Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS10_LEIIN

TriTrypDb:

LINF_040006500

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.694
CLV_NRD_NRD_1	241	243	PF00675	0.743
CLV_NRD_NRD_1	267	269	PF00675	0.483
CLV_NRD_NRD_1	28	30	PF00675	0.614
CLV_NRD_NRD_1	420	422	PF00675	0.424
CLV_NRD_NRD_1	429	431	PF00675	0.539
CLV_PCSK_FUR_1	149	153	PF00082	0.637
CLV_PCSK_KEX2_1	151	153	PF00082	0.694
CLV_PCSK_KEX2_1	182	184	PF00082	0.737
CLV_PCSK_KEX2_1	267	269	PF00082	0.483
CLV_PCSK_KEX2_1	28	30	PF00082	0.614
CLV_PCSK_KEX2_1	420	422	PF00082	0.424
CLV_PCSK_KEX2_1	429	431	PF00082	0.539
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.602
CLV_PCSK_PC7_1	178	184	PF00082	0.595
CLV_PCSK_SKI1_1	226	230	PF00082	0.661
CLV_PCSK_SKI1_1	267	271	PF00082	0.681
DEG_APCC_DBOX_1	266	274	PF00400	0.534
DEG_APCC_KENBOX_2	66	70	PF00400	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_SCF_FBW7_1	188	193	PF00400	0.647
DOC_MAPK_gen_1	314	323	PF00069	0.469
DOC_MAPK_gen_1	404	414	PF00069	0.468
DOC_MAPK_gen_1	420	426	PF00069	0.334
DOC_MAPK_MEF2A_6	197	205	PF00069	0.629
DOC_PP2B_PxIxI_1	200	206	PF00149	0.628
DOC_USP7_MATH_1	159	163	PF00917	0.606
DOC_USP7_MATH_1	176	180	PF00917	0.740
DOC_USP7_MATH_1	277	281	PF00917	0.518
DOC_USP7_MATH_1	344	348	PF00917	0.442
DOC_USP7_MATH_1	384	388	PF00917	0.527
DOC_USP7_UBL2_3	67	71	PF12436	0.502
DOC_WW_Pin1_4	16	21	PF00397	0.578
DOC_WW_Pin1_4	186	191	PF00397	0.709
DOC_WW_Pin1_4	192	197	PF00397	0.646
DOC_WW_Pin1_4	257	262	PF00397	0.532
LIG_14-3-3_CanoR_1	232	237	PF00244	0.609
LIG_14-3-3_CanoR_1	353	357	PF00244	0.618
LIG_14-3-3_CanoR_1	93	101	PF00244	0.589
LIG_Actin_WH2_2	213	228	PF00022	0.621
LIG_Actin_WH2_2	389	406	PF00022	0.464
LIG_BIR_III_2	21	25	PF00653	0.586
LIG_BRCT_BRCA1_1	168	172	PF00533	0.519
LIG_eIF4E_1	115	121	PF01652	0.544
LIG_FHA_1	13	19	PF00498	0.568
LIG_FHA_1	276	282	PF00498	0.560
LIG_FHA_1	388	394	PF00498	0.427
LIG_FHA_1	398	404	PF00498	0.407
LIG_FHA_2	100	106	PF00498	0.574
LIG_FHA_2	187	193	PF00498	0.692
LIG_FHA_2	52	58	PF00498	0.584
LIG_GBD_Chelix_1	281	289	PF00786	0.443
LIG_HCF-1_HBM_1	212	215	PF13415	0.541
LIG_LIR_Gen_1	110	121	PF02991	0.671
LIG_LIR_Nem_3	110	116	PF02991	0.516
LIG_LIR_Nem_3	367	372	PF02991	0.637
LIG_LIR_Nem_3	413	417	PF02991	0.339
LIG_SH2_CRK	328	332	PF00017	0.357
LIG_SH2_CRK	83	87	PF00017	0.505
LIG_SH2_STAT5	115	118	PF00017	0.512
LIG_SH2_STAT5	215	218	PF00017	0.622
LIG_SH2_STAT5	417	420	PF00017	0.373
LIG_SH2_STAT5	427	430	PF00017	0.533
LIG_SH3_3	329	335	PF00018	0.444
LIG_SH3_3	354	360	PF00018	0.614
LIG_SUMO_SIM_par_1	13	19	PF11976	0.572
