LeishMANIAdb
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Putative beta-fructofuranosidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative beta-fructofuranosidase
Gene product:
beta-fructofuranosidase - putative
Species:
Leishmania infantum
UniProt:
A4HS27_LEIIN
TriTrypDb:
LINF_040008200
Length:
485

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 32
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 10, no: 9
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HS27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS27

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 19
GO:0008152 metabolic process 1 20
GO:0044238 primary metabolic process 2 19
GO:0071704 organic substance metabolic process 2 19
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 20
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 19
GO:0004564 beta-fructofuranosidase activity 5 10
GO:0016787 hydrolase activity 2 20
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 318 322 PF00656 0.272
CLV_NRD_NRD_1 161 163 PF00675 0.490
CLV_NRD_NRD_1 34 36 PF00675 0.651
CLV_PCSK_KEX2_1 161 163 PF00082 0.461
CLV_PCSK_KEX2_1 34 36 PF00082 0.426
CLV_PCSK_SKI1_1 138 142 PF00082 0.467
CLV_PCSK_SKI1_1 199 203 PF00082 0.420
CLV_PCSK_SKI1_1 469 473 PF00082 0.612
DEG_APCC_DBOX_1 365 373 PF00400 0.487
DEG_COP1_1 261 272 PF00400 0.420
DOC_MAPK_gen_1 210 220 PF00069 0.527
DOC_MAPK_gen_1 34 43 PF00069 0.481
DOC_MAPK_HePTP_8 439 451 PF00069 0.442
DOC_MAPK_MEF2A_6 442 451 PF00069 0.442
DOC_PP1_RVXF_1 344 350 PF00149 0.477
DOC_PP2B_LxvP_1 12 15 PF13499 0.566
DOC_PP4_FxxP_1 154 157 PF00568 0.490
DOC_PP4_FxxP_1 88 91 PF00568 0.473
DOC_USP7_MATH_1 136 140 PF00917 0.460
DOC_USP7_MATH_1 24 28 PF00917 0.690
DOC_USP7_MATH_1 299 303 PF00917 0.480
DOC_USP7_MATH_1 316 320 PF00917 0.375
DOC_USP7_MATH_1 353 357 PF00917 0.346
DOC_USP7_UBL2_3 346 350 PF12436 0.505
DOC_WW_Pin1_4 15 20 PF00397 0.671
DOC_WW_Pin1_4 225 230 PF00397 0.547
DOC_WW_Pin1_4 393 398 PF00397 0.488
DOC_WW_Pin1_4 461 466 PF00397 0.661
LIG_14-3-3_CanoR_1 138 143 PF00244 0.414
LIG_14-3-3_CanoR_1 248 252 PF00244 0.484
LIG_14-3-3_CanoR_1 301 309 PF00244 0.379
LIG_Actin_WH2_2 285 303 PF00022 0.272
LIG_Actin_WH2_2 89 107 PF00022 0.369
LIG_APCC_ABBA_1 402 407 PF00400 0.344
LIG_APCC_ABBA_1 411 416 PF00400 0.344
LIG_APCC_ABBAyCdc20_2 128 134 PF00400 0.272
LIG_BRCT_BRCA1_1 138 142 PF00533 0.427
LIG_BRCT_BRCA1_1 150 154 PF00533 0.389
LIG_BRCT_BRCA1_1 334 338 PF00533 0.510
LIG_deltaCOP1_diTrp_1 37 43 PF00928 0.233
LIG_FHA_1 201 207 PF00498 0.389
LIG_FHA_1 228 234 PF00498 0.530
LIG_FHA_1 259 265 PF00498 0.311
LIG_FHA_1 285 291 PF00498 0.485
LIG_FHA_1 342 348 PF00498 0.404
LIG_FHA_1 381 387 PF00498 0.525
LIG_FHA_1 421 427 PF00498 0.365
LIG_FHA_1 432 438 PF00498 0.365
