Putative mitochondrial exoribonuclease DSS-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial exoribonuclease DSS-1 - putative

Species:

Leishmania infantum

UniProt:

A4HS28_LEIIN

TriTrypDb:

LINF_040008400

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

A4HS28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS28

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	6
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	6
GO:0008859	exoribonuclease II activity	7	6
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.544
CLV_C14_Caspase3-7	420	424	PF00656	0.501
CLV_C14_Caspase3-7	495	499	PF00656	0.525
CLV_C14_Caspase3-7	553	557	PF00656	0.495
CLV_C14_Caspase3-7	705	709	PF00656	0.571
CLV_C14_Caspase3-7	850	854	PF00656	0.604
CLV_NRD_NRD_1	241	243	PF00675	0.561
CLV_NRD_NRD_1	297	299	PF00675	0.354
CLV_NRD_NRD_1	3	5	PF00675	0.568
CLV_NRD_NRD_1	30	32	PF00675	0.729
CLV_NRD_NRD_1	359	361	PF00675	0.264
CLV_NRD_NRD_1	571	573	PF00675	0.354
CLV_NRD_NRD_1	604	606	PF00675	0.260
CLV_NRD_NRD_1	623	625	PF00675	0.665
CLV_NRD_NRD_1	723	725	PF00675	0.554
CLV_NRD_NRD_1	760	762	PF00675	0.773
CLV_PCSK_FUR_1	239	243	PF00082	0.551
CLV_PCSK_KEX2_1	2	4	PF00082	0.569
CLV_PCSK_KEX2_1	241	243	PF00082	0.561
CLV_PCSK_KEX2_1	297	299	PF00082	0.354
CLV_PCSK_KEX2_1	30	32	PF00082	0.729
CLV_PCSK_KEX2_1	359	361	PF00082	0.260
CLV_PCSK_KEX2_1	571	573	PF00082	0.354
CLV_PCSK_KEX2_1	604	606	PF00082	0.260
CLV_PCSK_KEX2_1	623	625	PF00082	0.619
CLV_PCSK_KEX2_1	723	725	PF00082	0.546
CLV_PCSK_KEX2_1	760	762	PF00082	0.703
CLV_PCSK_SKI1_1	185	189	PF00082	0.444
CLV_PCSK_SKI1_1	297	301	PF00082	0.260
CLV_PCSK_SKI1_1	3	7	PF00082	0.599
CLV_PCSK_SKI1_1	359	363	PF00082	0.264
CLV_PCSK_SKI1_1	550	554	PF00082	0.245
DEG_APCC_DBOX_1	184	192	PF00400	0.494
DEG_Kelch_Keap1_1	339	344	PF01344	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DEG_SPOP_SBC_1	37	41	PF00917	0.673
DEG_SPOP_SBC_1	634	638	PF00917	0.722
DEG_SPOP_SBC_1	751	755	PF00917	0.704
DOC_ANK_TNKS_1	240	247	PF00023	0.537
DOC_CKS1_1	17	22	PF01111	0.712
DOC_CKS1_1	465	470	PF01111	0.507
DOC_CKS1_1	775	780	PF01111	0.619
DOC_CYCLIN_RxL_1	182	189	PF00134	0.497
DOC_CYCLIN_yClb5_NLxxxL_5	422	429	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	745	751	PF00134	0.605
DOC_MAPK_gen_1	327	336	PF00069	0.471
DOC_MAPK_gen_1	604	611	PF00069	0.463
DOC_MAPK_gen_1	712	718	PF00069	0.469
DOC_MAPK_JIP1_4	761	767	PF00069	0.717
DOC_PP2B_LxvP_1	745	748	PF13499	0.657
DOC_PP2B_LxvP_1	749	752	PF13499	0.641
DOC_PP2B_PxIxI_1	476	482	PF00149	0.462
