Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS35_LEIIN

TriTrypDb:

LINF_040009100

Length:

1121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.679
CLV_C14_Caspase3-7	381	385	PF00656	0.668
CLV_C14_Caspase3-7	705	709	PF00656	0.733
CLV_C14_Caspase3-7	907	911	PF00656	0.660
CLV_C14_Caspase3-7	916	920	PF00656	0.610
CLV_NRD_NRD_1	100	102	PF00675	0.729
CLV_NRD_NRD_1	106	108	PF00675	0.668
CLV_NRD_NRD_1	132	134	PF00675	0.674
CLV_NRD_NRD_1	2	4	PF00675	0.581
CLV_NRD_NRD_1	209	211	PF00675	0.652
CLV_NRD_NRD_1	238	240	PF00675	0.583
CLV_NRD_NRD_1	248	250	PF00675	0.568
CLV_NRD_NRD_1	331	333	PF00675	0.673
CLV_NRD_NRD_1	347	349	PF00675	0.621
CLV_NRD_NRD_1	362	364	PF00675	0.578
CLV_NRD_NRD_1	418	420	PF00675	0.704
CLV_NRD_NRD_1	429	431	PF00675	0.616
CLV_NRD_NRD_1	52	54	PF00675	0.580
CLV_NRD_NRD_1	582	584	PF00675	0.700
CLV_NRD_NRD_1	751	753	PF00675	0.722
CLV_PCSK_FUR_1	359	363	PF00082	0.723
CLV_PCSK_KEX2_1	100	102	PF00082	0.729
CLV_PCSK_KEX2_1	105	107	PF00082	0.681
CLV_PCSK_KEX2_1	132	134	PF00082	0.674
CLV_PCSK_KEX2_1	2	4	PF00082	0.581
CLV_PCSK_KEX2_1	209	211	PF00082	0.707
CLV_PCSK_KEX2_1	238	240	PF00082	0.594
CLV_PCSK_KEX2_1	247	249	PF00082	0.610
CLV_PCSK_KEX2_1	331	333	PF00082	0.673
CLV_PCSK_KEX2_1	347	349	PF00082	0.621
CLV_PCSK_KEX2_1	361	363	PF00082	0.586
CLV_PCSK_KEX2_1	418	420	PF00082	0.694
CLV_PCSK_KEX2_1	429	431	PF00082	0.611
CLV_PCSK_KEX2_1	52	54	PF00082	0.622
CLV_PCSK_KEX2_1	582	584	PF00082	0.700
CLV_PCSK_KEX2_1	751	753	PF00082	0.725
CLV_PCSK_PC7_1	101	107	PF00082	0.658
CLV_PCSK_PC7_1	244	250	PF00082	0.618
CLV_PCSK_PC7_1	357	363	PF00082	0.723
CLV_PCSK_PC7_1	747	753	PF00082	0.727
CLV_PCSK_SKI1_1	752	756	PF00082	0.718
CLV_PCSK_SKI1_1	85	89	PF00082	0.653
DEG_Nend_UBRbox_1	1	4	PF02207	0.649
DEG_SCF_FBW7_1	771	777	PF00400	0.713
DEG_SPOP_SBC_1	124	128	PF00917	0.622
DEG_SPOP_SBC_1	801	805	PF00917	0.628
DEG_SPOP_SBC_1	808	812	PF00917	0.625
DOC_CKS1_1	1043	1048	PF01111	0.684
DOC_CKS1_1	342	347	PF01111	0.680
DOC_CKS1_1	771	776	PF01111	0.721
DOC_CKS1_1	948	953	PF01111	0.662
DOC_MAPK_gen_1	751	757	PF00069	0.714
DOC_PP4_FxxP_1	303	306	PF00568	0.642
DOC_USP7_MATH_1	109	113	PF00917	0.712
DOC_USP7_MATH_1	116	120	PF00917	0.666
DOC_USP7_MATH_1	125	129	PF00917	0.577
DOC_USP7_MATH_1	18	22	PF00917	0.678