LIG_FHA_1 446 452 PF00498 0.344
LIG_FHA_1 470 476 PF00498 0.563
LIG_FHA_2 139 145 PF00498 0.378
LIG_FHA_2 151 157 PF00498 0.336
LIG_FHA_2 166 172 PF00498 0.382
LIG_FHA_2 226 232 PF00498 0.543
LIG_FHA_2 248 254 PF00498 0.453
LIG_FHA_2 362 368 PF00498 0.480
LIG_LIR_Apic_2 151 157 PF02991 0.489
LIG_LIR_Apic_2 457 463 PF02991 0.631
LIG_LIR_Apic_2 85 91 PF02991 0.450
LIG_LIR_Gen_1 101 110 PF02991 0.411
LIG_LIR_Gen_1 127 136 PF02991 0.489
LIG_LIR_Gen_1 137 148 PF02991 0.491
LIG_LIR_Gen_1 240 249 PF02991 0.488
LIG_LIR_Gen_1 283 293 PF02991 0.350
LIG_LIR_Gen_1 473 484 PF02991 0.575
LIG_LIR_Nem_3 101 106 PF02991 0.381
LIG_LIR_Nem_3 114 118 PF02991 0.333
LIG_LIR_Nem_3 127 133 PF02991 0.365
LIG_LIR_Nem_3 137 143 PF02991 0.329
LIG_LIR_Nem_3 144 148 PF02991 0.256
LIG_LIR_Nem_3 153 158 PF02991 0.347
LIG_LIR_Nem_3 240 245 PF02991 0.569
LIG_LIR_Nem_3 283 288 PF02991 0.380
LIG_LIR_Nem_3 306 312 PF02991 0.422
LIG_LIR_Nem_3 473 479 PF02991 0.560
LIG_LIR_Nem_3 92 96 PF02991 0.371
LIG_LYPXL_yS_3 309 312 PF13949 0.484
LIG_NRBOX 474 480 PF00104 0.586
LIG_PCNA_yPIPBox_3 186 200 PF02747 0.484
LIG_PDZ_Class_2 480 485 PF00595 0.566
LIG_Pex14_1 39 43 PF04695 0.359
LIG_REV1ctd_RIR_1 91 101 PF16727 0.375
LIG_SH2_CRK 155 159 PF00017 0.380
LIG_SH2_CRK 285 289 PF00017 0.433
LIG_SH2_NCK_1 285 289 PF00017 0.433
LIG_SH2_PTP2 130 133 PF00017 0.489
LIG_SH2_SRC 155 158 PF00017 0.397
LIG_SH2_STAP1 440 444 PF00017 0.450
LIG_SH2_STAT5 103 106 PF00017 0.365
LIG_SH2_STAT5 115 118 PF00017 0.345
LIG_SH2_STAT5 130 133 PF00017 0.303
LIG_SH2_STAT5 263 266 PF00017 0.336
LIG_SH2_STAT5 285 288 PF00017 0.354
LIG_SH2_STAT5 336 339 PF00017 0.433
LIG_SH2_STAT5 371 374 PF00017 0.487
LIG_SH2_STAT5 427 430 PF00017 0.344
LIG_SH2_STAT5 454 457 PF00017 0.544
LIG_SH2_STAT5 78 81 PF00017 0.485
LIG_SH3_3 1 7 PF00018 0.483
LIG_SH3_3 13 19 PF00018 0.694
LIG_SH3_3 130 136 PF00018 0.488
LIG_SH3_3 20 26 PF00018 0.789
LIG_SH3_3 287 293 PF00018 0.360
LIG_SH3_3 362 368 PF00018 0.351
LIG_SUMO_SIM_par_1 215 222 PF11976 0.388
LIG_SUMO_SIM_par_1 447 452 PF11976 0.506
LIG_TYR_ITSM 151 158 PF00017 0.506
LIG_TYR_ITSM 238 245 PF00017 0.594
MOD_CK1_1 17 23 PF00069 0.514
MOD_CK1_1 283 289 PF00069 0.422
MOD_CK1_1 66 72 PF00069 0.492
MOD_CK2_1 165 171 PF00069 0.460
MOD_CK2_1 225 231 PF00069 0.483
MOD_CK2_1 361 367 PF00069 0.518
MOD_CK2_1 406 412 PF00069 0.433
MOD_GlcNHglycan 182 185 PF01048 0.357
MOD_GlcNHglycan 318 321 PF01048 0.465
MOD_GlcNHglycan 323 326 PF01048 0.423
MOD_GlcNHglycan 361 364 PF01048 0.375
MOD_GlcNHglycan 376 379 PF01048 0.296
MOD_GlcNHglycan 68 71 PF01048 0.432
MOD_GSK3_1 104 111 PF00069 0.369
MOD_GSK3_1 134 141 PF00069 0.468
MOD_GSK3_1 223 230 PF00069 0.551
MOD_GSK3_1 258 265 PF00069 0.460
MOD_GSK3_1 280 287 PF00069 0.348
MOD_GSK3_1 299 306 PF00069 0.431