LIG_TRAF2_1	209	212	PF00917	0.651
LIG_TYR_ITIM	81	86	PF00017	0.474
MOD_CDK_SPK_2	192	197	PF00069	0.531
MOD_CK1_1	195	201	PF00069	0.679
MOD_CK1_1	204	210	PF00069	0.635
MOD_CK1_1	302	308	PF00069	0.540
MOD_CK1_1	348	354	PF00069	0.533
MOD_CK1_1	387	393	PF00069	0.435
MOD_CK2_1	126	132	PF00069	0.582
MOD_CK2_1	186	192	PF00069	0.667
MOD_CK2_1	252	258	PF00069	0.608
MOD_CK2_1	47	53	PF00069	0.503
MOD_GlcNHglycan	161	164	PF01048	0.736
MOD_GlcNHglycan	226	229	PF01048	0.699
MOD_GlcNHglycan	34	37	PF01048	0.653
MOD_GlcNHglycan	350	353	PF01048	0.622
MOD_GlcNHglycan	360	363	PF01048	0.551
MOD_GlcNHglycan	49	52	PF01048	0.362
MOD_GSK3_1	12	19	PF00069	0.591
MOD_GSK3_1	134	141	PF00069	0.655
MOD_GSK3_1	174	181	PF00069	0.612
MOD_GSK3_1	186	193	PF00069	0.752
MOD_GSK3_1	20	27	PF00069	0.577
MOD_GSK3_1	234	241	PF00069	0.673
MOD_GSK3_1	32	39	PF00069	0.574
MOD_GSK3_1	344	351	PF00069	0.483
MOD_GSK3_1	383	390	PF00069	0.609
MOD_GSK3_1	47	54	PF00069	0.353
MOD_N-GLC_1	24	29	PF02516	0.584
MOD_N-GLC_1	348	353	PF02516	0.519
MOD_NEK2_1	370	375	PF00069	0.581
MOD_NEK2_1	47	52	PF00069	0.395
MOD_NEK2_1	85	90	PF00069	0.479
MOD_NEK2_2	51	56	PF00069	0.424
MOD_PIKK_1	85	91	PF00454	0.526
MOD_PIKK_1	92	98	PF00454	0.562
MOD_PKA_2	137	143	PF00069	0.600
MOD_PKA_2	150	156	PF00069	0.628
MOD_PKA_2	231	237	PF00069	0.607
MOD_PKA_2	275	281	PF00069	0.615
MOD_PKA_2	302	308	PF00069	0.567
MOD_PKA_2	345	351	PF00069	0.483
MOD_PKA_2	352	358	PF00069	0.602
MOD_PKA_2	428	434	PF00069	0.602
MOD_PKA_2	92	98	PF00069	0.570
MOD_PKA_2	99	105	PF00069	0.642
MOD_PKB_1	59	67	PF00069	0.530
MOD_Plk_2-3	252	258	PF00069	0.576
MOD_Plk_4	12	18	PF00069	0.572
MOD_Plk_4	277	283	PF00069	0.462
MOD_Plk_4	285	291	PF00069	0.388
MOD_Plk_4	389	395	PF00069	0.475
MOD_ProDKin_1	16	22	PF00069	0.577
MOD_ProDKin_1	186	192	PF00069	0.711
MOD_ProDKin_1	257	263	PF00069	0.523
TRG_DiLeu_BaEn_4	211	217	PF01217	0.566
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.503
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.530
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.422
TRG_ENDOCYTIC_2	328	331	PF00928	0.356
TRG_ENDOCYTIC_2	83	86	PF00928	0.506
TRG_ER_diArg_1	143	146	PF00400	0.668
TRG_ER_diArg_1	149	152	PF00400	0.713
TRG_ER_diArg_1	267	269	PF00400	0.474
TRG_ER_diArg_1	420	422	PF00400	0.418
TRG_ER_diArg_1	429	432	PF00400	0.537
TRG_ER_FFAT_2	169	177	PF00635	0.527
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVL6	Leptomonas seymouri	35%	100%
A0A3S5H580	Leishmania donovani	99%	100%
A4H3T5	Leishmania braziliensis	60%	100%
E9ACP7	Leishmania major	89%	100%
E9AJZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%