LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HS01_LEIIN
TriTrypDb:
LINF_040005600
Length:
529

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 19, 356, 68
Promastigote: 79
Promastigote/Amastigote: 187, 24, 338, 89

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HS01
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS01

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 161 163 PF00675 0.613
CLV_NRD_NRD_1 208 210 PF00675 0.438
CLV_NRD_NRD_1 232 234 PF00675 0.452
CLV_NRD_NRD_1 311 313 PF00675 0.500
CLV_NRD_NRD_1 325 327 PF00675 0.496
CLV_NRD_NRD_1 462 464 PF00675 0.476
CLV_NRD_NRD_1 505 507 PF00675 0.557
CLV_PCSK_KEX2_1 231 233 PF00082 0.459
CLV_PCSK_KEX2_1 311 313 PF00082 0.500
CLV_PCSK_KEX2_1 324 326 PF00082 0.571
CLV_PCSK_KEX2_1 450 452 PF00082 0.510
CLV_PCSK_KEX2_1 462 464 PF00082 0.386
CLV_PCSK_KEX2_1 505 507 PF00082 0.557
CLV_PCSK_PC1ET2_1 231 233 PF00082 0.459
CLV_PCSK_PC1ET2_1 450 452 PF00082 0.480
CLV_PCSK_SKI1_1 147 151 PF00082 0.551
CLV_PCSK_SKI1_1 210 214 PF00082 0.351
CLV_PCSK_SKI1_1 381 385 PF00082 0.537
DEG_APCC_DBOX_1 425 433 PF00400 0.421
DEG_Nend_UBRbox_1 1 4 PF02207 0.553
DOC_CKS1_1 185 190 PF01111 0.478
DOC_CYCLIN_yCln2_LP_2 272 278 PF00134 0.482
DOC_MAPK_gen_1 162 172 PF00069 0.552
DOC_MAPK_gen_1 426 434 PF00069 0.508
DOC_USP7_MATH_1 215 219 PF00917 0.440
DOC_USP7_MATH_1 490 494 PF00917 0.531
DOC_USP7_MATH_1 516 520 PF00917 0.637
DOC_USP7_MATH_1 95 99 PF00917 0.577
DOC_USP7_MATH_2 29 35 PF00917 0.568
DOC_USP7_UBL2_3 137 141 PF12436 0.592
DOC_USP7_UBL2_3 165 169 PF12436 0.499
DOC_USP7_UBL2_3 241 245 PF12436 0.509
DOC_USP7_UBL2_3 443 447 PF12436 0.451
DOC_WW_Pin1_4 184 189 PF00397 0.482
DOC_WW_Pin1_4 21 26 PF00397 0.627
DOC_WW_Pin1_4 324 329 PF00397 0.555
DOC_WW_Pin1_4 344 349 PF00397 0.623
DOC_WW_Pin1_4 65 70 PF00397 0.510
LIG_14-3-3_CanoR_1 2 8 PF00244 0.578
LIG_14-3-3_CanoR_1 225 230 PF00244 0.442
LIG_14-3-3_CanoR_1 311 316 PF00244 0.557
LIG_14-3-3_CanoR_1 350 354 PF00244 0.704
LIG_14-3-3_CanoR_1 381 390 PF00244 0.465
LIG_14-3-3_CanoR_1 505 512 PF00244 0.534
LIG_APCC_ABBAyCdc20_2 10 16 PF00400 0.504
LIG_APCC_ABBAyCdc20_2 415 421 PF00400 0.427
LIG_BRCT_BRCA1_1 507 511 PF00533 0.542
LIG_Clathr_ClatBox_1 417 421 PF01394 0.472
LIG_FHA_1 2 8 PF00498 0.548
LIG_FHA_2 382 388 PF00498 0.465
LIG_FHA_2 66 72 PF00498 0.516
LIG_IBAR_NPY_1 489 491 PF08397 0.525
LIG_LIR_Nem_3 223 229 PF02991 0.453
LIG_SH2_CRK 491 495 PF00017 0.466
LIG_SH2_STAP1 373 377 PF00017 0.460
LIG_SH2_STAP1 491 495 PF00017 0.466
LIG_SH2_STAP1 83 87 PF00017 0.503
LIG_SH3_2 158 163 PF14604 0.598
LIG_SH3_2 69 74 PF14604 0.512
LIG_SH3_3 152 158 PF00018 0.600
LIG_SH3_3 176 182 PF00018 0.534
LIG_SH3_3 360 366 PF00018 0.595
LIG_SH3_3 39 45 PF00018 0.535
LIG_SH3_3 66 72 PF00018 0.511
LIG_SH3_4 165 172 PF00018 0.481
LIG_SH3_4 241 248 PF00018 0.406
LIG_SUMO_SIM_par_1 386 393 PF11976 0.483
LIG_TRAF2_1 267 270 PF00917 0.587
LIG_TRAF2_1 520 523 PF00917 0.503
LIG_TRAF2_1 89 92 PF00917 0.594
LIG_TRAF2_2 512 517 PF00917 0.547
LIG_TRFH_1 33 37 PF08558 0.550
LIG_WW_3 327 331 PF00397 0.554
MOD_CDC14_SPxK_1 327 330 PF00782 0.548
MOD_CDC14_SPxK_1 347 350 PF00782 0.475
MOD_CDK_SPK_2 184 189 PF00069 0.482
MOD_CDK_SPK_2 65 70 PF00069 0.510
MOD_CDK_SPxK_1 324 330 PF00069 0.557
MOD_CDK_SPxK_1 344 350 PF00069 0.626
MOD_CK1_1 338 344 PF00069 0.607
MOD_CK1_1 352 358 PF00069 0.496
MOD_CK1_1 46 52 PF00069 0.575
MOD_CK1_1 500 506 PF00069 0.568
MOD_CK1_1 510 516 PF00069 0.513
MOD_CK2_1 373 379 PF00069 0.472
MOD_CK2_1 381 387 PF00069 0.433
MOD_CK2_1 47 53 PF00069 0.596
MOD_CK2_1 474 480 PF00069 0.428
MOD_CK2_1 523 529 PF00069 0.615
MOD_CK2_1 86 92 PF00069 0.607
MOD_Cter_Amidation 322 325 PF01082 0.538
MOD_GlcNHglycan 258 261 PF01048 0.475
MOD_GlcNHglycan 316 319 PF01048 0.576
MOD_GlcNHglycan 367 370 PF01048 0.543
MOD_GlcNHglycan 373 376 PF01048 0.419
MOD_GlcNHglycan 499 502 PF01048 0.509
MOD_GlcNHglycan 517 521 PF01048 0.471
MOD_GSK3_1 314 321 PF00069 0.596
MOD_GSK3_1 338 345 PF00069 0.563
MOD_GSK3_1 349 356 PF00069 0.639
MOD_GSK3_1 373 380 PF00069 0.467
MOD_GSK3_1 43 50 PF00069 0.567
MOD_GSK3_1 497 504 PF00069 0.646
MOD_GSK3_1 506 513 PF00069 0.595
MOD_GSK3_1 518 525 PF00069 0.510
MOD_GSK3_1 73 80 PF00069 0.623
MOD_N-GLC_1 21 26 PF02516 0.602
MOD_N-GLC_1 353 358 PF02516 0.593
MOD_N-GLC_1 65 70 PF02516 0.510
MOD_NEK2_1 353 358 PF00069 0.661
MOD_NEK2_2 244 249 PF00069 0.390
MOD_NEK2_2 335 340 PF00069 0.557
MOD_PIKK_1 381 387 PF00454 0.412
MOD_PIKK_1 401 407 PF00454 0.486
MOD_PIKK_1 510 516 PF00454 0.596
MOD_PIKK_1 518 524 PF00454 0.571
MOD_PKA_1 140 146 PF00069 0.589
MOD_PKA_1 311 317 PF00069 0.526
MOD_PKA_1 505 511 PF00069 0.555
MOD_PKA_2 1 7 PF00069 0.554
MOD_PKA_2 311 317 PF00069 0.529
MOD_PKA_2 349 355 PF00069 0.760
MOD_PKA_2 359 365 PF00069 0.567
MOD_PKA_2 504 510 PF00069 0.548
MOD_Plk_1 353 359 PF00069 0.570
MOD_Plk_2-3 31 37 PF00069 0.590
MOD_Plk_2-3 48 54 PF00069 0.442
MOD_Plk_2-3 523 529 PF00069 0.563
MOD_Plk_2-3 86 92 PF00069 0.520
MOD_Plk_4 373 379 PF00069 0.418
MOD_Plk_4 490 496 PF00069 0.472
MOD_ProDKin_1 184 190 PF00069 0.476
MOD_ProDKin_1 21 27 PF00069 0.628
MOD_ProDKin_1 324 330 PF00069 0.557
MOD_ProDKin_1 344 350 PF00069 0.626
MOD_ProDKin_1 65 71 PF00069 0.512
MOD_SUMO_for_1 37 40 PF00179 0.486
MOD_SUMO_rev_2 143 152 PF00179 0.567
MOD_SUMO_rev_2 202 212 PF00179 0.405
MOD_SUMO_rev_2 31 39 PF00179 0.497
TRG_DiLeu_BaEn_1 413 418 PF01217 0.476
TRG_DiLeu_BaLyEn_6 302 307 PF01217 0.482
TRG_ENDOCYTIC_2 491 494 PF00928 0.516
TRG_ER_diArg_1 324 326 PF00400 0.543
TRG_NES_CRM1_1 423 435 PF08389 0.421
TRG_NLS_MonoCore_2 161 166 PF00514 0.605
TRG_NLS_MonoExtC_3 161 166 PF00514 0.557
TRG_NLS_MonoExtN_4 137 143 PF00514 0.588
TRG_NLS_MonoExtN_4 161 167 PF00514 0.600
TRG_Pf-PMV_PEXEL_1 287 291 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.359
TRG_Pf-PMV_PEXEL_1 381 385 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 422 427 PF00026 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H573 Leishmania donovani 99% 100%
A4H3S6 Leishmania braziliensis 58% 100%
E9AJY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q95Z90 Leishmania major 88% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS