TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HS21_LEIIN

TriTrypDb:

LINF_040007700

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.669
CLV_C14_Caspase3-7	82	86	PF00656	0.644
CLV_NRD_NRD_1	199	201	PF00675	0.362
CLV_NRD_NRD_1	221	223	PF00675	0.548
CLV_NRD_NRD_1	251	253	PF00675	0.484
CLV_NRD_NRD_1	99	101	PF00675	0.540
CLV_PCSK_KEX2_1	199	201	PF00082	0.357
CLV_PCSK_KEX2_1	221	223	PF00082	0.548
CLV_PCSK_KEX2_1	99	101	PF00082	0.563
CLV_PCSK_SKI1_1	161	165	PF00082	0.446
CLV_PCSK_SKI1_1	173	177	PF00082	0.422
CLV_PCSK_SKI1_1	195	199	PF00082	0.393
CLV_PCSK_SKI1_1	221	225	PF00082	0.517
CLV_PCSK_SKI1_1	264	268	PF00082	0.476
DOC_ANK_TNKS_1	221	228	PF00023	0.443
DOC_MAPK_gen_1	199	207	PF00069	0.451
DOC_MAPK_gen_1	258	267	PF00069	0.522
DOC_MAPK_gen_1	51	57	PF00069	0.419
DOC_MAPK_MEF2A_6	258	267	PF00069	0.522
DOC_MAPK_NFAT4_5	260	268	PF00069	0.524
DOC_PP1_RVXF_1	262	268	PF00149	0.486
DOC_USP7_MATH_1	118	122	PF00917	0.676
DOC_USP7_MATH_1	229	233	PF00917	0.563
DOC_USP7_MATH_1	6	10	PF00917	0.654
DOC_WW_Pin1_4	116	121	PF00397	0.601
DOC_WW_Pin1_4	188	193	PF00397	0.490
DOC_WW_Pin1_4	2	7	PF00397	0.689
DOC_WW_Pin1_4	221	226	PF00397	0.550
LIG_14-3-3_CanoR_1	44	49	PF00244	0.475
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BIR_III_1	1	5	PF00653	0.541
LIG_BIR_III_3	1	5	PF00653	0.541
LIG_BRCT_BRCA1_1	184	188	PF00533	0.615
LIG_FHA_1	162	168	PF00498	0.399
LIG_FHA_1	237	243	PF00498	0.559
LIG_FHA_2	110	116	PF00498	0.689
LIG_FHA_2	120	126	PF00498	0.648
LIG_LIR_Nem_3	47	53	PF02991	0.453
LIG_PCNA_PIPBox_1	132	141	PF02747	0.517
LIG_PCNA_yPIPBox_3	130	139	PF02747	0.472
LIG_PCNA_yPIPBox_3	87	101	PF02747	0.621
LIG_SH2_CRK	50	54	PF00017	0.447
LIG_SH2_GRB2like	76	79	PF00017	0.559
LIG_SH2_PTP2	204	207	PF00017	0.533
LIG_SH2_SRC	156	159	PF00017	0.514
LIG_SH2_SRC	60	63	PF00017	0.506
LIG_SH2_STAP1	139	143	PF00017	0.528
LIG_SH2_STAT3	22	25	PF00017	0.559
LIG_SH2_STAT5	204	207	PF00017	0.500
LIG_SH2_STAT5	22	25	PF00017	0.524
LIG_SH2_STAT5	54	57	PF00017	0.386
LIG_SH2_STAT5	60	63	PF00017	0.393
LIG_TRAF2_1	122	125	PF00917	0.614
MOD_CDK_SPxxK_3	188	195	PF00069	0.523
MOD_CK1_1	116	122	PF00069	0.624
MOD_CK1_1	5	11	PF00069	0.656
MOD_CK1_1	68	74	PF00069	0.484
MOD_CK2_1	109	115	PF00069	0.733
MOD_CK2_1	118	124	PF00069	0.670
MOD_Cter_Amidation	250	253	PF01082	0.555
MOD_GlcNHglycan	115	119	PF01048	0.668
MOD_GlcNHglycan	184	187	PF01048	0.626
MOD_GlcNHglycan	231	234	PF01048	0.676
MOD_GlcNHglycan	67	70	PF01048	0.529
MOD_GlcNHglycan	8	11	PF01048	0.729
MOD_GlcNHglycan	87	90	PF01048	0.327
MOD_GSK3_1	109	116	PF00069	0.687
MOD_GSK3_1	182	189	PF00069	0.609
MOD_GSK3_1	2	9	PF00069	0.613
MOD_NEK2_1	138	143	PF00069	0.438
MOD_NEK2_1	74	79	PF00069	0.684
MOD_PIKK_1	133	139	PF00454	0.549
MOD_PIKK_1	242	248	PF00454	0.519
MOD_PKA_2	186	192	PF00069	0.539
MOD_Plk_1	133	139	PF00069	0.486
MOD_ProDKin_1	116	122	PF00069	0.596
MOD_ProDKin_1	188	194	PF00069	0.482
MOD_ProDKin_1	2	8	PF00069	0.692
MOD_ProDKin_1	221	227	PF00069	0.557
MOD_SUMO_rev_2	255	263	PF00179	0.541
MOD_SUMO_rev_2	47	53	PF00179	0.434
TRG_DiLeu_BaEn_1	124	129	PF01217	0.449
TRG_DiLeu_BaEn_4	124	130	PF01217	0.545
TRG_DiLeu_BaEn_4	133	139	PF01217	0.357
TRG_ENDOCYTIC_2	204	207	PF00928	0.533
TRG_ENDOCYTIC_2	50	53	PF00928	0.447
TRG_ENDOCYTIC_2	54	57	PF00928	0.450
TRG_ER_diArg_1	198	200	PF00400	0.385
TRG_ER_diArg_1	220	222	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG7	Leptomonas seymouri	52%	86%
A0A0S4J1V3	Bodo saltans	33%	100%
A0A1X0NLP6	Trypanosomatidae	32%	100%
A0A3R7L3M0	Trypanosoma rangeli	32%	100%
A0A3S5H590	Leishmania donovani	100%	100%
A4H3U6	Leishmania braziliensis	77%	100%
C9ZY14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AK08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q9XZY6	Leishmania major	93%	100%