Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS25_LEIIN

TriTrypDb:

LINF_040008100

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HS25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.654
CLV_NRD_NRD_1	126	128	PF00675	0.543
CLV_NRD_NRD_1	163	165	PF00675	0.461
CLV_NRD_NRD_1	176	178	PF00675	0.425
CLV_NRD_NRD_1	251	253	PF00675	0.523
CLV_NRD_NRD_1	255	257	PF00675	0.569
CLV_PCSK_FUR_1	130	134	PF00082	0.534
CLV_PCSK_KEX2_1	126	128	PF00082	0.543
CLV_PCSK_KEX2_1	132	134	PF00082	0.559
CLV_PCSK_KEX2_1	144	146	PF00082	0.577
CLV_PCSK_KEX2_1	163	165	PF00082	0.461
CLV_PCSK_KEX2_1	178	180	PF00082	0.435
CLV_PCSK_KEX2_1	255	257	PF00082	0.547
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.552
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.589
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.435
CLV_PCSK_SKI1_1	145	149	PF00082	0.636
DOC_CKS1_1	235	240	PF01111	0.629
DOC_CYCLIN_yClb3_PxF_3	119	127	PF00134	0.470
DOC_USP7_MATH_1	6	10	PF00917	0.539
DOC_USP7_UBL2_3	144	148	PF12436	0.567
DOC_WW_Pin1_4	184	189	PF00397	0.501
DOC_WW_Pin1_4	234	239	PF00397	0.640
LIG_14-3-3_CanoR_1	21	31	PF00244	0.536
LIG_eIF4E_1	95	101	PF01652	0.544
LIG_FHA_1	228	234	PF00498	0.619
LIG_FHA_1	77	83	PF00498	0.677
LIG_FHA_2	153	159	PF00498	0.449
LIG_FHA_2	235	241	PF00498	0.514
LIG_GBD_Chelix_1	100	108	PF00786	0.539
LIG_LIR_Gen_1	143	153	PF02991	0.504
LIG_LIR_Gen_1	155	165	PF02991	0.476
LIG_LIR_Gen_1	25	35	PF02991	0.702
LIG_LIR_Gen_1	92	102	PF02991	0.550
LIG_LIR_Nem_3	103	108	PF02991	0.418
LIG_LIR_Nem_3	143	149	PF02991	0.482
LIG_LIR_Nem_3	155	160	PF02991	0.457
LIG_LIR_Nem_3	25	31	PF02991	0.550
LIG_LIR_Nem_3	59	65	PF02991	0.561
LIG_LIR_Nem_3	92	98	PF02991	0.483
LIG_SH2_CRK	105	109	PF00017	0.457
LIG_SH2_CRK	146	150	PF00017	0.486
LIG_SH2_SRC	216	219	PF00017	0.595
LIG_SH2_STAP1	157	161	PF00017	0.468
LIG_SH2_STAP1	65	69	PF00017	0.544
LIG_SH2_STAT3	20	23	PF00017	0.642
LIG_SH2_STAT5	204	207	PF00017	0.612
LIG_SH2_STAT5	236	239	PF00017	0.513
LIG_SH2_STAT5	250	253	PF00017	0.462
LIG_SH2_STAT5	69	72	PF00017	0.539
LIG_SH3_3	116	122	PF00018	0.458
LIG_SH3_3	34	40	PF00018	0.697
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.424
LIG_TYR_ITAM	92	108	PF00017	0.547
LIG_TYR_ITIM	93	98	PF00017	0.480
MOD_CK1_1	9	15	PF00069	0.528
MOD_CK2_1	234	240	PF00069	0.497
MOD_GlcNHglycan	12	15	PF01048	0.630
MOD_GSK3_1	6	13	PF00069	0.517
MOD_NEK2_1	10	15	PF00069	0.566
MOD_NEK2_1	191	196	PF00069	0.589
MOD_PKA_2	227	233	PF00069	0.673
MOD_Plk_1	191	197	PF00069	0.518
MOD_Plk_4	152	158	PF00069	0.454
MOD_Plk_4	65	71	PF00069	0.559
MOD_ProDKin_1	184	190	PF00069	0.499
MOD_ProDKin_1	234	240	PF00069	0.635
TRG_DiLeu_BaEn_1	96	101	PF01217	0.536
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.555
TRG_ENDOCYTIC_2	105	108	PF00928	0.457
TRG_ENDOCYTIC_2	146	149	PF00928	0.483
TRG_ENDOCYTIC_2	157	160	PF00928	0.457
TRG_ENDOCYTIC_2	165	168	PF00928	0.393
TRG_ENDOCYTIC_2	95	98	PF00928	0.486
TRG_ER_diArg_1	126	128	PF00400	0.543
TRG_ER_diArg_1	162	164	PF00400	0.480
TRG_ER_diArg_1	195	198	PF00400	0.634
TRG_ER_diArg_1	254	256	PF00400	0.569
TRG_NLS_MonoExtC_3	251	256	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B4	Leptomonas seymouri	71%	87%
A0A0S4J2A8	Bodo saltans	46%	78%
A0A1X0NL02	Trypanosomatidae	60%	95%
A0A3S5H594	Leishmania donovani	100%	83%
A4H3V0	Leishmania braziliensis	92%	100%
C9ZY18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	93%
E9AK12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q9BLQ5	Leishmania major	96%	100%
V5ATQ3	Trypanosoma cruzi	60%	96%