DOC_USP7_MATH_1	188	192	PF00917	0.719
DOC_USP7_MATH_1	205	209	PF00917	0.524
DOC_USP7_MATH_1	251	255	PF00917	0.658
DOC_USP7_MATH_1	334	338	PF00917	0.691
DOC_USP7_MATH_1	343	347	PF00917	0.668
DOC_USP7_MATH_1	369	373	PF00917	0.722
DOC_USP7_MATH_1	374	378	PF00917	0.665
DOC_USP7_MATH_1	46	50	PF00917	0.694
DOC_USP7_MATH_1	506	510	PF00917	0.665
DOC_USP7_MATH_1	549	553	PF00917	0.685
DOC_USP7_MATH_1	596	600	PF00917	0.598
DOC_USP7_MATH_1	693	697	PF00917	0.626
DOC_USP7_MATH_1	71	75	PF00917	0.694
DOC_USP7_MATH_1	730	734	PF00917	0.679
DOC_USP7_MATH_1	801	805	PF00917	0.615
DOC_USP7_MATH_1	821	825	PF00917	0.597
DOC_USP7_MATH_1	842	846	PF00917	0.597
DOC_USP7_MATH_1	850	854	PF00917	0.553
DOC_USP7_MATH_1	932	936	PF00917	0.660
DOC_USP7_MATH_1	991	995	PF00917	0.701
DOC_WW_Pin1_4	1042	1047	PF00397	0.686
DOC_WW_Pin1_4	190	195	PF00397	0.681
DOC_WW_Pin1_4	22	27	PF00397	0.684
DOC_WW_Pin1_4	302	307	PF00397	0.655
DOC_WW_Pin1_4	341	346	PF00397	0.723
DOC_WW_Pin1_4	362	367	PF00397	0.726
DOC_WW_Pin1_4	370	375	PF00397	0.639
DOC_WW_Pin1_4	39	44	PF00397	0.531
DOC_WW_Pin1_4	602	607	PF00397	0.586
DOC_WW_Pin1_4	623	628	PF00397	0.665
DOC_WW_Pin1_4	634	639	PF00397	0.603
DOC_WW_Pin1_4	647	652	PF00397	0.592
DOC_WW_Pin1_4	65	70	PF00397	0.693
DOC_WW_Pin1_4	681	686	PF00397	0.690
DOC_WW_Pin1_4	694	699	PF00397	0.575
DOC_WW_Pin1_4	713	718	PF00397	0.534
DOC_WW_Pin1_4	720	725	PF00397	0.646
DOC_WW_Pin1_4	764	769	PF00397	0.704
DOC_WW_Pin1_4	770	775	PF00397	0.656
DOC_WW_Pin1_4	809	814	PF00397	0.666
DOC_WW_Pin1_4	824	829	PF00397	0.603
DOC_WW_Pin1_4	858	863	PF00397	0.798
DOC_WW_Pin1_4	928	933	PF00397	0.693
DOC_WW_Pin1_4	936	941	PF00397	0.653
DOC_WW_Pin1_4	942	947	PF00397	0.597
LIG_14-3-3_CanoR_1	1041	1046	PF00244	0.680
LIG_14-3-3_CanoR_1	1051	1060	PF00244	0.610
LIG_14-3-3_CanoR_1	1112	1120	PF00244	0.558
LIG_14-3-3_CanoR_1	225	234	PF00244	0.590
LIG_14-3-3_CanoR_1	302	306	PF00244	0.654
LIG_14-3-3_CanoR_1	646	651	PF00244	0.633
LIG_14-3-3_CanoR_1	661	668	PF00244	0.658
LIG_14-3-3_CanoR_1	751	757	PF00244	0.777
LIG_14-3-3_CanoR_1	846	850	PF00244	0.688
LIG_14-3-3_CanoR_1	863	870	PF00244	0.584
LIG_14-3-3_CanoR_1	923	927	PF00244	0.680
LIG_14-3-3_CanoR_1	949	955	PF00244	0.677
LIG_BIR_III_4	384	388	PF00653	0.684
LIG_BIR_III_4	996	1000	PF00653	0.693
