Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HS00_LEIIN

TriTrypDb:

LINF_040005500

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HS00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HS00

PDB structure(s): 7aih_BA , 7am2_BA , 7ane_BA

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.405
CLV_NRD_NRD_1	77	79	PF00675	0.432
CLV_PCSK_KEX2_1	131	133	PF00082	0.405
CLV_PCSK_KEX2_1	17	19	PF00082	0.440
CLV_PCSK_KEX2_1	77	79	PF00082	0.442
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.440
CLV_PCSK_SKI1_1	53	57	PF00082	0.554
CLV_PCSK_SKI1_1	80	84	PF00082	0.588
DOC_CYCLIN_RxL_1	51	60	PF00134	0.463
DOC_CYCLIN_RxL_1	77	84	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.413
DOC_MAPK_gen_1	108	115	PF00069	0.498
DOC_MAPK_gen_1	53	59	PF00069	0.551
DOC_USP7_MATH_1	139	143	PF00917	0.297
DOC_USP7_MATH_1	33	37	PF00917	0.620
DOC_USP7_MATH_1	39	43	PF00917	0.539
DOC_USP7_UBL2_3	7	11	PF12436	0.408
DOC_WW_Pin1_4	160	165	PF00397	0.560
DOC_WW_Pin1_4	81	86	PF00397	0.426
LIG_14-3-3_CanoR_1	122	130	PF00244	0.383
LIG_14-3-3_CanoR_1	34	38	PF00244	0.577
LIG_BIR_II_1	1	5	PF00653	0.424
LIG_Clathr_ClatBox_1	56	60	PF01394	0.504
LIG_FHA_2	46	52	PF00498	0.565
LIG_LIR_Gen_1	38	47	PF02991	0.506
LIG_LIR_Nem_3	38	43	PF02991	0.568
LIG_MYND_1	81	85	PF01753	0.410
LIG_SH2_CRK	19	23	PF00017	0.518
LIG_SH2_CRK	40	44	PF00017	0.540
LIG_SH2_STAT5	23	26	PF00017	0.540
LIG_SH3_3	150	156	PF00018	0.475
LIG_SH3_3	99	105	PF00018	0.385
LIG_SUMO_SIM_anti_2	147	154	PF11976	0.531
LIG_SUMO_SIM_par_1	55	60	PF11976	0.464
LIG_SUMO_SIM_par_1	67	74	PF11976	0.294
MOD_CDC14_SPxK_1	163	166	PF00782	0.516
MOD_CDK_SPxK_1	160	166	PF00069	0.511
MOD_CK2_1	103	109	PF00069	0.477
MOD_CK2_1	70	76	PF00069	0.463
MOD_GlcNHglycan	48	51	PF01048	0.516
MOD_GlcNHglycan	63	66	PF01048	0.470
MOD_GlcNHglycan	96	99	PF01048	0.389
MOD_GSK3_1	156	163	PF00069	0.687
MOD_GSK3_1	39	46	PF00069	0.591
MOD_GSK3_1	55	62	PF00069	0.420
MOD_N-GLC_2	125	127	PF02516	0.405
MOD_NEK2_1	43	48	PF00069	0.519
MOD_PKA_2	33	39	PF00069	0.511
MOD_Plk_2-3	70	76	PF00069	0.485
MOD_ProDKin_1	160	166	PF00069	0.562
MOD_ProDKin_1	81	87	PF00069	0.419
MOD_SUMO_rev_2	49	55	PF00179	0.401
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.407
TRG_ENDOCYTIC_2	28	31	PF00928	0.562
TRG_ENDOCYTIC_2	40	43	PF00928	0.419
TRG_ER_diArg_1	130	132	PF00400	0.391
TRG_ER_diArg_1	77	80	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ09	Leptomonas seymouri	69%	97%
A0A1X0NLF4	Trypanosomatidae	50%	100%
A0A3R7KUB4	Trypanosoma rangeli	48%	99%
A0A451EJV1	Leishmania donovani	100%	100%
A4H3S5	Leishmania braziliensis	80%	100%
C9ZXZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ACP5	Leishmania major	95%	100%
E9AJY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%