Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS03_LEIIN

TriTrypDb:

LINF_040005800

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS03

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.283
CLV_NRD_NRD_1	18	20	PF00675	0.493
CLV_PCSK_KEX2_1	134	136	PF00082	0.300
CLV_PCSK_KEX2_1	18	20	PF00082	0.465
CLV_PCSK_SKI1_1	209	213	PF00082	0.528
DOC_CYCLIN_RxL_1	59	70	PF00134	0.397
DOC_WW_Pin1_4	237	242	PF00397	0.529
LIG_14-3-3_CanoR_1	18	26	PF00244	0.465
LIG_14-3-3_CanoR_1	233	238	PF00244	0.437
LIG_14-3-3_CanoR_1	49	57	PF00244	0.434
LIG_Actin_WH2_2	119	136	PF00022	0.243
LIG_APCC_ABBA_1	140	145	PF00400	0.453
LIG_FHA_1	194	200	PF00498	0.377
LIG_FHA_1	234	240	PF00498	0.496
LIG_FHA_1	58	64	PF00498	0.479
LIG_FHA_2	19	25	PF00498	0.485
LIG_LIR_Apic_2	196	200	PF02991	0.364
LIG_LIR_Gen_1	100	110	PF02991	0.506
LIG_LIR_Gen_1	198	206	PF02991	0.530
LIG_LIR_Gen_1	23	34	PF02991	0.403
LIG_LIR_Nem_3	100	105	PF02991	0.400
LIG_LIR_Nem_3	138	143	PF02991	0.457
LIG_LIR_Nem_3	186	192	PF02991	0.461
LIG_LIR_Nem_3	198	204	PF02991	0.323
LIG_LIR_Nem_3	222	226	PF02991	0.424
LIG_LIR_Nem_3	229	235	PF02991	0.340
LIG_LIR_Nem_3	23	29	PF02991	0.401
LIG_LIR_Nem_3	90	96	PF02991	0.533
LIG_Pex14_1	16	20	PF04695	0.405
LIG_Pex14_1	197	201	PF04695	0.399
LIG_Pex14_2	140	144	PF04695	0.531
LIG_SH2_CRK	102	106	PF00017	0.370
LIG_SH2_CRK	223	227	PF00017	0.432
LIG_SH2_CRK	93	97	PF00017	0.482
LIG_SH2_STAP1	102	106	PF00017	0.462
LIG_SH2_STAP1	235	239	PF00017	0.493
LIG_SH2_STAP1	81	85	PF00017	0.529
LIG_SH2_STAT3	10	13	PF00017	0.448
LIG_SH2_STAT3	48	51	PF00017	0.529
LIG_SH2_STAT5	20	23	PF00017	0.480
LIG_SH2_STAT5	201	204	PF00017	0.436
LIG_SH2_STAT5	206	209	PF00017	0.401
LIG_SH2_STAT5	235	238	PF00017	0.410
LIG_SH3_1	113	119	PF00018	0.405
LIG_SH3_3	113	119	PF00018	0.522
LIG_SH3_3	236	242	PF00018	0.532
LIG_TRAF2_1	11	14	PF00917	0.485
LIG_TRAF2_1	21	24	PF00917	0.441
LIG_TYR_ITIM	199	204	PF00017	0.398
LIG_TYR_ITIM	221	226	PF00017	0.413
LIG_TYR_ITSM	98	105	PF00017	0.507
MOD_CK2_1	18	24	PF00069	0.446
MOD_CK2_1	8	14	PF00069	0.455
MOD_GlcNHglycan	101	105	PF01048	0.494
MOD_GSK3_1	205	212	PF00069	0.553
MOD_GSK3_1	233	240	PF00069	0.502
MOD_GSK3_1	65	72	PF00069	0.358
MOD_N-GLC_1	209	214	PF02516	0.531
MOD_N-GLC_1	219	224	PF02516	0.409
MOD_NEK2_1	204	209	PF00069	0.426
MOD_NEK2_1	57	62	PF00069	0.541
MOD_PKA_1	18	24	PF00069	0.487
MOD_PKA_2	18	24	PF00069	0.442
MOD_PKA_2	51	57	PF00069	0.536
MOD_Plk_1	100	106	PF00069	0.451
MOD_Plk_1	219	225	PF00069	0.506
MOD_Plk_2-3	149	155	PF00069	0.363
MOD_Plk_4	183	189	PF00069	0.521
MOD_Plk_4	28	34	PF00069	0.469
MOD_ProDKin_1	237	243	PF00069	0.542
MOD_SUMO_rev_2	76	86	PF00179	0.545
TRG_ENDOCYTIC_2	102	105	PF00928	0.376
TRG_ENDOCYTIC_2	189	192	PF00928	0.361
TRG_ENDOCYTIC_2	201	204	PF00928	0.322
TRG_ENDOCYTIC_2	223	226	PF00928	0.405
TRG_ENDOCYTIC_2	26	29	PF00928	0.413
TRG_ENDOCYTIC_2	93	96	PF00928	0.489
TRG_ER_diArg_1	133	135	PF00400	0.300
TRG_ER_diArg_1	18	20	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY0	Leptomonas seymouri	70%	100%
A0A0S4IH71	Bodo saltans	43%	93%
A0A0S4J8X8	Bodo saltans	42%	100%
A0A1X0NMV1	Trypanosomatidae	47%	100%
A0A3S5H574	Leishmania donovani	99%	100%
A0A422NN81	Trypanosoma rangeli	44%	100%
A4H3S8	Leishmania braziliensis	86%	100%
C9ZY01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AJZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q95Z88	Leishmania major	93%	100%
V5BI94	Trypanosoma cruzi	45%	100%