LIG_BRCT_BRCA1_1	961	965	PF00533	0.647
LIG_DLG_GKlike_1	961	969	PF00625	0.632
LIG_FHA_1	1026	1032	PF00498	0.633
LIG_FHA_1	1061	1067	PF00498	0.635
LIG_FHA_1	174	180	PF00498	0.639
LIG_FHA_1	328	334	PF00498	0.720
LIG_FHA_1	393	399	PF00498	0.663
LIG_FHA_1	595	601	PF00498	0.671
LIG_FHA_1	662	668	PF00498	0.658
LIG_FHA_1	685	691	PF00498	0.704
LIG_FHA_1	714	720	PF00498	0.738
LIG_FHA_2	150	156	PF00498	0.645
LIG_FHA_2	178	184	PF00498	0.682
LIG_FHA_2	31	37	PF00498	0.584
LIG_FHA_2	705	711	PF00498	0.727
LIG_LIR_Apic_2	301	306	PF02991	0.593
LIG_LIR_Gen_1	893	902	PF02991	0.738
LIG_LIR_Nem_3	140	146	PF02991	0.554
LIG_LIR_Nem_3	228	234	PF02991	0.666
LIG_LIR_Nem_3	893	899	PF02991	0.730
LIG_LYPXL_yS_3	841	844	PF13949	0.721
LIG_MYND_1	464	468	PF01753	0.544
LIG_SH2_SRC	1095	1098	PF00017	0.581
LIG_SH2_STAP1	1095	1099	PF00017	0.569
LIG_SH3_1	363	369	PF00018	0.726
LIG_SH3_1	64	70	PF00018	0.634
LIG_SH3_1	834	840	PF00018	0.652
LIG_SH3_1	985	991	PF00018	0.616
LIG_SH3_2	417	422	PF14604	0.679
LIG_SH3_2	717	722	PF14604	0.721
LIG_SH3_3	1066	1072	PF00018	0.675
LIG_SH3_3	118	124	PF00018	0.713
LIG_SH3_3	20	26	PF00018	0.686
LIG_SH3_3	363	369	PF00018	0.726
LIG_SH3_3	414	420	PF00018	0.675
LIG_SH3_3	435	441	PF00018	0.694
LIG_SH3_3	461	467	PF00018	0.610
LIG_SH3_3	468	474	PF00018	0.628
LIG_SH3_3	534	540	PF00018	0.629
LIG_SH3_3	588	594	PF00018	0.660
LIG_SH3_3	621	627	PF00018	0.700
LIG_SH3_3	64	70	PF00018	0.634
LIG_SH3_3	687	693	PF00018	0.661
LIG_SH3_3	714	720	PF00018	0.726
LIG_SH3_3	768	774	PF00018	0.708
LIG_SH3_3	834	840	PF00018	0.701
LIG_SH3_3	945	951	PF00018	0.702
LIG_SH3_3	985	991	PF00018	0.731
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.601
LIG_TRAF2_1	269	272	PF00917	0.689
LIG_TRAF2_1	285	288	PF00917	0.581
LIG_TRAF2_1	314	317	PF00917	0.667
LIG_WW_2	464	467	PF00397	0.542
MOD_CDC14_SPxK_1	637	640	PF00782	0.668
MOD_CDK_SPK_2	858	863	PF00069	0.750
MOD_CDK_SPxK_1	341	347	PF00069	0.726
MOD_CDK_SPxK_1	634	640	PF00069	0.669
MOD_CDK_SPxxK_3	1042	1049	PF00069	0.685
MOD_CDK_SPxxK_3	341	348	PF00069	0.728
MOD_CDK_SPxxK_3	942	949	PF00069	0.671
MOD_CK1_1	1004	1010	PF00069	0.697
MOD_CK1_1	1030	1036	PF00069	0.622
MOD_CK1_1	1056	1062	PF00069	0.679
MOD_CK1_1	111	117	PF00069	0.677
MOD_CK1_1	136	142	PF00069	0.634
MOD_CK1_1	170	176	PF00069	0.667
MOD_CK1_1	190	196	PF00069	0.663
MOD_CK1_1	208	214	PF00069	0.522
MOD_CK1_1	21	27	PF00069	0.677
MOD_CK1_1	255	261	PF00069	0.707
MOD_CK1_1	301	307	PF00069	0.606
MOD_CK1_1	377	383	PF00069	0.703
MOD_CK1_1	561	567	PF00069	0.682
MOD_CK1_1	58	64	PF00069	0.620
MOD_CK1_1	616	622	PF00069	0.742
MOD_CK1_1	626	632	PF00069	0.716
MOD_CK1_1	660	666	PF00069	0.714
MOD_CK1_1	669	675	PF00069	0.609
MOD_CK1_1	694	700	PF00069	0.672
MOD_CK1_1	713	719	PF00069	0.688
MOD_CK1_1	72	78	PF00069	0.574
MOD_CK1_1	733	739	PF00069	0.717
MOD_CK1_1	767	773	PF00069	0.715
MOD_CK1_1	795	801	PF00069	0.719
MOD_CK1_1	802	808	PF00069	0.660
MOD_CK1_1	824	830	PF00069	0.719
MOD_CK1_1	845	851	PF00069	0.632
MOD_CK1_1	858	864	PF00069	0.620
MOD_CK2_1	1095	1101	PF00069	0.668
MOD_CK2_1	733	739	PF00069	0.711
MOD_Cter_Amidation	130	133	PF01082	0.681
MOD_Cter_Amidation	50	53	PF01082	0.593
MOD_Cter_Amidation	98	101	PF01082	0.734
MOD_GlcNHglycan	1001	1004	PF01048	0.663
MOD_GlcNHglycan	1032	1035	PF01048	0.687
MOD_GlcNHglycan	1053	1056	PF01048	0.695
MOD_GlcNHglycan	1092	1095	PF01048	0.597
MOD_GlcNHglycan	111	114	PF01048	0.724
MOD_GlcNHglycan	135	138	PF01048	0.650
MOD_GlcNHglycan	139	142	PF01048	0.620
MOD_GlcNHglycan	158	161	PF01048	0.667
MOD_GlcNHglycan	16	19	PF01048	0.650
MOD_GlcNHglycan	27	30	PF01048	0.607
MOD_GlcNHglycan	281	284	PF01048	0.686
MOD_GlcNHglycan	33	36	PF01048	0.570
MOD_GlcNHglycan	336	339	PF01048	0.677
MOD_GlcNHglycan	442	445	PF01048	0.707
MOD_GlcNHglycan	48	51	PF01048	0.600
MOD_GlcNHglycan	491	494	PF01048	0.702
MOD_GlcNHglycan	508	511	PF01048	0.501
MOD_GlcNHglycan	526	529	PF01048	0.510
MOD_GlcNHglycan	668	671	PF01048	0.620
MOD_GlcNHglycan	713	716	PF01048	0.805
MOD_GlcNHglycan	752	755	PF01048	0.710
MOD_GlcNHglycan	774	777	PF01048	0.823
MOD_GlcNHglycan	782	785	PF01048	0.741
MOD_GlcNHglycan	794	797	PF01048	0.600
MOD_GlcNHglycan	798	801	PF01048	0.585
MOD_GlcNHglycan	819	822	PF01048	0.679
MOD_GlcNHglycan	823	826	PF01048	0.644
MOD_GlcNHglycan	934	937	PF01048	0.608
MOD_GlcNHglycan	961	964	PF01048	0.700
MOD_GlcNHglycan	965	968	PF01048	0.683
MOD_GlcNHglycan	988	991	PF01048	0.661
MOD_GSK3_1	1004	1011	PF00069	0.590
MOD_GSK3_1	1056	1063	PF00069	0.678
MOD_GSK3_1	12	19	PF00069	0.657
MOD_GSK3_1	132	139	PF00069	0.659
