.525
MOD_PIKK_1 357 363 PF00454 0.624
MOD_PIKK_1 480 486 PF00454 0.624
MOD_PIKK_1 704 710 PF00454 0.569
MOD_PKA_2 390 396 PF00069 0.533
MOD_PKA_2 85 91 PF00069 0.583
MOD_Plk_1 12 18 PF00069 0.631
MOD_Plk_1 169 175 PF00069 0.416
MOD_Plk_1 215 221 PF00069 0.431
MOD_Plk_1 293 299 PF00069 0.553
MOD_Plk_1 593 599 PF00069 0.537
MOD_Plk_1 647 653 PF00069 0.456
MOD_Plk_1 744 750 PF00069 0.549
MOD_Plk_2-3 178 184 PF00069 0.355
MOD_Plk_4 12 18 PF00069 0.671
MOD_Plk_4 215 221 PF00069 0.415
MOD_Plk_4 363 369 PF00069 0.564
MOD_Plk_4 535 541 PF00069 0.574
MOD_Plk_4 593 599 PF00069 0.558
MOD_Plk_4 647 653 PF00069 0.434
MOD_ProDKin_1 121 127 PF00069 0.681
MOD_ProDKin_1 194 200 PF00069 0.431
MOD_ProDKin_1 496 502 PF00069 0.561
MOD_ProDKin_1 510 516 PF00069 0.554
MOD_SUMO_for_1 324 327 PF00179 0.624
MOD_SUMO_rev_2 538 545 PF00179 0.600
TRG_DiLeu_BaEn_1 157 162 PF01217 0.410
TRG_DiLeu_BaEn_2 222 228 PF01217 0.333
TRG_DiLeu_BaEn_4 157 163 PF01217 0.414
TRG_DiLeu_BaLyEn_6 548 553 PF01217 0.606
TRG_ENDOCYTIC_2 163 166 PF00928 0.396
TRG_ENDOCYTIC_2 408 411 PF00928 0.575
TRG_ENDOCYTIC_2 443 446 PF00928 0.551
TRG_ENDOCYTIC_2 493 496 PF00928 0.555
TRG_ENDOCYTIC_2 537 540 PF00928 0.577
TRG_ENDOCYTIC_2 678 681 PF00928 0.465
TRG_ENDOCYTIC_2 696 699 PF00928 0.520
TRG_ENDOCYTIC_2 735 738 PF00928 0.419
TRG_ENDOCYTIC_2 771 774 PF00928 0.564
TRG_ER_diArg_1 319 322 PF00400 0.579
TRG_ER_diArg_1 335 338 PF00400 0.565
TRG_Pf-PMV_PEXEL_1 422 426 PF00026 0.364
TRG_Pf-PMV_PEXEL_1 479 484 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 51 56 PF00026 0.825

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8T6 Leptomonas seymouri 32% 100%
A0A0N1I8N2 Leptomonas seymouri 28% 87%
A0A0N1IGQ2 Leptomonas seymouri 31% 100%
A0A0N1ILF1 Leptomonas seymouri 34% 100%
A0A0N1IMH1 Leptomonas seymouri 29% 100%
A0A0N1P9P1 Leptomonas seymouri 71% 100%
A0A0N1PCA9 Leptomonas seymouri 32% 100%
A0A0N1PE91 Leptomonas seymouri 26% 96%
A0A0N1PFI4 Leptomonas seymouri 35% 100%
A0A0S4JLK6 Bodo saltans 28% 100%
A0A0S4JS70 Bodo saltans 25% 100%
A0A0S4KGT2 Bodo saltans 35% 100%
A0A1X0NJ19 Trypanosomatidae 28% 70%
A0A1X0NJK2 Trypanosomatidae 33% 100%
A0A1X0NJX8 Trypanosomatidae 32% 100%
A0A1X0NKT7 Trypanosomatidae 32% 100%
A0A1X0NKX8 Trypanosomatidae 31% 100%
A0A1X0NMT3 Trypanosomatidae 47% 100%
A0A1X0NW84 Trypanosomatidae 35% 100%
A0A1X0NW85 Trypanosomatidae 34% 100%
A0A1X0NW89 Trypanosomatidae 44% 99%
A0A1X0NWA6 Trypanosomatidae 29% 98%
A0A1X0NWW1 Trypanosomatidae 41% 100%
A0A3Q8IBS3 Leishmania donovani 41% 94%
A0A3Q8IDD4 Leishmania donovani 31% 100%
A0A3Q8IJT4 Leishmania donovani 27% 100%
A0A3S5H5A5 Leishmania donovani 100% 100%
A0A3S5ISG2 Trypanosoma rangeli 32% 100%
A0A3S7WW13 Leishmania donovani 28% 77%
A0A3S7WW18 Leishmania donovani 41% 100%
A0A3S7WW41 Leishmania donovani 31% 100%
A0A3S7WW71 Leishmania donovani 36% 100%
A0A3S7X430 Leishmania donovani 30% 100%
A0A3S7X438 Leishmania donovani 32% 91%