DOC_PP4_FxxP_1	311	314	PF00568	0.460
DOC_PP4_FxxP_1	472	475	PF00568	0.554
DOC_SPAK_OSR1_1	680	684	PF12202	0.505
DOC_USP7_MATH_1	248	252	PF00917	0.478
DOC_USP7_MATH_1	286	290	PF00917	0.524
DOC_USP7_MATH_1	45	49	PF00917	0.795
DOC_USP7_MATH_1	532	536	PF00917	0.577
DOC_USP7_MATH_1	565	569	PF00917	0.534
DOC_USP7_MATH_1	635	639	PF00917	0.551
DOC_USP7_MATH_1	656	660	PF00917	0.512
DOC_USP7_MATH_1	735	739	PF00917	0.632
DOC_WW_Pin1_4	16	21	PF00397	0.721
DOC_WW_Pin1_4	396	401	PF00397	0.525
DOC_WW_Pin1_4	41	46	PF00397	0.748
DOC_WW_Pin1_4	464	469	PF00397	0.509
DOC_WW_Pin1_4	598	603	PF00397	0.536
DOC_WW_Pin1_4	774	779	PF00397	0.664
DOC_WW_Pin1_4	97	102	PF00397	0.553
LIG_14-3-3_CanoR_1	121	131	PF00244	0.476
LIG_14-3-3_CanoR_1	297	306	PF00244	0.462
LIG_14-3-3_CanoR_1	327	333	PF00244	0.485
LIG_14-3-3_CanoR_1	359	364	PF00244	0.460
LIG_14-3-3_CanoR_1	531	539	PF00244	0.583
LIG_14-3-3_CanoR_1	550	556	PF00244	0.539
LIG_14-3-3_CanoR_1	571	577	PF00244	0.473
LIG_14-3-3_CanoR_1	670	674	PF00244	0.532
LIG_14-3-3_CanoR_1	733	741	PF00244	0.629
LIG_14-3-3_CanoR_1	760	766	PF00244	0.722
LIG_Actin_WH2_1	80	97	PF00022	0.519
LIG_Actin_WH2_2	81	97	PF00022	0.514
LIG_BIR_III_4	259	263	PF00653	0.460
LIG_BRCT_BRCA1_1	557	561	PF00533	0.554
LIG_BRCT_BRCA1_1	677	681	PF00533	0.507
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.435
LIG_deltaCOP1_diTrp_1	841	848	PF00928	0.545
LIG_EVH1_2	468	472	PF00568	0.557
LIG_FHA_1	106	112	PF00498	0.623
LIG_FHA_1	12	18	PF00498	0.710
LIG_FHA_1	124	130	PF00498	0.417
LIG_FHA_1	19	25	PF00498	0.610
LIG_FHA_1	218	224	PF00498	0.458
LIG_FHA_1	252	258	PF00498	0.460
LIG_FHA_1	300	306	PF00498	0.476
LIG_FHA_1	329	335	PF00498	0.460
LIG_FHA_1	340	346	PF00498	0.460
LIG_FHA_1	383	389	PF00498	0.537
LIG_FHA_1	465	471	PF00498	0.565
LIG_FHA_1	482	488	PF00498	0.431
LIG_FHA_1	528	534	PF00498	0.460
LIG_FHA_1	575	581	PF00498	0.477
LIG_FHA_1	598	604	PF00498	0.460
LIG_FHA_1	720	726	PF00498	0.399
LIG_FHA_1	818	824	PF00498	0.447
LIG_FHA_2	157	163	PF00498	0.545
LIG_FHA_2	184	190	PF00498	0.473
LIG_FHA_2	251	257	PF00498	0.482
LIG_FHA_2	320	326	PF00498	0.474
LIG_FHA_2	416	422	PF00498	0.471
LIG_FHA_2	542	548	PF00498	0.557
LIG_FHA_2	551	557	PF00498	0.462
LIG_FHA_2	70	76	PF00498	0.556
LIG_LIR_Apic_2	124	130	PF02991	0.436
LIG_LIR_Apic_2	471	475	PF02991	0.557
LIG_LIR_Gen_1	233	240	PF02991	0.447
LIG_LIR_Gen_1	331	338	PF02991	0.554
LIG_LIR_Gen_1	362	370	PF02991	0.467
LIG_LIR_Gen_1	70	77	PF02991	0.535
LIG_LIR_Gen_1	714	719	PF02991	0.472
LIG_LIR_Gen_1	777	788	PF02991	0.466
LIG_LIR_Gen_1	837	848	PF02991	0.489
LIG_LIR_Nem_3	233	238	PF02991	0.417
LIG_LIR_Nem_3	282	287	PF02991	0.512
LIG_LIR_Nem_3	307	313	PF02991	0.461
LIG_LIR_Nem_3	331	335	PF02991	0.555
LIG_LIR_Nem_3	362	366	PF02991	0.462
LIG_LIR_Nem_3	423	429	PF02991	0.540
LIG_LIR_Nem_3	678	684	PF02991	0.381
LIG_LIR_Nem_3	70	76	PF02991	0.537
LIG_LIR_Nem_3	714	718	PF02991	0.456
LIG_LIR_Nem_3	777	783	PF02991	0.461
LIG_LIR_Nem_3	837	843	PF02991	0.491
LIG_NRBOX	83	89	PF00104	0.384
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.480
LIG_PDZ_Class_2	849	854	PF00595	0.605
LIG_Pex14_1	682	686	PF04695	0.437
LIG_Pex14_1	78	82	PF04695	0.359
LIG_Pex14_1	844	848	PF04695	0.532
LIG_Pex14_2	332	336	PF04695	0.460
LIG_SH2_CRK	363	367	PF00017	0.524
LIG_SH2_CRK	91	95	PF00017	0.535
LIG_SH2_NCK_1	363	367	PF00017	0.452
LIG_SH2_NCK_1	543	547	PF00017	0.502
LIG_SH2_PTP2	193	196	PF00017	0.450
LIG_SH2_SRC	193	196	PF00017	0.450
LIG_SH2_SRC	73	76	PF00017	0.428
LIG_SH2_SRC	96	99	PF00017	0.640
LIG_SH2_STAP1	348	352	PF00017	0.502
LIG_SH2_STAP1	606	610	PF00017	0.443
LIG_SH2_STAP1	731	735	PF00017	0.547
LIG_SH2_STAP1	840	844	PF00017	0.570
LIG_SH2_STAT3	211	214	PF00017	0.558
LIG_SH2_STAT5	193	196	PF00017	0.426
LIG_SH2_STAT5	273	276	PF00017	0.471
LIG_SH2_STAT5	277	280	PF00017	0.462
LIG_SH2_STAT5	284	287	PF00017	0.458
LIG_SH2_STAT5	304	307	PF00017	0.462
LIG_SH2_STAT5	427	430	PF00017	0.554
LIG_SH2_STAT5	543	546	PF00017	0.498
LIG_SH2_STAT5	596	599	PF00017	0.546
LIG_SH2_STAT5	686	689	PF00017	0.445
LIG_SH2_STAT5	715	718	PF00017	0.472
LIG_SH2_STAT5	73	76	PF00017	0.368
LIG_SH2_STAT5	782	785	PF00017	0.384
LIG_SH2_STAT5	787	790	PF00017	0.386
LIG_SH3_1	95	101	PF00018	0.571
LIG_SH3_3	127	133	PF00018	0.454
LIG_SH3_3	14	20	PF00018	0.710
LIG_SH3_3	169	175	PF00018	0.441
LIG_SH3_3	280	286	PF00018	0.460
LIG_SH3_3	462	468	PF00018	0.552
LIG_SH3_3	642	648	PF00018	0.606
LIG_SH3_3	723	729	PF00018	0.557
LIG_SH3_3	756	762	PF00018	0.768
LIG_SH3_3	783	789	PF00018	0.497
LIG_SH3_3	95	101	PF00018	0.604
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.478
LIG_SUMO_SIM_par_1	484	491	PF11976	0.464
LIG_TRAF2_1	666	669	PF00917	0.442
LIG_TYR_ITIM	361	366	PF00017	0.311
MOD_CDC14_SPxK_1	44	47	PF00782	0.720
MOD_CDC14_SPxK_1	601	604	PF00782	0.315
MOD_CDK_SPxK_1	41	47	PF00069	0.734
MOD_CDK_SPxK_1	598	604	PF00069	0.315
MOD_CDK_SPxxK_3	598	605	PF00069	0.306
MOD_CK1_1	251	257	PF00069	0.314
MOD_CK1_1	279	285	PF00069	0.306
MOD_CK1_1	35	41	PF00069	0.741
MOD_CK1_1	49	55	PF00069	0.792
MOD_CK1_1	574	580	PF00069	0.343
MOD_CK1_1	629	635	PF00069	0.640
MOD_CK1_1	753	759	PF00069	0.707
MOD_CK1_1	99	105	PF00069	0.651
MOD_CK2_1	156	162	PF00069	0.545
MOD_CK2_1	183	189	PF00069	0.476
MOD_CK2_1	250	256	PF00069	0.306
MOD_CK2_1	286	292	PF00069	0.346
MOD_CK2_1	319	325	PF00069	0.324
MOD_CK2_1	338	344	PF00069	0.406
MOD_CK2_1	541	547	PF00069	0.374
MOD_CK2_1	734	740	PF00069	0.628
MOD_GlcNHglycan	113	116	PF01048	0.491
MOD_GlcNHglycan	250	253	PF01048	0.314
MOD_GlcNHglycan	408	411	PF01048	0.421
MOD_GlcNHglycan	632	635	PF01048	0.686
MOD_GlcNHglycan	637	640	PF01048	0.678
MOD_GlcNHglycan	664	667	PF01048	0.428
MOD_GlcNHglycan	69	72	PF01048	0.473
MOD_GlcNHglycan	693	696	PF01048	0.576
MOD_GlcNHglycan	737	740	PF01048	0.624
MOD_GSK3_1	248	255	PF00069	0.311
MOD_GSK3_1	32	39	PF00069	0.751
MOD_GSK3_1	41	48	PF00069	0.774
MOD_GSK3_1	481	488	PF00069	0.358
MOD_GSK3_1	49	56	PF00069	0.671
MOD_GSK3_1	527	534	PF00069	0.307
MOD_GSK3_1	551	558	PF00069	0.357
MOD_GSK3_1	590	597	PF00069	0.315
MOD_GSK3_1	625	632	PF00069	0.633
MOD_GSK3_1	735	742	PF00069	0.670
MOD_GSK3_1	743	750	PF00069	0.640
MOD_GSK3_1	751	758	PF00069	0.536
MOD_GSK3_1	774	781	PF00069	0.633
MOD_GSK3_1	96	103	PF00069	0.519
MOD_LATS_1	392	398	PF00433	0.250
MOD_N-GLC_1	198	203	PF02516	0.315
MOD_N-GLC_1	346	351	PF02516	0.335
MOD_N-GLC_1	676	681	PF02516	0.416
MOD_NEK2_1	111	116	PF00069	0.525
MOD_NEK2_1	122	127	PF00069	0.436
MOD_NEK2_1	156	161	PF00069	0.572
MOD_NEK2_1	299	304	PF00069	0.318
MOD_NEK2_1	527	532	PF00069	0.438
MOD_NEK2_1	555	560	PF00069	0.400
MOD_NEK2_1	566	571	PF00069	0.318
MOD_NEK2_1	591	596	PF00069	0.441
MOD_NEK2_1	69	74	PF00069	0.426
MOD_NEK2_1	734	739	PF00069	0.582
MOD_NEK2_1	793	798	PF00069	0.489
MOD_PIKK_1	116	122	PF00454	0.544
MOD_PIKK_1	493	499	PF00454	0.472
MOD_PIKK_1	739	745	PF00454	0.602
MOD_PIKK_1	817	823	PF00454	0.390
MOD_PIKK_1	847	853	PF00454	0.584
MOD_PK_1	346	352	PF00069	0.321
MOD_PKA_1	297	303	PF00069	0.438
MOD_PKA_1	359	365	PF00069	0.306
MOD_PKA_1	571	577	PF00069	0.438
MOD_PKA_2	11	17	PF00069	0.638
MOD_PKA_2	240	246	PF00069	0.314
MOD_PKA_2	297	303	PF00069	0.405
MOD_PKA_2	359	365	PF00069	0.306
MOD_PKA_2	527	533	PF00069	0.306
MOD_PKA_2	571	577	PF00069	0.438
MOD_PKA_2	669	675	PF00069	0.535
MOD_PKA_2	691	697	PF00069	0.571
MOD_Plk_1	198	204	PF00069	0.481
MOD_Plk_1	279	285	PF00069	0.306
MOD_Plk_1	287	293	PF00069	0.306
MOD_Plk_1	346	352	PF00069	0.316
MOD_Plk_1	382	388	PF00069	0.402
MOD_Plk_1	470	476	PF00069	0.417
MOD_Plk_1	555	561	PF00069	0.438
MOD_Plk_1	591	597	PF00069	0.438
MOD_Plk_1	676	682	PF00069	0.441
