Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS18_LEIIN

TriTrypDb:

LINF_040007400

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HS18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.549
CLV_NRD_NRD_1	248	250	PF00675	0.596
CLV_NRD_NRD_1	78	80	PF00675	0.497
CLV_PCSK_KEX2_1	108	110	PF00082	0.549
CLV_PCSK_KEX2_1	247	249	PF00082	0.604
CLV_PCSK_KEX2_1	78	80	PF00082	0.451
CLV_PCSK_SKI1_1	80	84	PF00082	0.491
DEG_SIAH_1	162	170	PF03145	0.771
DEG_SPOP_SBC_1	122	126	PF00917	0.738
DEG_SPOP_SBC_1	186	190	PF00917	0.710
DOC_CYCLIN_yClb3_PxF_3	162	168	PF00134	0.715
DOC_MAPK_gen_1	247	255	PF00069	0.780
DOC_PP1_RVXF_1	250	256	PF00149	0.768
DOC_PP1_RVXF_1	45	52	PF00149	0.378
DOC_PP2B_PxIxI_1	37	43	PF00149	0.536
DOC_USP7_MATH_1	215	219	PF00917	0.687
DOC_USP7_MATH_1	25	29	PF00917	0.497
DOC_WW_Pin1_4	109	114	PF00397	0.728
DOC_WW_Pin1_4	118	123	PF00397	0.649
DOC_WW_Pin1_4	131	136	PF00397	0.688
DOC_WW_Pin1_4	190	195	PF00397	0.774
DOC_WW_Pin1_4	216	221	PF00397	0.813
DOC_WW_Pin1_4	234	239	PF00397	0.647
DOC_WW_Pin1_4	34	39	PF00397	0.536
LIG_14-3-3_CanoR_1	108	113	PF00244	0.698
LIG_14-3-3_CanoR_1	147	152	PF00244	0.767
LIG_14-3-3_CanoR_1	227	231	PF00244	0.778
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_FHA_1	123	129	PF00498	0.727
LIG_FHA_1	35	41	PF00498	0.494
LIG_FHA_2	15	21	PF00498	0.465
LIG_FHA_2	238	244	PF00498	0.776
LIG_LIR_Nem_3	85	91	PF02991	0.678
LIG_PDZ_Class_2	253	258	PF00595	0.757
LIG_Pex14_1	89	93	PF04695	0.570
LIG_Pex14_2	52	56	PF04695	0.393
LIG_PTB_Apo_2	177	184	PF02174	0.774
LIG_PTB_Apo_2	3	10	PF02174	0.499
LIG_PTB_Phospho_1	177	183	PF10480	0.773
LIG_SH2_STAT5	183	186	PF00017	0.774
LIG_SH2_STAT5	195	198	PF00017	0.668
LIG_SH3_2	242	247	PF14604	0.808
LIG_SH3_3	157	163	PF00018	0.775
LIG_SH3_3	166	172	PF00018	0.679
LIG_SH3_3	211	217	PF00018	0.748
LIG_SH3_3	229	235	PF00018	0.707
LIG_SH3_3	239	245	PF00018	0.744
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.536
LIG_WRC_WIRS_1	72	77	PF05994	0.515
MOD_CK1_1	107	113	PF00069	0.788
MOD_CK1_1	190	196	PF00069	0.798
MOD_CK1_1	237	243	PF00069	0.740
MOD_CK1_1	251	257	PF00069	0.655
MOD_CK1_1	34	40	PF00069	0.493
MOD_CK2_1	14	20	PF00069	0.459
MOD_CK2_1	237	243	PF00069	0.778
MOD_CK2_1	24	30	PF00069	0.402
MOD_GlcNHglycan	189	192	PF01048	0.534
MOD_GSK3_1	104	111	PF00069	0.687
MOD_GSK3_1	118	125	PF00069	0.679
MOD_GSK3_1	147	154	PF00069	0.751
MOD_GSK3_1	186	193	PF00069	0.710
MOD_GSK3_1	234	241	PF00069	0.720
MOD_GSK3_1	67	74	PF00069	0.295
MOD_N-GLC_1	42	47	PF02516	0.672
MOD_N-GLC_1	98	103	PF02516	0.427
MOD_NEK2_1	67	72	PF00069	0.305
MOD_NEK2_2	204	209	PF00069	0.745
MOD_PIKK_1	129	135	PF00454	0.728
MOD_PIKK_1	151	157	PF00454	0.746
MOD_PK_1	141	147	PF00069	0.752
MOD_PKA_1	108	114	PF00069	0.690
MOD_PKA_1	248	254	PF00069	0.782
MOD_PKA_2	107	113	PF00069	0.735
MOD_PKA_2	151	157	PF00069	0.769
MOD_PKA_2	223	229	PF00069	0.778
MOD_PKA_2	248	254	PF00069	0.782
MOD_Plk_1	98	104	PF00069	0.590
MOD_Plk_4	204	210	PF00069	0.747
MOD_Plk_4	251	257	PF00069	0.758
MOD_Plk_4	67	73	PF00069	0.333
MOD_Plk_4	98	104	PF00069	0.606
MOD_ProDKin_1	109	115	PF00069	0.732
MOD_ProDKin_1	118	124	PF00069	0.649
MOD_ProDKin_1	131	137	PF00069	0.688
MOD_ProDKin_1	190	196	PF00069	0.776
MOD_ProDKin_1	216	222	PF00069	0.814
MOD_ProDKin_1	234	240	PF00069	0.647
MOD_ProDKin_1	34	40	PF00069	0.536
MOD_SUMO_for_1	82	85	PF00179	0.688
TRG_ENDOCYTIC_2	88	91	PF00928	0.675
TRG_ER_diArg_1	246	249	PF00400	0.802

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H588	Leishmania donovani	100%	100%
A4H444	Leishmania braziliensis	57%	99%
E9AK05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q9U191	Leishmania major	91%	100%