MOD_GSK3_1	167	174	PF00069	0.713
MOD_GSK3_1	21	28	PF00069	0.623
MOD_GSK3_1	251	258	PF00069	0.638
MOD_GSK3_1	298	305	PF00069	0.685
MOD_GSK3_1	370	377	PF00069	0.719
MOD_GSK3_1	506	513	PF00069	0.628
MOD_GSK3_1	545	552	PF00069	0.695
MOD_GSK3_1	555	562	PF00069	0.635
MOD_GSK3_1	626	633	PF00069	0.675
MOD_GSK3_1	634	641	PF00069	0.618
MOD_GSK3_1	65	72	PF00069	0.693
MOD_GSK3_1	657	664	PF00069	0.716
MOD_GSK3_1	666	673	PF00069	0.612
MOD_GSK3_1	693	700	PF00069	0.620
MOD_GSK3_1	711	718	PF00069	0.607
MOD_GSK3_1	746	753	PF00069	0.697
MOD_GSK3_1	755	762	PF00069	0.597
MOD_GSK3_1	770	777	PF00069	0.557
MOD_GSK3_1	791	798	PF00069	0.733
MOD_GSK3_1	817	824	PF00069	0.701
MOD_GSK3_1	887	894	PF00069	0.630
MOD_GSK3_1	928	935	PF00069	0.713
MOD_GSK3_1	959	966	PF00069	0.658
MOD_GSK3_1	991	998	PF00069	0.695
MOD_LATS_1	659	665	PF00433	0.667
MOD_N-GLC_1	1090	1095	PF02516	0.600
MOD_N-GLC_1	171	176	PF02516	0.670
MOD_N-GLC_1	298	303	PF02516	0.609
MOD_N-GLC_1	657	662	PF02516	0.713
MOD_NEK2_1	1053	1058	PF00069	0.727
MOD_NEK2_1	1090	1095	PF00069	0.576
MOD_NEK2_1	167	172	PF00069	0.695
MOD_NEK2_1	630	635	PF00069	0.679
MOD_NEK2_1	652	657	PF00069	0.726
MOD_NEK2_1	750	755	PF00069	0.707
MOD_NEK2_1	792	797	PF00069	0.686
MOD_NEK2_1	891	896	PF00069	0.629
MOD_NEK2_1	941	946	PF00069	0.720
MOD_PIKK_1	12	18	PF00454	0.643
MOD_PIKK_1	225	231	PF00454	0.633
MOD_PIKK_1	392	398	PF00454	0.662
MOD_PIKK_1	73	79	PF00454	0.686
MOD_PIKK_1	80	86	PF00454	0.608
MOD_PIKK_1	850	856	PF00454	0.647
MOD_PK_1	378	384	PF00069	0.701
MOD_PKA_1	132	138	PF00069	0.647
MOD_PKA_1	2	8	PF00069	0.580
MOD_PKA_2	1111	1117	PF00069	0.544
MOD_PKA_2	131	137	PF00069	0.715
MOD_PKA_2	174	180	PF00069	0.603
MOD_PKA_2	2	8	PF00069	0.580
MOD_PKA_2	208	214	PF00069	0.713
MOD_PKA_2	301	307	PF00069	0.654
MOD_PKA_2	377	383	PF00069	0.703
MOD_PKA_2	399	405	PF00069	0.651
MOD_PKA_2	55	61	PF00069	0.672
MOD_PKA_2	645	651	PF00069	0.616
MOD_PKA_2	660	666	PF00069	0.638
MOD_PKA_2	746	752	PF00069	0.677
MOD_PKA_2	792	798	PF00069	0.734
MOD_PKA_2	845	851	PF00069	0.736
MOD_PKA_2	922	928	PF00069	0.677
MOD_PKA_2	999	1005	PF00069	0.685
MOD_PKB_1	1049	1057	PF00069	0.694
MOD_PKB_1	223	231	PF00069	0.567
MOD_Plk_1	1090	1096	PF00069	0.597
MOD_Plk_1	255	261	PF00069	0.642
MOD_Plk_1	289	295	PF00069	0.671
MOD_Plk_1	315	321	PF00069	0.662
MOD_Plk_1	613	619	PF00069	0.781
MOD_Plk_2-3	887	893	PF00069	0.623
MOD_Plk_2-3	904	910	PF00069	0.494
MOD_Plk_4	1062	1068	PF00069	0.677
MOD_Plk_4	18	24	PF00069	0.639
MOD_Plk_4	497	503	PF00069	0.606
MOD_Plk_4	555	561	PF00069	0.673
MOD_Plk_4	596	602	PF00069	0.628
MOD_Plk_4	626	632	PF00069	0.692
MOD_Plk_4	686	692	PF00069	0.614
MOD_Plk_4	887	893	PF00069	0.623
MOD_ProDKin_1	1042	1048	PF00069	0.685
MOD_ProDKin_1	190	196	PF00069	0.677
MOD_ProDKin_1	22	28	PF00069	0.682
MOD_ProDKin_1	302	308	PF00069	0.656
MOD_ProDKin_1	341	347	PF00069	0.726
MOD_ProDKin_1	362	368	PF00069	0.728
MOD_ProDKin_1	370	376	PF00069	0.638
MOD_ProDKin_1	39	45	PF00069	0.532
MOD_ProDKin_1	602	608	PF00069	0.586
MOD_ProDKin_1	623	629	PF00069	0.664
MOD_ProDKin_1	634	640	PF00069	0.604
MOD_ProDKin_1	647	653	PF00069	0.592
MOD_ProDKin_1	65	71	PF00069	0.691
MOD_ProDKin_1	681	687	PF00069	0.690
MOD_ProDKin_1	694	700	PF00069	0.577
MOD_ProDKin_1	713	719	PF00069	0.532
MOD_ProDKin_1	720	726	PF00069	0.647
MOD_ProDKin_1	764	770	PF00069	0.707
MOD_ProDKin_1	774	780	PF00069	0.616
MOD_ProDKin_1	809	815	PF00069	0.666
MOD_ProDKin_1	824	830	PF00069	0.601
MOD_ProDKin_1	858	864	PF00069	0.799
MOD_ProDKin_1	928	934	PF00069	0.692
MOD_ProDKin_1	936	942	PF00069	0.654
MOD_ProDKin_1	947	953	PF00069	0.538
MOD_SUMO_for_1	885	888	PF00179	0.656
MOD_SUMO_rev_2	1062	1072	PF00179	0.675
MOD_SUMO_rev_2	402	411	PF00179	0.672
MOD_SUMO_rev_2	574	580	PF00179	0.657
TRG_DiLeu_BaEn_1	320	325	PF01217	0.632
TRG_DiLeu_BaEn_4	393	399	PF01217	0.639
TRG_DiLeu_BaEn_4	575	581	PF01217	0.715
TRG_ENDOCYTIC_2	1079	1082	PF00928	0.744
TRG_ENDOCYTIC_2	143	146	PF00928	0.553
TRG_ENDOCYTIC_2	841	844	PF00928	0.721
TRG_ER_diArg_1	1	3	PF00400	0.594
TRG_ER_diArg_1	105	107	PF00400	0.684
TRG_ER_diArg_1	222	225	PF00400	0.629
TRG_ER_diArg_1	247	249	PF00400	0.691
TRG_ER_diArg_1	331	333	PF00400	0.673
TRG_ER_diArg_1	347	349	PF00400	0.621
TRG_ER_diArg_1	359	362	PF00400	0.611
TRG_ER_diArg_1	417	419	PF00400	0.679
TRG_ER_diArg_1	750	752	PF00400	0.727
TRG_Pf-PMV_PEXEL_1	970	975	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5A2	Leishmania donovani	100%	100%
A4H3W1	Leishmania braziliensis	63%	95%
E9AK22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9NFA7	Leishmania major	89%	99%