MOD_Plk_1	739	745	PF00069	0.602
MOD_Plk_1	778	784	PF00069	0.548
MOD_Plk_2-3	319	325	PF00069	0.341
MOD_Plk_2-3	485	491	PF00069	0.320
MOD_Plk_4	279	285	PF00069	0.326
MOD_Plk_4	300	306	PF00069	0.306
MOD_Plk_4	591	597	PF00069	0.438
MOD_Plk_4	614	620	PF00069	0.437
MOD_Plk_4	669	675	PF00069	0.454
MOD_Plk_4	69	75	PF00069	0.419
MOD_Plk_4	711	717	PF00069	0.490
MOD_Plk_4	83	89	PF00069	0.402
MOD_ProDKin_1	16	22	PF00069	0.722
MOD_ProDKin_1	396	402	PF00069	0.397
MOD_ProDKin_1	41	47	PF00069	0.750
MOD_ProDKin_1	464	470	PF00069	0.375
MOD_ProDKin_1	598	604	PF00069	0.413
MOD_ProDKin_1	774	780	PF00069	0.658
MOD_ProDKin_1	97	103	PF00069	0.557
MOD_SUMO_for_1	666	669	PF00179	0.511
MOD_SUMO_rev_2	476	484	PF00179	0.372
TRG_AP2beta_CARGO_1	423	433	PF09066	0.372
TRG_DiLeu_BaEn_1	118	123	PF01217	0.531
TRG_DiLeu_BaEn_1	669	674	PF01217	0.464
TRG_DiLeu_BaEn_1	740	745	PF01217	0.631
TRG_DiLeu_BaEn_2	306	312	PF01217	0.306
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.356
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.442
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.330
TRG_DiLeu_LyEn_5	118	123	PF01217	0.531
TRG_ENDOCYTIC_2	273	276	PF00928	0.332
TRG_ENDOCYTIC_2	284	287	PF00928	0.309
TRG_ENDOCYTIC_2	363	366	PF00928	0.315
TRG_ENDOCYTIC_2	581	584	PF00928	0.442
TRG_ENDOCYTIC_2	606	609	PF00928	0.306
TRG_ENDOCYTIC_2	715	718	PF00928	0.421
TRG_ENDOCYTIC_2	73	76	PF00928	0.505
TRG_ENDOCYTIC_2	731	734	PF00928	0.449
TRG_ENDOCYTIC_2	840	843	PF00928	0.573
TRG_ENDOCYTIC_2	91	94	PF00928	0.438
TRG_ER_diArg_1	1	4	PF00400	0.606
TRG_ER_diArg_1	226	229	PF00400	0.369
TRG_ER_diArg_1	297	299	PF00400	0.438
TRG_ER_diArg_1	358	360	PF00400	0.306
TRG_ER_diArg_1	433	436	PF00400	0.312
TRG_ER_diArg_1	437	440	PF00400	0.312
TRG_ER_diArg_1	570	572	PF00400	0.439
TRG_ER_diArg_1	603	605	PF00400	0.306
TRG_ER_diArg_1	723	725	PF00400	0.521
TRG_ER_diArg_1	759	761	PF00400	0.779
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	531	536	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	685	689	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA76	Leptomonas seymouri	69%	100%
A0A0S4J212	Bodo saltans	42%	100%
A0A1X0NLV5	Trypanosomatidae	53%	100%
A0A3S5H597	Leishmania donovani	100%	100%
A0A422NN62	Trypanosoma rangeli	52%	100%
A4H3V2	Leishmania braziliensis	82%	98%
C9ZY19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AK15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q86MA2	Trypanosoma brucei brucei	52%	100%
Q9XZX1	Leishmania major	95%	100%
V5B958	Trypanosoma cruzi	53%	100%