MOD_GSK3_1 372 379 PF00069 0.387
MOD_GSK3_1 59 66 PF00069 0.422
MOD_GSK3_1 69 76 PF00069 0.426
MOD_N-GLC_1 123 128 PF02516 0.389
MOD_N-GLC_1 237 242 PF02516 0.557
MOD_N-GLC_1 280 285 PF02516 0.476
MOD_N-GLC_1 321 326 PF02516 0.393
MOD_N-GLC_1 469 474 PF02516 0.612
MOD_N-GLC_2 343 345 PF02516 0.410
MOD_NEK2_1 104 109 PF00069 0.369
MOD_NEK2_1 123 128 PF00069 0.369
MOD_NEK2_1 148 153 PF00069 0.436
MOD_NEK2_1 188 193 PF00069 0.434
MOD_NEK2_1 315 320 PF00069 0.471
MOD_NEK2_1 332 337 PF00069 0.344
MOD_NEK2_1 372 377 PF00069 0.370
MOD_NEK2_1 471 476 PF00069 0.584
MOD_NEK2_1 478 483 PF00069 0.487
MOD_NEK2_1 73 78 PF00069 0.364
MOD_NEK2_2 150 155 PF00069 0.490
MOD_PIKK_1 200 206 PF00454 0.497
MOD_PIKK_1 280 286 PF00454 0.482
MOD_PIKK_1 372 378 PF00454 0.438
MOD_PKA_2 160 166 PF00069 0.470
MOD_PKA_2 247 253 PF00069 0.484
MOD_PKA_2 300 306 PF00069 0.489
MOD_Plk_1 237 243 PF00069 0.562
MOD_Plk_1 280 286 PF00069 0.488
MOD_Plk_1 406 412 PF00069 0.344
MOD_Plk_2-3 452 458 PF00069 0.457
MOD_Plk_4 150 156 PF00069 0.461
MOD_Plk_4 237 243 PF00069 0.619
MOD_Plk_4 259 265 PF00069 0.464
MOD_Plk_4 334 340 PF00069 0.479
MOD_Plk_4 406 412 PF00069 0.354
MOD_Plk_4 455 461 PF00069 0.470
MOD_Plk_4 471 477 PF00069 0.592
MOD_Plk_4 478 484 PF00069 0.527
MOD_Plk_4 73 79 PF00069 0.421
MOD_ProDKin_1 15 21 PF00069 0.669
MOD_ProDKin_1 225 231 PF00069 0.550
MOD_ProDKin_1 393 399 PF00069 0.488
MOD_ProDKin_1 461 467 PF00069 0.660
MOD_SUMO_for_1 414 417 PF00179 0.474
MOD_SUMO_rev_2 195 201 PF00179 0.442
TRG_DiLeu_BaEn_2 400 406 PF01217 0.474
TRG_DiLeu_BaLyEn_6 365 370 PF01217 0.488
TRG_ENDOCYTIC_2 103 106 PF00928 0.407
TRG_ENDOCYTIC_2 130 133 PF00928 0.473
TRG_ENDOCYTIC_2 145 148 PF00928 0.311
TRG_ENDOCYTIC_2 155 158 PF00928 0.322
TRG_ENDOCYTIC_2 242 245 PF00928 0.422
TRG_ENDOCYTIC_2 285 288 PF00928 0.354
TRG_ENDOCYTIC_2 309 312 PF00928 0.438
TRG_ENDOCYTIC_2 476 479 PF00928 0.555
TRG_NES_CRM1_1 417 429 PF08389 0.474
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.432

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4P1 Leptomonas seymouri 48% 100%
A0A0N1PBT6 Leptomonas seymouri 73% 75%
A0A0S4J9J2 Bodo saltans 32% 100%
A0A1X0NTL0 Trypanosomatidae 36% 77%
A0A1X0NTM3 Trypanosomatidae 38% 77%
A0A1X0NY19 Trypanosomatidae 38% 77%
A0A1X0NYR4 Trypanosomatidae 36% 89%
A0A1X0P322 Trypanosomatidae 36% 77%
A0A1X0P5Y7 Trypanosomatidae 37% 75%
A0A3S5H595 Leishmania donovani 99% 75%
A0A3S5H596 Leishmania donovani 100% 100%
A4H3V1 Leishmania braziliensis 81% 100%
A4HS26 Leishmania infantum 100% 100%
A4IAW1 Leishmania infantum 59% 69%
E9AK13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AK14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q9XTP3 Leishmania major 93% 100%
Q9XZX0 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS