C-type lectin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS33_LEIIN

TriTrypDb:

LINF_040008900

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HS33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.736
CLV_C14_Caspase3-7	235	239	PF00656	0.730
CLV_NRD_NRD_1	183	185	PF00675	0.457
CLV_NRD_NRD_1	226	228	PF00675	0.587
CLV_NRD_NRD_1	83	85	PF00675	0.657
CLV_PCSK_KEX2_1	155	157	PF00082	0.623
CLV_PCSK_KEX2_1	183	185	PF00082	0.494
CLV_PCSK_KEX2_1	226	228	PF00082	0.587
CLV_PCSK_KEX2_1	83	85	PF00082	0.597
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.623
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.501
DEG_SPOP_SBC_1	121	125	PF00917	0.385
DOC_MAPK_RevD_3	169	184	PF00069	0.380
DOC_PP2B_LxvP_1	21	24	PF13499	0.409
DOC_USP7_MATH_1	24	28	PF00917	0.409
DOC_USP7_MATH_1	73	77	PF00917	0.381
DOC_WW_Pin1_4	148	153	PF00397	0.560
DOC_WW_Pin1_4	45	50	PF00397	0.448
LIG_14-3-3_CanoR_1	83	88	PF00244	0.368
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BRCT_BRCA1_1	219	223	PF00533	0.699
LIG_BRCT_BRCA1_1	26	30	PF00533	0.325
LIG_deltaCOP1_diTrp_1	82	88	PF00928	0.439
LIG_FHA_1	172	178	PF00498	0.407
LIG_FHA_1	56	62	PF00498	0.355
LIG_FHA_1	84	90	PF00498	0.372
LIG_FHA_2	131	137	PF00498	0.427
LIG_LIR_Apic_2	148	153	PF02991	0.558
LIG_LIR_Gen_1	27	36	PF02991	0.426
LIG_LIR_Gen_1	82	90	PF02991	0.355
LIG_LIR_Nem_3	115	120	PF02991	0.342
LIG_LIR_Nem_3	133	138	PF02991	0.431
LIG_LIR_Nem_3	203	207	PF02991	0.695
LIG_LIR_Nem_3	27	33	PF02991	0.422
LIG_LIR_Nem_3	82	88	PF02991	0.434
LIG_LYPXL_yS_3	138	141	PF13949	0.433
LIG_SH2_CRK	150	154	PF00017	0.526
LIG_SH2_GRB2like	135	138	PF00017	0.466
LIG_SH2_GRB2like	144	147	PF00017	0.393
LIG_SH2_GRB2like	78	81	PF00017	0.434
LIG_SH2_NCK_1	150	154	PF00017	0.560
LIG_SH2_SRC	78	81	PF00017	0.424
LIG_SH2_STAP1	53	57	PF00017	0.464
LIG_SH2_STAT3	144	147	PF00017	0.428
LIG_SH2_STAT5	53	56	PF00017	0.412
LIG_SH2_STAT5	74	77	PF00017	0.316
LIG_SH2_STAT5	78	81	PF00017	0.332
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.413
LIG_TYR_ITSM	113	120	PF00017	0.324
LIG_Vh1_VBS_1	164	182	PF01044	0.408
LIG_WRC_WIRS_1	30	35	PF05994	0.421
MOD_CDK_SPxxK_3	148	155	PF00069	0.561
MOD_CK1_1	14	20	PF00069	0.572
MOD_CK1_1	195	201	PF00069	0.744
MOD_CK1_1	203	209	PF00069	0.687
MOD_CK1_1	214	220	PF00069	0.699
MOD_CK1_1	221	227	PF00069	0.741
MOD_CK1_1	228	234	PF00069	0.690
MOD_CK2_1	228	234	PF00069	0.728
MOD_Cter_Amidation	153	156	PF01082	0.703
MOD_GlcNHglycan	130	133	PF01048	0.590
MOD_GlcNHglycan	16	19	PF01048	0.617
MOD_GlcNHglycan	230	233	PF01048	0.523
MOD_GlcNHglycan	75	78	PF01048	0.611
MOD_GSK3_1	104	111	PF00069	0.423
MOD_GSK3_1	192	199	PF00069	0.736
MOD_GSK3_1	203	210	PF00069	0.655
MOD_GSK3_1	214	221	PF00069	0.650
MOD_GSK3_1	222	229	PF00069	0.737
MOD_GSK3_1	230	237	PF00069	0.739
MOD_GSK3_1	24	31	PF00069	0.370
MOD_GSK3_1	40	47	PF00069	0.409
MOD_GSK3_1	51	58	PF00069	0.384
MOD_GSK3_1	95	102	PF00069	0.477
MOD_N-GLC_1	100	105	PF02516	0.628
MOD_N-GLC_1	145	150	PF02516	0.739
MOD_N-GLC_1	200	205	PF02516	0.494
MOD_N-GLC_1	214	219	PF02516	0.483
MOD_NEK2_1	11	16	PF00069	0.556
MOD_NEK2_1	222	227	PF00069	0.718
MOD_NEK2_1	99	104	PF00069	0.466
MOD_PIKK_1	100	106	PF00454	0.439
MOD_PIKK_1	232	238	PF00454	0.733
MOD_PIKK_1	40	46	PF00454	0.420
MOD_PKA_1	226	232	PF00069	0.784
MOD_PKA_1	83	89	PF00069	0.261
MOD_PKA_2	225	231	PF00069	0.727
MOD_PKA_2	83	89	PF00069	0.363
MOD_Plk_1	100	106	PF00069	0.432
MOD_Plk_4	218	224	PF00069	0.728
MOD_Plk_4	95	101	PF00069	0.468
MOD_ProDKin_1	148	154	PF00069	0.563
MOD_ProDKin_1	45	51	PF00069	0.445
MOD_SUMO_rev_2	66	71	PF00179	0.411
TRG_ENDOCYTIC_2	117	120	PF00928	0.301
TRG_ENDOCYTIC_2	138	141	PF00928	0.361
TRG_ER_diArg_1	83	85	PF00400	0.397
TRG_NLS_MonoExtC_3	182	188	PF00514	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRH3	Leptomonas seymouri	27%	88%
A0A0N1PAN6	Leptomonas seymouri	26%	85%
A0A0N1PBW5	Leptomonas seymouri	37%	83%
A0A3S7WNP1	Leishmania donovani	99%	100%
A4H3V9	Leishmania braziliensis	66%	100%
E9AK20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q9XZX6	Leishmania major	92%	100%