A0A3S7X460 Leishmania donovani 31% 100%
A0A3S7X463 Leishmania donovani 30% 91%
A0A3S7X470 Leishmania donovani 34% 100%
A0A422MYU1 Trypanosoma rangeli 44% 93%
A0A422MYX0 Trypanosoma rangeli 35% 100%
A4H3W4 Leishmania braziliensis 85% 100%
A4HE81 Leishmania braziliensis 30% 100%
A4HJ14 Leishmania braziliensis 30% 100%
A4HJ21 Leishmania braziliensis 28% 96%
A4HJ22 Leishmania braziliensis 30% 100%
A4HJ24 Leishmania braziliensis 31% 100%
A4HYN0 Leishmania infantum 41% 100%
A4HYW1 Leishmania infantum 41% 84%
A4HYW2 Leishmania infantum 36% 100%
A4HYW3 Leishmania infantum 31% 100%
A4HYW4 Leishmania infantum 28% 86%
A4I1J4 Leishmania infantum 31% 100%
A4I6E4 Leishmania infantum 34% 100%
A4I6E6 Leishmania infantum 31% 100%
A4I6F0 Leishmania infantum 32% 91%
A4I6K4 Leishmania infantum 30% 100%
A4I6K5 Leishmania infantum 30% 91%
A4I6K6 Leishmania infantum 27% 100%
C9ZIE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 79%
C9ZIE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZIE9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZN52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZN53 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZWY4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZY36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E8NHG6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 98%
E8NHG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E8NHG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E8NHM2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E8NHM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E8NHM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AIH1 Leishmania braziliensis 41% 100%
E9AIH3 Leishmania braziliensis 37% 100%
E9AIH4 Leishmania braziliensis 33% 100%
E9AK26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AUQ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AUQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AUR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AXM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B1J0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B1J2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B1J6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4Q6L7 Leishmania major 31% 100%
Q4Q6L9 Leishmania major 34% 100%
Q4Q6M0 Leishmania major 31% 100%
Q4Q6M2 Leishmania major 28% 100%
Q4Q6M3 Leishmania major 29% 100%
Q4Q6M4 Leishmania major 31% 100%
Q4Q9U3 Leishmania major 31% 98%
Q4QCS6 Leishmania major 32% 100%
Q4QCS7 Leishmania major 36% 100%
Q4QCS8 Leishmania major 41% 100%
Q4QCS9 Leishmania major 41% 100%
Q9U0T9 Leishmania major 96% 100%
V5AYJ1 Trypanosoma cruzi 30% 100%
V5B5I4 Trypanosoma cruzi 43% 100%
V5BA05 Trypanosoma cruzi 40% 100%
V5BEL3 Trypanosoma cruzi 34% 100%
V5BII7 Trypanosoma cruzi 28% 69%
V5BN20 Trypanosoma cruzi 31% 100%
V5D5V8 Trypanosoma cruzi 29% 100%
V5D9Y2 Trypanosoma cruzi 46% 100%
V5DES7 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS