TPR_REGION domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HS36_LEIIN

TriTrypDb:

LINF_040009200

Length:

361

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HS36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS36

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.593
CLV_PCSK_KEX2_1	8	10	PF00082	0.593
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.655
CLV_PCSK_SKI1_1	137	141	PF00082	0.404
CLV_PCSK_SKI1_1	271	275	PF00082	0.328
CLV_PCSK_SKI1_1	308	312	PF00082	0.421
CLV_PCSK_SKI1_1	39	43	PF00082	0.340
DEG_ODPH_VHL_1	53	65	PF01847	0.428
DOC_CDC14_PxL_1	51	59	PF14671	0.441
DOC_SPAK_OSR1_1	97	101	PF12202	0.451

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D5	Leptomonas seymouri	77%	98%
A0A0S4JCG4	Bodo saltans	44%	75%
A0A1X0NKZ6	Trypanosomatidae	42%	100%
A0A3R7R703	Trypanosoma rangeli	44%	100%
A0A3S5H5A3	Leishmania donovani	100%	100%
A4H3W2	Leishmania braziliensis	92%	100%
C9ZY33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AK23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O97220	Leishmania major	98%	100%
V5D9X8	Trypanosoma cruzi	44%	100%

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