LeishMANIAdb
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Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania infantum
UniProt:
A4HS16_LEIIN
TriTrypDb:
LINF_040007200
Length:
290

Annotations

Annotations by Jardim et al.

Plasma membrane, Surface antigen-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 1
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4HS16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 260 262 PF00675 0.716
CLV_NRD_NRD_1 55 57 PF00675 0.515
CLV_PCSK_KEX2_1 12 14 PF00082 0.651
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.651
DEG_SPOP_SBC_1 136 140 PF00917 0.420
DEG_SPOP_SBC_1 141 145 PF00917 0.402
DEG_SPOP_SBC_1 163 167 PF00917 0.478
DEG_SPOP_SBC_1 180 184 PF00917 0.414
DOC_CKS1_1 77 82 PF01111 0.370
DOC_MAPK_gen_1 12 20 PF00069 0.610
DOC_MAPK_gen_1 56 63 PF00069 0.363
DOC_MAPK_MEF2A_6 13 22 PF00069 0.526
DOC_USP7_MATH_1 137 141 PF00917 0.468
DOC_USP7_MATH_1 181 185 PF00917 0.532
DOC_USP7_MATH_1 223 227 PF00917 0.379
DOC_USP7_MATH_1 237 241 PF00917 0.367
DOC_USP7_MATH_1 260 264 PF00917 0.436
DOC_USP7_MATH_1 44 48 PF00917 0.335
DOC_WW_Pin1_4 150 155 PF00397 0.465
DOC_WW_Pin1_4 268 273 PF00397 0.448
DOC_WW_Pin1_4 6 11 PF00397 0.482
DOC_WW_Pin1_4 73 78 PF00397 0.373
LIG_14-3-3_CanoR_1 242 250 PF00244 0.355
LIG_BIR_II_1 1 5 PF00653 0.490
LIG_FHA_1 106 112 PF00498 0.259
LIG_FHA_1 170 176 PF00498 0.459
LIG_FHA_1 203 209 PF00498 0.348
LIG_FHA_1 269 275 PF00498 0.276
LIG_FHA_1 91 97 PF00498 0.371
LIG_FHA_2 77 83 PF00498 0.370
LIG_LIR_Gen_1 253 260 PF02991 0.361
LIG_LIR_Nem_3 253 259 PF02991 0.427
LIG_LIR_Nem_3 38 43 PF02991 0.355
LIG_LYPXL_yS_3 117 120 PF13949 0.371
LIG_LYPXL_yS_3 40 43 PF13949 0.382
LIG_SH2_CRK 256 260 PF00017 0.361
LIG_SH2_NCK_1 256 260 PF00017 0.361
LIG_SH2_SRC 89 92 PF00017 0.310
LIG_SH2_STAP1 204 208 PF00017 0.351
LIG_SH2_STAP1 250 254 PF00017 0.351
LIG_SH2_STAP1 71 75 PF00017 0.318
LIG_SH2_STAT5 123 126 PF00017 0.485
LIG_SH2_STAT5 204 207 PF00017 0.347
LIG_SH2_STAT5 256 259 PF00017 0.355
LIG_SH3_1 85 91 PF00018 0.323
LIG_SH3_3 108 114 PF00018 0.323
LIG_SH3_3 74 80 PF00018 0.410
LIG_SH3_3 85 91 PF00018 0.347
LIG_SUMO_SIM_par_1 28 33 PF11976 0.531
LIG_SUMO_SIM_par_1 59 65 PF11976 0.360
LIG_SxIP_EBH_1 252 262 PF03271 0.370
LIG_TYR_ITIM 115 120 PF00017 0.376
LIG_TYR_ITIM 254 259 PF00017 0.362
LIG_UBA3_1 60 68 PF00899 0.351
MOD_CDC14_SPxK_1 9 12 PF00782 0.480
MOD_CDK_SPxK_1 6 12 PF00069 0.483
MOD_CDK_SPxxK_3 6 13 PF00069 0.483
MOD_CK1_1 140 146 PF00069 0.543
MOD_CK1_1 153 159 PF00069 0.463
MOD_CK1_1 184 190 PF00069 0.416
MOD_CK1_1 263 269 PF00069 0.405
MOD_CK1_1 62 68 PF00069 0.338
MOD_CK1_1 76 82 PF00069 0.363
MOD_CK2_1 241 247 PF00069 0.362
MOD_CK2_1 76 82 PF00069 0.368
MOD_GlcNHglycan 1 4 PF01048 0.602
MOD_GlcNHglycan 139 142 PF01048 0.698
MOD_GlcNHglycan 183 186 PF01048 0.640
MOD_GlcNHglycan 210 213 PF01048 0.605
MOD_GlcNHglycan 217 220 PF01048 0.541
MOD_GlcNHglycan 262 265 PF01048 0.685
MOD_GlcNHglycan 32 35 PF01048 0.606
MOD_GSK3_1 126 133 PF00069 0.481
MOD_GSK3_1 136 143 PF00069 0.426
MOD_GSK3_1 144 151 PF00069 0.493
MOD_GSK3_1 153 160 PF00069 0.463
MOD_GSK3_1 162 169 PF00069 0.431
MOD_GSK3_1 170 177 PF00069 0.528
MOD_GSK3_1 180 187 PF00069 0.439
MOD_GSK3_1 223 230 PF00069 0.443
MOD_GSK3_1 237 244 PF00069 0.307
MOD_GSK3_1 250 257 PF00069 0.343
MOD_GSK3_1 69 76 PF00069 0.370
MOD_N-GLC_1 237 242 PF02516 0.516
MOD_N-GLC_2 241 243 PF02516 0.557
MOD_NEK2_1 215 220 PF00069 0.337
MOD_NEK2_1 252 257 PF00069 0.376
MOD_NEK2_1 30 35 PF00069 0.529
MOD_OFUCOSY 190 195 PF10250 0.569
MOD_OFUCOSY 221 227 PF10250 0.692
MOD_PKA_2 241 247 PF00069 0.321
MOD_PKA_2 260 266 PF00069 0.514
MOD_Plk_1 45 51 PF00069 0.353
MOD_Plk_4 119 125 PF00069 0.387
MOD_ProDKin_1 150 156 PF00069 0.464
MOD_ProDKin_1 268 274 PF00069 0.293
MOD_ProDKin_1 6 12 PF00069 0.483
MOD_ProDKin_1 73 79 PF00069 0.377
TRG_ENDOCYTIC_2 117 120 PF00928 0.371
TRG_ENDOCYTIC_2 256 259 PF00928 0.355
TRG_ENDOCYTIC_2 40 43 PF00928 0.382

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZJ5 Leptomonas seymouri 32% 100%
A0A3S5H586 Leishmania donovani 92% 100%
A4H439 Leishmania braziliensis 25% 92%
A4H446 Leishmania braziliensis 30% 100%
E9AK03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
Q9XZY1 Leishmania major 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS